Clinical trials: Bleed Intracranial
Brain Infarction, Ischemic Stroke
Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome
BACKGROUND: In industrialized countries a considerable and increasing proportion of strokes occur at younger ages. Stroke at young age causes marked disability at worst and thus long-standing socioeconomic consequences and…
- Conditions
- Brain Infarction, Ischemic Stroke, Thrombosis, Foramen Ovale, Patent
- Trial name
- SECRETO (NCT01934725)
- Where
- 19 sites in Estonia, Finland and 11 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- SECRETO Study Consortium
Intracerebral Hemorrhage
Remote Ischemic Conditioning for Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) results from the rupture of small vessels damaged by chronic hypertension, amyloid angiopathy or other disease.
- Trial name
- RICH (NCT03930940)
- Testing
- remote ischemic conditioning, Regular treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Capital Medical University
Head Trauma, Subarachnoid Hemorrhage
Problems With Morphine Use in Patients With a Severe Brain Injury
Hypothesis: During severe brain trauma (injury, surgery) the ensuing inflammatory response in the central nervous system (CNS) results in a decrease in the expression of the transporter protein p-glycoprotein (PGP) in the blood…
- Conditions
- Head Trauma, Subarachnoid Hemorrhage, Close Head Injury
- Trial name
- NCT00196131
- Testing
- morphine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Dalhousie University
Intracerebral Hemorrhage, Intracranial Hemorrhages
Tenecteplase (TNK) in the Treatment of Intracerebral Hemorrhage (ICH)
The overall purpose of this study is to look at the safety and effectiveness of administering Tenecteplase (TNK) into the brain bleed (hematoma) instead of another clot-dissolving drug known as recombinant tissue plasminogen…
- Conditions
- Intracerebral Hemorrhage, Intracranial Hemorrhages, Hemorrhagic Strokes
- Trial name
- TNK in ICH (NCT06696131)
- Testing
- TNK
- Volunteers
- 5 people
- Sponsor
- Gaurav Gupta, MD
Hematoma, Subdural
Platelet Activity Monitoring for Patients Under Adp Medication Using Verify Now in Subdural Hematoma
The brain is encased in three membranes: the pia mater, arachnoid, and dura mater. A subdural hematoma is often a post-traumatic accumulation of blood between the dura mater and the brain, occurring when a trauma tears a small…
- Trial name
- PAPAYE (NCT06415422)
- Testing
- Biological samples
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Vasospasm, Intracranial, Subarachnoid Hemorrhage
An Evaluation of Non-invasive Acoustic Approach to Detect and Monitor Cerebral Vasospasm
HeadSense (HS)-1000 device, a proprietary non-invasive brain monitor, is expected to safely and accurately monitor physiological signs of the brain with minimal discomfort to patients, providing information about normal or…
- Trial name
- NCT02704637
- Testing
- HS-1000
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- HeadSense Medical
Stroke Hemorrhagic
Rapid Evacuation and Access of Cerebral Hemorrhage Trial
The main purpose of this study is to compare patients with a deep bleed in the brain undergoing surgery to patients receiving routine medical care.
- Trial name
- REACH (NCT06870812)
- Testing
- Surgical management, Medical Management
- Where
- 24 sites in United States
- Volunteers
- 600 people
- Sponsor
- Emory University
Immune Thrombocytopenic Purpura
A Randomized Study of IVIG vs. IVIG With High Dose Methylprednisolone in Childhood ITP.
Childhood immune thrombocytopenia purpura (ITP) is a disorder characterized by the production of antibodies against platelets, resulting in enhanced destruction of platelets.
- Trial name
- NCT00376077
- Testing
- Methylprednisolone and IVIG
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- The Hospital for Sick Children
Intracerebral Hemorrhage (ICH)
Improving the Prognosis for Cerebral Hemorrhage A Study of Clinical, Biological, and Imaging Markers
This study will establish a prospective, multicenter national cohort of patients with spontaneous intracerebral hemorrhage (ICH).
- Trial name
- TIPITCH (NCT07444853)
- Where
- 4 sites in France
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Tours
Intracerebral Hemorrhage, Arterio-venous Malformation
Multicenter Validation of the AVICH Score
The primary objective of this multicenter study is to validate the AVICH score in terms of patient outcome prediction in AVM patients with associated ICH. Secondary objectives are the impact of pretreatment of the AVICH score.
- Trial name
- AVICH (NCT02920645)
- Testing
- AVM-related ICH
- Volunteers
- 500 people
- Sponsor
- University of Zurich
Hematoma, Subdural, Chronic
The Role of Meningeal Lymphatic Vessels in the Absorption of Chronic Subdural Hematoma and Its Injury Mechanism
Chronic subdural hematoma (CSDH) is a very common hemorrhagic disease of the nervous system, accounting for about 10% of hemorrhagic strokes.
- Trial name
- NCT05426889
- Testing
- subdural hematoma burr hole drainage, drug conservative treatment
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cerebrovascular Event, Acute Ischemic Stroke
Prospective Italian Validation of SMS in Patients With Suspected Acute Stroke
The overall objective of the study is to prospectively validate the diagnostic accuracy of the Stroke Mimics Score (SMS). This score is calculated using information collected at the time of the patient's arrival in the Emergency…
- Conditions
- Cerebrovascular Event, Acute Ischemic Stroke, Intracerebral Hemorrhage, TIA (Transient Ischemic Attack)
- Trial name
- PIVA-SMS (NCT07601659)
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Traumatic Brain Injury, Cerebral Infarction
Characteristics of Blood- Brain Barrier Permeability in Neurological Patients
The main goal of the present study is to challenge the hypothesis that blood- brain barrier disruption following brain injury increases the risk for long-term disability, development of brain dysfunction, epileptic seizures and…
- Conditions
- Traumatic Brain Injury, Cerebral Infarction, Cerebral Hemorrhage
- Trial name
- NCT00419874
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Infant, Newborn, Infant, Small for Gestational Age
Vitamin E for Extremely Preterm Infants
The purpose of this pilot trial is to test the safety and efficacy of administering one dose of vitamin E, via a tube into the stomach, to extremely preterm infants (less than 27 weeks gestation and less than 1000 grams birth…
- Conditions
- Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature
- Trial name
- NCT01193270
- Testing
- Vitamin E
- Where
- 16 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Cerebral Vasospasm
Safety Study of Nicardipine to Treat Cerebral Vasospasm
The purpose of this study is to determine if intrathecal nicardipine is safe for the treatment of cerebral vasospasm.
- Trial name
- NCT01810302
- Testing
- Nicardipine hydrochloride, Preservative-free normal saline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Delayed Cerebral Ischemia, Aneurysmal Subarachnoid Hemorrhage
Micro- and Macrovascular Parameters in Delayed Cerebral Ischemia
Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) results from a complex combination of macro- and microvascular processes.
- Trial name
- PDMMS (NCT05483751)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Maastricht University Medical Center
Stroke Hemorrhagic, Intracerebral Haemorrhage
Tranexamic Acid for Spontaneous Acute Cerebral Hemorrhage Trial
This study aims to explore the effectiveness of tranexamic acid (also known as trans amine or TXA) in reducing hematoma expansion in patients with hemorrhagic stroke when given in the acute phase.
- Trial name
- TRANSACT (NCT03044184)
- Testing
- Tranexamic Acid
- Where
- Hong Kong
- Volunteers
- 220 people
- Sponsor
- Kwong Wah Hospital
Aneurysmal Subarachnoid Heamorrhage, Nontraumatic Subarachnoid Haemorrhage
Cardiopulmonary Complication in Aneurysmal Subarachnoid Haemorrhage Patients
This is a prospective cohort study investigating cardiac function and cardiac biomarkers in patients with acute Aneurysmal Subarachnoid Haemorrhage (aSAH).
- Trial name
- SAHHEART (NCT01670838)
- Where
- 3 sites in Finland, Switzerland
- Volunteers
- 198 people
- Sponsor
- Kuopio University Hospital
Intracranial Hemorrhages
BLANDISH (Brain, Loss of Function, Aneurism, Disease, Injury, Stroke, Hemorrhage)
The goal of this observational study is to train a machine learning system based on data from patients affected by spontaneous Intracranial Hemorrage.
- Trial name
- BLANDISH (NCT06320132)
- Testing
- Treatment of spontaneous intracranial hemorrhage
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- IRCCS Ospedale San Raffaele
Aneurysm, Ruptured, Vasospasm, Intracranial
Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH)
Previous work has demonstrated patients presenting with ruptured aneurysms that develop radiographic and clinical vasospasm have a higher permeability of the blood brain membrane.
- Conditions
- Aneurysm, Ruptured, Vasospasm, Intracranial, Delayed Cerebral Ischemia, Blood Brain Barrier Defect
- Trial name
- NCT04876638
- Testing
- Minocyclin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
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