Clinical trials: Bispectral Index
Postoperative Cognitive Dysfunction, Delirium, Postoperative
Evaluation of the Predictive Impact of Serum S100B and S100B Polymorphisms on Postoperative Cognitive Dysfunction and Delirium
Postoperative cognitive disorders, including postoperative cognitive dysfunction (POCD) and postoperative delirium (POD), are common complications following surgery and anesthesia, particularly in vulnerable patient populations.
- Trial name
- NCT07509372
- Testing
- Perioperative Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 137 people
- Sponsor
- Ankara University
Disorder; Mental, Sedative, Depressed Level of Consciousness
Use of Bispectral Index Monitoring to Detect Deep Sedation in Mechanically Ventilated Patients: Validity Study
In the previous study, the investigators obtained the cutoff value of Bispectral Index to detect early deep sedation in patients with mechanical ventilation.
- Conditions
- Disorder; Mental, Sedative, Depressed Level of Consciousness, Mechanical Ventilation Complication, Psychosis Associated With Intensive Care
- Trial name
- NCT02439840
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Capital Medical University
Critical Illness
Combining Objective and Subjective Sedation Assessment Tools
The purpose of this study is to determine if the use of a device called the BIS monitor in addition to the Richmond Agitation Sedation Scale will give better assessment of a subject's level of sedation.
- Trial name
- COST_2 (NCT00734409)
- Testing
- Bispectral Index (BIS) Monitor
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Emergency Airway Management
Bispectral Index and First-Pass Intubation
This prospective observational study aims to evaluate the association between anesthetic depth, measured by the Bispectral Index (BIS), and first-pass endotracheal intubation success in adult patients undergoing rapid sequence…
- Trial name
- NCT07690254
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Akdeniz University Hospital
Consciousness, Level Depressed, Intraoperative Awareness
Awareness During Blended Anaesthesia
the aim of this study was to estimate the relations between Bispectral Index values and explicit or implicit memory or dreams during two different minimal alveolar concentration (MAC) of sevoflurane in patients undergoing blended…
- Trial name
- NCT01800578
- Testing
- monitor for depth of hypnosis
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Germano De Cosmo
Intraoperative Neurophysiological Monitoring
Multi Modal Brain Monitoring and Cardiac Surgery
Multimodal brain monitoring is feasible and can be used in formulating therapeutic strategies during cardiac surgery. Such monitoring may help to improve patient outcome and to reduce costs after cardiac surgery with CPB.
- Trial name
- NCT02916069
- Testing
- Nearinfrared Spectroscopy (NIRS), Transcranial Doppler (TCD), Bispectral index (BIS)
- Where
- Egypt
- Volunteers
- 1,200 people
- Sponsor
- Assiut University
Emergence Agitation
The Effect of Depth of Anesthesia as Measured by Bispectral Index (BIS) on Emergence Agitation in Children
The purpose of this study is to determine whether depth of anesthesia has an effect on emergence agitation (EA) in children age 2 - 8 years old.
- Trial name
- NCT00990769
- Testing
- Depth of anesthesia
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Target Controlled Infusion, Induction of Anesthesia
Slow Stepwise Propofol TCI Induction for Titration Anesthesia Maintenance
The purpose of this study is to determine if a slow stepwise propofol TCI induction with Marsh model (Ke0 0.26), allows for an accurate estimation of the effect site concentration required for maintenance of the general…
- Conditions
- Target Controlled Infusion, Induction of Anesthesia, Bispectral Index
- Trial name
- (TITINDUC) (NCT02999126)
- Testing
- Propofol, Remifentanil Hydrochloride
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital Italiano de Buenos Aires
Strabismus
Propofol Versus Sevoflurane Anesthesia in Pediatric Strabismus Surgery: Feasibility of BIS Monitoring
This study is conducted to evaluate importance of bispectral index (BIS) monitoring in patients undergoing strabismus surgery when using propofol in comparison to sevoflurane anesthesia regarding their effects on oculocardiac…
- Trial name
- NCT04485117
- Testing
- Bispectral Index Monitor, Laryngeal Mask Airway, Sevoflurane
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sameh Fathy
Remimazolam, Total Intravenous Anesthesia
Remimazolam TIVA-Flumazenil Antagonism in Short-duration ENT Surgeries
This study plans to categorize patients who underwent short-duration ENT surgeries with remimazolam TIVA combined with flumazenil antagonism based on whether their intraoperative BIS values were maintained below 60.
- Conditions
- Remimazolam, Total Intravenous Anesthesia, Bispectral Index
- Trial name
- TIVA (NCT07389798)
- Where
- China
- Volunteers
- 511 people
- Sponsor
- Tongji Hospital
Loss of Consciousness at End of Life
Measuring Depth of Unconsciousness at the End of Life Using Bispectral Index (BIS)
The purpose of this study is to use the BIS monitor to assess the degree of consciousness in pre-terminal palliative patients admitted to our palliative care unit and to ascertain if this tool provides a more accurate assessment…
- Trial name
- BISSOPS (NCT01768416)
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Ghent
One-Lung Ventilation
Estimating Blood Concentrations of Anaesthetics During One-Lung Ventilation (OLV)
The aims of the study is to determine if end-tidal concentrations of the anaesthetic gases isoflurane and sevoflurane as measured by a standard gas monitor are related to the blood levels during one-lung ventilation.
- Trial name
- NCT02821455
- Testing
- Lung Surgery with One-Lung Ventilation
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Edinburgh
General Anesthesia, Intraoperative Monitoring
Equivalent MAC in General Anesthesia
This observational study aims to evaluate the clinical applicability of the Equivalent Minimum Alveolar Concentration (eMAC) parameter during general anesthesia.
- Conditions
- General Anesthesia, Intraoperative Monitoring, Anesthetic Depth
- Trial name
- NCT07197567
- Testing
- Sevoflurane + Remifentanil, Sevoflurane + Propofol + Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Breast Cancer, General Anaesthesia
Effect of Rocuronium on BIS Values
Aim of this trial is to define if Trend of Four (TOF) values after a bolus of rocuronium is correlated with Bispectral Index BIS values during standard general anaesthesia for breast surgery.
- Trial name
- NCT05681611
- Testing
- Rocuronium
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- University of Padova
Knee Osteoarthritis, Replacement, Knee
Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.
The goal of this clinical trial is to determine the appropriate Bispectral Index (BIS) range and propofol effect-site concentration required to maintain adequate anesthesia depth during total intravenous anesthesia (TIVA)…
- Conditions
- Knee Osteoarthritis, Replacement, Knee, Elective Surgical Patients, ASA Class I/II Patients
- Trial name
- NCT07736352
- Testing
- Propofol + Remifentanil +Midazolam, Propofol + Remifentanil + Dexmedetomidine, Propofol + Remifentanil + Esketamine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Healthy Participants Study, General Anesthesia
Safety, Pharmacokinetics, and Pharmacodynamics of Continuous KL0011034 Infusion in Healthy Chinese Adults
This Phase 1 study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of continuous intravenous infusion of KL0011034 Injection in healthy Chinese adults.
- Trial name
- NCT07841626
- Testing
- KL0011034 Injection, Propofol Injectable Emulsion
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Conscious Sedation
Closed-loop Sedation of Propofol for Patients Undergoing Spinal Anesthesia
The purpose of this study is to compare the administration of a standard anesthetic drug (propofol) using an automatic, expert-based system versus a manually controlled system by the anesthesiologist.
- Trial name
- NCT01020643
- Testing
- controlled administration of propofol
- Where
- Canada
- Volunteers
- 203 people
- Sponsor
- Thomas Hemmerling
Ventilation
Bispectral Index (BIS) on Ventilated Patients in the Prehospital Setting
To evaluate the effectiveness of use of the bispectral index for monitoring of depth of sedation in ventilated patients during their prehospital management by a physician- staffed EMS.
- Trial name
- OHBIS (NCT00919971)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Beaujon Hospital
Bronchoscopy
Narcotrend Versus Bispectral Index Monitoring During Sufentanil-Midazolam Anesthesia for Bronchoscopy
This study was aimed to determine whether narcotrend monitoring was better than bispectral index monitoring during sufentanil-midazolam anesthesia for bronchoscopy under conscious sedation.
- Trial name
- NCT03738137
- Testing
- Narotrend, BIS, Sufentanil
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Acute Neurological Insult
Comparing Simplified EEG Monitoring Tool With Standard EEG Monitoring in Patients With Acute Neurological Insult
After any acute brain injury, a primary pathophysiological response arises, enabling the brain to develop seizures and/or a status epilepticus (SE).
- Trial name
- NCT02545816
- Testing
- Bispectral index (BIS) EEG monitoring
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Hasselt University