Clinical trials: Birth
Substance-Related Disorders, Substance Use
Siyakhana Peer: Evaluating a Peer Recovery Coach Model to Reduce Substance Use Stigma in South African HIV Care
Alcohol and other drug use is common among people living with HIV in South Africa and is associated with worse engagement in HIV care.
- Conditions
- Substance-Related Disorders, Substance Use, Substance Use Disorders, Stigma, Social
- Trial name
- NCT05907174
- Testing
- Siyakhana - P
- Where
- South Africa
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Type 1 Diabetes
The International Diabetes Closed Loop (iDCL) Trial: Protocol 4
The investigators aim to compare the efficacy and safety of an AID system using an adaptive MPC algorithm versus SAP (which may or may not include PLGS; to be referred to as SAP) in people with type 1 diabetes.
- Trial name
- DCLP4 (NCT04436796)
- Testing
- interoperable Artificial Pancreas System (iAPS), Sensor-Augmented Pump (SAP)/Predictive Low Glucose Suspend (PLGS)
- Where
- 5 sites in United States
- Volunteers
- 35 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes Mellitus
Automated Insulin Delivery in Elderly With Type 1 Diabetes (AIDE T1D)
A multi-center, randomized, crossover trial consisting of three sequential 12-week periods, with the HCL feature used during one period, the PLGS feature used during one period and SAP therapy (control) during one period.
- Trial name
- AIDE T1D (NCT04016662)
- Testing
- Tandem t:slim X2 with HCL or PLGS
- Where
- 4 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Jaeb Center for Health Research
Growth Hormone Disorder, Growth Hormone Deficiency in Children
Norditropin NordiFlex® Device Compared to the Device Previously Used by Patients or Parents
This study is conducted in Europe. The aim of this study is to compare the easiness of use of Norditropin NordiFlex® device to the device previously used by patients or parents.
- Conditions
- Growth Hormone Disorder, Growth Hormone Deficiency in Children, Foetal Growth Problem, Small for Gestational Age
- Trial name
- NCT01245374
- Testing
- Norditropin NordiFlex®
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Novo Nordisk A/S
Serious Systemic Infections, Necrotizing Enterocolitis
Metronidazole Pharmacokinetics (PK) in Premature Infants
Yearly in the United States over 500,000 newborns are delivered prematurely. This population is at high risk of catastrophic bowel disease known as necrotizing enterocolitis.
- Trial name
- PTN_METRO (NCT01222585)
- Testing
- Metronidazole
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Michael Cohen-Wolkowiez
Small Bowel Disease, Inflammatory Bowel Disease
Evaluation of PillCam® Express Capsule Endoscopy Delivery System
The purpose of this study is to evaluate the safety and efficacy of a trans-endoscopic capsule placement Capsule Endoscopy Delivery System.
- Trial name
- RD-300 (NCT01088646)
- Testing
- PillCam® Express Capsule Endoscopy Delivery System
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Medtronic - MITG
Anxiety
Interpretation Training to Reduce Anxiety: Evaluating Technology-based Delivery Models and Methods to Reduce Attrition
The project aims to compare effectiveness and target engagement of CBM-I delivered via computer vs. mobile phone, and test if adding minimal human contact for participants at risk of dropout improves retention and outcomes.
- Trial name
- NCT03498651
- Testing
- Cognitive Bias Modification - Interpretation training, Coaching, Online psychoeducation about anxiety
- Where
- United States
- Volunteers
- 1,748 people
- Sponsor
- University of Virginia
Length of Pregnancy Prolongation in Hours
Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam
Preterm birth remains a major health concern affecting up to 12% of all live births prior to 37 weeks gestation. As preterm birth can often be associated with infection our proposal is to evaluate in a randomized fashion…
- Trial name
- NCT00589329
- Testing
- erythromycin and metronidazole (antibiotics)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Cesarean Section
Comparison of Surgical Conditions in Cesarean Section Under General Anesthesia With Deep Neuromuscular Blockade Versus Succinylcholine
Cesarean delivery under general anesthesia is one of few only surgical procedures, where the most important factor of safety is the speed of the surgery, as a newborn adaptation strongly depends on a time between induction to the…
- Trial name
- NCT01941628
- Testing
- Rocuronium, Succinylcholine
- Where
- Czechia
- Volunteers
- 91 people
- Sponsor
- Charles University, Czech Republic
Depressive Symptoms, Anxiety
Health Care Workers and Mental Health
The purpose of this proposal is to deploy digital health interventions to bring timely, easily accessible resources and care to address the mental health and well-being needs of HCWs with direct patient care that are experiencing…
- Conditions
- Depressive Symptoms, Anxiety, Well-Being
- Trial name
- NCT05028075
- Testing
- Cobalt +
- Where
- United States
- Volunteers
- 1,275 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hemophilia A
Evaluation Of Acceptability And Satisfaction Of Hemophilia Patients Treated With FusENGO
This study aims to investigate prospectively throughout a period of 3- 6 months and not to exceed 12 months (according to local therapeutic plans) patients experiences of treatment with Factor VIII in the new device named…
- Trial name
- NCT01959919
- Testing
- Refacto FusENGO
- Where
- 19 sites in Italy
- Volunteers
- 86 people
- Sponsor
- Pfizer
Chronic Sinusitis, Polyposis
Nasal Packing as a Drug Delivery System Postoperatively in Chronic Sinusitis With Polyposis
That high-dose steroid applied to the nasal cavity immediately post-operatively will improve olfaction and healing following endoscopic sinus surgery.
- Trial name
- NCT01197612
- Testing
- pulmicort
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan
Venous Thromboembolism
Open Label Study Comparing Efficacy and Safety of Dabigatran Etexilate to Standard of Care in Paediatric Patients With Venous Thromboembolism (VTE)
The main objectives of this large phase IIb/III paediatric study are to assess the efficacy and safety of dabigatran etexilate relative to standard of care and to document the appropriateness of the proposed dabigatran etexilate…
- Trial name
- NCT01895777
- Testing
- dabigatran etexilate, standard of care
- Where
- 65 sites in United States, Argentina and 24 more
- Volunteers
- 267 people
- Sponsor
- Boehringer Ingelheim
Malaria, Human Immunodeficiency Virus
Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE-BC2)
This is a double-blinded, randomized controlled trial of 200 HIV-infected pregnant women living in Tororo, Uganda, an area of high malaria transmission.
- Trial name
- NCT02282293
- Testing
- Monthly dihydroartemisinin-piperaquine (DP) + daily trimethoprim/sulfamethoxazole (TS)
- Where
- Uganda
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Paranasal Sinus Disease
Effectiveness of Antibiotic Delivery Via Bio-absorbable Sponge
This study will evaluate the efficacy of a nasopore sponge dressing soaked in Bacitracin VS a sponge soaked in Saline / and the administration of oral antibiotics.
- Trial name
- NCT01222832
- Testing
- Bacitracin
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Prematurity, Very Low Birth Weight
The Safety Evaluation of Silver Alginate (Algidex™) Dressing in Very Low Birth Weight (VLBW) Infants
The purpose of this study is to test the safety of silver alginate (Algidex™) dressing in VLBW infants in preparation for a large efficacy trial.
- Trial name
- NCT00593684
- Testing
- Silver Alginate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Contraception, Ovulation Inhibition
Efficacy and Safety of Two Flexible Extended Regimens of BAY86-5300 (SH T00186D) in Comparison With the Conventional Regimen of YAZ
The purpose of this study is to determine whether the study drug is safe and effective.
- Conditions
- Contraception, Ovulation Inhibition, Contraceptives, Oral
- Trial name
- NCT00567164
- Testing
- EE20/DRSP (BAY86-5300), EE20/DRSP (YAZ, BAY86-5300)
- Where
- 85 sites in United States
- Volunteers
- 1,887 people, healthy volunteers welcome
- Sponsor
- Bayer
Economics, Fraud
The Effect of Informative Letters on the Prescription and Receipt of Schedule II Controlled Substances
Fraud and waste is estimated to cost the American health care system nearly $200 billion each year, and the public Medicare and Medicaid programs about $60 billion each year.
- Conditions
- Economics, Fraud, Delivery of Health Care, Health Expenditures
- Trial name
- NCT02345434
- Testing
- Informative letter
- Volunteers
- 1,525 people, healthy volunteers welcome
- Sponsor
- Abdul Latif Jameel Poverty Action Lab
Infant, Newborn, Infant, Small for Gestational Age
Donor Milk vs. Formula in Extremely Low Birth Weight (ELBW) Infants
The Milk Trial seeks to determine the effect on neurodevelopmental outcomes at age 22-26 months of donor human milk as compared to preterm infant formula as the in-hospital diet for infants whose mothers choose not to provide…
- Conditions
- Infant, Newborn, Infant, Small for Gestational Age, Infant, Extremely Low Birth Weight
- Trial name
- NCT01534481
- Testing
- Donor Milk, Preterm Formula
- Where
- 17 sites in United States
- Volunteers
- 483 people
- Sponsor
- NICHD Neonatal Research Network
Cataract
Clinical Study to Evaluate the RxSight Light Adjustable Lens With the Light Delivery Device in Subjects With Preoperative Corneal Astigmatism
For patients undergoing cataract surgery, the purpose of this study is to evaluate a patient's far vision without glasses and quality of vision after implantation and UV treatment of the RxSight Light Adjustable Lens…
- Trial name
- NCT03771352
- Testing
- RxSight RxLAL
- Where
- 3 sites in Germany, United Kingdom
- Volunteers
- 55 people
- Sponsor
- RxSight, Inc.