Clinical trials: Bleeding Ugi, open to volunteers
Upper Gastrointestinal Hemorrhage
Efficacy of Proton Pump Inhibitors in Cirrhotic Patients With Acute Variceal Bleeding
Acute Variceal Bleeding (AVB) in patients with liver cirrhosis is a common clinical critical disease. There is little evidence for the effect of proton pump inhibitor (PPI) use in patients with AVB, and there is no study on the…
- Trial name
- NCT05624229
- Testing
- Proton Pump Inhibitors, No Proton Pump Inhibitors
- Volunteers
- 672 people
- Sponsor
- West China Hospital
Acute Non-variceal Upper Gastrointestinal Bleeding
Clinical Prediction Model for In-Hospital Rebleeding in Acute Non-Variceal Upper Gastrointestinal Bleeding
ANVUGIB is a serious condition that can cause symptoms like vomiting blood or passing black stools. Although treatments have improved, about 10% to 30% of patients experience rebleeding shortly after their initial treatment…
- Trial name
- NCT06697691
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Junwei Yan
Upper Gastrointestinal Bleeding
PuraStat® Combined With Adrenaline Versus Standard of Care in Upper Gastrointestinal Bleeding
PuraStat® is a novel gel that offers several advantages over traditional hemostatic powders. Its transparency allows for continuous visualization of the bleeding site, and it can be applied in narrow spaces or in combination with…
- Trial name
- NCT06896409
- Testing
- PuraStat® combined with Adrenaline, Standard of Care
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Tallaght University Hospital
Upper Gastrointestinal Bleeding (UGIB), Glasgow-Blatchford Score
External Validation of the Glasgow-Blatchford Bleeding Score in a Tunisian Population
This study aims to externally validate the Glasgow-Blatchford Score (GBS) in a Tunisian population presenting with non-traumatic upper gastrointestinal bleeding.
- Trial name
- NCT07089277
- Where
- Tunisia
- Volunteers
- 250 people
- Sponsor
- Hôpital Universitaire Sahloul
Occult Gastrointestinal Bleeding, Upper Gastrointestinal Bleeding (UGIB)
PillSense Use in Anemia and Hemoccult
In this study, participants will be offered a PillSense™ capsule, a small capsule to swallow, which can detect the presence of blood in the upper digestive tract within about 10 minutes.
- Trial name
- PillSense™ (NCT06951490)
- Testing
- PillSense™
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- AdventHealth
Upper Gastrointestinal Bleeding
HALP as a Novel Score for Prediction of Mortality and re_bleeding in Upper GIT Bleeding
Evaluation of the prognostic utility of the HALP score in patients with upper gastrointestinal bleeding, particularly in predicting re_bleeding risk and mortality in internal medicine department in Sohag University Hospitals.
- Trial name
- NCT07114042
- Testing
- Upper endoscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Liver Cirrhosis
Terlipressin vs. Somatostatin in Cirrhotic Patients With Acute Variceal Bleeding and Renal Dysfunction
Acute upper gastrointestinal bleeding (AUGIB) is a common complication in the decompensated stage of liver cirrhosis, of which approximately 70% is acute variceal bleeding (AVB) caused by portal hypertension.
- Trial name
- NCT07252401
- Testing
- 2-4 mg of terlipressin, 3 mg of somatostatin
- Where
- China
- Volunteers
- 64 people
- Sponsor
- General Hospital of Shenyang Military Region
Small Bowel Bleeding
Early Videocapsule Endoscopy for Upper Gastrointestinal Bleeding
The objective of this study is to determine whether early video capsule endoscopy (VCE) immediately after a negative gastroscopy in the setting of suspected upper gastrointestinal bleeding (UGIB) improves patient outcomes as…
- Trial name
- NCT05108844
- Testing
- Videocapsule endoscopy
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Non-variceal Upper Gastrointestinal Bleeding
Keverprazan vs Pantoprazole for the Treatment of ANVUGIB
Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is a common medical emergency requiring hospitalization. The cornerstone of ANVUGIB management is effective gastric acid suppression.
- Trial name
- NCT07776730
- Testing
- Pantoprazole, Keverprazan
- Where
- China
- Volunteers
- 908 people
- Sponsor
- General Hospital of Shenyang Military Region
Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB)
FENOX Trial (Comparative Effectiveness of Fexuprazan Co-therapy in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants)
Background Non-vitamin K antagonist oral anticoagulants (NOACs) are recommended for stroke prevention in non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB), Gastrointestinal Hemorrhage (Clinically Important, Upper), Drug-Related Side Effects and Adverse Reactions
- Trial name
- FENOX (NCT07497893)
- Testing
- Fexuprazan, NOAC therapy
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Upper Gastrointestinal Bleeding (UGIB)
Study of Patients With Drug-induced Non-variceal Upper Gastrointestinal Bleeding
To study the association between non-variceal UGIB and the use of NSAIDs, VKAs, DOACs and antiplatelet therapy. To compare the severity of bleeding related to specified drugs.
- Trial name
- NCT06945328
- Testing
- Upper endoscopy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Melena, Gastrointestinal Bleeding
A Study to Evaluate the Performance of a Wireless Optical Sensor Capsule in Detection of UGIB
Upper gastrointestinal bleeding (UGIB) is a common and potentially lethal medical emergency, which requires hospitalization and healthcare resources.
- Conditions
- Melena, Gastrointestinal Bleeding, Hematemesis
- Trial name
- Hemopill-Pro (NCT06715293)
- Testing
- Hemopill, OGD
- Where
- Hong Kong
- Volunteers
- 193 people
- Sponsor
- Chinese University of Hong Kong
Bleeding Ugi
PillSense for Suspected Upper Gastrointestinal Bleeding
This study aims to evaluate the efficacy and safety of a novel blood sensing capsule (PillSense), to help emergency doctors better evaluate if patients have active upper digestive tract bleeding, to determine if they can be…
- Trial name
- BLEED (NCT06500468)
- Testing
- PillSense System
- Where
- Singapore
- Volunteers
- 84 people
- Sponsor
- Tan Tock Seng Hospital
Volatile Organic Compound, Gastrointestinal Hemorrhage
Rapid Diagnostic Technology for AUGIB Based on Analysis of VOCs in Exhaled Breath
This study aims to develop a non-invasive and rapid diagnostic technology for acute upper gastrointestinal bleeding (AUGIB) by analyzing volatile organic compounds (VOCs) in exhaled breath.
- Trial name
- VOCsAUGIB (NCT06877507)
- Testing
- Gastroscopy, Gas Chromatography - Mass Spectrometry
- Volunteers
- 200 people
- Sponsor
- Beijing 302 Hospital
Acute Non-variceal Upper Gastrointestinal Hemorrhage, Coronary Heart Disease
Timing of Endoscopy in Coronary Heart Disease Patients Taking Antiplatelet Drugs With Acute Non-variceal Upper Gastrointestinal Bleeding
This is a prospective randomized controlled trial (RCT) evaluating the optimal timing of endoscopy in patients with coronary heart disease who are taking antiplatelet drugs and present with acute non-variceal upper…
- Trial name
- PACT-UGIB (NCT07507162)
- Testing
- Urgent Endoscopy (Within 12 Hours of Admission), Early Endoscopy (12-24 Hours After Admission)
- Volunteers
- 212 people
- Sponsor
- Beijing Anzhen Hospital
Ischemic Stroke, Transient Ischemic Attack
Zastaprazan for the prEvention of Upper GI Bleeding in Ischemic Stroke
The goal of this clinical trial is to learn if zastaprazan can help prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or…
- Trial name
- NCT07730840
- Testing
- Zastaprazan
- Where
- 15 sites in South Korea
- Volunteers
- 984 people
- Sponsor
- Asan Medical Center
Upper GI Bleeding, Proton Pump Inhibitors
PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers
Vonoprazan (VPZ), an oral potassium-competitive acid blocker (P-CAB) has emerged as an alternative potent acid-suppressant.It has a faster onset of action in 1 day (3-5 days in PPI), and is more stable in acidic condition than…
- Trial name
- NCT05582174
- Testing
- Vonoprazan, esomeprazole
- Where
- 8 sites in China
- Volunteers
- 594 people
- Sponsor
- Chinese University of Hong Kong
Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding
Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients
The goal of this randomized controlled clinical trial is to evaluate the efficacy of Tranexamic acid and vitamin K injection versus placebo in control of upper gastrointestinal bleeding (UGIB) in Egyptian cirrhotic patients.
- Conditions
- Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding, Cirrhosis
- Trial name
- NCT06881628
- Testing
- Tranexamic Acid and vitamin K
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Tanta University
Acute Upper Gastrointestinal Bleeding, Capsule Endoscopes
Detachable String Magnetically Controlled Capsule Endoscopy for Patients with AUGIB
Use CE for pre-examination of patients with AUGIB symptoms in emergency centers may reduce the need for emergency electronic gastroscopy and have certain advantages in clinical work.
- Trial name
- NCT06725056
- Testing
- DS-MCE and EGD examinations
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Upper GI Bleeding
Detection of Blood in the GI Lumen With HemoPill Acute
The goal of this clinical trial is to learn if the HemoPill acute (trial device) can detect the presence of blood in participants suspected of having upper gastrointestinal bleeding.
- Trial name
- DIRECT (NCT07868068)
- Testing
- HemoPill acute
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stony Brook University