Clinical trials: Bladder Tumors
Bladder Cancer
Gemcitabine and Pazopanib in Chemotherapy Naïve Patients With Advanced/Metastatic Urothelial Carcinoma Ineligible for Cisplatin-based Chemotherapy
Gemcitabine and Cisplatin are standard chemotherapy drugs used to treat advanced urothelial cancer. There is no standard chemotherapy for patients who cannot receive Cisplatin.
- Trial name
- NCT01622660
- Testing
- Gemcitabine, Pazopanib
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stomach Neoplasms, Colonic Neoplasms
Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients
Postoperative delirium（POD）is a common complication that can directly affect important clinical outcomes, and exert an enormous burden on patients, their families, hospitals, and public resources.
- Conditions
- Stomach Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Sigmoid Neoplasms
- Trial name
- NCT05068180
- Testing
- low-dose neuroleptanalgesia
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Urothelial Carcinoma, Urothelial Cancer
Trial of EP0057, a Nanoparticle Camptothecin With Olaparib in People With Relapsed/Refractory Small Cell Lung Cancer
Background: EP0057 (formerly CRLX101) consists of a sugar molecule cyclodextrin linked to a chemotherapy drug called camptothecin. The combined molecule or "nanoparticle drug conjugate" travels through the blood.
- Conditions
- Urothelial Carcinoma, Urothelial Cancer, Lung Neoplasms, Small Cell Lung Cancer
- Trial name
- NCT02769962
- Testing
- EP0057, olaparib, CT scan
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Transitional Cell Carcinoma, Transurethral Resection
BCG + MMC: Adding Mitomycin C to BCG in High-risk, Non-muscle-invasive Bladder Cancer
Instillation of Bacillus of Calmette-Guerin (BCG) into the urinary bladder (intravesical administration) improves rates of disease recurrence and progression after transurethral resection (TUR) of high risk, non-muscle-invasive…
- Trial name
- NCT06462001
- Testing
- Bacillus Calmette-Guerin Vaccine Intravesical, Mitomycin
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Muscle-Invasive Bladder Carcinoma
Clinical Study of Neoadjuvant Therapy Outcome Prediction of Muscle-invasive Bladder Cancer Based on PTC Drug Sensitivity Detection
In this study, investigators plan to conduct the 3D in vitro culture PTC drug sensitivity testing of fresh tumor specimen which obtained by endoscopic biopsy or other methods.
- Trial name
- NCT05767528
- Testing
- Patient-derived tumor-like cell clusters (PTC) drug sensitivity testing
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese PLA General Hospital
Urothelial Carcinoma of the Urinary Bladder
Intravesical Cabazitaxel, Gemcitabine, and Cisplatin (CGC) in the Treatment Urothelial Carcinoma of the Bladder
The investigators intend to evaluate the safety and toxicity profile of intravesically administered multidrug regimen of Cabazitaxel, Cisplatin and Gemcitabine in treatment refractory Transitional Cell Carcinoma.The investigators…
- Trial name
- CGC (NCT02202772)
- Testing
- Cabazitaxel, Gemcitabine, Cisplatin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Guarionex J. Decastro
Bladder Tumors
Laser Treatment of Bladder Tumors in the Outpatient Department
Primary Objective: To show that small pTa bladder tumors can be removed with diode laser in an outpatient department. Secondary Objective: To evaluate the patients' symptoms during and after the laser TURBT.
- Trial name
- NCT02659332
- Testing
- TURBT
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Gregers G Hermann
Non-Muscle-Invasive Bladder Cancer (NMIBC)
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SIM0237 Alone or in Combination with BCG in NMIBC
This is an open-label, multicenter phase 1 study to evaluate the safety, efficacy, and pharmacokinetics (PK) characteristics of SIM0237 alone or in combination with bacillus Calmette-Guerin (BCG) in participants with…
- Trial name
- NCT06186414
- Testing
- SIM0237, SIM0237 and BCG
- Where
- 14 sites in China
- Volunteers
- 152 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Bladder Cancer
Mapping 3D Bladder
This is a single centre, single arm feasibility study assessing the feasibility of using computer vision methods to recreate the 3D bladder shape and to then map the cystoscopy images onto this bladder shape.
- Trial name
- NCT05260788
- Testing
- Cystoscopy
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Cancer
Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer
Phase I trial to study the effectiveness of trastuzumab plus R115777 in treating patients who have advanced or metastatic cancer.
- Trial name
- NCT00005842
- Testing
- trastuzumab, tipifarnib
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer
Evaluating Safety and Efficacy of Prostate-sparing Radical Cystectomy
The purpose of this clinical trial is to determine if prostate-capsule-sparing cystectomy improves functional outcomes without comprising oncologic outcomes in male patients receiving a radical cystectomy.
- Trial name
- NCT05792722
- Testing
- Prostate capsule-sparing radical cystectomy, Nerve sparing radical cystectomy
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Johns Hopkins University
Bladder Cancer, Squamous Cell Carcinoma of the Bladder
Adjuvant Radiation for High Risk Bladder Cancer
This phase II trial studies how well modern, conformal radiation therapy after surgery works in treating patients with high-risk bladder cancer.
- Conditions
- Bladder Cancer, Squamous Cell Carcinoma of the Bladder, Stage III Bladder Cancer, Stage IV Bladder Cancer
- Trial name
- NCT01954173
- Testing
- 3D conformal radiation therapy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Emory University
Bladder Cancer
Standard Surgery or Minimal-Access Surgery in Treating Patients With Bladder Cancer
RATIONALE: Minimal-access surgery uses a smaller opening in the body to remove the tumor than is used in standard surgery. It is not yet known whether minimal-access surgery to remove the bladder is more effective than standard…
- Trial name
- NCT01196403
- Testing
- questionnaire administration, quality-of-life assessment, robot-assisted laparoscopic surgery
- Where
- 4 sites in United Kingdom
- Volunteers
- 92 people
- Sponsor
- Wales Cancer Trials Unit
Bladder Tumor (TURBT)
Holmium Laser En-Bloc Resection Versus Conventional Transurethral Resection of Bladder Tumors for Treatment of Non-muscle- Invasive Bladder Cancer
This study is a prospective randomized controlled trial comparing holmium laser en-bloc resection of bladder tumor (HoLERBT) with conventional transurethral resection of bladder tumor (cTURBT) in patients with suspected…
- Trial name
- NCT07534631
- Testing
- Holmium Laser En-Bloc Resection of Bladder Tumor, Conventional Transurethral Resection of Bladder Tumor
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Recurrent or Metastatic Bladder Cancer
An Open, Dose-escalation Clinical Study of Chimeric Exosomal Tumor Vaccines for Recurrent or Metastatic Bladder Cancer
1. Based on the applicant's previous work and combined with the clinical medical resources of our unit, tumor cells were isolated from the lesion site of cancer patients, dendritic cells or macrophages were isolated from…
- Trial name
- NCT05559177
- Testing
- Chimeric exosomal tumor vaccines
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Pudong Hospital
Non Muscle Invasive Bladder Cancer
Prospective Randomized Comparison of Transurethral Resection by Mean of White Light and Narrow Band Imaging
To date, fluorescence and narrow band imaging cystoscopy have been tested in many prospective within patient trials but only as an "add on" procedure.
- Trial name
- NCT01004211
- Testing
- Narrow band imaging transurethral resection, Standard transurethral resection
- Where
- 2 sites in Italy
- Volunteers
- 188 people
- Sponsor
- Paolo Puppo
Bladder Cancer
Detecting Bladder Cancer Using the UroMark Test.
DETECT I is a prospective multicentre observational diagnostic study to assess the performance of the UroMark assay to rule out bladder cancer in patients with haematuria.
- Trial name
- DETECT I (NCT02676180)
- Testing
- Group
- Where
- 2 sites in United Kingdom
- Volunteers
- 3,700 people
- Sponsor
- University College, London
Bladder Cancer
A Study of Rapamycin Combined With Intravesical BCG in Patients With Non-muscle Invasive Bladder Cancer
This study is looking at the effects of Sirolimus (Rapamycin) on BCG-specific immunity during treatment of non-muscle invasive bladder cancer (NMIBC) with maintenance BCG.
- Trial name
- NCT02753309
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Prostate Cancer, Bladder Cancer
Using PROMIS as Part of Routine Clinical Care for Racially Diverse Prostate and Bladder Cancer Patients
In this pilot study, a total of 80 patients with prostate or bladder cancer (40 black, 40 white) will complete 3 patient-reported outcome (PRO) surveys: baseline (pre-treatment), during treatment, and after treatment.
- Trial name
- NCT03156244
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Malignant Neoplasm, Malignant Neoplasm of Rectum
Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial
The investigators hypothesize that an increase in dietary fiber intake during radiation therapy may provide better long-term intestinal health for the cancer survivor.
- Conditions
- Malignant Neoplasm, Malignant Neoplasm of Rectum, Malignant Neoplasm of Anus, Malignant Neoplasm of Urinary Bladder
- Trial name
- FIDURA (NCT04534075)
- Where
- Sweden
- Volunteers
- 354 people
- Sponsor
- Sahlgrenska University Hospital
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