Clinical trials: Bladder Outlet Obstruction
Benign Prostatic Hyperplasia, Lower Urinary Track Symptoms
Ejaculation-Preserving Versus Conventional Dual Wavelength Diode Laser Vaporization of the Prostate
Surgery to relieve urinary blockage caused by an enlarged prostate works well, but most men lose antegrade ejaculation afterwards, because semen passes backwards into the bladder instead of forwards.
- Conditions
- Benign Prostatic Hyperplasia, Lower Urinary Track Symptoms, Bladder Outlet Obstruction
- Trial name
- EP-TUVP (NCT07777068)
- Testing
- Conventional dual-wavelength diode laser vaporization of the prostate, Ejaculation-preserving dual wavelength diode laser vaporization of the prostate
- Where
- Iraq
- Volunteers
- 119 people
- Sponsor
- ALI KAMAL M. SAMI
Benign Prostatic Hyperplasia, BPH
Phase 3 Evaluation of Re-Injection of NX-1207 for the Treatment of Benign Prostatic Hyperplasia (BPH)(NX02-0022)
This study is designed to demonstrate the safety and efficacy of a second transrectal intraprostatic injection of NX-1207 given to subjects with Benign Prostatic Hyperplasia (BPH) who previously received an injection of NX-1207…
- Conditions
- Benign Prostatic Hyperplasia, BPH, Lower Urinary Tract Symptoms (LUTS), LUTS
- Trial name
- NCT01846793
- Testing
- NX-1207
- Where
- 17 sites in United States
- Volunteers
- 160 people
- Sponsor
- Nymox Corporation
Benign Prostatic Hyperplasia, Bladder Outlet Obstruction
Thulium Laser Enucleation With Bladder Neck Incision for Small-Volume Benign Prostatic Hyperplasia
This study will evaluate the safety and effectiveness of different surgical treatments for men with small-volume benign prostatic hyperplasia (BPH).
- Conditions
- Benign Prostatic Hyperplasia, Bladder Outlet Obstruction, Lower Urinary Tract Symptoms (LUTS)
- Trial name
- ThuLEP-BNI (NCT07569874)
- Testing
- Thulium Laser Enucleation of the Prostate Combined With Bladder Neck Incision, Thulium Laser Enucleation of the Prostate, Transurethral Resection of the Prostate
- Where
- China
- Volunteers
- 932 people
- Sponsor
- Chinese PLA General Hospital
Male Urogenital Diseases, Genital Diseases, Male
Office Based Transperineal Laser Ablation for Benign Prostatic Hyperplasia HYPERPLASIA
This study is set up as a phase I-II prospective, single center, interventional pilot study carried in Office setting under local anesthesia.
- Conditions
- Male Urogenital Diseases, Genital Diseases, Male, Prostatic Disease, Prostatic Hyperplasia
- Trial name
- NCT04760483
- Testing
- SoracteLite(TM) TPLA for BPH
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Urological Research Network, LLC
Bladder Neck Obstruction, Bladder Outlet Obstruction
Effectiveness and Safety of Adipose-derived Regenerative Cells for Reduction of Risk of Bladder Neck Contracture
Autologous adipose-derived regenerative cells (ADRC) will be extracted from lipoaspirate by enzymatic digestion from a portion of the fat harvested from the patient's front abdominal wall.
- Conditions
- Bladder Neck Obstruction, Bladder Outlet Obstruction, Benign Prostatic Hyperplasia, Urinary Bladder Neck Obstruction
- Trial name
- NCT02869061
- Testing
- Liposuction, Transurethral bladder neck resection., ADRC
- Where
- 2 sites in Russia
- Volunteers
- 12 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Bladder Outlet Obstruction, Multiple Sclerosis
GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology
Male self catherterisng observational study.
- Conditions
- Bladder Outlet Obstruction, Multiple Sclerosis, Cauda Equina Syndrome, Enlarged Prostate With Lower Urinary Tract Symptoms
- Trial name
- NCT05470751
- Testing
- Intermittent self-catheterisation
- Where
- 16 sites in United States, France and 1 more
- Volunteers
- 72 people
- Sponsor
- ConvaTec Inc.
Urinary Bladder, Overactive, Prostatic Hyperplasia, Benign
Comparison of Concurrent Endoscopic Prostate Surgery With Botox-A Injection and Postoperative Medical Therapy in BPH Patients With Overactive Bladder Symptoms
Intravesical OnabotulinumtoxinA (BoNT-A) injection performed concurrently with endoscopic prostate surgery provides superior clinical improvement at the 12th postoperative week compared to standard medical therapy in patients…
- Conditions
- Urinary Bladder, Overactive, Prostatic Hyperplasia, Benign, Bladder Outlet Obstruction, Botulinium Toxin-A
- Trial name
- BOPROST (NCT07554989)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Taksim Egitim ve Arastirma Hastanesi
Benign Prostatic Hyperplasia, Bladder Outlet Obstruction
Bipolar Transurethral Enucleation (BipolEP) vs Bipolar Transurethral Resection of the Prostate
The aim of this study is to compare two different surgical methods for treating benign prostatic obstruction (BPO). The investigators are going to compare the risks and benefits of bipolar transurethral resection of the prostate…
- Trial name
- NCT03503721
- Testing
- BipolEP, bipolarTURP
- Where
- 2 sites in Austria, Switzerland
- Volunteers
- 84 people
- Sponsor
- Salzburger Landeskliniken
Chronic Kidney Diseases, Bladder Dysfunction
Concomitant Renal and Urinary Bladder Allograft Transplantation
The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.
- Conditions
- Chronic Kidney Diseases, Bladder Dysfunction, Bladder Absence, Posterior Urethral Valve
- Trial name
- NCT04626167
- Testing
- Concomitant Renal and Urinary Bladder Allograft Transplantation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Benign Prostatic Hyperplasia (BPH), Lower Urinary Tract Symptom
A Prospective Comparative Study Evaluating the Safety and Efficacy of Transurethral Thulium Fiber Laser, Holmium Laser and Bipolar Enucleation of Large Sized Prostate
This study compares the safety and efficacy of three endoscopic enucleation techniques for large prostates (>100 mL) in patients with benign prostatic hyperplasia (BPH): Thulium Fiber Laser Enucleation (ThuFLEP), Holmium Laser…
- Conditions
- Benign Prostatic Hyperplasia (BPH), Lower Urinary Tract Symptom, Bladder Outlet Obstruction
- Trial name
- NCT07627178
- Testing
- Thulium Fiber Laser Enucleation of the Prostate (ThuFLEP), Holmium Laser Enucleation of the Prostate (HoLEP), Bipolar Transurethral Enucleation of the Prostate (B-TUEP)
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tanta University
HoLEP, Trifecta Achievement
Predictors of Trifecta Achievement After HoLEP
Holmium laser enucleation of the prostate (HoLEP) is a surgical treatment option for men experiencing bothersome lower urinary tract symptoms due to an enlarged prostate.
- Conditions
- HoLEP, Trifecta Achievement, Urinary Incontinence Following Surgical Procedure, Clavien Dindo Surgical Complication Scale
- Trial name
- ReMIUS-BPO (NCT07429994)
- Testing
- Transurethral Holmium Laser Enuclation of the Prostate
- Where
- Turkey (Türkiye)
- Volunteers
- 604 people
- Sponsor
- Ondokuz Mayıs University
Bladder Cancer, Bladder Stone
A Study Comparing a Disposable Flexible Cystoscope With Reusable Scopes in Adult Patients.
This study will compare the time required for a cystoscopy procedure in adult participants using the Redpine® Rflex endo(trademark) High-Definition Cystoscope or the site's standard of care reusable flexible cystoscope in…
- Conditions
- Bladder Cancer, Bladder Stone, Bladder Outlet Obstruction, Renal Stone
- Trial name
- NCT06422312
- Testing
- Cystoscopy with RedPine flexible disposable cystoscope, Cystoscopy with standard of care flexible reusable scope
- Where
- 3 sites in United States
- Sponsor
- Guangzhou Red Pine Medical Instrument Co., Ltd.
Detrusor Underactivity, Bladder Outlet Obstruction
DU and BOO in Women With and Without Symptoms of VD
Women with symptoms of voiding dysfunction may be associated with detrusor underactivity or bladder outlet obstruction. However, the prevalence of detrusor underactivity and bladder outlet obstruction remained obscure.
- Trial name
- NCT04981080
- Testing
- Urodynamic study
- Where
- Taiwan
- Volunteers
- 1,886 people
- Sponsor
- National Taiwan University Hospital
Lower Urinary Tract Obstructive Syndrome, Lower Urinary Tract Obstruction, Congenital
Fetal Cystoscopy for Severe Lower Urinary Tract Obstruction
The purpose of the study is to study the outcomes of maternal and fetal patients who are undergoing fetal intervention for severe isolated lower urinary tract obstruction (LUTO).
- Conditions
- Lower Urinary Tract Obstructive Syndrome, Lower Urinary Tract Obstruction, Congenital, Bladder Outlet Obstruction, Bladder Outflow Obstruction
- Trial name
- CYSTO (NCT03281798)
- Testing
- Fetoscopes, Fetal Cystoscopy
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Rodrigo Ruano
Urinary Stress Incontinence
Midurethral Synthetic Tape With Tension Control Mechanism Versus Midurethral Free Tape
This is a prospective, comparative randomized controled trial. The general purposes of this study is to compare the efficacy and safety of midurethral synthetic tape with tension control mechanism and conventional midurethral…
- Trial name
- NCT04101279
- Testing
- surgical management of stress urinary incontinence with midurethral tension free tape., surgical management of stress urinary incontinence with synthetic tape with tension control mechanism.
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Moscow State University of Medicine and Dentistry
Prostate Hyperplasia, Prostatic Hypertrophy
Low Energy HoLEP on IPSS
The purpose of this study is to prove that low-energy (30W) Holmium laser prostatectomy (Holeb) is not inferior to high-energy (100W) Holmium laser prostatectomy (safety and effectiveness)
- Conditions
- Prostate Hyperplasia, Prostatic Hypertrophy, Surgery, Bladder Outlet Obstruction
- Trial name
- NCT04514718
- Testing
- Holmium laser
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Bladder Outlet Obstruction
Bladder Outlet Obstruction Observation Using Dynamic Urine Vibration "Holter"
Current gold standard of bladder outlet diagnosis is pressure flow study. This study is invasive time consuming and requires expensive and complex set-up.
- Trial name
- NCT01779349
- Testing
- Dynamic Urine Vibration "Holter"
- Where
- 2 sites in Israel
- Volunteers
- 45 people
- Sponsor
- P. Square Medical Ltd
Hypospadias
The Change of the Detrusor Thickness After Hypospadias Repair - Comparison With the Normal Control Group
Even successfully managed hypospadias without any complication, voiding problem could be developed due to the increased urethral resistance.
- Trial name
- NCT01762007
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yonsei University
Prostate Cancer Stage I, Bladder Outlet Obstruction
Transurethral Prostate Enucleation in Surveillance Protocol for Low Risk Prostate Cancer
We will compare oncological and functional outcomes of anatomical endoscopic enucleation of the prostate (AEEP) versus continued medical treatment in low-risk prostate cancer patients for whom an active surveillance protocol was…
- Trial name
- NCT05631080
- Testing
- Anatomical Endoscpic enucleation of the Prostate
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia
PRescription Exercise for Older Men With Urinary Disease
This is a single-center pilot randomized controlled trial among 68 physically "inactive" older men with lower urinary tract symptoms (LUTS) attributed to benign prostatic hyperplasia (LUTS/BPH) assessing a 12-week remote exercise…
- Trial name
- PROUD (NCT06225479)
- Testing
- Exercise, Calls and Newsletter
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- University of California, San Francisco