Clinical trials: Bite Block, active
Stroke, Acute Ischemic, Medium Vessel Occlusion
INTRA-ARTERIAL MeVO TREATMENT (IMP-ACT) Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
This domain will be conducted as part of ACT-GLOBAL platform trial and will have the nested domain name of IMP-ACT. Acute ischemic stroke (AIS) caused by intracranial arterial occlusion remains a major cause of disability and…
- Trial name
- IMP-ACT (NCT07906275)
- Testing
- Mechanical Endovascular Thrombectomy, Intravenous Thrombolysis, Tenecteplase/Alteplase- depending upon availability at each treating centre
- Where
- 4 sites in Canada
- Volunteers
- 800 people
- Sponsor
- University of Calgary
Stroke Ischemic, Medium Vessel Occlusions
Advancing Reperfusion Therapy for Ischemic Stroke: Perfusion-guided Endovascular Intervention for Medium Vessel Occlusion Therapy
The investigators initiated a multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled trial to evaluate the efficacy and safety of perfusion-guided endovascular treatment (EVT) compared to standard…
- Trial name
- ARTS-PIVOT (NCT07323368)
- Testing
- Endovascular treatment, Best medical treatment (BMT)
- Where
- 6 sites in China
- Volunteers
- 568 people
- Sponsor
- Beijing Tiantan Hospital
Colorectal Cancer, Neoadjuvant Chemotherapy
Camrelizumab Combined With Neoadjuvant Chemotherapy After Stent Placement for Left-Sided Obstructive Colonic Cancer
Patients with obstruction are associated with worse oncologic outcomes compared with those having nonobstructive tumors. Conventionally, patients with malignant large bowel obstruction receive emergency surgery, with morbidity…
- Conditions
- Colorectal Cancer, Neoadjuvant Chemotherapy, Stent, Obstruction
- Trial name
- NACSOC-02 (NCT05202314)
- Testing
- Immunotherapy (Camrelizumab)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Chao Yang Hospital
Coronary Chronic Total Occlusions
The Prospective Segeberg Registry for Coronary Chronic Total Occlusions (CTO)
A Prospective Follow-up Assessment in Bad Segeberg with Patients undergoing Recanalization for Coronary Chronic Total Occlusion Lesion/s
- Trial name
- CTO Registry (NCT06957613)
- Testing
- Revascularization/Conservative management
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Segeberger Kliniken GmbH
Chronic Total Occlusion
Antiplatelet Therapy After Successful Percutaneous Coronary Intervention for Chronically Occluded Coronary Artery
Coronary arteries are in charge of oxygen supply for the myocardium. When coronary arteries develop stenosis the coronary blood flow (i.e. oxygen flow) is reduced.
- Trial name
- DAPT-CTO (NCT06175377)
- Testing
- Percutaneous coronary intervention, Short dual Aspirin/Clopidogrel therapy, Long dual Aspirin/Clopidogrel therapy
- Volunteers
- 660 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Ischemic Stroke
Rescue Distal Thrombectomy in Treatment for Persistent Distal Occlusions
The goal of this clinical trial is to determine whether rescue distal mechanical thrombectomy can improve outcomes in patients with persistent distal occlusions after successful proximal mechanical thrombectomy for acute ischemic…
- Trial name
- 2BE3-PhaseII (NCT07533253)
- Testing
- Proximal mechanical thrombectomy, Rescue distal mechanical thrombectomy, Conservative management
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Total Knee Anthroplasty, Postoperative Pain
Proximal Spread in Adductor Canal Block(ACB)
This prospective, randomized clinical study is designed to evaluate the effects of two different injection levels of adductor canal block (ACB) on the proximal spread of local anesthetic and clinical outcomes in patients…
- Trial name
- ACB (NCT07595471)
- Testing
- Comparison of Proximal Adductor Canal Block, Comparison True Distal Adductor Canal Block.
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Ankara Etlik City Hospital
Venous Thromboses, Venous Disease
The GORE® VIABAHN® FORTEGRA Venous Stent IVC Study
This study is a prospective, multicenter, non-randomized, single-arm study to evaluate the performance, safety, and efficacy of the GORE® VIABAHN® FORTEGRA Venous Stent (formerly known as GORE® VIAFORT Vascular Stent) for…
- Conditions
- Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis
- Trial name
- NCT05409976
- Testing
- GORE® VIAFORT Vascular Stent
- Where
- 17 sites in United States, Australia and 5 more
- Volunteers
- 136 people
- Sponsor
- W.L.Gore & Associates
Pain, Postoperative
Pain Management Study
This study aims to better understand the role that narcotic vs. non-narcotic multimodal pain management play in patients' pain following bariatric surgery (Laproscopic Surgery and Robotic Assisted Surgery).
- Trial name
- NCT05231460
- Testing
- Active Comparator: narcotic regimen with TAP block, Active Comparator: narcotic regimen with no TAP block, non-narcotic regimen with TAP block
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- University of Arizona
Cholangiocarcinoma, Klatskin Tumor
Endoscopic Radiofrequency Ablation for Unresectable Cholangiocarcinoma
The goal of this clinical trial is to learn about radiofrequency ablation in patients with unresectable bile duct cancer who receive systemic chemotherapy and bile duct stenting.
- Conditions
- Cholangiocarcinoma, Klatskin Tumor, Bile Duct Cancer, Liver Cancer
- Trial name
- ACTICCA-2 (NCT06175845)
- Testing
- Intraductal biliary radiofrequency ablation
- Where
- 9 sites in Germany
- Volunteers
- 130 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Stroke, Ischemic, Medium Vessel Occlusions
Advancing Reperfusion Therapy for Ischemic Stroke (ARTS): Tenecteplase in Medium Vessel Occlusion (MeVO) for Acute Ischemic Stroke
Results from recent several trials provided data showing limits to the effectiveness of thrombectomy for ischemic stroke due to medium vessel occlusions.The benefit-risk profile of thrombolysis for these patients has never been…
- Trial name
- ARTS-MeVO (NCT07047014)
- Testing
- Tenecteplase (0.25mg/kg), Standard medical treatment
- Where
- 7 sites in China
- Volunteers
- 596 people
- Sponsor
- Beijing Tiantan Hospital
Intensive Care Unit, Intraventricular Hemorrhage
Prediction of Undesired Obstruction in External Ventricular Drains.
Acute obstructive hydrocephalus often complicates intraventricular hemorrhage (IVH). The insertion of an external ventricular drain (EVD) is typically necessary in order to alleviate intracranial pressure by draining excess…
- Conditions
- Intensive Care Unit, Intraventricular Hemorrhage, External Ventricular Drain
- Trial name
- EVD-OBS (NCT06466811)
- Testing
- Patients of intensive care unit, Patients of surgical intensive care unit
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Nantes University Hospital
Pain, Postoperative
Bupivacaine With or Without Dexmedetomidine for Postoperative Pain Relief in Abdominal Surgery
This study investigates the effectiveness of adding dexmedetomidine to bupivacaine for postoperative analgesia in patients undergoing abdominal surgeries.
- Trial name
- NCT07285083
- Testing
- Bupivacaine with Dexmedetomidine (TAP Block), Bupivacaine (TAP Block)
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Sheikh Zayed Medical College
Urodynamic Studies, Urodynamics
Urodynamics: Prone Vs. Seated Position
To demonstrate the feasibility of a pressure-flow study using a urinary condom with drainage tube in the sitting and lying position in everyday clinical practice and the comparability of the measured values with the…
- Conditions
- Urodynamic Studies, Urodynamics, Outlet Obstruction
- Trial name
- NCT06864117
- Testing
- Body position during urodynamics
- Volunteers
- 200 people
- Sponsor
- Kantonsspital Winterthur KSW
Urethral Stricture
ROBUST III- Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease
ROBUST III is a prospective, multi-center, randomized controlled adaptive sample size clinical trial to establish the safety and effectiveness for the Optilume Stricture Drug Coated Balloon (DCB).
- Trial name
- ROBUST-III (NCT03499964)
- Testing
- Optilume Drug Coated Balloon (DCB), Control Treatment
- Where
- 22 sites in United States, Canada
- Volunteers
- 127 people
- Sponsor
- Urotronic Inc.
Chronic Total Occlusion of Coronary Artery
Evaluation of Effectiveness and Safety of Antegrade and Retrograde Approach of Percutaneous Coronary Intervention for Chronic Total Occlusions
Objective of this study is to 1) analyze the clinical, anatomical and periprocedural differences of patients who underwent a procedure related to coronary CTO through the antergrade approach and retrograde approach; 2) analyze…
- Trial name
- STRIKE-CTO (NCT03667196)
- Testing
- antegrade and retrograde approach
- Where
- 32 sites in South Korea
- Volunteers
- 4,000 people
- Sponsor
- Seung-Whan Lee, M.D., Ph.D.
Colorectal Cancer, Colorectal Surgery
Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimally Invasive Left-Sided Colorectal Resection (BAPTAP)
Effective postoperative pain management is essential for enhanced recovery after laparoscopic colorectal surgery. This randomized, controlled, double-blind trial will compare conventional postoperative analgesia (intravenous…
- Conditions
- Colorectal Cancer, Colorectal Surgery, Anesthesia, Autonomic Nerve Block
- Trial name
- BAPTAP (NCT07388953)
- Testing
- Minimally Invasive Left-Sided Colorectal Resection, BAPTAP (Peripheral Autonomic Blockade + TAP Block), Trocar/Incision Infiltration
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Faculdade de Ciências Médicas de Minas Gerais
Patients With Spinal Stenosis Indicated for MIS TLIF
ESP Block in MIS Lumbar Spine Surgery
This is a prospective, randomized controlled trial of patients undergoing minimally invasive transforaminal lumbar interbody fusion.
- Trial name
- NCT05856539
- Testing
- Erector spinae plane (ESP) block
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Hospital for Special Surgery, New York
Medium Vessel Occlusion Stroke (MeVO), Stroke Acute
SAIL-MEVO: Endovascular Treatment Versus Best Medical Therapy for Distal Vessel Occlusions
Patients with acute ischemic stroke caused by distal or medium vessel occlusions (MeVOs) may experience significant disability despite receiving the current standard medical treatment.
- Conditions
- Medium Vessel Occlusion Stroke (MeVO), Stroke Acute, Acute Ischemic Stroke, Cerebral Artery Occlusion
- Trial name
- SAIL MEVO (NCT07843797)
- Testing
- best medical therapy, Endovascular Treatment
- Where
- Spain
- Volunteers
- 420 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Endovascular Thrombectomy, Large Vessel Occlusion
Triage of Patients Presenting Beyond 24 Hours With Acute Ischemic Stroke Due to Large Vessel Occlusions (TRACK-LVO Late)
The objective of this study is to create a comprehensive, multi-center, TRACK-LVO registry-linked cohort of consecutive patients with acute ischemic stroke (AIS) caused by large vessel occlusions (LVO) and presenting to each…
- Conditions
- Endovascular Thrombectomy, Large Vessel Occlusion, Acute Ischemic Stroke
- Trial name
- TRACK-LVO Late (NCT06200753)
- Testing
- Mechanical Thrombectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tianjin Huanhu Hospital