Clinical trials: Bladder
Neurogenic Bladder, Bladder Dysfunction
Vascularized Composite Bladder Allograft Transplantation
This phase 0 trial tests the feasibility, functionality, and sustainability of vascularized composite bladder allograft transplantation in treating patients with terminal bladder pathology.
- Conditions
- Neurogenic Bladder, Bladder Dysfunction, Immunosuppression
- Trial name
- NCT05462561
- Testing
- Quality-of-Life Assessment, Robotic Vascularized Composite Bladder Allograft Transplantation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Southern California
Chronic Prostatitis With Chronic Pelvic Pain Syndrome
Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain
The purpose of this study is to evaluate the efficacy of D-Cycloserine versus placebo treatment in reducing pain from urological chronic pelvic pain syndrome (UCPPS).
- Trial name
- UCPPS (NCT02385266)
- Testing
- D-Cycloserine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Northwestern University
Bladder Cancer
Artificial Intelligence-assisted Uro-Cam Catheter Assessment System for Diagnosing Bladder Cancer
This is a single-arm study investigating the safety, feasibility and diagnostic performance of AI-assisted Uro-Cam catheter assessment that will be performed at the Prince of Wales Hospital.
- Trial name
- NCT07095751
- Testing
- AI Uro-Cam
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Endometriosis Related Pain, Overactive Bladder
A Trial to Learn How a New Liquid Form of BAY1817080 is Tolerated and Taken up by the Body of Healthy Male Participants (Part A). By Labeling BAY1817080 With a Radioactive Substance (Carbon 14) Researchers Want to Learn How the Study Drug is Processed and Excreted by the Body After Dosing (Part B)
Researchers are looking for a new way to treat people suffering either from a condition where the bladder is unable to hold urine normally (overactive bladder), or a condition in which tissue similar to the tissue that normally…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04487431
- Testing
- BAY1817080, [14C]BAY1817080
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bayer
Overactive Bladder, Obstructive Sleep Apnea
Tolterodine Relieves Overactive Bladder Symptoms in Women With Moderate-to-severe Obstructive Sleep Apnea Syndrome
In this study, we aim to determine whether combined tolterodine and CPAP therapy is a more effective treatment for patients with OSAS than CPAP treatment only.
- Conditions
- Overactive Bladder, Obstructive Sleep Apnea, Overactive Bladder Syndrome
- Trial name
- NCT05250245
- Testing
- Tolterodine Tartrate 4 MG, Continuous positive airway pressure therapy (CPAP)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yuzuncu Yil University
Stroke, Catheter Associated Urinary Tract Infection
Pilot Study of Avoidance of Bladder Catheters in Stroke Patients to Avoid Urinary Tract Infections
The purpose of this study is to determine whether bladder catheterization can be safely avoided in patients admitted to the hospital with stroke using a nursing protocol, and whether this decreases the incidence of urinary tract…
- Trial name
- NCT01275261
- Testing
- Nursing protocol to avoid Foley catheter placement
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Francisco
Overactive Bladder, Parkinson Disease
Neurogenic Overactive Bladder Treatment on Parkinson's Disease Through Back Tibial Nerve Electrostimulation
Dysfunctions of the lower urinary tract are non-motor symptoms common engines in Parkinson's disease (PD). Urodynamic changes in PD include overactive bladder (OB), characterized by urgency with or without urge incontinence …
- Trial name
- NOVTPD (NCT02583529)
- Testing
- Back Tibial Nerve Electrostimulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Tatiane Gomes de Araujo
Hematuria, Urination Disorders
Rigid Versus Flexible Cystoscopy in Women
The study will help define the best tolerated approach to cystoscopy in women by randomly comparing flexible to rigid cystoscopy.
- Conditions
- Hematuria, Urination Disorders, Voiding Dysfunction, Recurrent Urinary Tract Infection
- Trial name
- NCT00214045
- Testing
- Flexible Cystoscopy, Rigid Cystoscopy
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Solid Tumors
Dose Escalation of RMC-4630 Monotherapy in Relapsed/Refractory Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of escalating doses of RMC-4630 monotherapy in adult participants with relapsed/refractory solid tumors…
- Trial name
- NCT03634982
- Testing
- RMC-4630
- Where
- 12 sites in United States
- Volunteers
- 133 people
- Sponsor
- Revolution Medicines, Inc.
Metastatic Solid Tumor, Recurrent Solid Tumor
A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors
The purpose of this study is to find out whether the study drug, LY4101174, is safe, tolerable and effective in participants with select advanced or metastatic solid tumors.
- Conditions
- Metastatic Solid Tumor, Recurrent Solid Tumor, Advanced Solid Tumor, Urinary Bladder Neoplasm
- Trial name
- EXCEED (NCT06238479)
- Testing
- LY4101174
- Where
- 28 sites in United States, Australia and 5 more
- Volunteers
- 490 people
- Sponsor
- Eli Lilly and Company
Pregnant Women, Cesarean Section
Evaluation of the Absence of Intraoperative Bladder Catheterization in Case of Planned Cesarean Section
The hypothesis of this trial is that the absence of systematic bladder catheterization in patients performing spontaneous urination in the hour preceding the planned cesarean section under spinal anesthesia would not lead to more…
- Trial name
- C2S (NCT06357546)
- Testing
- Spontaneous urination during the hour before caesarean section., Systematic bladder catherization during caesarean section.
- Where
- 2 sites in France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Montpellier
Chagas' Disease (Chronic) With Other Organ Involvement
Lower Urinary Tract Dysfunction in Chronic Chagas' Disease : Clinical and Urodynamic Presentation
Chagas disease is one of the most neglected vector-borne infectious disease worldwide. The first decades following the discovery of the pathology drove an international research enthusiasm, mainly concentrated on understanding…
- Trial name
- NCT03189056
- Testing
- Chagas serology, Creatinina, Urodynamic exploration
- Where
- Bolivia
- Volunteers
- 152 people
- Sponsor
- Institut de Recherche pour le Developpement
Hematuria, Urothelial Carcinoma
Performance Evaluation of Urine DNA Methylation Testing for the Detection of Urothelial Carcinoma in Patients With Hematuria
Background Urothelial carcinoma (UC) is the most common malignancy of the urinary system. Hematuria is a significant clinical manifestation of UC, often diagnosed through invasive procedures.
- Conditions
- Hematuria, Urothelial Carcinoma, Bladder Cancer, Ureter Cancer
- Trial name
- NCT06469229
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Changhai Hospital
Detrusor Underactivity, Bladder Outlet Obstruction
DU and BOO in Women With and Without Symptoms of VD
Women with symptoms of voiding dysfunction may be associated with detrusor underactivity or bladder outlet obstruction. However, the prevalence of detrusor underactivity and bladder outlet obstruction remained obscure.
- Trial name
- NCT04981080
- Testing
- Urodynamic study
- Where
- Taiwan
- Volunteers
- 1,886 people
- Sponsor
- National Taiwan University Hospital
Overactive Bladder
This is a Prospective, Randomized, Double-Blind Study Comparing Intravesical Injection of Botox® to Placebo.
The current study will investigate the comparative efficacy, safety and patient satisfaction of intradetrusor injections BOTOX® injections (200U) versus placebo (saline) injections in the treatment of OAB secondary to benign…
- Trial name
- BTX0621 (NCT00479596)
- Testing
- Botox
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Urological Sciences Research Foundation
Urologic Cancer, Urologic Neoplasms
A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest
This research study is a pilot clinical trial, which hypothesizes that the combination of electromagnetic tracking in conjunction with laparoscope imaging and ultrasound probe imaging will aid in reducing the complexity of both…
- Conditions
- Urologic Cancer, Urologic Neoplasms, Bladder Cancer, Prostate Cancer
- Trial name
- NCT05899361
- Testing
- Electromagnetic Guided Laparoscopy, Ultrasound
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Brigham and Women's Hospital
Urologic Injuries, Urodynamic Changes
Urodynamic Changes Following Bladder Injury
This study is a unique one as it si done for first time to all patients following bladder injury in PAS surgery. Bladder function will be assessed by urodynamic study.
- Conditions
- Urologic Injuries, Urodynamic Changes, Bladder Dysfunction
- Trial name
- Uro-PAS (NCT04835766)
- Testing
- Urodynamic study
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Bladder Urothelial Carcinoma, Stage I Bladder Cancer AJCC v6 and v7
Paclitaxel and Radiation Therapy With or Without Trastuzumab in Treating Patients Who Have Undergone Surgery for Bladder Cancer
This phase I/II trial is studying the side effects of giving paclitaxel together with radiation therapy with or without trastuzumab and to see how well it works to kill any remaining tumor cells in patients who have undergone…
- Conditions
- Bladder Urothelial Carcinoma, Stage I Bladder Cancer AJCC v6 and v7, Stage II Bladder Cancer AJCC v6 and v7, Stage III Bladder Cancer AJCC v6 and v7
- Trial name
- NCT00238420
- Testing
- Paclitaxel, Radiation Therapy, Trastuzumab
- Where
- 184 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer, Infections
Infectious Complications After Cystectomy: A Prospective Observational Study
Patients undergoing cystectomy for either oncological or non-oncological indications are prospectively enrolled following informed consent.
- Conditions
- Bladder Cancer, Infections, Infection, Bacterial, Infection, Hospital
- Trial name
- NCT05153694
- Testing
- Cystectomy
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Urinary Incontinence, Urinary Bladder, Neurogenic
Feasibility of Triggered Sacral Neuromodulation for Neurogenic Bladder
Incontinence associates with military service and post-traumatic stress disorder in both male and female Veterans. Neurogenic detrusor overactivity (NDO) is caused by spinal cord injury or disorder, or peripheral…
- Trial name
- NCT05141487
- Testing
- UroMonitor, ASCU
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
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