Clinical trials: Bladder
Lower Urinary Tract Symptoms, Voiding Disorders
Comparison of a Paper and Automated Bladder Diary in Pediatric Patients
The purpose of this study is to compare an automated bladder diary (autoBD) to a paper bladder diary (pBD) on their level of agreement, patient compliance and satisfaction. It is a mixed methods, randomized 2x2 crossover trial.
- Conditions
- Lower Urinary Tract Symptoms, Voiding Disorders, Enuresis, Overactive Bladder
- Trial name
- NCT06070675
- Testing
- Minze Diary Pod, Paper bladder diary
- Where
- 5 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Universiteit Antwerpen
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
Fluorouracil in Treating Patients With Recurrent or Metastatic Bladder Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of fluorouracil given as a continuous infusion in treating…
- Conditions
- Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Urethral Cancer
- Trial name
- NCT00003175
- Testing
- fluorouracil
- Where
- 62 sites in Brazil, Canada and 6 more
- Volunteers
- 45 people
- Sponsor
- Medical Research Council
Bladder Cancer, Brain and Central Nervous System Tumors
High-dose ICE With Amifostine
The purpose of the study is to evaluate the combination of amifostine and high dose chemotherapy with blood stem cell support. Amifostine is a druf developed to protect normal tissues against the toxicities of chemotherapy and…
- Conditions
- Bladder Cancer, Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary, Extragonadal Germ Cell Tumor
- Trial name
- NCT00003657
- Testing
- filgrastim, Amifostine, Carboplatin
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Dana-Farber Cancer Institute
Colorectal Cancer, Bladder Cancer
Feasibility Testing of Patient Reported Outcomes - Informed Symptom Management System (PRISMS)
This is a proof-of-concept pilot randomized clinical trial to test the feasibility of the innovative Patient-Reported Outcomes-Informed Symptom Management System (PRISMS) to enhance personalized supportive care for cancer…
- Conditions
- Colorectal Cancer, Bladder Cancer, Ovarian Cancer, Cervical Cancer
- Trial name
- PRISMS (NCT04492007)
- Testing
- Patient-Reported Outcomes-Informed Symptom Management System (PRISMS)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
BPH, Prostate Hyperplasia
MRI Guided Transrectal Prostate Laser Ablation for Benign Prostatic Hypertrophy (BPH)
Over 100,000 BPH procedures are performed annually in the US. The purpose of this study is to evaluate the effectiveness of performing MRI guided transrectal laser ablation using a 980 nm laser (VisualaseTM by Medtronic, Inc., a…
- Conditions
- BPH, Prostate Hyperplasia, Urinary Frequency/Urgency
- Trial name
- NCT03131544
- Testing
- MRI Guided Transrectal Periuretheral Transitional Zone Ablation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Prostate Laser Center, PLLC
Bladder (Urothelial, Transitional Cell) Cancer
Clinical Trial on the Protective Role of Vitamin B3 in Enhancing Immunotherapy for Bladder Cancer Patients
When bladder cancer patients are treated to mobilize their own immune system to fight the tumor, drugs that kill the bacteria can impair the effectiveness of the treatment.
- Trial name
- NCT07119996
- Testing
- Tislelizumab, Cisplatin, Gemcitabine and Vitamin B3
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Catheter Site Discomfort
Pudendal Nerve Block for Catheter-related Bladder Discomfort Prevention
Catheter-related bladder discomfort (CRBD) is not uncommon in male patients under general anesthesia, and it may cause patient agitation and exacerbated postoperative pain.
- Trial name
- NCT02683070
- Testing
- Bilateral pudendal nerve block, Intravenous tramadol
- Where
- China
- Volunteers
- 94 people
- Sponsor
- West China Hospital
Urinary Bladder, Overactive
Open-label Study of the Efficacy and Safety of VESIcare® in Patients With Overactive Bladder Symptoms
To evaluate the safety and efficacy of solifenacin succinate in subjects with overactive bladder symptoms (urgency, with or without urge incontinence, usually with frequency and nocturia).
- Trial name
- VOLT (NCT00463541)
- Testing
- solifenacin succinate
- Where
- 198 sites in United States
- Volunteers
- 2,225 people
- Sponsor
- Astellas Pharma Inc
Non-muscle-invasive Bladder Cancer
Safety and Efficacy of BCG Combined With Tislelizumab for BCG-untreated Patients With High-risk Non-muscle Invasive Bladder Cancer
For patients with high-risk non-muscle-invasive bladder cancer (NMIBC), intravesical therapy of BCG is the standard treatment proved to reduce the risk of recurrence and progression.
- Trial name
- NCT05580354
- Testing
- BCG combined with Tislelizumab
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Ruijin Hospital
Urothelial Bladder Cancer
Consolidative Radiotherapy for Metastatic Urothelial Bladder Cancer Patients Without Progression and With no More Than Three Residual Metastatic Lesions Following First Line Systemic Therapy
This is a Phase II, multicenter, randomized open-label and comparative study that has been designed to evaluate whether local consolidative radiotherapy in addition to standard of care improves overall survival as compared with…
- Trial name
- BLAD-RAD01 (NCT04428554)
- Testing
- Experimental arm
- Where
- 20 sites in France
- Volunteers
- 130 people
- Sponsor
- Institut Claudius Regaud
Bladder Cancer
Toripalimab Combined With BCG Perfusion for the Treatment of HR-NMIBC After TURBT Surgery Exploration
This is a single-center, prospective, open-label, non-randomized clinical study initiated and conducted by the Department of Urology, Shanghai Changhai Hospital.
- Trial name
- MARINE-01 (NCT07307456)
- Testing
- Treatment with toripalimab combined with BCG perfusion following transurethral resection of bladder tumor (TURBT)
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Changhai Hospital
Postoperative Urinary Retention
The Effect of Hot-Cold Application to the Bladder After Orthopedic Surgery on Postoperative Urinary Retention
The development of postoperative urinary retention (PUR) is a significant complication in patients undergoing treatment due to orthopedic surgery.
- Trial name
- PUR (NCT05969145)
- Testing
- application of thermophor
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Circulatory Function, Laparoscopic Radical Cystectomy for Bladder Cancer
Circulatory Function in Laparoscopic Radical Cystectomy for Bladder Cancer
To optimize the perioperative management of patients undergoing laparoscopic radical cystectomy(LPC) for bladder cancer through observation of perioperative changes of Brain Natriuretic Peptide(BNP), stroke volume variation(SVV)…
- Trial name
- NCT03892031
- Where
- China
- Volunteers
- 186 people
- Sponsor
- RenJi Hospital
Bladder Cancer
Comprehensive Geriatric Assessment for Perioperative Optimization in Cystectomy
Patients with muscle-invasive bladder cancer are often older and multimorbid, thus in an increased risk of perioperative mortality and morbidity in relation to radical cystectomy (RC).
- Trial name
- COMPETENCE (NCT05679557)
- Testing
- Perioperative geriatric assessment and intervention
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Aarhus University Hospital
Stress Urinary Incontinence
Factors Affecting the Cure of Overactive Bladder Syndrome in Women Underwent Mid-urethral Sling Procedure
We will estimate the incidence of patients with overactive bladder syndrome after surgery and explore related predictors.
- Trial name
- NCT04412928
- Testing
- mid-urethral sling procedure
- Where
- Taiwan
- Volunteers
- 591 people
- Sponsor
- Far Eastern Memorial Hospital
Bladder Cancer
Validity of Parametric MRI Using VIRADS
Our aim in this prospective study is to evaluate the validity of the non-contrast biparametric MRI (bp-MRI), including T2-WI and DWI sequences, and the availability of an alternative to the mp-MRI, for the muscle invasiveness…
- Trial name
- metricMRI (NCT05783271)
- Testing
- Gadolinium
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Assiut University
Bladder Pain Syndrome, Pregabalin
Efficacy and Safety of Pregabalin Combined With Educational and Behavioral Intervention for Bladder Pain Syndrome/Interstitial Cystitis
Bladder pain syndrome/interstitial cystitis (IC/BPS) brings long-term pelvic pain, frequent urination and poor sleep quality, which severely lowers patients' daily life quality.
- Conditions
- Bladder Pain Syndrome, Pregabalin, Educational Behavioral Intervention, Urinary Urgency
- Trial name
- PEBI-ICBPS (NCT07752134)
- Testing
- Educational and Behavioral Management Program (EBMP), Pregabalin
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
Advanced Cancer, Metastatic Cancer
A Study of LY3076226 in Participants With Advanced or Metastatic Cancer
The main purpose of this study is to evaluate the safety of the study drug known as LY3076226 in participants with advanced or metastatic cancer.
- Trial name
- NCT02529553
- Testing
- LY3076226
- Where
- 4 sites in United States, Canada
- Volunteers
- 25 people
- Sponsor
- Eli Lilly and Company
Overactive Bladder Syndrome
Comparison of Solifenacin and Mirabegron in Treatment of Overactive Bladder Symptoms in Men After TURP
Urinary frequency urgency and urgency urinary incontinence (UUI) are commonly encountered in patients after transurethral prostatectomy (TURP) or transurethral incision of the prostate (TUIP).
- Trial name
- NCT03632772
- Testing
- Solifenacin 5Mg, Mirabegron 50 MG
- Where
- Taiwan
- Volunteers
- 130 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Breast Cancer, Non Small Cell Lung Cancer
Study of ADCT-502 in Patients With Advanced Solid Tumors Withhuman Epidermal Growth Factor Receptor-2 (HER2) Expression
This study evaluated ADCT-502 in participants with Advanced Solid Tumors with HER2 Expression. Participants participated in a dose-escalation phase (Part 1) and were due to participate in the dose expansion phase (Part 2).
- Conditions
- Breast Cancer, Non Small Cell Lung Cancer, GastroEsophageal Cancer, Bladder Cancer
- Trial name
- NCT03125200
- Testing
- ADCT-502
- Where
- 5 sites in United States, Belgium
- Volunteers
- 21 people
- Sponsor
- ADC Therapeutics S.A.
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