Clinical trials: Bleeding Peptic Ulcer
Bleeding Peptic Ulcer, Active Bleeding
Urgent vs. Early Endoscopy in High Risk Patients With Upper Gastrointestinal Bleeding (UGIB)
Acute upper gastrointestinal bleeding (UGIB) is one of the commonest medical emergencies. The condition accounts for 150 per 100,000 populations. A National United Kingdom reported a crude overall mortality rate of 10%.
- Conditions
- Bleeding Peptic Ulcer, Active Bleeding, Gastrointestinal Bleeding
- Trial name
- NCT01675856
- Testing
- Urgent endoscopy, Early endoscopy
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Chinese University of Hong Kong
Bleeding, Peptic Ulcer
Early Selective TAE to Severely Bleeding Peptic Ulcers After Their Initial Endoscopic Hemostasis
The aim of this study is to determine if early angiographic embolization can forestall recurrent bleeding in selected high risk ulcers after their initial endoscopic control; to validate prospectively the investigators proposed…
- Conditions
- Bleeding, Peptic Ulcer, Arterial Embolization
- Trial name
- NCT01142180
- Testing
- TAE, No TAE
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Chinese University of Hong Kong
Peptic Ulcer Bleeding
Study to Evaluate Efficacy and Safety of Wound Dressing Solution Containing EGF in Patients With Peptic Ulcers Bleeding
This is a prospective, single-blinded, randomized study to evaluate the efficacy and safety of CEGP003 in patients with acute peptic ulcers bleeding, compared to endoscopic epinephrine injection therapy.
- Trial name
- CEGP003 (NCT03469167)
- Testing
- CEGP003, Injection Tx
- Volunteers
- 76 people
- Sponsor
- CGBio Inc.
Bleeding Peptic Ulcers
Hemostasis of Active Gastrointestinal (GI) Luminal Tract Bleeding
The objective of this study is to show that Hemospray is effective in achieving initial hemostasis and documenting rate of further bleed when compared to standard of care.
- Trial name
- HALT (NCT01306864)
- Testing
- Hemospray Kit
- Where
- 12 sites in Canada, Hong Kong and 2 more
- Volunteers
- 67 people
- Sponsor
- Cook Group Incorporated
Peptic Ulcer Bleeding
Doppler-guided Endoscopic Treatment in Peptic Ulcer Bleeding
The present study is a randomized controlled trial (RCT) that examines if the outcome of peptic ulcer bleeding could be improved by use of doppler-guided endoscopic treatment.
- Trial name
- NCT02434978
- Testing
- Supplementary endoscopy with doppler-guided therapy, IV. PPI, Endoscopic treatment at primary endoscopy
- Where
- 2 sites in Denmark
- Volunteers
- 125 people
- Sponsor
- Odense University Hospital
Bleeding Peptic Ulcers Disease
Optimal Dose of Omeprazole After Endoscopic Treatment of Bleeding Peptic Ulcers
Bleeding peptic ulcers are one of the major causes of morbidity and mortality for hospital emergency admissions.The initial treatment is endoscopic therapy followed by intravenous omeprazole.
- Trial name
- NCT00519519
- Testing
- Omeprazole
- Where
- 4 sites in Singapore
- Volunteers
- 126 people
- Sponsor
- Singapore General Hospital
Peptic Ulcer Bleeding
Risk Factors of Rebleeding After Peptic Ulcer Bleeding: a Nationwide Cohort Study
The purpose of the investigators study is to investigate the factors associated with rebleeding in patients with peptic ulcer bleeding.
- Trial name
- KPUB (NCT02152904)
- Where
- South Korea
- Volunteers
- 892 people
- Sponsor
- Joon Sung Kim
Bleeding Peptic Ulcer
High Dose Esomeprazole Na for Prevention of Rebleeding After Successful Endoscopic Therapy of a Bleeding Peptic Ulcer
To describe the rate of clinically significant rebleeding during 72 hours continuous i.v. infusion of high dose esomeprazole Na in patients in China with primary successful endoscopic haemostatic therapy of a bleeding peptic…
- Trial name
- NCT01757275
- Testing
- Esomeprazole Na, Cimetidine, Esomeprazole Mg
- Where
- 12 sites in China
- Volunteers
- 239 people
- Sponsor
- AstraZeneca
Active Peptic Ulcer Disease/GI Bleeding
Efficacy of Hemostasis by Soft Coagulation Using Endoscopic Hemostatic Forceps for Acute Peptic Ulcer Bleeding
Endoscopic high-frequency soft coagulation is available for the management of bleeding or nonbleeding visible vessels during endoscopic submucosal dissection.
- Trial name
- NCT02020603
- Testing
- epinephrine injection plus soft coagulation using hemostatic forceps, epinephrine injection plus argon plasma coagulation
- Where
- South Korea
- Volunteers
- 151 people
- Sponsor
- Kyunghee University Medical Center
Peptic Ulcer Bleeding
The Efficacy of Double Doses of Oral Esomeprazole in Preventing Rebleeding for Patients With Bleeding Peptic Ulcers
Patients with comorbidities have an increased risk of ulcer re-bleeding, especially within the 14 days after first bleeding event.
- Trial name
- DDE (NCT01591083)
- Testing
- esomeprazole (Nexium®, AstraZeneca AB, Södertälje, Sweden)
- Where
- Taiwan
- Volunteers
- 474 people
- Sponsor
- National Cheng-Kung University Hospital
Peptic Ulcer, Bleeding
Effect of IV and Oral Esomeprazole in Prevention of Recurrent Bleeding From Peptic Ulcers After Endoscopic Therapy
The investigators previously showed that the use of a high-dose intravenous PPI regimen after endoscopic control of bleeding from peptic ulcers reduced rate of recurrent bleeding, decreased the need for endoscopic and surgical…
- Trial name
- IOE (NCT01142245)
- Testing
- Oral esomeprazole, Intravenous Esomeprazole
- Where
- 2 sites in China
- Volunteers
- 263 people
- Sponsor
- Chinese University of Hong Kong
Bacterial Infection Due to Helicobacter Pylori (H. Pylori), Peptic Ulcer Bleeding
Helicobacter Pylori and the Long-term Risk of Peptic Ulcer Bleeding
Low-dose aspirin (ASA) has emerged as the most important cause of peptic ulcer bleeding worldwide. In western countries, ASA has overtaken non steroidal antiinflammatory drugs (NSAIDs) as a major cause of peptic ulcer bleeding in…
- Trial name
- 2NA3NANC (NCT01591486)
- Where
- China
- Volunteers
- 904 people
- Sponsor
- Chinese University of Hong Kong
Bleeding Peptic Ulcer
Multicenter Validation on Predicting Mortality for Patients With Bleeding Peptic Ulcers
This study aimed to validate CU prediction model on mortality for patients with high risk bleeding peptic ulcers after therapeutic endoscopy.
- Trial name
- NCT02245802
- Where
- China
- Volunteers
- 785 people
- Sponsor
- Chinese University of Hong Kong
Bleeding Ulcers
Argon Plasma Coagulation for Bleeding Peptic Ulcers
Background: A second endoscopic method added to injection therapy is recommended for high-risk bleeding peptic ulcers. Many endoscopic devices have been proved as useful hemostatic instruments, whereas the hemostatic efficacy of…
- Trial name
- NCT02241044
- Testing
- Argon plasma coagulation, Distilled water
- Where
- Taiwan
- Volunteers
- 116 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Bleeding Peptic Ulcer
Prevention of Gastric Ulcer Bleeding by Using "Computer-alert" in General Practice
The purpose of this study is to investigate if a computerised decision-support tool used in general practice, can reduce the frequency of peptic ulcer bleeding related to the use of NSAIDs (Non-Steroidal-antiinflammatory-drug)…
- Trial name
- NCT01845168
- Testing
- Computer-alert, A computer alerts which pops up when the GP presribes NSAID/ASA to a patient with risk-factors
- Where
- 2 sites in Denmark
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Endoscopy, Peptic Ulcer
High Dose Versus Standard Dose Proton Pump Inhibitor (PPI) in High-risk Bleeding Peptic Ulcers After Combined Endoscopic Treatment
The study was designed to evaluate the efficacy an adjuvant use of standard dose or high dose of proton pump inhibitor after combined endoscopic hemostasis therapy.
- Conditions
- Endoscopy, Peptic Ulcer, Bleeding, Proton Pump Inhibitors
- Trial name
- NCT00709046
- Testing
- High dose pantoprazole infusion, Standard dose pantoprazole infusion
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Non-variceal Upper Gastrointestinal Bleeding, Gastrointestinal Ulcer
European Survey of Non-Variceal Upper Gastro Intestinal Bleeding (NVUGIB)
The aim of this study is to assess the current management strategies in a pan-European "real-life" setting to uncover the unmet need in this area: non-variceal gastrointestinal bleedings.
- Conditions
- Non-variceal Upper Gastrointestinal Bleeding, Gastrointestinal Ulcer, Gastrointestinal Hemorrhage
- Trial name
- ENERGIB (NCT00797641)
- Where
- 97 sites in Belgium, Greece and 5 more
- Volunteers
- 2,500 people
- Sponsor
- AstraZeneca
Peptic Ulcers, Upper Gastrointestinal Bleeding
High Versus Standard Dose of Proton Pump Inhibitors (PPIs) in Peptic Ulcer Bleeding
High intravenous dosage of Proton Pump Inhibitors is not better than standard dosage in bleeding peptic ulcers successfully treated by endoscopic therapy
- Trial name
- NCT00374101
- Testing
- omeprazole, pantoprazole
- Where
- 10 sites in Italy
- Volunteers
- 450 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Bleeding Peptic Ulcer
Surveillance of Bleeding Peptic Ulcer Using Wireless Capsule Endoscopy
To investigate the adjunctive role of "Capsule Endoscope" in continuous endoscopic monitoring and early detection of recurrent ulcer bleeding after endoscopic therapy in patients presenting with bleeding peptic ulcers
- Trial name
- NCT00164827
- Testing
- Endoscopic placement of Capsule endoscope adjacent to the peptic ulcer
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong