Clinical trials: Bladder
Bladder Cancer
A Prospective Randomized Controlled Clinical Trial of Standard Versus Goal-Directed Perioperative Fluid Management (GDT) for Patients Undergoing Radical Cystectomy
The purpose of this study is to help us learn what is the best amount of fluid to give to patients during bladder surgery in order to avoid delayed bowel function after surgery, which could prolong hospital stay.
- Trial name
- NCT02145871
- Testing
- standard fluid management, fluid management guided by the EV1000
- Where
- 5 sites in United States
- Volunteers
- 282 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Superficial Bladder Cancer
Intravesical Administration of rAd-IFN/Syn3 in Patients With BCG-Refractory or Relapsed Bladder Cancer
This Phase 2 study is designed to assess the efficacy and safety of INSTILADRIN (rAd-IFN with Syn3) when given intravesically to patients with high grade non-muscle invasive bladder cancer who are refractory to or have relapsed…
- Trial name
- NCT01687244
- Testing
- INSTILADRIN
- Volunteers
- 40 people
- Sponsor
- FKD Therapies Oy
Urinary Urge Incontinence (UUI), Urinary Frequency (UF)
PMCF Study of the Axonics SNM System Model 5101 (R20) for the Indication of OAB
Post-market clinical follow-up for continued assessment of safety and performance to confirm long-term outcomes of the Axonics SNM System INS Model 5101.
- Conditions
- Urinary Urge Incontinence (UUI), Urinary Frequency (UF), Overactive Bladder (OAB)
- Trial name
- NCT06789406
- Testing
- Axonics SNM System INS Model 5101 (R20)
- Where
- 6 sites in United States, United Kingdom
- Volunteers
- 55 people
- Sponsor
- Axonics, Inc.
Benign Prostatic Hyperplasia, Bladder Outlet Obstruction
Bipolar Transurethral Enucleation (BipolEP) vs Bipolar Transurethral Resection of the Prostate
The aim of this study is to compare two different surgical methods for treating benign prostatic obstruction (BPO). The investigators are going to compare the risks and benefits of bipolar transurethral resection of the prostate…
- Trial name
- NCT03503721
- Testing
- BipolEP, bipolarTURP
- Where
- 2 sites in Austria, Switzerland
- Volunteers
- 84 people
- Sponsor
- Salzburger Landeskliniken
Urinary Retention
First-in-man Safety and Efficacy Trial of a Novel Non-invasive Bladder Emptying Device: The NIBED Study
The non-invasive bladder emptying device (NIBED) is a handheld medical device that is applied to the penis during urinating to aid bladder emptying in urinary retention patients with increased residual urine volume.
- Trial name
- NIBED pilot (NCT04919798)
- Testing
- Non-invasive bladder emptying device
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cystitis, Urinary Tract Infections
Treatment and/or Prevention of Urinary Tract Infections
The purpose of the study is to determine the effect of an investigational oral rinse in reducing uropathogens and treating uncomplicated urinary tract infections.
- Trial name
- UTI (NCT00801021)
- Testing
- Frio Mouth Rinse
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Biomedical Development Corporation
Urinary Incontinence, Stress, Mixed Incontinence
Treatment for Stress and Mixed Urinary Incontinence and Vaginal Vault Prolapse
The primary objective of this study is to further evaluate the safety and effectiveness of the use of a sling device in women for stress and mixed urinary incontinence as well as vaginal vault prolapse.
- Conditions
- Urinary Incontinence, Stress, Mixed Incontinence, Vaginal Vault Prolapse
- Trial name
- NCT00223106
- Testing
- Vaginal Sling
- Where
- United States
- Volunteers
- 467 people
- Sponsor
- Medtronic - MITG
Neurogenic Bladder, Detrusor Underactivity
A Comparative Analysis of Portable Bladder Scanner to Determine Age/ Volume Specific Accuracy in 0-6 Years of Children
As a part of the urodynamic studies, urinary catheterization is inserted to measure residual urine, however, it has shown to be an invasive procedure, cause urinary tract infection, and traumatic experience.
- Conditions
- Neurogenic Bladder, Detrusor Underactivity, Detrusor Overactivity
- Trial name
- NCT04543552
- Testing
- Bladder scan
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Hospital
Bladder Neoplasm
En-Bloc Resection of Bladder Tumors
Observational data shows that "en bloc" resection of bladder tumor (EBR-BT) may entail advantages when compared with conventional transurethral bladder tumor resection (TURBT).
- Trial name
- NCT04784507
- Testing
- En Bloc Resection, Conventional Transurethral Resection Bladder Tumor (Mono/Bipolar)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Betul Kartal
Uterine Cervical Neoplasms
The Role of Clean Intermittent Catheterization in Patients Undergoing Radiotherapy After Radical Hysterectomy for Cervical Cancer
Through a prospective, randomized and controlled research design method, this study implemented intermittent catheterization for patients with urinary dysfunction after postoperative radiotherapy of cervical cancer, formulated a…
- Trial name
- NCT05410444
- Testing
- Clean Intermittent Catheterization, Indwelling catheterization
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhejiang Cancer Hospital
Bladder Cancer
Study of Gemcitabine, Carboplatin, and Panitumumab (GCaP) as Neoadjuvant Chemotherapy in Patients With Muscle-Invasive Bladder Cancer
The purpose of this study is to find out if using the combination of standard chemotherapy (gemcitabine and carboplatin) plus this new drug (panitumumab) can help to shrink the tumor before the patient undergoes surgery for…
- Trial name
- NCT01916109
- Testing
- Gemcitabine, Carboplatin, Panitumumab
- Where
- 5 sites in United States
- Volunteers
- 4 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Overactive Bladder Syndrome
Predictors Affecting Long-term Use of Solifenacin or Mirabegron in Women With Overactive Bladder Syndrome
A retrospective analysis of medical records at Far Eastern Memorial Hospital from January 2008 to May 2020 about female patients with overactive bladder syndrome, who received Solifenacin or Mirabegron as the initial treatment.
- Trial name
- NCT05040984
- Testing
- Solifenacin Oral Tablet, Mirabegron 25mg
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Far Eastern Memorial Hospital
Bladder Cancer
Computed Tomography Urography (CTU) vs Intravenous Urography (IVU) on Patients at Risk of Urothelial Tumors
The goal of this clinical research study is to use computed tomography urography (CTU) scans and intravenous urography (IVU) scans to check the status of urothelial cancer, in order to try to learn the level of effectiveness of…
- Trial name
- NCT00567684
- Testing
- Computed Tomography Urography (CTU), Intravenous Urography (IVU)
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- M.D. Anderson Cancer Center
Bladder Carcinoma, Recurrent Bladder Carcinoma
Erlotinib Hydrochloride in Treating Patients With Bladder Cancer Undergoing Surgery
This randomized phase II trial studies how well erlotinib hydrochloride works in treating patients with bladder cancer undergoing surgery.
- Trial name
- NCT02169284
- Testing
- Erlotinib Hydrochloride, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer, Urothelial Carcinoma
Neoadjuvant Durvalumab Alone Versus Durvalumab With Olaparib in Patients Ineligible for Cisplatin With Muscle-Invasive Urothelial Carcinoma of the Bladder Followed by Radical Cystectomy
This study is a phase II, randomized, open-label, clinical trial including patients with muscle-invasive transitional cell carcinoma of the bladder candidates for radical cystectomy.
- Trial name
- NCT04579133
- Testing
- Olaparib, Durvalumab
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Latin American Cooperative Oncology Group
Fibromyalgia, Irritable Bowel Syndrome
Observational Study of Control Participants for the MAPP Research Network
The Control Study for the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network has been established to focus on a broader approach to the study of Interstitial Cystitis (IC)/Painful Bladder…
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Fatigue Syndrome, Chronic
- Trial name
- MAPP-Control (NCT01098292)
- Where
- 8 sites in United States
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Treatment of Patients Suffering From Overactive Bladder (OAB)
BlueWind RENOVA iStim™ System for the Treatment of OAB
The OASIS study is prospective, interventional, multi-center study to evaluate the safety and efficacy of the BlueWind RENOVA iStim™ implantable tibial neuromodulation System for the treatment of patients diagnosed with…
- Trial name
- OASIS (NCT03596671)
- Testing
- RENOVA iStim™ System
- Where
- 23 sites in United States, Belgium and 2 more
- Volunteers
- 282 people
- Sponsor
- BlueWind Medical
Urinary Dysfunction
Effects of Pelvic Floor Muscle Training Combined With Bladder Training on Some Parametrs of Men With Urinary Frequency
This prospective, single-center, parallel-group, assessor-blinded randomized controlled trial will include 120 voluntary male participants who have had complaints of urinary frequency for at least 3 months and meet the inclusion…
- Trial name
- NCT07719400
- Testing
- Bladder training plus pelvic floor muscle training, Bladder Training
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bingol University
Patient Discharge, Urinary Complication
Postoperative Bladder Filling After Outpatient Laparoscopic Hysterectomy and Time to Discharge
The investigators hypothesize that backfilling the bladder postoperatively will reduce time to spontaneous void and subsequent discharge from the post-anesthesia care unit.
- Trial name
- NCT06737393
- Testing
- Backfill
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Overactive Bladder
Comparison of Efficacy and Safety Between Imidafenacin and Fesoterodine in Patients With Overactive Bladder
To evaluate the efficacy and safety after 12 weeks oral administration of Imidafenacin 0.1mg b.i.d versus Fesoterodine 4mg once daily for the urge incontinence and/or increased urinary frequency associated with urgency as may…
- Trial name
- NCT01578304
- Testing
- Imidafenacin, Fesoterodine
- Where
- South Korea
- Volunteers
- 207 people
- Sponsor
- LG Life Sciences
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