Clinical trials: Bleeds Gastric
Esophageal and Gastric Varices
Comparison of Endoscopic Band Ligation Plus 24-hour Versus 72-hour Terlipressin Therapy
In the Western world, liver cirrhosis is a significant issue. Acute variceal bleeding (AVB) is a considerable complication of cirrhosis associated with high mortality.
- Trial name
- NCT05331768
- Testing
- banding ligation plus terlipressin infusion
- Where
- Mexico
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Peptic Ulcers
Oral Versus IV Proton Pump Inhibitor in High-risk Bleeding Peptic Ulcers After Endoscopic Hemostasis
Endoscopic hemostasis has been documented by a number of clinical studies to be effective in decreasing rebleeding, need for emergency surgery, and hospitalization days.
- Trial name
- NCT01182597
- Testing
- Pantoprazole (Pantoloc), Lansoprazole (Takepron OD)
- Where
- 2 sites in Taiwan
- Volunteers
- 190 people
- Sponsor
- National Taiwan University Hospital
Gastrointestinal Hemorrhage, Anemia
Iron Substitution After Upper Gastro-Intestinal Bleeding
The trial is a double-blind randomized trial designed to examine whether compliant iron therapy (intravenous or oral) for 3 months after discharge increases hemoglobin levels more and faster than no treatment - in patients with…
- Trial name
- NCT00978575
- Testing
- ferricarboxymaltose, Ferrosulfate
- Where
- Denmark
- Volunteers
- 97 people
- Sponsor
- University of Aarhus
Gastrointestinal Bleeding
Evaluation of Gastric Juice Samples During Standard Gastroscopy Procedure
Development of a new diagnostic detection tool for gastrointestinal bleeding.
- Trial name
- NCT01267318
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Medtronic - MITG
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
Enteral Nutrition, Gastro Intestinal Bleeding
Effects of Enteral Nutrition on Stress Ulcer Hemorrage. Multicenter Randomized Controlled Trial
Enteral nutrition can provides prophylaxis against stress ulcer bleeding in critically ill patients and there may be no need to use acid suppressing drugs for stress ulcer bleeding prophylaxis in these patients.
- Conditions
- Enteral Nutrition, Gastro Intestinal Bleeding, Stress Ulcer Prophylaxis, Proton Pump Inhibitor
- Trial name
- NCT03098537
- Testing
- enteral nutrition + proton pump inhibitor, enteral nutrition only
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- TC Erciyes University
Hemorrhage, Esophageal Varices
Short Course Terlipressin for Control of Acute Variceal Bleeding
The purpose of this study is to determine whether 24 hours of Terlipressin is as effective as 72 hours of Terlipressin in preventing re-bleed once esophageal variceal bleed has been controlled with endoscopic therapy (variceal…
- Conditions
- Hemorrhage, Esophageal Varices, Portal Hypertension
- Trial name
- NCT00369694
- Testing
- Terlipressin, Terlipressin & then Dummy
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Aga Khan University
Gastric Varices Bleeding, Cirrhosis
EUS-Guided Coil and Glue vs Glue Injection for Bleeding Gastric Varices in Cirrhosis
Gastric variceal bleeding is a life-threatening complication of portal hypertension in patients with cirrhosis and is associated with significant morbidity and mortality.
- Trial name
- NCT07855913
- Testing
- EUS-guided Coil and Cyanoacrylate Glue Injection, Endoscopic Cyanoacrylate Glue Injection
- Where
- 2 sites in United States, India
- Volunteers
- 110 people
- Sponsor
- Medanta, The Medicity, India
Gastrointestinal Hemorrhage
A Comparison of Gastric pH Control With High Dose Intravenous or Oral Esomeprazole
The investigators hypothesize that high dose esomeprazole 80mg given as a bolus, followed by 8mg/h would render gastric pH near neutral and that pH control with esomeprazole given in such a high dose either intravenous or orally…
- Trial name
- NCT00164788
- Testing
- Intravenous bolus injection of esomeprazole, Oral esomeprazole
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Chinese University of Hong Kong
Cirrhosis, Portal Vein Thrombosis
Safety of Anticoagulant Therapy After Endoscopic Treatment
The investigators aimed to verify the efficacy and safety of nadroparin calcium warfarin sequential (NWS) anticoagulation therapy after endoscopic therapy in PVT patients with cirrhosis and AVB.
- Conditions
- Cirrhosis, Portal Vein Thrombosis, Esophageal and Gastric Varices, Anticoagulant-induced Bleeding
- Trial name
- NCT04976543
- Testing
- nadroparin calcium-warfarin sequential anticoagulation
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Qilu Hospital of Shandong University
Variceal Bleeding
Efficacy and Safety of Intravenous Vitamin K1 in Management of Acute Variceal Bleeding
The administration of Vitamin K1 (Vit-K1) injection is frequently utilized in clinical practice for managing upper gastrointestinal bleeding (UGIB) associated with liver cirrhosis, despite insufficient evidence supporting its…
- Trial name
- NCT06839352
- Testing
- Vitamin K1
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Zagazig University
Acute Upper Gastrointestinal Non Variceal Hemorrhage
Endoscopic Diagnosis and Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding
Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a common critical disease in gastroenterology. Due to the development of modern medical technology, the incidence rate of ANVUGIB has been decreasing in recent years…
- Trial name
- NCT04895904
- Testing
- No intervention
- Volunteers
- 3,200 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Liver Cirrhosis, Esophageal Varices
Banding Versus Propranolol for Primary Prophylaxis of Variceal Bleeding
Whether beta-blockers or banding is the best therapy for primary prophylaxis of variceal bleeding is subject to debate. A randomized comparison between the two treatments was performed in candidates for liver transplantation.
- Trial name
- NCT00337740
- Testing
- endoscopic variceal banding, propranolol
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Padova
Liver Cirrhosis and Hepatoma., Gastric Variceal Bleeding
Endoscopic Cyanoacrylate Obliteration vs. Nadolol Treatment in the Prevention of Gastric Variceal Rebleeding
Gastric variceal bleeding has a very high rebleeding rate even after endoscopic variceal injection of cyanoacrylate (GVO) which is considered the first choice of endoscopic treatment.
- Trial name
- GVO-nadolol (NCT00567216)
- Testing
- Nadolol
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Duodenal Ulcer Bleeding
Prophylactic Injection Therapy Reduces Recurrent Bleeding In Forrest Type IIb Duodenal Ulcers
The purpose of this study is to determine whether prophylactic injection therapy reduces recurrent bleeding rate for duodenal ulcers which has the endoscopic stigmata of recent bleeding.
- Trial name
- NCT01471496
- Testing
- prophylactic injection therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Hematemesis, Portal Hypertension
Comparing Two Methods to Stop Vomiting of Blood Using the Endoscope
Band ligation and injection sclerotherapy are two modalities of treatment that are applied using the endoscope. The purpose of this study is to determine which of two methods is better for controlling bleeding from the upper gut.
- Trial name
- NCT01131962
- Testing
- Endoscopic control of hematemesis
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- University of Alexandria
Gastric Volume, Aspiration
Ultrasound Evaluation of Gastric Volume in Pediatric Patients Undergoing Adenotonsillectomy Surgery
Adenoidectomy and/or tonsillectomy are performed for many reasons such as recurrent tonsil and adenoid infections, sleep apnea, symptomatic adenotonsillar hypertrophy, halitosis, peritonsillar abscess, and it is one of the most…
- Conditions
- Gastric Volume, Aspiration, Nausea, Bleeding
- Trial name
- NCT05734937
- Testing
- gastric assessment of gastric volume
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Morbid Obesity
Efficiency of TISSEEL for Sleeve Gastrectomy Complications
Laparoscopic Sleeve Gastrectomy has emerged over the last 20 years as a treatment of choice in the surgical management of patients with morbid obesity.
- Trial name
- TISSEEL (NCT01613664)
- Testing
- tisseel, no tisseel
- Where
- 2 sites in France
- Volunteers
- 597 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Morbid Obesity
Evaluation of Endostapled Anastomoses for Laparoscopic Gastric Bypass (EEA-LGB)
Laparoscopic gastric bypass surgery is a common procedure being performed for the treatment of morbid obesity. The procedure consists of a creation of a small gastric pouch and rerouting the small bowel to bypass the stomach and…
- Trial name
- EEA-LGB (NCT00254072)
- Testing
- 3.5 mm vs 4.8 mm Stapler During Laparoscopic Gastric Bypass
- Where
- 6 sites in United States
- Volunteers
- 355 people
- Sponsor
- University of California, Irvine
Occlusive Portal Vein Thrombosis (OPVT), Cavernous Transformation of Portal Vein
Mesenteric Vein Access for OPVT-Related Recurrent Variceal Bleeding: An Ambispective Cohort
Occlusive portal vein thrombosis (OPVT) is defined as complete thrombosis of the main portal vein trunk, resulting in total interruption of portal venous inflow and representing the most severe form of portal vein thrombosis.
- Conditions
- Occlusive Portal Vein Thrombosis (OPVT), Cavernous Transformation of Portal Vein, Gastroesophageal Varices Bleeding
- Trial name
- NCT07666256
- Testing
- Percutaneous mesenteric vein-assisted interventional treatment
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Air Force Military Medical University, China