Clinical trials: Blister
Healthy Volunteer, Dermatologic Diseases
The Acquisition of Blood and Skin Samples From Normal Volunteers to Support Research Activities on Dermatologic Diseases
Background: -This protocol is concerned with the acquisition of blood, skin, or mucosal samples from healthy volunteers or patients with selected skin diseases to support the basic science and clinical research activities of the…
- Conditions
- Healthy Volunteer, Dermatologic Diseases, Systemic Diseases
- Trial name
- NCT00001505
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Epidermolysis Bullosa Simplex
Injections of Botulinic Toxin in Plantar Lesions of Localized Epidermolysis Bullosa Simplex
The investigators hypothesize that palmar injections of botulinic toxin, via an inhibition of the sudation, would limit the occurrence of blisters in localized epidermolysis bullosa simplex (LEBS).
- Trial name
- EBTox (NCT03453632)
- Testing
- Botulinic toxin
- Where
- 4 sites in France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Blister of Foot, Blister
NanoSALV vs Standard Topical Care Pathway in Sports-Related Skin Lesions
This randomized, double-blind, two-arm parallel trial evaluates the efficacy of NanoSALV Catalytic for treating acute, sport-related friction blisters in ultra-distance runners.
- Trial name
- NCT07807904
- Testing
- NanoSALV Catalytic, Standard Topical Care Pathway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shahab Alizadeh
Pemphigoid, Bullous
Evaluation of Safety, Efficacy and Pharmacodynamic Effect of Bertilimumab in Patients With Bullous Pemphigoid
This is an open-label, proof-of-concept, single group study in adult participants with newly diagnosed, moderate to extensive BP.
- Trial name
- NCT02226146
- Testing
- Bertilimumab
- Where
- 8 sites in United States, Israel
- Volunteers
- 11 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Opioid Use, Opioid Prescribing, Dispensing, and Patient Use
Opioid Package Prototype (OPP)
The overall objective of this clinical trial is to identify the impact of selected package features, known as the Opioid Package Prototype (OPP), on the safe and effective use of opioids.
- Trial name
- NCT04598074
- Testing
- Opioid Package Prototype (OPP), Usual Care (standard amber vial)
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- UConn Health
Bullous Pemphigoid
Efficacy and Safety of add-on Dapsone Versus add-on Methotrexate in Patients With Bullous Pemphigoid
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disorder most commonly affecting the older population between 60-80 years old.
- Trial name
- NCT05984381
- Testing
- Prednisolone, Dapsone, Methotrexate
- Where
- India
- Volunteers
- 62 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Breast Cancer, Healthy Volunteer
An Exploratory Evaluation of Biomarkers in Blister Fluid in Healthy Volunteers and Irradiated Skin
Background: Blister fluid contains many of the same biomarkers (substances that can be used to determine the effects of certain kinds of treatments) as blood and urine samples, particularly regarding changes in the skin.
- Conditions
- Breast Cancer, Healthy Volunteer, Prostate Cancer
- Trial name
- NCT00923104
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- National Cancer Institute (NCI)
Spontaneous Pneumothorax, Idiopathic Pneumothorax
Thoracoscopy for Idiopathic Pneumothorax in Children
The goal of this retrospective study is to describe the outcomes of spontaneous idiopathic pneumothorax treated by thoracoscopy with pleural abrasion and blebectomy.
- Conditions
- Spontaneous Pneumothorax, Idiopathic Pneumothorax, Bleb Lung, Child, Only
- Trial name
- THOPED (NCT06734442)
- Testing
- Video-Assisted Thoracoscopy with blebectomy and pleural abrasion
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Clermont-Ferrand
Bullous Pemphigoid
A Study to Investigate the Use of Benralizumab in Patients With Bullous Pemphigoid.
The purpose of this study is to investigate the use of benralizumab is effective in the treatment of patients symptomatic Bullous Pemphigoid (BP).
- Trial name
- FJORD (NCT04612790)
- Testing
- Benralizumab
- Where
- 39 sites in United States, Australia and 9 more
- Volunteers
- 67 people
- Sponsor
- AstraZeneca
Unintentional Ingestion of Prescriptions Within Vials and Blisters
Visual Distraction as a Means of Enhancing Child Resistance
Unintentional poisonings of children continues to be a major issue in the US. According to a study conducted by Cincinnati Children's Hospital Medical Centers, during the period from 2001-2008, emergency room visits for children…
- Trial name
- VDCR (NCT01859780)
- Testing
- Visual distractor
- Where
- 3 sites in United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Blister, Wound of Skin
Safety, Tolerability, and Pharmacokinetics of Ascending Topical Doses of TCP-25 Applied to Epidermal Suction Blister Wounds, Non-Healing Leg Ulcers and Patients With Dystrophic Epidermolysis Bullosa.
This is a three-part, Phase I, first-in-human study designed to evaluate the safety, tolerability, and potential systemic exposure of multiple topical doses of TCP-25.
- Conditions
- Blister, Wound of Skin, Epidermolysis Bullosa, Varicose Ulcer of Lower Limb
- Trial name
- NCT05378997
- Where
- Sweden
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Xinnate AB
Vesicle
Spectroscopic Profiling of Extracellular Vesicles By Resonant Gold Nanostructures in the Infrared
Extracellular vesicles, due to their ease of extraction and ability to represent the cells from which they originate, have high potential in the field of personalized medicine, especially in the identification of new early…
- Trial name
- PROVEIR_1 (NCT06266195)
- Testing
- sierological test
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lung Injury, Bleb Lung
Polypropylene vs Polyglactin in Suturing of the Lung
Comparative study comparing polypropylene and Polyglactin in suturing of the lung
- Conditions
- Lung Injury, Bleb Lung, Lung Cancer
- Trial name
- NCT06115447
- Testing
- lung suturing with polyglactin, ung suturing with polypropylene
- Volunteers
- 100 people
- Sponsor
- Assiut University
Cardiovascular Diseases, Vesicle
Kinetics of cEVs Over the 24-hour Dosing Interval After Low-dose Aspirin Administration
Extracellular vesicles (EVs) are small vesicles deriving from all cell types during cell activation, involved in transcellular communication, and regarded as predictors of vascular damage and of cardiovascular events.
- Trial name
- NCT05584943
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Inflammation; Skin, Resolution
Pro-Resolving Mediators in Acute Inflammation in Humans
The investigators are undertaking a clinical blister model with or without dietary supplementation with omega-3 fatty acids (i.e., Lovaza) to determine the role of specialized pro-resolving mediators - endogenous lipids converted…
- Conditions
- Inflammation; Skin, Resolution, Blister
- Trial name
- NCT04308889
- Testing
- Lovaza, Cantharone, Phlebotomy
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Blister of Foot, Sport Injury
Evaluation of the Effectiveness of the Local Application of Lemon in the Prevention of Blisters in Ultra-trail Runners
For more than a decade, worldwide participation in ultra-marathons and ultra-trails (running races longer than the 42.195 km marathon) has been increasing.
- Trial name
- BS-2 (NCT05086640)
- Testing
- Lemon foot to prevent blister
- Where
- France
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Institut de Formation et de Recherche en Médecine de Montagne
Sport Injury, Blister of Foot
Epidemiological Characteristics and Prevention Methods of Blisters in Ultra-trail Runners
PRIMARY OBJECTIVE : To evaluate the methods of prevention of the appearance of blisters set up by the runners before and during an ultra-trail SECONDARY OBJECTIVES : To evaluate : The main locations of blisters.
- Trial name
- NCT05071651
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Institut de Formation et de Recherche en Médecine de Montagne
Blister of Foot
Blister Eradication Looking at Impact of Experimental Versus Established Regimens
The specific aim of this study is to evaluate whether RockTape has similar efficacy to Elastikon in the treatment of foot blisters in ultramarathon runners.
- Trial name
- BELIEVER (NCT03835806)
- Testing
- Elastikon, Rocktape
- Where
- 3 sites in Chile, Mongolia and 1 more
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Stanford University
Staphylococcus Aureus Skin Infection
Human Immunity Against Staphylococcus Aureus Skin Infection
Background: Staphylococcus aureus, or staph, is commonly found on the skin and in the respiratory system. Sometimes people who get sick with staph infection do not get better with standard treatment.
- Trial name
- NCT02262819
- Testing
- S. aureus
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Arthritis, Rheumatoid
Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects
This exploratory study aims to assess exposure of healthy subjects to systemic challenge with either LPS or GM-CSF. This will be done by measuring inflammatory mediators and cellular activation markers both in circulation and in…
- Trial name
- NCT03306589
- Testing
- Cantharidin, Lipopolysaccharide, Granulocyte-Macrophage Colony-Stimulating Factor
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline