Clinical trials: Bladder
Urinary Bladder, Underactive
Amplifying Sensation in Underactive Bladder
The purpose of this study is to determine the influence of intravesical (bladder) electrical stimulation and intraurethral electrical stimulation on bothersome symptoms and bladder function in neurologically-intact adult women…
- Trial name
- AMPLIFY (NCT04516434)
- Testing
- Neurometer Neurotron CPT, Cystometry, Pressure-flow study
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Urinary Incontinence
Urge Incontinence Bladder Overactivity Study
Examine the efficacy and safety of duloxetine in subjects with symptoms of bladder overactivity due to pure detrusor instability or sensory urgency.
- Trial name
- NCT00475696
- Testing
- Duloxetine
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Bladder Cancer
To Detect the Sensitivity of the UroMark Assay
This is a prospective multicentre observational study to assess the sensitivity of the UroMark assay to detect bladder cancer in participants with new or recurrent disease.
- Trial name
- DETECT II (NCT02781428)
- Where
- 19 sites in United Kingdom
- Volunteers
- 1,643 people
- Sponsor
- University College, London
Muscle-invasive Bladder Cancer
Remodeling of MHC-related Immune Microenvironment in MIBC After Neoadjuvant Therapy
In this study, the relevant biomarkers for predicting the efficacy of neoadjuvant therapy in patients with MIBC were further explored.
- Trial name
- NCT07440901
- Testing
- Immunotherapy plus chemotherapy
- Volunteers
- 30 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Overactive Bladder Syndrome
Therapeutic Efficacy and Safety of Mirabegron Treatment on Patients With Overactive Bladder Syndrome in Taiwan
Recent phase III trials have confirmed the efficacy and safety of mirabegron in the treatment of overactive bladder (OAB) in Europeans, Australians, North Americans, Japanese and Asians.
- Trial name
- NCT03044912
- Testing
- mirabegron
- Where
- Taiwan
- Volunteers
- 574 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8
Tumor-informed ctDNA in Muscle-invasive Bladder Cancer for Evaluation of Residual/Recurrent Disease - the TiMBER Trial
This study investigates the feasibility of the Labcorp Plasma Detect, which is an assay (test) that looks for circulating tumor DNA (ctDNA) in patients who have muscle-invasive (MI) urothelial carcinoma (also known as MI bladder…
- Conditions
- Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8, Stage IIIA Bladder Cancer AJCC v8
- Trial name
- NCT07726602
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- OHSU Knight Cancer Institute
Bladder Cancer, Radiomics
The Efficacy of Radiomics to Predict Tumor Microenvironment Markers and Comprehensive Therapy for Bladder Cancer
The aim of this study was to develop an radiomic model based on CT images to evaluate markers of the bladder cancer microenvironment, such as TSR,TIL, and IP.
- Conditions
- Bladder Cancer, Radiomics, Immunotherapy
- Trial name
- NCT06381895
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Overactive Bladder
Intravaginal Electrical Stimulation With Different Treatment Frequency in Women With Idiopathic Overactive Bladder
Electrical stimulation (ES) is one of the techniques used in urogynecological physiotherapy, which uses implanted or non-implanted electrodes.
- Trial name
- NCT04734301
- Testing
- Intravaginal Electrical Stimulation (2 times/week), Intravaginal Electrical Stimulation (5 times/week)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Pamukkale University
Overactive Bladder
Is 10 Injections of Bladder Botox Less Painful Than 20 Injections?
The purpose of this research study is to help determine if 10 injections of Botox ® 100 units is less painful than 20 injections of Botox ® 100 units based on effectiveness in reducing urge incontinence episodes.
- Trial name
- NCT04124939
- Testing
- OnabotulinumtoxinA 100 Units
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wake Forest University Health Sciences
Functional Mitral Regurgitation, Heart Failure
The BOSS Study: An Acute Evaluation of Anatomical and Geometric Changes Using the Bladder on a Stick System (BOSS)
The objective of the BOSS Study is to assess acute anatomical and geometric annular and ventricular changes that occur when strategically positioned an external inflatable chambers are applied to the outside of the heart.
- Trial name
- BOSS (NCT03228381)
- Testing
- BOSS Device
- Where
- 3 sites in United States, Paraguay
- Volunteers
- 4 people
- Sponsor
- Mardil Medical
Spinal Cord Injuries
Turkish Version of the Neurogenic Bladder Symptom Score Questionnaire: a Cross-cultural Adaptation, Reliability and Validity Study
Turkish version of the Neurogenic Bladder Symptom Score questionnaire: a cross-cultural adaptation, reliability and validity study
- Trial name
- NCT03964077
- Testing
- Neurogenic Bladder Symptom Score Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Malignant Neoplasms of Urinary Tract, Bladder Cancer
Investigation of Sugammadex in Outpatient Urological Procedures
The goal of this clinical research study is to determine whether using sugammadex, given with a standard muscle relaxation drug during bladder surgeries, improves anesthesia conditions and recovery time.
- Trial name
- NCT03138967
- Testing
- Rocuronium, Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- M.D. Anderson Cancer Center
Uncomplicated Urinary Tract Infection, Cystitis
Oral Omadacycline vs. Oral Nitrofurantoin for the Treatment of Cystitis
The purpose of this study is to evaluate the safety and efficacy of oral omadacycline as compared to oral nitrofurantoin in the treatment of female adults with cystitis.
- Trial name
- NCT03425396
- Testing
- Omadacycline tablets, Nitrofurantoin capsules
- Where
- 23 sites in United States
- Volunteers
- 225 people
- Sponsor
- Paratek Pharmaceuticals Inc
Catheter Complications
Diphenhydramine in Catheter Related Bladder Discomfort
Diphenhydramine has H1-antihistamine action, it also possesses anti-muscarinic properties. Thus, diphenhydramine might be able to reduce the problem of catheter related bladder discomfort by inhibiting smooth muscle spasm of the…
- Trial name
- NCT06345261
- Testing
- DiphenhydrAMINE 50 Mg/mL Injectable Solution, Saline
- Where
- Egypt
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Cairo University
Patients With High-risk MIBC
Adjuvant Radiotherapy in Patients With Pathological High-risk Bladder Cancer (GETUG-AFU 30)
This is a randomized multicentre study in patients with high-risk MIBC to investigate adjuvant radiotherapy after radical cystectomy and pelvic lymph node dissection.
- Trial name
- Bladder-ART (NCT03333356)
- Testing
- pelvic radiotherapy
- Where
- 17 sites in France
- Volunteers
- 81 people
- Sponsor
- UNICANCER
Bladder Dysfunction, Overactive Bladder
Noninvasive Ultrasound Assessment of Detrusor Dysfunction
The purpose of this study is to test a new ultrasound method called Quantitative Ultrasound Bladder Vibrometry to detect abnormal bladder function.
- Conditions
- Bladder Dysfunction, Overactive Bladder, BPH With Urinary Obstruction
- Trial name
- NUADD (NCT05652023)
- Where
- United States
- Volunteers
- 2,023 people
- Sponsor
- Mayo Clinic
Distal Urethral Cancer, Proximal Urethral Cancer
Gemcitabine Hydrochloride and Cisplatin Before Surgery in Treating Patients With Muscle Invasive Bladder Cancer
The purpose of this research study is to find out what effects, good and/or bad, dose-dense (every 14 days) chemotherapy with gemcitabine (gemcitabine hydrochloride) and cisplatin given before surgery have on patients and their…
- Conditions
- Distal Urethral Cancer, Proximal Urethral Cancer, Squamous Cell Carcinoma of the Bladder, Stage II Bladder Cancer
- Trial name
- NCT01611662
- Testing
- gemcitabine hydrochloride, cisplatin, therapeutic conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Fox Chase Cancer Center
Urge Urinary Incontinence
Brain Imaging Plus Urodynamics to Investigate the Brain's Control of the Bladder
The goal of this project is to evaluate the applicability of non-invasive optical imaging for the measurement of brain function during investigation of the lower urinary tract.
- Trial name
- NIRS/fBFB (NCT01619995)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Overactive Bladder
This is a Prospective, Randomized, Double-Blind Study Comparing Intravesical Injection of Botox® to Placebo.
The current study will investigate the comparative efficacy, safety and patient satisfaction of intradetrusor injections BOTOX® injections (200U) versus placebo (saline) injections in the treatment of OAB secondary to benign…
- Trial name
- BTX0621 (NCT00479596)
- Testing
- Botox
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Urological Sciences Research Foundation
Breast Cancer, Melanoma
Immunological Variables Associated to ICI Toxicity in Cancer Patients
This is a monocentric, prospective, pilot study that will enrol 435 subjects with solid tumours that are treated with immune checkpoint inhibitor(s) (ICI) alone or in combination with chemotherapy or targeted therapy.
- Conditions
- Breast Cancer, Melanoma, Non Small Cell Lung Cancer, Non-melanoma Skin Cancer
- Trial name
- NCT05429866
- Testing
- Checkpoint Blockade, Immune
- Where
- Belgium
- Volunteers
- 441 people
- Sponsor
- Jules Bordet Institute
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.