Clinical trials: Blood Loss,
Chronic Rhinosinusitis (Diagnosis)
Functional Endoscopic Sinus Surgery Study
The aim of this study is to evaluate the effect of the addition of epinephrine to bilateral real time ultrasound guided pterygopalatine ganglion blocks on intra-operative bleeding and blood loss during functional endoscopic sinus…
- Trial name
- FESS (NCT03970655)
- Testing
- Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 1, Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 2
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Florida
Placental Blood Drainage
Comparison of Blood Loss in Using vs Not Using Placental Cord Drainage After Spontaneous Vaginal Delivery
Comparison of effectiveness of placental blood drainage after spontaneous vaginal delivery in decreasing the duration, blood loss,and complications of the third stage, against no drainage of placental blood.
- Trial name
- NCT03020355
- Testing
- Placental Blood Drainage, not Placental Blood Drainage
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Morbidity
PPIs and In-Hospital Morbidity in Acute Variceal Bleeding With Chronic Liver Disease
With this study, the investigators pretend to describe intrahospital morbidity in patients living with cirrhosis (PLC) who present to the emergency department with variceal bleeding (VB).
- Trial name
- Liver-IMPACT (NCT06861478)
- Testing
- Omeprazole 40 mg IV, pantoprazole 40 mg iv
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Morbid Obesity, Anastomotic Leak
Stratafix vs. Vicryl OAGB / MGB Suture Study
To compare shorttime (6 months) results of two competitive suture materials with regard to time demanded to perform the concerned surgical step and secondary to study anastomotic site safety and complications like leakage and…
- Conditions
- Morbid Obesity, Anastomotic Leak, Anastomotic Stenosis, Hemorrhage Postoperative
- Trial name
- NCT04613635
- Testing
- Stratafix, Vicryl
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- St. Franziskus Hospital
Intraoperative Bleeding
Effect of Topical and Systemic Tranexemic Acid on Bleeding During Ear Exploration Surgery
The effect of tranexamic acid (TXA) on bleeding and improvement of surgical field during ear exploration surgery is not clear yet. This study will conducted to answer this question.
- Trial name
- NCT03112135
- Testing
- Tranexamic Acid, Adrenalin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Hemorrhage
POCUS-PEAC to Reduce Femoral Arterial Blood Flow
The aim of this study is to evaluate the efficacy on healthy subjects of Point of Care ultrasonographically guided external aortic compression compared to the manual technique already described.
- Trial name
- NCT04745585
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Subarachnoid Hemorrhage, Aneurysmal
Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) is bleeding into the space between the brain and the tissues that surround the brain as a result of a ruptured aneurysm and is a type of stroke associated with high morbidity and…
- Trial name
- PENDULUM (NCT05032118)
- Testing
- Ketamine Hydrochloride, Propofol
- Sponsor
- Jenna L Leclerc MD, PhD
Intracerebral Hemorrhage, Low T3 Syndrome
Efficacy of Thyroid Hormone Replacement for Secondary Hypothyroidism Following Intracerebral Hemorrhage
Low levels of serum triiodothyronine (T3) thyroid hormones (T4) are a strong predictor of mortality and poor prognosis in critical care patients. Few reports, however, have focused on neurocritical patients.
- Conditions
- Intracerebral Hemorrhage, Low T3 Syndrome, Neurocritical Care, Hormone Replacement Therapy
- Trial name
- NCT06353555
- Testing
- Euthyrox
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Bleeding
TXA in the EMS on the Helicopter and the Ambulance
Coagulopathy in trauma increases mortality and morbidity. Early administration of tranexamic acid (TXA) seems to improve survival and outcome.
- Trial name
- TXASRZREGA (NCT02354885)
- Testing
- Tranexamic Acid
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Aneurysm, Ruptured, Subarachnoid Hemorrhage
Clinical Efficacy of In-situ Thrombolysis in Case of Intraventricular Haemorraghia by Aneurysm Rupture
The purpose of this study is to determine the impact of in situ fibrinolysis on the mortality at 30 days in case of subarachnoid hemorrhage.
- Trial name
- NCT00823485
- Testing
- fibrinolysis in situ, drainage
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Coronary Artery Disease, Subclinical Atherosclerotic Cardiovascular Disease
Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Controlled Trial
In patients with subclinical coronary artery disease, the ASCAD-P study aims to assess the feasibility of a larger phase 3 pragmatic randomized controlled trial comparing prescription versus no prescription of low-dose aspirin in…
- Trial name
- ASCAD-P (NCT07524335)
- Testing
- Prescription of Aspirin, No prescription
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Montreal Heart Institute
Hemorrhage; Intracerebral, Nontraumatic, Ischemic Strokes
Effect of Ischemic Strokes on Recovery From Intracerebral Hemorrhages
Intracerebral hemorrhage (ICH) occurs when small arteries in the brain rupture due to weakening by age, high blood pressure, and/or elevated cholesterol.
- Conditions
- Hemorrhage; Intracerebral, Nontraumatic, Ischemic Strokes, Diffusion Weighted Imaging Lesions
- Trial name
- NCT01417117
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Rush University Medical Center
ST Elevation Myocardial Infarction
Safety of Ticagrelor Monotherapy After Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction and the Effect on Intramyocardial Haemorrhage
The main goal of this clinical trial is to assess whether direct omission of aspirin after Percutaneous Coronary Intervention (PCI) with the continuation of ticagrelor monotherapy for 12 months versus 12 months ticagrelor plus…
- Trial name
- STOP-IMH (NCT05986968)
- Testing
- Ticagrelor, Aspirin
- Where
- 5 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Acute Coronary Syndrome, Myocardial Infarction
What is the Optimal Antithrombotic Strategy in Patients With Atrial Fibrillation Undergoing PCI?
The optimal antithrombotic management in patients with coronary artery disease (CAD) and concomitant atrial fibrillation (AF) is unknown.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Atrial Fibrillation, Atrial Flutter
- Trial name
- WOEST-3 (NCT04436978)
- Testing
- 30-day DAPT, Guideline-directed therapy
- Where
- 20 sites in Belgium, Netherlands
- Volunteers
- 2,000 people
- Sponsor
- St. Antonius Hospital
Healthy
Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Fentanyl
The purpose of this project is to test how fentanyl, an analgesic currently employed in the pre-hospital setting by the US Army, alters the capacity to tolerate a hemorrhagic insult in humans.
- Trial name
- NCT04136548
- Testing
- Fentanyl
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Placenta Previa, Vaginal Bleeding
The Rate and Predictors of Vaginal Bleeding Among Women With Placenta Previa
Placenta previa is usually diagnosed when the placenta implanted in the lower uterine segment, thus partially or totally overlying the internal os . It occurs with an incidence of 0.3-0.5%.
- Conditions
- Placenta Previa, Vaginal Bleeding, Antepartum Hemorrhage
- Trial name
- NCT05645848
- Testing
- Ultrasonography
- Volunteers
- 250 people
- Sponsor
- Assiut University
Congenital Bleeding Disorder, Haemophilia A
Project to Update the Study of Congenital Haemophilia in Spain
This study is conducted in Europe. The aim of the study is to update the knowledge about the prevalence and severity of congenital haemophilia (A and B) in Spain.
- Conditions
- Congenital Bleeding Disorder, Haemophilia A, Haemophilia B
- Trial name
- PUCHS (NCT01959555)
- Testing
- No treatment given
- Where
- Spain
- Volunteers
- 1,157 people
- Sponsor
- Novo Nordisk A/S
Rheumatoid Purpura, Pediatric ALL
Validation of the IgA1 Detection Method With Gradient Glycosylation by Mass Spectrometry as a Potential Marker of Renal Involvement in Pediatric Rheumatoid Purpura
In this ancillary study on the FoxTreg cohort, the study investigators will select variables to input and thus develop two models (Linear Discriminant Analysis and Decision Tree).
- Trial name
- FOXIGA-2020 (NCT04655378)
- Testing
- Mass Sepctrometry
- Where
- 2 sites in France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Subarachnoid Aneurysm Hemorrhage
Minocycline as Neuroprotectant After Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to determine the safety and efficacy of a drug minocycline in improving outcomes at 3 months after rupture of an aneurysm in the head.
- Trial name
- NCT02113176
- Testing
- Minocycline
- Where
- United States
- Sponsor
- University at Buffalo
Secondary Amenorrhea
A Phase 3, Randomized, Three-Cycle, Double-Blind, Placebo-Controlled Study to Evaluate Induction of Secretory Conversion of Endometrium and Withdrawal Bleeding for Secondary Amenorrhea
This study will be a Phase 3, randomized, three-cycle, double-blind, placebo-controlled, parallel group, multiple-dose design. The study design has four phases: Screening Period; Open-Label Estrogen-Priming Period (Run-In…
- Trial name
- SPRY (NCT02019589)
- Testing
- Progesterone
- Where
- 22 sites in United States
- Volunteers
- 6 people
- Sponsor
- TherapeuticsMD
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