Clinical trials: Blood Flow
Traumatic Brain Injury
Effects of Early Skull Repair With Titanium Mesh on Cerebral Blood Flow and Neurological Recovery
To evaluate the feasibility of CT perfusion technique to monitor the changes of blood perfusion in the brain tissue before and after skull repair using titanium mesh.
- Trial name
- NCT03222297
- Testing
- early skull repair, late-stage skull repair
- Volunteers
- 86 people
- Sponsor
- Taihe Hospital
Neurodegeneration
Effects of Flavonoids on Cognitive Performance in Healthy Young Adults
The purpose of this study is to investigate changes in cerebral blood flow, blood flavonoid levels, brain-derived neurotrophic factor, vascular reactivity and cognitive performance in young adults as a result of acute…
- Trial name
- NCT01312597
- Testing
- Fruit juice beverage
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Reading
Circulatory Shock
Efficacy of the Use of Vasopressin as a Primary Vasoconstrictor in Critically Ill Patients
Current guidelines recommend the inititaion of noradrenaline and if shock is refractory, then vasopressin should be administered. Data indicate that the earlier use of vasopressin may improve survival.
- Trial name
- NCT06265259
- Testing
- Initiation of vasopressine as a first vasoconstrictive drug, Initiation of noradrenaline as a first vasoconstrictive drug
- Where
- Greece
- Volunteers
- 145 people
- Sponsor
- University of Thessaly
Idiopathic Pulmonary Arterial Hypertension
Acute Effects of Benzbromaron on the Pulmonary Circulation
Actual studies suggest that a calcium activated chlorid channel (TMEM16A) may play a relevant role in the pathogenesis of pulmonary arterial hypertension (PAH).
- Trial name
- NCT02790450
- Testing
- Benzbromarone
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
Hemophilia
Resistance Training With Blood Flow Restriction in Hemophilia
The main objectives of this study are to evaluate safety and chronic effects of a low-load resistance exercise intervention (elbow flexions and extensions, and knee extensions) with blood flow restriction in people with…
- Trial name
- HemoBFR (NCT05568524)
- Testing
- BFRT, Control
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- University of Valencia
Diabetes Mellitus, Dysglycemia
Accuracy of Continuous Glucose Monitoring in Patients With Diabetes. A Prospective Observational Study
The goal of this observational study is to investigate the accuracy of the continuous glucose monitoring (CGM) compared to standard point-of-care (POC) blood glucose measurements in patients with diabetes in patients who during…
- Conditions
- Diabetes Mellitus, Dysglycemia, Perioperative Complication, Circulatory; Complications
- Trial name
- NCT06297850
- Testing
- Dexcom G7 Continuous Glucose Monitoring (CGM) System (G7)
- Where
- 4 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Near-Infrared Spectroscopy, Iliac Artery Stenosis
NIRS and Exercise Intensity in Patients With FLIA
The research objectives of this project are to increase the understanding of pathophysiology and performance limitations related to sport-related flow limitation in the iliac artery (FLIA) using non-invasive measurement of muscle…
- Conditions
- Near-Infrared Spectroscopy, Iliac Artery Stenosis, Iliac Artery Disease, Iliac Artery Occlusion
- Trial name
- NCT05229250
- Testing
- Cycling test, Occlusion tests, NIRS during cycling
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Headache Disorders
Carbon Monoxide Headache Triggering Properties as Well as Effects on the Brain's Vessels and Blood Flow
Studying Carbon monoxide effects on brain vessels in healthy volunteers with magnetic resonance imaging.
- Trial name
- NCT03385174
- Testing
- Carbon monoxide
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Blood Flow
The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes
This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in…
- Trial name
- GA-17b (NCT06426823)
- Testing
- GIPR antagonist / study tool
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Copenhagen
Acute Circulatory Failure During One-lung Ventilation Surgery
Use of Mini-fluid Challenge for Fluid Responsiveness Prediction During One-lung Ventilation
During thoracic surgery, an excessive use of fluid results in pulmonary complications. Dynamic fluid responsiveness predictors are not easily usable during one lung ventilation.
- Trial name
- NCT02858115
- Testing
- Fluid challenge, Trans-oesophageal echography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Iron, Cerebral Blood Flow
16 Weeks' Dietary Supplementation With Iron and Iron + Vitamin C on Cerebral Blood Flow and Energy Expenditure in Women of Reproductive Age
Iron deficiency is the most prevalent nutritional deficiency worldwide with one in four estimated to be affected by iron deficiency anaemia.
- Conditions
- Iron, Cerebral Blood Flow, Energy Metabolism, Cognitive Function
- Trial name
- NCT04477018
- Testing
- Iron bis-glycinate chelate and vitamin C, Iron bis-glycinate chelate
- Where
- United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Small Vessel Cerebrovascular Disease, Stroke
Intensive Blood Pressure Control in Ischaemic Stroke Patients With Severe Cerebral Small Vessel Disease
Objectives: Cerebral small vessel disease (SVD) is a common disease in patients with ischemic stroke and the most common cause of vascular dementia. Blood pressure (BP)-lowering is generally considered neuroprotective.
- Trial name
- NCT05690997
- Testing
- Intensive treatment, Standard treatment
- Where
- Hong Kong
- Volunteers
- 104 people
- Sponsor
- The University of Hong Kong
Peripheral Arterial Disease
Effect of Single-versus Double-limb Cycling Exercise on Blood Flow in Patients With Peripheral Artery Disease
This study will be conducted to investigate the effect of single limb cycling exercise and the effect of double limb cycling exercise on blood flow in patients with peripheral artery disease and compare between both effects.
- Trial name
- NCT06518590
- Testing
- Cycle
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cairo University
Muscle Strength, Resistance Training
Effects of Blood Flow Restriction vs. High-Load Resistance Training on Arm Strength
This study investigated the effects of low-load resistance training combined with blood flow restriction (BFRT) compared to traditional high-load resistance training on arm muscle strength and isokinetic contraction parameters in…
- Conditions
- Muscle Strength, Resistance Training, Blood Flow Restriction
- Trial name
- BFRT-ARM (NCT07462520)
- Testing
- Low Load Blood Flow Restriction Training, High Load Resistance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Gazi University
Normal Subjects
A Feasibility Study to Determine PET/CT Imaging of Blood Flow to the Bone
To evaluate if a commonly used medical bone scan, called positron emission tomography/computed tomography (PET/CT) with sodium fluoride can measure bone blood flow to the hip.
- Trial name
- PETCT (NCT03557450)
- Testing
- PET/CT Scan
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Circulatory Failure
Fluid Responsiveness Evaluation by AbdomiNal Compression in Kids Based on the STARLING Concept
Purpose: Fluid responsiveness in a context of circulatory failure can be predicted by different way. Dynamic criteria such as pulse pressure variation, stroke volume variation during an end-expiratory occlusion maneuver or a…
- Trial name
- FRANCK (NCT02505646)
- Testing
- Observational study. No special intervention will be made
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Hopital Louis Pradel
CLABSI - Central Line Associated Bloodstream Infection
Epidemiological Investigation of Central Venous Catheter-related Bloodstream Infections in Icus in China
In recent years, with the rapid advancement of medical technology and the rapid development of critical care medicine, the use of various central venous catheters in icus has been increasing day by day.
- Trial name
- NCT07255105
- Where
- China
- Volunteers
- 1,846 people
- Sponsor
- Jianfeng Xie
Healthy, Physiology
Assessment of the Changes in Cortical and Medullary Renal Blood Flow During Exercise in Healthy Subjects Using Contrast Enhanced Ultrasound
Renal parenchymal blood flow can be divided in cortical and medullary blood flow. Changes and factors affecting renal medullary blood flow have not been studied in detail previously as investigators/doctors did not have tools to…
- Trial name
- NCT02672722
- Testing
- Definity, Exercise, Kidney Ultrasound
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cardiac Surgery, Extracorporeal Circulation
Impact of VARIation of OXYdo-reduction Potential in Cardiac Surgery on Post-operative Outcome
Observational, prospective, monocentric study conducted in the cardiac surgery department about biological markers to predict the short-term outcome of heart surgery patients.
- Trial name
- VARIOXY (NCT06840327)
- Testing
- Blood and tissue samples, walking test
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Toulouse