Clinical trials: Bleeding Varices
Decompensated Cirrhosis, Portal Vein Thrombosis
Transjugular Intrahepatic Portosystemic Shunt (TIPS) for Prevention of Variceal Rebleeding in Cirrhotic Patients With Portal Vein Thrombosis
Portal vein thrombosis (PVT) refers to an obstruction in the trunk of the portal vein. It can extend downstream to the portal branches, or upstream to the splenic and/or the mesenteric veins.
- Conditions
- Decompensated Cirrhosis, Portal Vein Thrombosis, Bleeding Varices
- Trial name
- NCT01326949
- Testing
- Transjugular intrahepatic portosystemic shunt (TIPS), ET+NSBB
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Air Force Military Medical University, China
Variceal Bleeding
Time Interval for Endoscopic Variceal Ligation
Patients with liver disease frequently present to the hospital with bleeding from dilated veins in their foodpipe (called esophageal varices).
- Trial name
- NCT01291277
- Testing
- Endoscopic Variceal Ligation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Southern California
Acute Bleeding Esophageal Varices
RCT of Stent Versus Standard Therapy in Oesophageal Variceal Haemorrhage
The mortality rates from Acute Variceal Haemorrhage remain significant and first line therapy may fail in 15-25% of patients. The self-expandable metal stent has been described in case series as having a very high efficacy at…
- Trial name
- SOV (NCT01851564)
- Testing
- Self-expanding mesh-metal oesophageal stent (SEMS), Standard Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College, London
Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis
TIPS for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis and CTPV
To date, there is no treatment strategies for these patients according to American Association of the Study of Liver Disease (AASLD) practice guidelines and Baveno V consensus.
- Conditions
- Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis, Liver Cirrhosis, Bleeding Esophageal Varices
- Trial name
- NCT02853526
- Testing
- TIPS, Propranolol, Endoscopic therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zaibo Jiang
Decompensated Cirrhosis, Portal Hypertension
TIPS With 8- OR 10-mm Covered Stent for Preventing Variceal Rebleeding
The purpose of this study is to determine whether transjugular intrahepatic portosystemic shunt (TIPS) with 10-mm covered stent is associated with lower shunt dysfunction in comparing TIPS with 8-mm covered stent in cirrhotic…
- Conditions
- Decompensated Cirrhosis, Portal Hypertension, Bleeding Varices
- Trial name
- T8/10SVB (NCT01410591)
- Testing
- 8-mm covered stent group, 10-mm covered stent group
- Where
- China
- Volunteers
- 127 people
- Sponsor
- Air Force Military Medical University, China
Bleeding Gastric Varices
To Compare the Efficacy of Endoscopic Ultrasound Assisted Endoscopic Glue Injection and Conventional Endoscopic Injection Therapy for Prevention of Gastric Variceal Rebleed
Consecutive patients who meet the eligibility criteria will be enrolled into the study. All patients with gastric varices with no history of gastric variceal bleed (Group C) will undergo Endoscopic ultrasound and Upper…
- Trial name
- NCT01631890
- Testing
- Endoscopic Ultrasound assisted endoscopic glue injection, Standard Endotherapy
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Hypertension, Portal
Efficacy of Statin Association With Standard Treatment in Prevention of Recurrent Hemorrhage in Patient With Cirrhosis and Variceal Bleeding
This is a prospective, double blind controlled trial in which patients with esophagic variceal bleeding treated with standard therapy (endoscopic variceal ligation(EVL) + B-blockers), will be randomized to receive statins or…
- Conditions
- Cirrhosis, Hypertension, Portal, Bleeding Esophageal Varices, Portal Vein Thrombosis
- Trial name
- NCT01095185
- Testing
- Simvastatin
- Where
- 15 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Juan A. Arnaiz
Esophageal Varices, Bleeding
Self-expandable Esophageal Stent Versus Balloon Tamponade in Refractory Esophageal Variceal Bleeding.
In the last years, important advances have been done in the treatment and prevention of esophageal variceal bleeding. Experts agree that the combination of pharmacological and endoscopic therapy should be the first line therapy…
- Conditions
- Esophageal Varices, Bleeding, Cirrhosis
- Trial name
- NCT01242280
- Testing
- Stent, Tamponade
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Hospital Clinic of Barcelona
Decompensated Cirrhosis, Portal Hypertension
The Effectiveness of L-ornithine-L-aspartate (LOLA) on Plasma Ammonia in Cirrhotic Patients After TIPS
The aim of this study is to evaluate the effectiveness of L-ornithine-L-aspartate (LOLA) on plasma ammonia in cirrhotic patients after Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedure.
- Conditions
- Decompensated Cirrhosis, Portal Hypertension, Bleeding Varices, Refractory Ascites
- Trial name
- NCT01440829
- Testing
- L-ornithine-L-aspartate
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Air Force Military Medical University, China
Gastrointestinal Bleeding, Oesophageal Varices
Follow-up of Glypressin (Terlipressin) Clinical Efficacy in the Treatment of Bleeding Oesophageal Varices
Terlipressin is an effective and safe treatment for bleeding caused by rupture of oesophageal varices, which are life-threatening complications of liver cirrhosis.
- Trial name
- NCT01335516
- Testing
- Glypressin (terlipressin)
- Where
- Romania
- Volunteers
- 20 people
- Sponsor
- Ferring Pharmaceuticals
Acute Bleeding Esophageal Varices, Portal Hypertension
A Trial of Somatostatin With Endoscopic Variceal Ligation (EVL) in Control of Acute Variceal Bleeding
Background: Efficacy of endoscopic variceal sclerotherapy in achieving initial control of acute variceal bleeding and five-day haemostasis has been shown to significantly improve when vasoactive drug is added.
- Conditions
- Acute Bleeding Esophageal Varices, Portal Hypertension, Cirrhosis
- Trial name
- AVB-EVL+S (NCT01267669)
- Testing
- Somatostatin
- Where
- India
- Volunteers
- 61 people
- Sponsor
- Govind Ballabh Pant Hospital
Esophageal Varices, Bleeding
EVL (Endoscopic Variceal Ligation) Plus Vasoconstrictor vs.Ligation Plus PPI( Proton Pump Inhibitor) in the Control of Acute Esophageal Variceal Bleeding
Previous studies showed that combination of endoscopic therapy with vasoconstrictor is better than either vasoconstrictor or endoscopic therapy alone in achieving the successful hemostatsis of acute variceal bleeding.
- Trial name
- EVL (NCT01112852)
- Testing
- pantoloc 40 mg, somatostatin or terlipressin
- Volunteers
- 118 people
- Sponsor
- National Science and Technology Council, Taiwan
Esophageal Varices, Portal Hypertension
Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding
The main objective of this study is to determine the efficacy of early administration of Sanvar® in combination with endoscopic treatment for the control of acute variceal bleeding.
- Conditions
- Esophageal Varices, Portal Hypertension, Gastric Varices, Esophageal Bleeding
- Trial name
- NCT00331188
- Testing
- Sanvar® (vapreotide)
- Where
- 19 sites in United States
- Volunteers
- 70 people
- Sponsor
- Debiovision