Clinical trials: Blood Donors
Healthy Volunteers
Transfusion of Biotin-Labeled Red Blood Cells
The purpose of this research is to evaluate the impact of genetic and biologic factors in blood donors on red blood cell storage stability after autologous transfusion over the different range of storage period of 5-7 days and…
- Trial name
- NCT03364686
- Testing
- Biotin-Labeled Red Blood Cells
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
Blood Donors
The Effect of Recruiting Inactive Blood Donors Using Different Means
14098 inactive donors were randomly divided into three groups according to age, sex, blood donation frequency,time of last donation and blood donation site, one group acted as the control group, one will be recruited by telephone…
- Trial name
- NCT04078893
- Testing
- telephone recruitment
- Where
- China
- Volunteers
- 14,098 people, healthy volunteers welcome
- Sponsor
- Guangzhou Blood Center
Normal Physiology
Pharmacokinetics of Granulocyte Colony Stimulating Factor in the Breast Milk of Volunteer Peripheral Blood Stem Cell Donor
Background: The drug filgrastim (rGCSF) increases the number of blood-forming cells in the bloodstream. These cells can be collected from donors bloodstreams and used for transplant.
- Trial name
- NCT02322151
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Blood Donation, Blood Transfusion
Donor Lifestyle and Nutritional Status, Blood Component Quality, and Patient Safety (ESENCIA)
The goal of this observational study is to evaluate how blood donors' lifestyle and nutritional status influence the quality of packed red blood cells (pRBCs) during storage and their impact on patient safety in transfused…
- Trial name
- ESENCIA (NCT07558369)
- Where
- Mexico
- Volunteers
- 1,014 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Perinatologia
Blood Donation
Sucrosomial Iron and Iron Sulphate to Blood Donors
2 different oral iron supplementations after blood donation are compared.
- Trial name
- NCT05678647
- Testing
- Sucrosomial Iron, Iron Sulfate
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Uppsala University Hospital
HIV, Herpes Simplex 2
Improving Blood Safety and HIV Testing in Brazil
Conduct a randomized controlled trial (RCT) to test the hypothesis that offering client-centered HIV counseling and testing (HCT) to blood donor candidates will reduce the risk of HIV contamination in the blood supply and also…
- Conditions
- HIV, Herpes Simplex 2, Hepatitis C, Hepatitis B
- Trial name
- NCT01681420
- Testing
- HIV Counseling and Testing, Blood Donation
- Where
- Brazil
- Volunteers
- 11,900 people, healthy volunteers welcome
- Sponsor
- Vitalant Research Institute
Iron Deficiency
Microbiome of Donor Iron Deficient Study
The goal of this pilot study is to test whether the microbiome is affected by intravenous iron repletion.
- Trial name
- NCT02990988
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Columbia University
Blood Donors, Blood Transfusion
Transfusion Infections Pediatric Prospective Study (TRIPPS)
To conduct a prospective study of pediatric transfusion recipients to determine the risk of transmitting various infectious agents by blood transfusion.
- Conditions
- Blood Donors, Blood Transfusion, Cytomegalovirus Infections, Hepatitis, Viral, Human
- Trial name
- TRIPPS (NCT00029406)
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Naomi Luban
Syncope, Vasovagal
Preventing Negative Reactions in First Time Blood Donors to Encourage Subsequent Blood Donations
Many individuals experience negative reactions when donating blood, including dizziness, lightheadedness, or fainting. Such reactions may discourage them from donating again.
- Trial name
- NCT00302900
- Testing
- Pre-Donation Water Consumption, Muscle Tensing Exercise During Donation, Muscle Tensing Exercise Prior to Donation
- Where
- 2 sites in United States
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- Ohio University
Healthy Donors
Impact of Leukoreduction Timing on Plasma Citrullinated Histone H3 (H3cit) Dynamics and Red Blood Cell Storage Lesions
Impact of Leukoreduction Timing on Plasma Citrullinated Histone H3 (H3cit) Dynamics and Red Blood Cell Storage Lesions To measure H3cit levels immediately after filtration on Days 0, 1, 3, and 5.
- Trial name
- NCT07821736
- Testing
- H3Cit
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Myeloproliferative Disorders, Leukemia
Measuring Changes in Blood in Patients at High Risk of Cytomegalovirus Infection After Undergoing Donor Bone Marrow Transplant or Peripheral Blood Stem Cell Transplant
RATIONALE: Tests that measure certain changes in blood in patients at high risk of cytomegalovirus infection may help doctors learn more about predicting cytomegalovirus infection after donor stem cell transplant.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00716911
- Testing
- ganciclovir, polymerase chain reaction, flow cytometry
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Hypertension, Cardiovascular Diseases
Effect of Sublingually Generated S-nitroso-N-acetylcysteine on Systemic Blood Pressure.
The purpose of the study is to increase the in vivo levels of nitric oxide by generating nitric oxide donor compound S-nitrosoacetylcysteine (SNOAC) using the mixture of sodium nitrite and N-acetylcysteine crystals in the…
- Trial name
- NCT05798481
- Testing
- Mixture of Sodium Nitrite and N-acetylcysteine (NAC) crytals.
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Leukemia, Lymphoma
A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation From Related or Matched Unrelated Donors in Pediatric Patients With Solid Tumors and Leukemias
Background: Bone marrow stem cells, which are found in the bone marrow and blood stream, can be collected and transplanted to treat a variety of types of cancer in a process known as hematopoietic stem cell transplantation…
- Trial name
- NCT01287104
- Testing
- Natural Killer (NK) Cell Infusion, Stem Cell Infusion
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Living Kidney Donation
The Living Kidney Donor Safety Study
The main goal of this study is to understand the long-term effects of kidney donation on blood pressure, kidney function, and patient-reported health-related quality of life.
- Trial name
- LKD (NCT00936078)
- Where
- 13 sites in Australia, Canada
- Volunteers
- 1,438 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Healthy Volunteers
Recruiting Blood Donor With Allogeneic Natural Killer Cell
This study on manufacture of MG4101 (allogeneic natural killer cell) to use for Hepatocellular carcinoma(HCC) after Transarterial Chemoembolization(TACE) will be harvested WBC(white blood cell) and plasma from healthy donors, or…
- Trial name
- NCT02716571
- Testing
- Leukapheresis or Plasmapheresis
- Where
- South Korea
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Transmission, Blood, Recipient/Donor
Clinical Investigation to Evaluate the Haemonetics POLFA Modified Sample Needle Assembly With Vacuum Tube Holder
This study evaluates whether whole blood transferred through the new POLFA needle assembly meets supernatant hemoglobin acceptability standards.
- Trial name
- NCT02476851
- Testing
- POLFA (Needle Assembly), Kawasumi (Needle Assembly)
- Where
- 3 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Haemonetics Corporation
Multiple Myeloma, Non-Hodgkin Lymphoma
Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL
This is a phase I trial with pilot expansion of HLA-haploidentical or HLA-mismatched related donor nicotinamide expanded-natural killer (NAM-NK) cell based therapy for patients with relapsed or refractory multiple myeloma (MM) or…
- Conditions
- Multiple Myeloma, Non-Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, Mantle-Cell Lymphoma
- Trial name
- NCT03019666
- Testing
- Nicotinamide Expanded Haploidentical or Mismatched Related Donor Natural Killer Cells
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota