Clinical trials: Blood Loss,
Postpartum Haemorrhage, Immediate Postpartum Hemorrhage
Prevention of Post-partum Haemorrhage
The primary purpose of the trial is to evaluate whether the management of placental delivery with controlled cord traction (CCT) reduces the incidence of postpartum haemorrhage, compared with management waiting for clinical signs…
- Trial name
- TRACOR (NCT01044082)
- Testing
- controlled cord traction, Clinical signs of placental separation
- Where
- France
- Volunteers
- 4,382 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Surgical Blood Loss, Fibroid
Hemostatic Effect of Intrauterine Instillation Of Tranexamic Acid In Hysteroscopic Myomectomy
Study Design: Randomized Controlled Clinical Trial. Study Population: The study population will be a consecutive series of participants attending the Early Cancer Detection Unit (ECDU) at Ain Shams University Maternity Hospital.
- Trial name
- NCT03122782
- Testing
- Topical application Tranexamic acid
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Hypotension
Efficacy Study of a Facemask Device to Treat Hypotension
The purpose of this study is to determine if the impedance threshold device (ITD) attached to a facemask can increase blood pressure in patients who present to the emergency department with hypotension secondary to hypovolemia.
- Trial name
- NCT00256724
- Testing
- Impedance Threshold Device
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Advanced Circulatory Systems
Liver Cirrhosis, Portal Hypertension
Endoscopic Ruler for the Assessment of Variceal Bleeding Risks (CHESS2005)
The presence of varices is a serious complication of portal hypertension in liver disease. To prevent variceal haemorrhage, screening and surveillance aims to detect high-risk varices related to varices size and determine the…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Gastroesophageal Varices
- Trial name
- NCT04639323
- Testing
- Endoscopic ruler
- Where
- 7 sites in China
- Volunteers
- 266 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Sleep
Stable Sleep Pattern Before Sleep Loss
Sleep is now recognized as important for disease prevention. Too little or too much sleep contributes to cardiovascular disease. Leading health organizations recommend adults sleep 7-9 hours per night for optimal health.
- Trial name
- NCT06201390
- Testing
- Sleep consistency
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Adolescent Idiopathic Scoliosis
Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery
The Finnish Paediatric Orthopaedic Study Group will perform a prospective randomized, multicenter, clinical trial comparing Gelatin matrix with human derived thrombin (Floseal, Baxter) and without use of Floseal in adolescents…
- Trial name
- NCT01451788
- Testing
- Gelatin matrix with human derived thrombin (Floseal, Baxter)
- Where
- 3 sites in Finland
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Atrial Fibrillation, Hemorrhage
Management of Major Bleeding Events in Atrial Fibrillation Patients Using Pradaxa
This study is being conducted to collect data on the management of major bleeding events occurring in patients with atrial fibrillation taking dabigatran etexilate.
- Trial name
- NCT02149303
- Testing
- Dabigatran 75 mg, Dabigatran 150 mg
- Where
- 5 sites in United States
- Volunteers
- 191 people
- Sponsor
- Boehringer Ingelheim
Peptic Ulcer Hemorrhage
Study Evaluating Pantoprazole in Peptic Ulcer Hemorrhage
This is a multicenter, randomized, double-blind, parallel-group, dose-ranging, comparator-controlled study of the effect of pantoprazole on intragastric pH after successful endoscopic hemostasis in hospitalized patients.
- Trial name
- NCT00037570
- Testing
- Pantoprazole
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Subarachnoid Hemorrhage, Aneurysmal, Headache
Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage
The goal of this clinical trial is to learn if an infusion of lidocaine, with or without steroids, into the middle meningeal artery (MMA) helps relieve severe headaches in patients with spontaneous subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Headache, Opiate Dependence, Opioid Use
- Trial name
- NCT07294118
- Testing
- Lidocaine, Lidocaine and Dexamethasone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Hemoptysis, Pulmonary Embolism
Prevalence Of Pulmonary Embolism In Patients With HEmoptysis (POPEIHE)
Estimation of the incidence of pulmonary embolism in patients presenting to the Emergency Department with hemoptysis.
- Trial name
- POPEIHE (NCT06067997)
- Testing
- pulmonary embolism diagnosis
- Where
- Italy
- Volunteers
- 550 people
- Sponsor
- Società Italiana di Medicina di Emergenza-Urgenza
Obesity
Cyanoacrylate Versus Omentum for Staple-Line Reinforcement in Sleeve Gastrectomy
Study Title: Comparing Surgical Glue (Cyanoacrylate) vs. Omentum Tissue to Strengthen Staple Lines in Weight-Loss Sleeve Surgery What is the purpose of this study? This study will compare two ways to strengthen the staple line…
- Trial name
- NCT07339020
- Testing
- Glubran® 2 surgical glue (n-butyl-2-cyanoacrylate mixture) and its specific applicator., Autologous Greater Omentum, Staple Line Reinforcement during Laparoscopic Sleeve Gastrectomy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Chronic Hepatitis B (HBeAg-negative)
HBsAg Loss Adding Pegylated Interferon in HBeAg-negative Patients
Chronic hepatitis B (CHB) affects more than 350 million people worldwide. The most common form in Europe is CHB HBeAg-negative. Antiviral treatment of CHB HBeAg-negative patients includes chronic administration of nucleos(t)ide…
- Trial name
- NCT02743182
- Testing
- Pegylated interferon alfa-2a
- Volunteers
- 119 people
- Sponsor
- José Antonio Carrion
Intraoperative Bleeding
Comparison Between Atenolol,Propnalol and Ivabradine
The aim of this work is to compare atenolol, propranolol, and ivabradine as a premedication to achieve bloodless field anesthesia primarily controlling heart rate in lumbar spine surgery.
- Trial name
- NCT06670690
- Testing
- Atenolol 50 MG, Propranolol Pill, Ivabradine
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Liver Transplantation, Erythrocyte Transfusion
Blood Salvage From Liver Donors: a Feasibility Pilot Study
Blood recovery is a common procedure that limits patient exposure to allogeneic blood products. Blood recovery is usually performed during different types of surgery, including cardiac and vascular surgery, or liver…
- Trial name
- BLEED (NCT05835882)
- Testing
- Red Blood Cell concentrates from organ donor
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Blood Loss, Surgical
Tranexamic Acid in Major Vascular Surgery
The purpose of this study is to determine whether tranexamic acid is effective in reducing intraoperative blood loss and necessity for haemotransfusion in patients undergoing open abdominal aortic aneurysm repair
- Trial name
- NCT02335359
- Testing
- tranexamic acid diluted in 100 ml of saline solution (loading dose), tranexamic acid undiluted (continous infusion)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Gastrointestinal Hemorrhage
Efficacy and Safety Study of Esomeprazole vs Omeprazole to Treat Acute Non-Variceal Upper Gastrointestinal Bleeding
The purpose of this study is to assess the efficacy and safety of Esomeprazole and Omeprazole intravenous every 12 hours for 5 days in subjects with acute non-variceal upper gastrointestinal bleeding
- Trial name
- NCT00402259
- Testing
- Esomeprazole IV, Omeprazole IV
- Where
- 7 sites in China
- Volunteers
- 440 people
- Sponsor
- AstraZeneca
Congenital Bleeding Disorder, Congenital FXIII Deficiency
Safety of Monthly Recombinant Factor XIII Replacement Therapy in Subjects With Congenital Factor XIII Deficiency: An Extension to Trial F13CD-1725
This trial is conducted in Asia, Europe and North America. The aim of the trial is to investigate the safety of monthly replacement therapy of recombinant factor XIII in patients with congenital FXIII deficiency.
- Trial name
- mentor™2 (NCT00978380)
- Testing
- catridecacog
- Where
- 34 sites in United States, Austria and 10 more
- Volunteers
- 63 people
- Sponsor
- Novo Nordisk A/S
HIV Infection, HIV Care Loss to Followup
Birmingham Access to Care Study
The purpose of this study is to determine whether a modified form of the ARTAS (Antiretroviral Treatment and Access to Services) intervention, adapted for HIV patients who have fallen out of care, can be successful in re-engaging…
- Trial name
- BA2C (NCT02525146)
- Testing
- Modified ARTAS (Antiretroviral Treatment and Access to Services) intervention
- Volunteers
- 170 people
- Sponsor
- University of Alabama at Birmingham
Hemorrhagic Shock, Trauma Injury
Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children
The MATIC-2 is a multicenter clinical trial enrolling children who are less than 18 years of age with hemorrhagic shock potentially needing significant blood transfusion.
- Trial name
- MATIC-2 (NCT06070350)
- Testing
- Low Titer Group O Whole Blood (LTOWB), Tranexamic Acid (TXA), Component Therapy (CT)
- Where
- 23 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Philip Spinella
Intracranial Hemorrhages, Intracranial Hemorrhage, Hypertensive
Start or STop Anticoagulants Randomised Trial (SoSTART)
Primary research question: For adults surviving spontaneous (non-traumatic) symptomatic intracranial haemorrhage with persistent/paroxysmal atrial fibrillation/flutter (AF), does starting full treatment dose oral anticoagulation…
- Conditions
- Intracranial Hemorrhages, Intracranial Hemorrhage, Hypertensive, Subarachnoid Hemorrhage, Subdural Hematoma
- Trial name
- SoSTART (NCT03153150)
- Testing
- Apixaban, Rivaroxaban, Edoxaban
- Where
- 67 sites in United Kingdom
- Volunteers
- 203 people
- Sponsor
- University of Edinburgh
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