Clinical trials: Blood Circulation Disorder
Coronary Arterial Disease (CAD), Angina (Stable)
The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow
The goal of this clinical trial is to investigate the effect of sublingual nitroglycerin on absolute coronary blood flow in adult patients undergoing coronary angiography.
- Trial name
- FLOW-NITRO (NCT06823843)
- Testing
- Glycerin trinitrate (GTN)
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Cognitive Decline
Investigate the Effect of Tart Montmorency Cherry Juice (Prunus Cerasus) on Cerebral Blood Flow and Cognitive Function
Scientific studies in humans suggest that diets high in fruit and vegetables may be able to improve some aspects of mental performance such as improving memory and reaction times.
- Trial name
- NCT02381860
- Testing
- 60mL tart Montmorency cherry juice
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Kidney Diseases
The Effects of Glucagon on Renal Regional Blood Flow in Humans Measured by Magnetic Resonance.
This study will investigating the effects of glucagon on renal blood flow in humans using MRI technology. Glucagon, a hormone produced by the pancreas, plays a key role in regulating blood sugar levels.
- Trial name
- NCT06872060
- Testing
- Glucagon, Glucagon+Exendin9-39, Sodium chloride
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Asymptomatic Condition
Instrument Assisted Soft Tissue Mobilization Effect on Blood Flow
This study is designed to evaluate the short term change in blood flow in the superficial human tissue layers after the application of 3 min Graston instrumented assisted soft tissue mobilization on the plantar aspect of the foot…
- Trial name
- NCT04785079
- Testing
- Graston Instrument assisted Soft tissue Mobilization
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Florida Gulf Coast University
Prostate Cancer
Study to Monitor the Effects of Androgen Suppression Treatment on the Heart
Suppression of effects of androgens with male sex hormones, androgen suppression treatment (AST), has been known to reduce deaths and prolong life in advanced prostate cancer.
- Trial name
- AST (NCT01230905)
- Testing
- PET scan and ultrasound
- Where
- Canada
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Vasospasm
Effect of Glucose on Ocular Blood Flow
The primary objective is to assess the effect of glucose on retinal vascular diameter in otherwise healthy vasospastic subjects compared to non-vasospastic controls.
- Trial name
- NCT00350129
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Nicotine Dependence, Cigarettes
Acute Oral Effects of Heated Tobacco Products
Heated tobacco products (HTP) are devices which heat, but not burn tobacco. They do not produce cigarette smoke but rather an aerosol. HTPs are marketed as less harmful alternatives to smoking.
- Trial name
- NCT05538702
- Testing
- IQOS 3.0 DOU with bland taste unit (Heated Tobacco Product), IQOS 3.0 DUO with menthol taste unit (Heated Tobacco Product), Marlboro Gold (Conventional cigarette)
- Where
- Hungary
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Orthodontic Treatment
Curve of Spee: Speed of Leveling Using Different Orthodontic Archwires
The objectives if this study was to evaluate the efficacy of 3 different rectangular archwires in the correction of the curve of Spee (COS), to record the time needed to level excessive COS in the mandibular arch using the 3…
- Trial name
- NCT04549948
- Testing
- 0.017X0.025 Stainless steel, 0.019X0.025 Stainless steel, 0.021X0.025 B-Titanium archwire
- Where
- Jordan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Stroke, Acute
Exercise and RIC and TCD
The first week after a stroke is a particularly important time, as improving blood flow may limit secondary ischaemic damage to the brain and help reduce the overall burden neurological injury and future disability.
- Trial name
- NCT03968068
- Testing
- Exercise Procedure, Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Cystic Fibrosis
Blood Flow and Vascular Function in Cystic Fibrosis
Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-FLOW (NCT02057458)
- Testing
- Sildenafil (Acute-1 hour), Sildenafil (Subchronic-4 weeks)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Augusta University
Central Serous Chorioretinopathy
Optical Coherence Tomography Angiography (OCT-A) and Central Serous Chorioretinopathy (CSC)
Optical Coherence Tomography Angiography (OCT-A) is a noninvasive imaging technique that allows one to see blood vessels in the retina.
- Trial name
- OPACITY (NCT03950089)
- Testing
- Optical Coherence Tomography Angiography (OCT-A)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Shoulder Pain, Bone Mineral Density
BFR After Bicep Tenodesis
A randomized controlled pilot study evaluating the effect of occlusion training on bone density and function of the upper extremity following a biceps tenodesis.
- Conditions
- Shoulder Pain, Bone Mineral Density, Muscle Strength
- Trial name
- NCT03437239
- Testing
- Delfi PTS II Portable Tourniquet System
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Hypertension
Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
The purpose of this study is to determine if Nebivolol improves microvascular perfusion in skeletal muscle during exercise in hypertensive patients and whether this improvement is accompanied by reduction in vascular oxidative…
- Trial name
- NCT01501929
- Testing
- Metoprolol succinate, Nebivolol, Non-invasive measurement of Cardiac Output (CO)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cardiovascular Diseases
Effects of Oral Antioxidant Cocktail in Cardiovascular Disease Patients
Title: Effects of oral antioxidant cocktail on vascular function and muscle function in cardiovascular disease patients Cardiovascular disease (CVD) generally refers to various conditions involving narrowed or blocked…
- Trial name
- NCT03629613
- Testing
- Oral antioxidant cocktail, Baseline
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Hypotension on Induction
Carotid Artery Corrected Flow Time and Respiratory Variation of Blood Flow Peak Velocity for Prediction of Hypotension After Induction of General Anaesthesia in Adult Patients With Chronic Liver Disease
Baseline Measurements For the ultrasound parameters, it is the average of three readings In supine position . The investigators will continuously monitoring during induction and 10 minutes after.
- Trial name
- NCT07370103
- Where
- Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pruritus
Influence of Antipruritics on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin.
In order to validate the accuracy and reliability of the histamine skin prick model for histaminergic itch and vasodilation, the dermal blood flow response induced by a histamine skin prick will be evaluated after the…
- Trial name
- NCT04399148
- Testing
- Desloratadine 5 mg, Aprepitant 125 mg, Ketotifen 1 MG
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pregnancy, Polycystic Ovary Syndrome
Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women
A more recent prospective nonrandomized placebo-controlled double-blind clinical study demonstrated that metformin exerts a slight but significant deleterious effect on serum homocysteine (Hcy) levels in patients with PCOS, and…
- Trial name
- NCT01115140
- Testing
- Metformin plus folic acid
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Skeletal Muscle Atrophy
Post-operative Electrical Muscle Stimulation to Stimulate Muscle Protein Synthesis in Humans
Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence.
- Trial name
- PoEMS (NCT05997095)
- Testing
- Neuromuscular electrical stimulation (NMES/0
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Female Sexual Dysfunction, Female Sexual Dysfunction Due to Physical Condition
Effect of Peripheral Neuromodulation on Vaginal Blood Flow - Study 2
The overall purpose of this research is to improve sexual function in women with sexual dysfunction. The goal of this study is to see if either of two nerve stimulation interventions cause a short-term change in vaginal blood…
- Trial name
- NCT06999265
- Testing
- Transcutaneous electrical nerve stimulation - Tibial Nerve, Transcutaneous electrical nerve stimulation - Genital Nerve, Neutral and Erotic Film Clip Alternation
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Michigan