Clinical trials: Blindness, open to volunteers
Usher Syndromes
Natural History Study of Usher Syndrome ( Light4Deaf )
Clinical centres in the LIGHT4DEAF consortium have developed and will continue to improve a reliable, early molecular diagnosis and protocols for full clinical characterisation of Usher syndrome, which will be valuable for the…
- Trial name
- Light4Deaf (NCT04665726)
- Where
- 4 sites in France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Glaucoma, Diabetic Retinopathy (DR)
"My Eyes, My Light": Amar Chokh, Amar Alo
Eye disease affects 2.2 billion people globally, which in turn adversely affects schooling, economic productivity, and participation in social life.
- Conditions
- Glaucoma, Diabetic Retinopathy (DR), Hypertensive Retinopathy, Cataract
- Trial name
- ACA2 (NCT07135570)
- Testing
- Multimodal Screening for Eye Disease, cataract surgery
- Where
- Bangladesh
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Data Yakka, Inc.
Vision and Hearing Loss, Vision Impairment
SENSE-Brain Health Pro for Older Adults With Sensory Loss
The goal of this study is to learn about the outcomes, usability, and accessibility of the online Brain Health Pro program for older adults with hearing difficulties, vision difficulties, or both.
- Conditions
- Vision and Hearing Loss, Vision Impairment, Hearing Impairment, Vision Difficulty
- Trial name
- SENSE-BHPro (NCT07856888)
- Testing
- Brain Health Pro
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Université de Montréal
Presbyopia Correction, Visual Impairment and Blindness (Excl Colour Blindness)
Effect of Presbyopia Correction on Livelihood and Repayment Among Solar Customers in Western Region, Kenya
With age, people lose the ability to see things that are near them clearly. This is known as presbyopia. Although this is a normal ageing process, it can be corrected with near vision eyeglasses - colloquially known as reading…
- Conditions
- Presbyopia Correction, Visual Impairment and Blindness (Excl Colour Blindness), Repayment Behaviour, Livelihoods
- Trial name
- NCT06774183
- Testing
- Near vision glasses for presbyopia correction
- Volunteers
- 1,085 people
- Sponsor
- Dot Glasses Kenya
Wolfram Syndrome 1, Optic Atrophies, Hereditary
Does Recessive Optic Atrophy Due to WFS1 Exist?
All patients with Wolfram syndrome and recessive optic atrophy due to a mutation of the WFS1 from a single Center were included in a retrospective study.
- Trial name
- NCT07336966
- Testing
- analyse study
- Volunteers
- 45 people
- Sponsor
- Hôpital Necker-Enfants Malades
Onchocerciasis (River Blindness), Schistosomiasis
Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations
Neglected Tropical Diseases (NTDs) are among the most common groups of diseases affecting over one billion people globally and are disproportionately concentrated in remote, underserved, and marginalized communities.
- Conditions
- Onchocerciasis (River Blindness), Schistosomiasis, Soil Transmitted Helminth (STH) Infections, Lymphatic Filariasis
- Trial name
- MISSION (NCT07707817)
- Testing
- Modified Mass Administration of Medicines Strategy, Albendazole 400 mg, Praziquantel 40 mg/kg
- Where
- Nigeria
- Volunteers
- 5,760 people, healthy volunteers welcome
- Sponsor
- Uwemedimo Friday Ekpo
Hemianopia, Homonymous, Cortical Blindness, Unspecified Side of Brain
Ameliorating Stroke-induced Hemianopia Via Multisensory Training
This study seeks to determine the extent of the visual capabilities that can be restored in hemianopic stroke patients by a multisensory training technique and evaluate changes in the brain that the training induces.
- Trial name
- NCT05894434
- Testing
- Multisensory Training, Unisensory Training
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Wake Forest University Health Sciences
Retinal Degeneration, Age-Related Macular Degeneration
Adaptive Optics Imaging of Outer Retinal Diseases
The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina including photoreceptor, retinal pigment epithelium (RPE), basement…
- Conditions
- Retinal Degeneration, Age-Related Macular Degeneration, Retinitis Pigmentosa, Hydroxychloroquine Retinopathy
- Trial name
- NCT05355415
- Testing
- Adaptive optics imaging
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Food and Drug Administration (FDA)
Chronic Venous Insufficiency, CVI
Clinical Investigation of Safety and Effectiveness for the enVVe® System
A staged prospective, randomized, non-blinded, multicenter study.
- Trial name
- TAVVE (NCT07609927)
- Testing
- envve system
- Volunteers
- 220 people
- Sponsor
- Hancock Jaffe Laboratiores, Inc
Central Visual Impairment, Macular Degeneration
Factors in Learning And Plasticity: Macular Degeneration
A greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has the potential to benefit millions of individuals suffering from low vision.
- Trial name
- FLAP (NCT05454124)
- Testing
- Training visual sensitivity, Combination training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Cerebral Visual Impairment
joyVision: The Superiority of Co-design in the Development of a Serious Game for Children With Cerebral Visual Impairment
The goal of this clinical trial is to evaluate the superiority of the through codesign redesigned game joyVision over the iVision game for children with a cognitive age between 3 and 12 with CVI.
- Trial name
- NCT07893379
- Testing
- serious game
- Volunteers
- 34 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Leber Congenital Amaurosis 10, Blindness
Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)
The purpose of this double-masked, randomized, placebo-controlled, paired-eye study is to evaluate the efficacy, safety and tolerability of Sepofarsen in subjects with Leber Congenital Amaurosis (LCA) due to the c.2991+1655A>G…
- Conditions
- Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Sensation Disorders
- Trial name
- HYPERION (NCT06891443)
- Testing
- sepofarsen
- Where
- 18 sites in United States, Australia and 8 more
- Volunteers
- 32 people
- Sponsor
- Laboratoires Thea
Cerebral Visual Impairment
Neurodevelopmental Outcomes in Cerebral Visual Impairment
Cerebral visual impairment (CVI) is one of the leading causes of pediatric visual impairment and negatively impacts the development of motor, language, and cognitive skills.
- Trial name
- CVI-ND (NCT07212010)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Venous Insufficiency, CVI, Chronic Venous Insufficiency C2 or Higher
Reducing Skin Tone Inequities in Chronic Venous Insufficiency
The aim of this project is to define assessment criteria for chronic venous insufficiency (CVI) in people with dark skin tones. It will inform future interventions and modifications to practice for the assessment of CVI in people…
- Conditions
- Chronic Venous Insufficiency, CVI, Chronic Venous Insufficiency C2 or Higher, Chronic Venous Disease of Lower Limbs, Venous Leg Ulcer (VLU)
- Trial name
- NCT06798766
- Where
- 2 sites in United Kingdom
- Volunteers
- 51 people
- Sponsor
- King's College London
Chronic Venous Disease, Chronic Venous Insufficiency, CVI
The ReCAna for Lower ExtremIty Venous OBstructions and In-StEnt Restenosis Registry
The goal of this observational study is to gather additional safety and performance (effectiveness) data on the device for the treatment of symptomatic lower extremity venous obstructions and occlusions.
- Conditions
- Chronic Venous Disease, Chronic Venous Insufficiency, CVI, Venous Thrombosis, Thrombosis (Stent Thrombosis)
- Trial name
- CALIBER (NCT07529756)
- Testing
- Recanalization and debulking
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Intervene, Inc.
Low Vision Blindness, Visual Impairment
Development of a Multi-sensory Rehabilitation Program for People With Ultra Low Vision
This research is aimed to address one of the big gaps in the current vision rehabilitation protocols for people with profound visual impairment by evaluating a multisensory approach.
- Conditions
- Low Vision Blindness, Visual Impairment, Quality of Life, Functional Visual Loss
- Trial name
- NCT05028712
- Testing
- Visual Information Training, Multimodal training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- State University of New York College of Optometry
Primary Photoreceptor Disease, Retinitis Pigmentosa (RP)
A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)
Study OpCT-001-101 is a Phase 1/2a first-in-human, multisite, 2-part interventional study to evaluate the safety, tolerability, and the effect on clinical outcomes of OpCT-001 in approximately 54 adults with primary photoreceptor…
- Conditions
- Primary Photoreceptor Disease, Retinitis Pigmentosa (RP), Usher Syndrome, Inherited Retinal Disease (IRD)
- Trial name
- CLARICO (NCT06789445)
- Testing
- OpCT-001
- Where
- 5 sites in United States
- Volunteers
- 54 people
- Sponsor
- BlueRock Therapeutics
Hemianopsia, Homonymous, Brain Injury
Biofeedback for Hemianopia Vision Rehabilitation
Patients with brain injury secondary to stroke, surgery, or trauma frequently suffer from homonymous hemianopia, defined as vision loss in one hemifield secondary to retro- chiasmal lesion.
- Conditions
- Hemianopsia, Homonymous, Brain Injury, Stroke, Brain Tumor
- Trial name
- NCT05397873
- Testing
- Biofeedback training
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University Health Network, Toronto
Vision Disorders, Vision, Low
Viewing Strategy Training in Children With (Cerebral) Visual Impairment
Viewing strategies are strategies used to process visual Information. Many children with visual impairment seem to lack systematic viewing strategies.
- Trial name
- NCT05600140
- Testing
- Viewing strategy training
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Royal Dutch Visio
Hemianopia, Visual Field Defect Following Cerebrovascular Accident
Screening and Rehabilitation of Visual Field Defects in Post-Stroke Patients
In this study, the investigators will use a wearable device capable of performing this bedside assessment to evaluate the incidence of visual field loss in post-stroke patients.
- Trial name
- SCRiCaViPS (NCT07317739)
- Testing
- Early multisensory audio-visual stimulation training, Early visual field test
- Volunteers
- 300 people
- Sponsor
- Fondazione David Chiossone - Impresa Sociale