Clinical trials: Blastocysts
Infertility (IVF Patients)
Cleavage-stage Versus Blastocyst-stage Embryo Transfer in IVF Patients With Few Embryos
Infertility affects more than 6 million women the United States and is a major life event that results in a wide range of socio-cultural, emotional, physical and financial problems.
- Trial name
- PRECiSE (NCT06746129)
- Testing
- embryo transfer
- Where
- United States
- Volunteers
- 1,126 people
- Sponsor
- Beth Israel Deaconess Medical Center
Infertility
Comparing the Ongoing Pregnancy Rate for Vitrification of Day-4 Morula With Day-5 Blast
Comparing the vitrification at Day-4 (morula stage) with the blastocyst stage vitrification outcomes with the transfer of all day 5 after warming seems need evaluation.
- Trial name
- NCT03787901
- Testing
- Morula Vitrification
- Where
- 4 sites in Egypt
- Volunteers
- 53 people
- Sponsor
- Egyptian Foundation of Reproductive Endocrinology
Infertility
Prospective Observational Correlation of Sperm Assay Results With Blastocyst Formation
We will investigate potential correlation between SpermComet DNA fragmentation assay results and IVF cycle outcome.
- Trial name
- NCT02031549
- Testing
- SpermComet assay
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bruce Shapiro M.D.
Abnormal Karyotype
The Effectiveness of Blastocentesis Versus Trophectoderm Biopsy
For the purpose of this study, the investigators will perform the removal of trophectoderm (TE) the cells as required for the purpose of pre-implantation genetic screening, in order to perform the genetic analysis.
- Trial name
- NCT02915276
- Testing
- Blastocentisis, Trophectoderm biopsy
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Center for Reproductive an Genetic Health
Chromosome Translocation, Genetic Disorders in Pregnancy
Investigation and Diagnosis of the Chromosome Variation in Donated/abandoned Blastocyst
Blastocysts derived from patients seeking infertility treatment were generated by in vitro fertilization and embryo culture as previously described, and were evaluated using the Gardner system.
- Conditions
- Chromosome Translocation, Genetic Disorders in Pregnancy, Recurrent Miscarriage
- Trial name
- NCT05216068
- Testing
- NGS
- Where
- Taiwan
- Volunteers
- 57 people
- Sponsor
- Chang Gung Memorial Hospital
Controlled Ovarian Stimulation
Impact of Blastocyst Morphological Development and Blastocoele Re-expansion on Pregnancy Outcome After Using REKOVELLE®
The purpose of this observational study is to examine the development and appearance of embryos before and after freezing following a single controlled ovarian stimulation cycle using REKOVELLE® (follitropin delta) as the…
- Trial name
- NCT03697031
- Testing
- Follitropin Delta
- Where
- Denmark
- Volunteers
- 362 people
- Sponsor
- Ferring Pharmaceuticals
Infertility
Efficiency of Comprehensive Chromosomal Testing of Trophectoderm Biopsies of Blastocysts in In Vitro Fertilization
Preimplantation embryo aneuploidy is a major source of adverse outcomes in human reproduction since it leads to implantation failure, early pregnancy loss or severe chromosomal diseases.
- Trial name
- Devit (NCT04758819)
- Testing
- Comprehensive chromosomal Testing of Trophectoderm biopsies of Blastocysts (CTTEB)
- Where
- 10 sites in France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fertility Disorders
Performance of CHLOE Algorithm on the Prediction of Blastocyst Formation
This is an observational, prospective, single-arm, multi-center, clinical study to evaluate the performance of CHLOE, an Artificial Intelligence (AI)-based software application, as adjunct information to support identifying…
- Trial name
- CHLOE (NCT05455281)
- Testing
- CHLOE
- Where
- 3 sites in United States, Israel
- Volunteers
- 55 people
- Sponsor
- Fairtility
Primary Maternal and Neonatal Outcomes; Assisted Reproductive Technology
Retrospective Comparison of Pregnancy Outcome of Infertile Patients After Fresh and Warmed Single Blastocyst Transfer From 2014 to 2018.
The investigators retrospectively analysed the maternal and neonatal outcomes following a single fresh blastocyst transfer and a single warmed blastocyst transfer from procedures performed between 2014 and 2018 in a tertiary…
- Trial name
- NCT04310761
- Testing
- one single blastocyst transfer, both fresh and warmed
- Volunteers
- 4,613 people
- Sponsor
- Istituto Clinico Humanitas
Other Complications Associated With Artificial Fertilization
Comparison of Individual Culture and Group Culture of Preimplantation Embryos in Human IVF Treatments
Prospective randomized comparison of two widely used in vitro culture system in human IVF treatments. In vitro fertilized oocytes and embryos are cultured in individual culture media droplets using conventional petridish or in…
- Trial name
- GroupCulture (NCT01774006)
- Testing
- individual embryo culture or group culture
- Where
- Hungary
- Volunteers
- 532 people
- Sponsor
- Semmelweis University
Infertility
Whether Using Sequential pH Would Improve Human Blastocyst Formation
Any drift in extracellular pH (pHe) from the intercellular pH (pHi) could alter the mechanism regulating transporters and exchangers through the plasma membrane.
- Trial name
- NCT03641014
- Testing
- pH Effect on blastocyst formation
- Where
- 3 sites in Egypt
- Volunteers
- 1,312 people
- Sponsor
- Ibn Sina Hospital
Infertility
The Effect of Baseline Bilateral Uterine Artery Doppler Velocimetry on Obstetric Outcomes in HRT-FET Cycles
Researchers aim to determine how baseline (pre-conceptional) uterine perfusion characteristics affect implantation rates and obstetric complications in women who underwent high-quality blastocyst transfer.
- Trial name
- NCT05526014
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Infertility
Study of Nolasiban to Increase Pregnancy Rates in Women Undergoing IVF
The primary objective of this study is to confirm the efficacy of a single oral 900 mg dose of nolasiban versus placebo to increase the ongoing clinical pregnancy rate at 10 weeks post-embryo transfer (ET) day.
- Trial name
- IMPLANT4 (NCT03758885)
- Testing
- Nolasiban
- Where
- 50 sites in Belgium, Canada and 8 more
- Volunteers
- 820 people
- Sponsor
- ObsEva SA
Infertility
Comparison of Vaginal and Intramuscular Progesterone in Vitrified-warmed Blastocyst Transfer Cycles
The aim of this study is to test the hypothesis that the pregnancy rates of women (ages 18-50 years) undergoing transfer of vitrified-warmed blastocysts (frozen at less than 41 years of age) as part of their IVF treatment are not…
- Trial name
- NCT02772120
- Testing
- Vaginal progesterone gel (Crinone® 8%), Intramuscular Progesterone
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Infertility, Recurrent Pregnancy Loss
Preimplantation Genetic Diagnosis Using Blastocyst Biopsy and Array CGH
The investigators propose to perform a clinical randomized trial to evaluate the effect of single embryo (blastocyst) transfer (SET) with array CGH for the evaluation of the complete chromosome complement of the blastocyst in…
- Trial name
- NCT01546350
- Testing
- PGD
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Reprogenetics
Fertility, Implantation, Embryo
Cycle-to-cycle Variability of Progesterone in the Endometrium in Patients Undergoing an Euploid Blastocyst Transfer in a Hormone Replacement Therapy (HRT) Cycle (PROMICOFET)
This study looks at progesterone, a hormone that prepares the womb lining (endometrium) for pregnancy, in women having a frozen embryo transfer after IVF.
- Trial name
- PROMICOFET (NCT07818278)
- Testing
- Oestrogel® 0.75 mg (estradiol transdermal gel), Progesterone 200 mg vaginal capsules, Endometrial biopsy
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Infertility
CuMulativE Live bIrth Rate of Patients at High Risk of OHSS After Freeze-all Embryos at Cleavage or blAstocyst Stage
Ovarian stimulation for the induction of multifollicular growth by gonadotrophins represents an important part of In Vitro Fertilization (IVF).
- Trial name
- MELISSA (NCT03817060)
- Testing
- cryopreservation of embryos at cleavage stage, cryopreservation of embryos at blastocyst stage
- Volunteers
- 128 people
- Sponsor
- Université Libre de Bruxelles
IVF
Prolonged Protocol of Early Follicular or Mid Luteal Phase
Due to the injection of gonadotropin releasing hormone agonist (GnRH-a) before controlled ovarian hyperstimulation (COH), the scheme of prolonged early follicular period protocol has obvious advantages in achieving ideal egg…
- Trial name
- NCT04522479
- Testing
- Change the injection time of long acting GnRH-a
- Where
- China
- Volunteers
- 1,150 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Embryonic Development, Embryo Morphokinetics
Embryo Culture Under Constant 5% vs Gradient 8%, 5%, 2% Oxygen Concentration
The purpose of this study is to investigate the development of human embryos in vitro under two different oxygen concentrations; a static 5% during all five days of culture or under an oxygen gradient, starting with 8% from day-0…
- Conditions
- Embryonic Development, Embryo Morphokinetics, Embryo Morphometry
- Trial name
- NCT05898178
- Testing
- Experimental intervention: 8-5-2% oxygen gradient concentration in the incubator
- Where
- Slovenia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor