Clinical trials: Bleed Intracranial
Ischemic and Hemorrhagic Stroke, Subarachnoid Hemorrhage
Early Tracheostomy in Ventilated Stroke Patients 2
Patients with severe ischemic and hemorrhagic strokes, who require mechanical ventilation, have a particularly bad prognosis. If they require long-term ventilation, their orotracheal tube needs to be, like in any other intensive…
- Trial name
- SETPOINT2 (NCT02377167)
- Testing
- Tracheostomy
- Where
- Germany
- Volunteers
- 380 people
- Sponsor
- University Hospital Heidelberg
Aneurysmal Subarachnoid Hemorrhage
Human Albumin for Clinical Outcome in Aneurysmal Subarachnoid Hemorrhages
Aneurysmal subarachnoid hemorrhage (aSAH) is a dreadful acute neurological condition with overwhelmingly high rate of associated morbidities and mortality.
- Trial name
- HASH (NCT06548477)
- Testing
- Human albumin
- Where
- Qatar
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Subarachnoid Haemorrhage (SAH)
Serum GFAP and UCHL1: Evaluation of Their Predictive Value for SAH
To verify the analytical performance of GFAP and UCH-L1 biomarkers marketed by Abbott Diagnostics and to assess diagnostic accuracy of these biomarkers in predicting subarachnoid haemorrhage
- Trial name
- SAH (NCT06581757)
- Where
- United Kingdom
- Volunteers
- 144 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Basal Ganglia Haematoma
Sterotactic Operation Integrating With Thrombolysis in Basal Ganglion Hemorrhage Evacuation
Spontaneous cerebral hemorrhage is one of the main causes of death and disability all over the world, accounting for 20%-30% of all cerebrovascular diseases.
- Trial name
- SOITBE (NCT03957707)
- Testing
- stereotactic surgery plus thrombolysis, Guideline-based standard medical management
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage
Monitoring Brain Activity in Human Brain Injury
The outcome of brain injury (physical or stroke) may be related to a brain electrical phenomenon known as Cortical Spreading Depression (CSD). This is a brief cessation of function in a local region of brain tissue.
- Conditions
- Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage, Cerebral Infarction, Cerebral Hemorrhage
- Trial name
- NCT00258505
- Testing
- Procedure: intracranial monitoring up to 9 days after injury
- Where
- 2 sites in Germany, Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Subarachnoid Hemorrhage, Aneurysmal
Noninvasive Assessment of Cerebral Oxygenation and Cardiac Function in Patients With Neurovascular Diseases
This prospective observational study will assess the regional cerebral oxygen saturation and cardiac output non-invasively in patients with subarachnoid hemorrhage during nimodipine administration for the prevention/management of…
- Trial name
- NCT02991157
- Testing
- Nimodipine
- Where
- India
- Volunteers
- 25 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Stroke, Cerebral Infarction
SouthErn China REgisTry for Stroke on Traditional Chinese Medicine
Stroke is the first most common cause of death in China and one of the major causes of functional disability in the adult population.The burden of stoke is significantly increased in China in recent years.
- Conditions
- Stroke, Cerebral Infarction, Transient Ischemic Attack, Cerebral Hemorrhage
- Trial name
- SECRETS-TCM (NCT03380481)
- Testing
- observational only-no intervention
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Yefeng Cai
Chronic Subdural Hematoma
Bedside Versus Operating Room Burr-Hole Drainage of Chronic Subdural Hematoma (DECIDE)
DECIDE (Bedside versus Operating Room Burr-Hole DrainagE of ChronIc SubDural HEmatoma) CSDH is an abnormal collection of blood between the layers of the brain causing brain tissue compression leading to neurological…
- Trial name
- DECIDE (NCT03053895)
- Testing
- CSDH - Bedside twist drill technique, CSDH - Operating Room Burr-hole technique
- Volunteers
- 486 people
- Sponsor
- Hamilton Health Sciences Corporation
Intracranial Hemorrhages, Atrial Fibrillation (AF)
Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding.
Atrial fibrillation is the most common cardiac arrhythmia. In atrial fibrillation, there is a risk that clots can form in the heart, especially in the left atrium. If these clots come loose, there is a risk of stroke.
- Conditions
- Intracranial Hemorrhages, Atrial Fibrillation (AF), Atrial Flutter
- Trial name
- CLEARANCE (NCT04298723)
- Testing
- Percutaneous closure of the LAA (Watchman / Watchman FLX)
- Where
- 39 sites in Germany, Poland
- Volunteers
- 530 people
- Sponsor
- Jena University Hospital
Intraventricular Hemorrhage of Prematurity
Research on Prevention, Early Detection, and Clinical Evaluation of Intracranial Hemorrhage in Preterm Infants
1. Establish a reference curve for the lateral ventricular diameter of premature infants and determine the intervention threshold for hydrocephalus after hemorrhage in premature infants based on the reference curve, providing a…
- Trial name
- ROPEDACEOIHIPI (NCT07157020)
- Testing
- ommaya capsule implantation technique
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Acute Brain Injury, Traumatic Brain Injury
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury
Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the…
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus
- Trial name
- CUPID-Peds (NCT07772323)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Intracerebral Hemorrhage
A Study to Evaluate the Safety, Tolerability and the Effects of Ixodes Ricinus-Contact Phase Inhibitor (Ir-CPI) in Adult Patients With Spontaneous Intracerebral Haemorrhage
The purpose of the study is to provide a first assessment of safety, tolerability and efficacy of Ir-CPI, administered on top of standard-of-care, on secondary brain injury in patients with spontaneous intracerebral haemorrhage.
- Trial name
- BIRCH (NCT05970224)
- Testing
- Ir-CPI
- Where
- 8 sites in Belgium
- Volunteers
- 23 people
- Sponsor
- Bioxodes S.A.
Intracerebral Hemorrhage
Minimally Invasive Soft Channel Brain Haemorrhage Evacuation for Acute Basal Ganglia Haemorrhage--Small Hemorrhage Evacuation (MIRACLE-S)
The objective of this study is to determine whether minimally invasive soft channel brain hemorrhage evacuation (scMIS), compared to usual care, leads to superior functional recovery as measured by utility-weighted modified…
- Trial name
- MIRACLE-S (NCT06688162)
- Testing
- Usual Care, Minimally Invasive Soft Channel Brain Haemorrhage Evacuation (scMIS)
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Capital Medical University
Usability
Summative Usability Study of CEREBO® - a Non Invasive Intracranial Hemorrhage Detector
Traumatic brain injury is one of the most common reasons for visits to the Emergency Department. More than 90% of patients who have suffered from head trauma present with a mild traumatic brain injury.
- Trial name
- NCT05340127
- Testing
- CEREBO®
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bioscan Research Pvt. Ltd.
Intracerebral Hemorrhage
Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III
A phase III, randomized, case-controlled, open-label, 500-subject clinical trial of minimally invasive surgery plus rt-PA in the treatment of intracerebral hemorrhage (ICH).
- Trial name
- MISTIE-III (NCT01827046)
- Testing
- rt-PA
- Where
- 84 sites in United States, Australia and 7 more
- Volunteers
- 499 people
- Sponsor
- Johns Hopkins University
Subarachnoid Hemorrhage
Evaluation of the Level and Prognostic Relevance of New Neuroinflammation Markers in Subarachnoid Haemorrhage
Subarachnoid hemorrhage (SAH) consists of blood extravasation into the space between arachnoid and pia mater. Bleeding is a consequence of cerebral aneurysm rupture in most cases.
- Trial name
- ESA-MICROPN (NCT03411746)
- Testing
- Subarachnoid haemorrhage
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Subarachnoid Hemorrhage, Aneurysmal, Emergency Medical Services
A Registry Study for Emergency Medical Service of Aneurysmal Subarachnoid Hemorrhage in China
This is a staged registry study of early treatment strategy management of acute aneurysmal subarachnoid hemorrhage(aSAH) among different economic development levels areas in China.
- Trial name
- CIAP-5 (NCT03115905)
- Where
- 2 sites in China
- Volunteers
- 6,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Hypertensive Intracerebral Hemorrhage, Intraventricular Hemorrhage
Neuroinflammatory Response in Patients With ICH and IVH Treated With rtPA
This study compares the neuroinflammatory response in patients with hypertensive ICH associated with IVH treated with intraventriculary applied rtPA, and the control group.
- Conditions
- Hypertensive Intracerebral Hemorrhage, Intraventricular Hemorrhage, Brain Injuries
- Trial name
- NCT03452722
- Testing
- intraventricual recombinant tissue plasminogen activator application
- Volunteers
- 88 people
- Sponsor
- University of Rijeka
Intraventricular Hemorrhage, Intracerebral Hemorrhage
The Natural History of Procalcitonin in Hemorrhagic Stroke
Approximately 12% of strokes in the United States are hemorrhagic.1 Hemorrhagic stroke can lead to multiple complications including fever that is not infectious.
- Trial name
- NCT01498705
- Testing
- Procalcitonin level
- Where
- United States
- Sponsor
- CAMC Health System
Intracerebral Hemorrhage, Atrial Fibrillation
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF).
- Trial name
- ASPIRE (NCT03907046)
- Testing
- Apixaban, Aspirin
- Where
- 187 sites in United States
- Volunteers
- 700 people
- Sponsor
- Yale University
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