Clinical trials: Blood Biomarkers
Atopic Dermatitis, Psoriasis
Identification of Cutaneous and Blood Biomarkers Predictive of Response to Systemic Treatments During Chronic Inflammatory Skin Diseases
Chronic inflammatory skin diseases constitute a heterogeneous group of pathologies. They affect the skin but also other organs (joints, lungs, muscles, etc.). Their prognosis and response to treatments is extremely variable.
- Conditions
- Atopic Dermatitis, Psoriasis, Hidradenitis Suppurativa, Lichen Planus
- Trial name
- ImmuneSkinBank (NCT06599411)
- Testing
- Sampling
- Where
- France
- Volunteers
- 830 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatitis C
Evaluation of Serum Chemokines for Patients Undergoing Treatment With Boceprevir.
The purpose of the study is to determine differences in levels of serum chemokines from patients undergoing treatment with Boceprevir.
- Trial name
- NCT01949077
- Where
- United States
- Sponsor
- University of North Carolina, Chapel Hill
Peripheral Neuropathy, Secondary to Drugs or Chemicals
Peripheral Blood Biomarkers Associated With CIPN
The investigators are doing a research study that will teach us about the tingly pain that people develop when they get chemotherapy.
- Trial name
- NCT02661399
- Volunteers
- 100 people
- Sponsor
- St. Louis University
Adherence, Patient
Identification of Surrogate Blood and/or Urine Biomarker for Immulina TM (Trademark) in Normal Humans
This is a pilot study for identifying plasma and/or urine-derived adherence/surrogate biomarker candidates for verifying Immulina™ ingestion by human volunteers (collected before and after consumption of Immulina™, a natural…
- Trial name
- NCT05556967
- Testing
- Immulina
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Cervical Adenocarcinoma, Cervical Squamous Cell Carcinoma
Feasibility Study of Blood Biomarker Identification in Cervical Cancer
This study aims to explore whether a simple blood test can be used to help detect and monitor cervical cancer. The investigators are studying tiny fragments and particles found in blood, called cell-free DNA (cfDNA) and…
- Trial name
- CLARITY (NCT07796672)
- Testing
- Blood Sample Collection, cfDNA and Extracellular Vesicle Biomarker Analysis, Patient-Reported Outcome and Quality-of-Life Assessment
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Atrial Fibrillation
Role of Cardiac Biomarkers in Prediction of Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation
The purpose of this study is to assess if pre-ablation levels of inflammatory biomarkers serve as independent predictors of procedure outcome To evaluate the inflammatory activation following catheter ablation by measuring…
- Trial name
- IMPACTII (NCT02208102)
- Testing
- Radio-frequency catheter ablation
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Periodontitis
Biomarkers for Periodontitis Relapse
In this clinical study, we have collected GCF at diseased teeth and at the same time drawn blood, both before and at 3, 6 and 12 months after periodontal surgical treatment.
- Trial name
- NCT04663165
- Testing
- Periodontal surgery, Regenerative periodontal surgery
- Where
- 2 sites in Sweden
- Volunteers
- 21 people
- Sponsor
- Anders Holmlund
Delirium, Hip Arthroplasty
Delirium, Intraoperative Cerebral Perfusion and EEG Abnormalities After Total Hip Arthroplasty
The overall objective of this study is to test for perturbations in intraoperative electroencephalogram (EEG) , cerebral blood flow (CBF), cerebral metabolic rate of oxygen consumption (CMRO2), oxygen extraction fraction (OEF)…
- Conditions
- Delirium, Hip Arthroplasty, Elderly
- Trial name
- NCT02818764
- Testing
- Blood Draw, Cerebral Spinal Fluid collection, Electroencephalogram
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Pennsylvania
Colorectal Cancer
Detection of Colorectal Cancer in Peripheral Blood by Septin 9 DNA Methylation Assay
Epigenomics is developing a colon cancer screening assay based on differential methylation of specific CpG sites for the detection of early stage disease.
- Trial name
- NCT00696345
- Where
- 5 sites in Germany, Hungary
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Dementia Alzheimers
Blood-based Biomarkers for Diagnosis of Alzheimer's
Alzheimer's disease (AD) may currently be diagnosed using molecular biomarkers in cerebrospinal fluid (CSF) and/or positron emission tomography (PET).
- Trial name
- NCT05187819
- Testing
- predictive value of a blood test
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Helse Stavanger HF
Cancer, Biomarker Discovery and Validation
Biomarkers for Cancer Treatment
Circulating biomarkers, such as miRNAs and proteomics, undergo identifiable and measurable changes during and following treatment for cancer, compared to pre-treatment baseline.
- Trial name
- NCT07803289
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Gastric Cancer, MicroRNAs
MicroRNAs From Blood Samples as Biomarkers for Gastric Cancer Detection
The goal of this observational study is to compare specific microRNA levels from the plasma of gastric cancer patients and healthy volunteers to see if there is an upregulated expression in gastric cancer patients.
- Trial name
- NCT05901376
- Testing
- MicroRNA
- Where
- Thailand
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Infections, Sepsis
A Blood Test to Diagnose Sepsis in Symptomatic Adults and Children
A case-control cohort study to develop and validate the performance of a whole blood gene expression test to distinguish sepsis infection from uninfected systemic inflammatory response syndrome cases in symptomatic adults and…
- Conditions
- Infections, Sepsis, SIRS
- Trial name
- NCT05142813
- Testing
- Diagnostic Test: Blood specimen collection
- Volunteers
- 1,100 people
- Sponsor
- mProbe Inc.
Blood Pressure
Postpartum ASA and NT-proBNP
This study is a double-blinded randomized-controlled trial in which patients will be randomized to 81 mg of aspirin or placebo to be continued for 6 weeks' postpartum.
- Trial name
- NCT05889468
- Testing
- Aspirin 81Mg Ec Tab
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Duke University
Lung Cancer
Methylated Genes in Blood as Biomarkers for Advanced Lung Cancer
The purpose of this study is to study whether the presence of lung cancer in your body can be detected by testing the blood, and if the results of these blood tests change as your tumor shrinks or grows.
- Trial name
- NCT00579462
- Testing
- Blood and Tissue studies
- Where
- United States
- Volunteers
- 281 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lung Cancer
Biomarker Study of Blood Samples From Patients With Non-Small Cell Lung Cancer Treated With Carboplatin and Paclitaxel With or Without Bevacizumab
RATIONALE: Studying samples of blood in the laboratory from patients undergoing treatment for non-small cell lung cancer may help doctors predict how patients will respond to treatment.
- Trial name
- NCT00898417
- Testing
- bevacizumab, carboplatin, paclitaxel
- Volunteers
- 90 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Vagal Syncope
Validation of a Non Invasive Blood Marker of SIDS and Vagal Disorders
Context The investigators recently demonstrated a highly significant increase in muscarinic receptor density in the myocardium of infants deceased from sudden infant death syndrome (SIDS) compared to those of infants deceased…
- Trial name
- NCT01358461
- Testing
- Blood sampling, ECG-Holter 24 h tape and sino-carotid stimulation test
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Pancreatic Cyst
Hyperpolarized C Pyruvate Magnetic Resonance Imaging, and Blood-Based Biomarkers for Early Detection of Pancreatic Adenocarcinoma in Patients With Intraductal Papillary Mucinous Neoplasms
The purpose of this study is for researchers to find ways of detecting pancreatic ductal adenocarcinoma/PDAC early to avoid the invasive procedure of surgery.
- Trial name
- NCT06305728
- Testing
- 89Zr-DFO-HuMab-5B1 immunoPET, HP MRI, Blood assay
- Where
- 8 sites in United States
- Volunteers
- 25 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Delirium - Postoperative, Neuronal Damage
The Association Between Postoperative Inflammatory and Neurological Serum Biomarker Concentrations and Occurrence of Postoperative Delirium
Postoperative delirium is a frequent and serious complication in older surgical patients, linked to prolonged hospitalization and long-term cognitive decline.
- Conditions
- Delirium - Postoperative, Neuronal Damage, Blood Brain Barrier Defect, Postoperative Complications
- Trial name
- SPOT_ON_BRAIN (NCT07411612)
- Testing
- laboratory biomarker analysis, 3D-CAM/CAM-ICU
- Where
- Austria
- Volunteers
- 1,170 people
- Sponsor
- Medical University of Vienna
Out-of-Hospital Cardiac Arrest
Transitions Between Clinical Circulatory States After Out-of-hospital Cardiac Arrest
Extensive research exists for cardio-pulmonary resuscitation (CPR) and the chance of successful return of spontaneous circulation (ROSC) is improved.
- Trial name
- NCT02648061
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Norwegian University of Science and Technology