Clinical trials: Blinking
Healthy
Brain Control of Blinking
This study will use transcranial magnetic stimulation (TMS) to study how the brain controls movement of muscles in the face-in particular, those involved in eye blinking.
- Trial name
- NCT00030199
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dry Eye Disease (DED), Glaucoma
Blinking Exercise Study
The goal of this clinical trial is to evaluate whether a structured blinking exercise can improve symptoms and signs of dry eye disease (DED) in adults with glaucoma who are using topical intraocular pressure-lowering…
- Trial name
- NCT07554937
- Testing
- Structured Blinking Exercise Training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
General Anesthesia, Intraoperative Awareness
Neuro-Mimic Indicators of Anesthesia Depth During General Anesthesia
This prospective observational study will evaluate neuro-mimic indicators of anesthesia depth, including eyelid reflex, eyeball movements, and pupil responses, in patients undergoing elective surgery under general anesthesia.
- Conditions
- General Anesthesia, Intraoperative Awareness, Eye Movements
- Trial name
- NCT07199049
- Testing
- Neuro-Mimic Observation Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Myopia, Dry Eye Disease (DED)
Study of Eye Fatigue From Digital Screens and Its Impact on Visual Performance in People With Normal Vision and Myopia, With and Without Dry Eye Symptoms and Signs
The goal of this observational study is to investigate the effects of eye fatigue induced by screen task on dry eye disease (DED) signs and symptoms, visual performance, and visual behavior in young adults with and without DED…
- Trial name
- RReye (NCT07844408)
- Testing
- Eye Exams, Ocular Biometry and Aberrometry, Wearing a Smartwatch
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Essilor International
Blinking, Deep Learning
Development and Validation of Deep Neural Networks for Blinking Identification and Classification
Primary objective of this study is the development and validation of a system of deep neural networks which automatically detects and classifies blinks as "complete" or "incomplete" in image sequences.
- Trial name
- NCT04828187
- Testing
- Comparison of the proposed artificial network with the ground truth
- Where
- 2 sites in Greece
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Learning; Lack of (Specific)
Predictors of Probabilistic Selection Task Performance
The project aims to investigate whether tDCS has an effect on reward and punishment learning sensitivity. Further, whether tDCS will modulate extraversion and impulsivity personality traits, and eye-blink-rate's effect on…
- Trial name
- NCT04798105
- Testing
- Effects of tDCS of dlPFC on Probabilistic Selection Task
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charles Darwin University
Dry Eye
Patient Satisfaction and Tear Osmolarity With the Use of Blink Tears, Blink Gel Tears and Systane Balance
This is a single center clinical study designed to determine patient satisfaction and the effect of the use of artificial tears on tear osmolarity with time after instillation of three commercially available artifical tear eye…
- Trial name
- NCT01589640
- Testing
- Blink Tears lubricating Eye Drops, Blink Gel Tears Lubricating Eye Drops, Systane Balance Lubricant Eye Drop
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Connecticut
Daily Activities, Eye Health
Nursing Intervention of Blinking Exercises to Alleviate Dry Eye and Enhance Daily Life in Older Adults
The study aimed to evaluate the effect of blinking exercises in improving eye dryness and daily life in older adults. Participants aged 60 years and older of both genders, diagnosed with dry eyes and patients who were alert and…
- Trial name
- blinking dry (NCT07110467)
- Testing
- blinking exercises
- Where
- Saudi Arabia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Norther Private Collage of Nursing
Head Pain
QST, Blink Reflex and Nociceptive Flexion Reflex in Headache
The aim of this study is to compare central and peripheric sensitization in headache patients at Baseline (T0) and 1 month after (T1) a treatment with an anti-CGRP (Fremanezumab-Ajovy).
- Trial name
- NCT04585698
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Liege
Sleep Apnea Syndrome, Obstructive, Drowsiness
Ocular Parameters in Patients With Sleep Apnea
The aim of this study is to assess the ocular parameters of drowsiness in patients with diagnosed Obstructive Sleep Apnea Syndrome through objective methods of ocular imaging and subjective evaluation methods (questionnaire)
- Conditions
- Sleep Apnea Syndrome, Obstructive, Drowsiness, Blinking, Concentration Ability Impaired
- Trial name
- NCT05911737
- Testing
- Short video and Questionnaire
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Fear
Effect of D-cycloserine on Extinction of Fear Conditioning
This study will evaluate whether the drug D-cycloserine (DCS) can improve a type of learning called classical conditioning, in which the brain learns to associate neutral stimuli with stimuli that elicit emotional or…
- Trial name
- NCT00352586
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Blepharospasm
Brain Changes in Blepharospasm
This study will examine the role of certain areas of the brain in blepharospasm, a type of dystonia (abnormality of movement and muscle tone) that causes unwanted or uncontrollable blinking or closing of the eyelids.
- Trial name
- NCT00500799
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Eye Movement Desensitization and Reprocessing
Exploring the Role of Working Memory Saturation in Eye Movement Desensitization and Reprocessing (EMDR) Using the Eye Blink Conditioning Paradigm
Eye Movement Desensitization and Reprocessing (EMDR) is a well-established, evidence-based treatment for posttraumatic stress disorder (PTSD).
- Trial name
- NCT06878807
- Testing
- eye movement, TMT-B
- Where
- Spain
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Blepharospasm
Photic Blink Reflex in People With Blepharospasm and Increased Blinking
Background: Some people who have increased blinking may later develop blepharospasm. Blepharospasm is a neurological disorder that causes involuntary closing of the eyes.
- Trial name
- NCT03263000
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amyotrophic Lateral Sclerosis
Contralateral R1 in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Electroneuromyography is an important tool for the diagnosis.
- Trial name
- MOTOBLINK (NCT06206629)
- Testing
- blink reflex evaluation
- Where
- 2 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Migraine
Neurophysiology of Prophylactic Treatment in Migraine
This study aims to improve the pathophysiological understanding of migraine in in a longitudinal observational study investigating changes of established neurophysiological and imaging parameters in line with changes of the…
- Trial name
- NCT04019496
- Testing
- antibodies against calcitonin-gene related peptide or its receptor
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Caffeine
Effects of Caffeine on EEG Theta/Beta Ratio and Cognitive Control
Cognitive control driven by the prefrontal cortex (PFC) of the brain is thought to be important for goal-directed control over stimulus-driven processes.
- Trial name
- NCT02940808
- Testing
- Caffeine (200mg)
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Colorectal Polyp, Colorectal Cancer
Assessment of the Blink (First) Impression Regarding the Presence of Cancer Within Colorectal Polyps
Colorectal cancer (CRC) is a leading cause of death in the Western world. It can be effectively prevented by removal of pre-malignant polyps during colonoscopy.
- Conditions
- Colorectal Polyp, Colorectal Cancer, Colono
- Trial name
- NCT05699954
- Testing
- Presence of Blink impression features for cancer in colorectal polyps
- Where
- Belgium
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Aging, Hearing Loss
Working Memory Changes With Aging and Hearing Loss
Hearing loss is one of the most common health concerns affecting 1 in 3 Americans over 60 years of age rising to 1 in 2 for those over 85 years old.
- Trial name
- NCT01253031
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Disorders of Consciousness, Acquired Brain Injury
Spontaneous Eye Blinking Evaluation for Cognitive Assessment of Individuals With Severe Acquired Brain Injury
Assessment of consciousness and attention in individuals with severe Acquired Brain Injury (sABI) is crucial for planning rehabilitation, but it is often hindered by coexisting sensory-motor and/or cognitive-behavioural…
- Trial name
- SEE-ABI (NCT06464549)
- Testing
- EEG-EOG recording at rest and during an auditory oddball paradigm
- Where
- 2 sites in Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Alfonso Magliacano