Clinical trials: Bleeding
Chronic Subdural Hematoma
Postoperative Balloninflation After Evacuation of cSDH
In this prospective, randomized, multicenter trial shall patients with chronic subdural hematoma (cSDH) recruited, who were surgically treated.
- Trial name
- BANISH (NCT04060186)
- Testing
- Balloninflation
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Stroke, Microbial Disease
Estimate the Relationship Between Oral Microbiota and Stroke
Oral bacteria constitute the second largest population of the human microbiome. Recent studies have identified their role in the development of systemic diseases, such as cardiovascular and cerebrovascular diseases.
- Trial name
- NCT06479915
- Where
- 2 sites in China
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Myocardial Ischemia, Hypotension
Cardiac Effects of Oxytocin Administrated During Cesarean Section, Signs of Myocardial Ischemia
Oxytocin has cardio vascular effects as hypotension, tachycardia and possibly coronary spasm. The uterotonic effect of the drug is used during cesarean section, to minimize blood loss.ECG changes suggestive of cardiac ischemia…
- Conditions
- Myocardial Ischemia, Hypotension, Bloodloss
- Trial name
- NCT00777166
- Testing
- oxytocin
- Where
- Sweden
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Left Atrial Appendage Closure, Thrombosis
Short-Term Anticoagulation Versus Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure
The objective of the study is to compare short-term (8 weeks) anticoagulation therapy (DOAC) vs. antiplatelet therapy for the prevention of device thrombosis following transcatheter LAAC.
- Conditions
- Left Atrial Appendage Closure, Thrombosis, Stroke, TIA
- Trial name
- ANDES (NCT03568890)
- Testing
- Rivaroxaban, dabigatran, apixaban, or edoxaban, Clopidogrel -75 mg/day, Low dose aspirin -80 to 125 mg/day-
- Where
- Canada
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Skin Health, Skin Aging of Face and Hands
The Effect of Nutritional Supplementation on Actinic Purpura: A Pilot Study
Purpura is a macule or papule of blood in the skin. It is mostly seen in mature skin that is often prone to significant bruising.
- Conditions
- Skin Health, Skin Aging of Face and Hands, Healthy, Ecchymosis
- Trial name
- NCT06840574
- Testing
- Cyruta Plus: A Whole-Food Based Vitamin C supplement containing organic buckwheat (aerial parts) juice powder, organic buckwheat flour, bovine adrenal Cytosol™ extract, oat flour, honey, ascorbic acid, Low Dose Vitamin C, High Dose Vitamin C
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Standard Process Inc.
Placenta Previa Without Hemorrhage
Uterine Artery Ligation to Decrease Blood Loss With Central Placenta Previa
This trial will address the effect of uterine artery ligation during Cesarean section in cases with placenta previa to decrease blood loss.
- Trial name
- NCT02002026
- Testing
- Uterine artery ligation
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Minia Maternity University Hospital
Management of Delivery
Effectiveness of Placental Drainage in the Third Stage of Labor: a Randomized Clinical Trial
The purpose of this study is to determine if placental drainage shortens third period of labor and reduces postpartum blood lost.
- Trial name
- PLADRAINAGE (NCT01655576)
- Testing
- Placental drainage
- Where
- Brazil
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Radius Fracture Distal, Hematoma
Systemic Absorption of Lidocaine After Hematoma Block
This study will measure in children how much numbing medicine, lidocaine, is absorbed into the bloodstream after it is injected into a blood clot (hematoma) around a forearm fracture for pain control when the broken bone is moved…
- Conditions
- Radius Fracture Distal, Hematoma, Lidocaine, Pediatrics
- Trial name
- NCT04359017
- Testing
- Lidocaine 1% Injectable Solution
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy Subjects, Purpura, Thrombocytopenic, Idiopathic
Eltrombopag Taste Testing in Healthy Adult Volunteers
Based on a need for a pediatric formulation of eltrombopag for the treatment of pediatric thrombocytopenia, this study will help determine the best tasting pediatric formulation of eltrombopag.
- Trial name
- NCT00487968
- Testing
- eltrombopag
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pregnancy Complications, Hemorrhage
Tranexamic Acid to Reduce Blood Loss in Hemorrhagic Caesarean Delivery
TRACES trial is a multicenter randomized double blind placebo control therapeutic and pharmaco-biological dose ranging study to measure the effect on blood loss reduction of a single intravenous infusion of two doses regimens…
- Trial name
- TRACES (NCT02797119)
- Testing
- tranexamic acid 1 g (TA1), tranexamic acid 0.5 g (TA1/2), Saline Solution (TA0)
- Where
- 5 sites in France
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Blood Loss, Blood Transfusion
Oral Versus Intravenous Tranexamic Acid
The goal of this randomized clinical control trial is to determine whether oral TXA dosing in THA/TKA result in more blood loss and more transfusions compared to IV TXA dosing in patients undergoing THA/TKA under neuraxial…
- Trial name
- NCT04089865
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Dental Plaque, Gingival Bleeding
Comparison Between Interdental Brush and Water Floss on Plaque Accumulation and Gingival Inflammation in Patients Undergoing Fixed Orthodontic Treatment.
The goal of this clinical trial is to test the ability of water flosser to remove plaque and reduce gingival inflammation in patients undergoing fixed orthodontic treatment.
- Trial name
- NCT07240428
- Testing
- Interdental brush, Water floss
- Where
- Jordan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Abdominal Aortic Aneurysm, Coronary Heart Disease NOS
Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study
Study of heterogeneity in associations between social deprivation and the initial presentation of 12 cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease NOS, Unheralded Corronary Death, Intracerebral Haemorrhage
- Trial name
- IP4 (NCT01937065)
- Testing
- No treatment
- Where
- United Kingdom
- Volunteers
- 1,937,360 people, healthy volunteers welcome
- Sponsor
- University College, London
Anticoagulants, Platelet Aggregation Inhibitors
WOEST ( What is the Optimal antiplatElet & Anticoagulant Therapy in Patients With Oral Anticoagulation and Coronary StenTing)
The study will assess the hypothesis that the combination warfarin \& clopidogrel 75 mg/day is superior to triple therapy (warfarin + clopidogrel 75mg/day + aspirin 80mg/day) with respect to bleeding complications while equally…
- Conditions
- Anticoagulants, Platelet Aggregation Inhibitors, Stents, Atrial Fibrillation
- Trial name
- WOEST (NCT00769938)
- Testing
- PCI (percutaneous coronary intervention)
- Where
- 15 sites in Belgium, Netherlands
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- R&D Cardiologie
Blood Loss
Clonidine Versus Tranexamic Acid in Reduction of Blood Loss
Tranexamic acid is an antifibrinolytics agent that has been widely used in the reduction of blood loss at surgeries. Oral clonidine is an alpha-2 adrenergic agonist that has been used in various surgeries including Caesarean…
- Trial name
- NCT05371574
- Testing
- clonidine group
- Where
- Nigeria
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Uwakwe Emmanuel Chijioke
Early Pregnancy Bleeding, Recurrent Pregnancy Loss
Maternal and Newborn Safety Profile of Progestogens in EARLY Pregnancy
This multinational, prospective, active surveillance, registry study following two cohorts will include study participants who are pregnant and seeking any type of medical treatment, including dydrogesterone and other…
- Trial name
- PEARLY (NCT05186779)
- Testing
- Progestagen
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Hemostasis, Perioperative Bleeding
Appropriateness of Hemostatic Agent Use in Cardiovascular Surgery (HAEMOVAX)
Hemostatic agents are widely used in cardiac and vascular surgery to support intraoperative bleeding control. Despite their clinical relevance and substantial economic impact, little is known about real-world patterns of use…
- Conditions
- Hemostasis, Perioperative Bleeding, Cardiovascular Surgery, Cardiac Surgery
- Trial name
- HAEMOVAX (NCT07699016)
- Testing
- observational study
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Milan
Skull Fractures, Stroke
Simulation Training in Emergency Department Imaging 2
Background and study aims: Computerised Tomography (CT) head scans are frequently requested by Emergency Department (ED) clinicians as one of the investigations for their patients.
- Conditions
- Skull Fractures, Stroke, Intracranial Bleed, Brain Tumor
- Trial name
- STEDI2 (NCT05427838)
- Testing
- Online training
- Where
- 6 sites in United Kingdom
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Post Partum Hemorrhage
Prophylactic Regimen of Intravenous Oxytocin, Intravenous Tranexamic Acid, and Intramuscular Ergot Derivative for Primary Prevention of Postpartum Hemorrhage in Intrapartum Cesarean Section Versus Intravenous Carbetocin Alone
While Carbetocin is effective in reducing PPH, the combination of oxytocin, Tranexamic acid, and Ergot derivatives may offer additional benefits in high-risk populations.
- Trial name
- NCT07318467
- Testing
- Intravenous Oxytocin, Intravenous Tranexamic Acid, and Intramuscular Ergot Derivative, Intravenous Carbetocin alone
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postpartum Hemorrhage
In Vitro Evaluation of Spontaneous and Oxytocin-induced Contractility of Pregnant Human Myometrium During Exposure to Dexmedetomidine
Postpartum hemorrhage (PPH) remains to be one of the leading causes of maternal morbidity and mortality. It has been noted that an increasing number of PPH is attributed to the increased incidence of uterine atony.
- Trial name
- NCT05511415
- Testing
- Oxytocin, Dexmedetomidine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
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