Clinical trials: Blood Loss,
Uterine Fibroids, Heavy Menstrual Bleeding
Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids
The primary objective of this study is to demonstrate the superior efficacy versus placebo of OBE2109 alone and in combination with add-back therapy for the reduction of heavy menstrual bleeding associated with uterine fibroids…
- Trial name
- PRIMROSE 2 (NCT03070951)
- Testing
- OBE2109, Add-back
- Where
- 96 sites in United States, Bulgaria and 7 more
- Volunteers
- 511 people
- Sponsor
- ObsEva SA
Ovarian Cancer, Perioperative Blood Loss
Comparison of Single-Dose Tranexamic Acid Vs. Placebo in Ovarian Cancer Surgery
This study evaluated the effectiveness of a single dose of tranexamic acid compared to a placebo in reducing blood loss and the need for blood transfusions in women undergoing surgery for ovarian cancer.
- Conditions
- Ovarian Cancer, Perioperative Blood Loss, Blood Transfusion Events
- Trial name
- NCT06879353
- Testing
- Tranexamic Acid (TXA)
- Where
- Pakistan
- Volunteers
- 372 people
- Sponsor
- Sheikh Zayed Medical College
Proliferative Diabetic Retinopathy
Endolaserless Vitrectomy With Intravitreal IAI for PDR-Related VH
This is a phase I/II open label, randomized, interventional clinical trial. Study eyes will receive one preoperative intravitreal aflibercept injection (IAI) <21 days but >7 days prior to vitrectomy and one intraoperative IAI at…
- Trial name
- LASERLESS (NCT02976012)
- Testing
- Aflibercept, Endolaserless Vitrectomy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Southeast Retina Center, Georgia
Blood Loss, Surgical
Non-invasive Perioperative Hb Monitoring in Spinal Surgery
The decision to transfuse or not to transfuse blood products is one of the main issues in patients undergoing surgery. The standard laboratory method of hemoglobin assessment is time-consuming, gives intermittent data, and…
- Trial name
- NCT02908412
- Testing
- Digital nerve block with bupivacaine
- Where
- Iran
- Volunteers
- 23 people
- Sponsor
- Tehran University of Medical Sciences
Femur Surgery
The Use of Tranexamic Acid (TXA) Intravenously, to Reduce Blood Loss in Proximal Femur Surgery
The use of Tranexamic Acid (TXA) intravenously, to Reduce Blood Loss in proximal femur surgery.
- Trial name
- NCT02164565
- Testing
- Tranexamic Acid (TXA) treatment, control grup: without Tranexamic Acid (TXA) treatment.
- Where
- Israel
- Sponsor
- HaEmek Medical Center, Israel
Hemophilia
Are There Differences Between Carriers of Haemophilia A and B?
This study aims to develop a systematic genetic screening strategy for (potential) female carriers of haemophilia by identifying as many female carriers as possible within the families of haemophilia patients regularly followed…
- Trial name
- NCT05217992
- Testing
- Genetic assessment (hemophilia testing)
- Where
- Belgium
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Thrombotic Thrombocytopenic Purpura, Atypical Hemolytic Uremic Syndrome
TTP and aHUS in Complicated Pregnancies
A single site observational study aiming to: (i) Identify cases of previously undiagnosed thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic syndrome (aHUS) in a cohort of women with complicated pregnancies (ii)…
- Conditions
- Thrombotic Thrombocytopenic Purpura, Atypical Hemolytic Uremic Syndrome, Pre-Eclampsia, HELLP Syndrome
- Trial name
- NCT03605511
- Testing
- ADAMTS 13, complement and angiogenic biomarkers
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University College, London
Ischemic Stroke
One Pass Tirofiban In Management of Ischemic Stroke Thrombectomy In China
In recent years, the positive results of trials for mechanical thrombectomy (MT) have brought a new era for large artery occlusion patients, especially those beyond the time window of intravenous thrombolysis.
- Trial name
- OPTIMISTIC (NCT04851457)
- Testing
- Intravenous tirofiban combination therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai East Hospital
Intra Cerebral Hemorrhage, Stroke
Ultra-Early, Minimally inVAsive intraCerebral Haemorrhage evacUATion Versus Standard trEatment
A randomized controlled trial of ultra-early, minimally invasive, hematoma evacuation versus standard care within 8 hours of intracerebral hemorrhage.
- Trial name
- EVACUATE (NCT04434807)
- Testing
- Minimally invasive hematoma evacuation
- Where
- 13 sites in Australia
- Volunteers
- 240 people
- Sponsor
- University of Melbourne
Immune Thrombocytopenia, Immune Thrombocytopenic Purpura
Molecular Analysis of Thrombocytopenia and Cancer (MATAC): Investigating Antigenic Mimicry Between Platelets and Tumor Cells in Patients With Immune Thrombocytopenia (ITP) Associated With Cancer
The association between hematologic malignancies and ITP is well described, but this link is much less clear with solid cancers.
- Conditions
- Immune Thrombocytopenia, Immune Thrombocytopenic Purpura, Neoplasms, Cancer
- Trial name
- MATAC (NCT06444477)
- Testing
- ITP and cancer
- Where
- 20 sites in France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Bordeaux
Gynaecological Cancers, Ovarian Cancer
Methylation Profiling in Self-samples for Identification of (Epi)Genetic Biomarkers for Gynecological Cancers
The goal of the MYSSELF study is to investigate which biological markers (i.e., (epi)genetic biomarkers) found in self-collected samples, such as first-void urine and vaginal samples, are linked to the presence of endometrial…
- Conditions
- Gynaecological Cancers, Ovarian Cancer, Endometrial Cancer, Vulvar Cancer
- Trial name
- MYSSELF (NCT07902375)
- Testing
- Colli-Pee 20 mL device with UCM, Evalyn Brush
- Where
- Belgium
- Volunteers
- 730 people
- Sponsor
- Universiteit Antwerpen
Obesity, Body Weight
Effects of Capsimax on Appetite, Energy Intake and Blood Pressure
Obesity is an ongoing major public health problem in most countries of the world for which the agrifood industry still remains criticized because of the abundant offer of high sugar-lipid-energy dense foods, particularly in the…
- Conditions
- Obesity, Body Weight, Weight Loss, Overweight
- Trial name
- NCT04874701
- Testing
- Capsimax, Energy restriction
- Where
- Canada
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Laval University
Bleeding, Real-world Study
Post-marketing Safety and Efficacy Surveillance of Motherwort Injection
This study aims to provide evidence concerning the safety and efficacy of motherwort injection in real-world settings.
- Conditions
- Bleeding, Real-world Study, Adverse Events
- Trial name
- NCT06636422
- Testing
- Motherwort injection
- Volunteers
- 20,000 people
- Sponsor
- Zhong Wang
Coronary Heart Disease, GI Bleeding
Platelet Inhibitory Effect of Clopidogrel in Patients Treated With Omeprazole, Pantoprazole, or Famotidine
Current guidelines recommend the addition of proton pump inhibitors (PPI) to patients taking double anti-platelet therapy (Aspirin and Clopidogrel) to prevent upper GI bleeding1.
- Trial name
- NCT00950339
- Testing
- omeprazole, 20mg twice daily, famotidine 40mg twice daily, pantoprazole 40mg once daily
- Where
- Israel
- Volunteers
- 63 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Immune Thrombocytopenia
A Study of ATRA in the Treatment of ITP
An open-label, multicenter study to compare the efficacy and safety of ATRA for the treatment of adults with primary immune thrombocytopenia (ITP)
- Trial name
- NCT04618328
- Testing
- all trans retinoic acid
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Atrial Fibrillation, Anticoagulants and Bleeding Disorders
Safety and Efficacy of Edoxaban in Thoracoscopic Ablation
The aim of this study is to compare the safety and efficacy of edoxaban and warfarin for prevention of stroke during a 6-month follow up after total thoracoscopic ablation.
- Trial name
- NCT04121767
- Testing
- Edoxaban, Warfarin
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Postpartum Hemorrhage
Effect of Uterine Massage Versus Sustained Uterine Compression on Blood Loss After Vaginal Delivery
The purpose of this study is to compare trans-abdominal uterine massage to sustained uterine compression after vaginal delivery with respect to blood loss and maternal pain.
- Trial name
- NCT02396771
- Testing
- Uterine Massage, Uterine Compression
- Where
- Lebanon
- Volunteers
- 445 people
- Sponsor
- American University of Beirut Medical Center
Bleeding Complications
Clopidogrel Monotherapy in Patients With High Bleeding Risk
The goal of this research is to show that a shorter duration of two antiplatelet medications (compared to the standard of care) is safe and effective while reducing the risk of bleeding complications.
- Trial name
- NCT05223335
- Testing
- Clopidogrel, Prasugrel, Tricagrelor
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Mayo Clinic
Isthmocele, Cesarean Scar Defect
Clinical Impact of Uterine Repair During Cesarean Section With Barbed Suture on the Incidence of Isthmocele
Pregnant women, irrespective of their pregnancy risk, who undergo a cesarean section for any reason will be randomized to one of two suturing techniques: conventional suture or barbed suture for uterine repair after the cesarean…
- Conditions
- Isthmocele, Cesarean Scar Defect, Pelvic Pain, Spotting
- Trial name
- CESARIS (NCT06691750)
- Testing
- Barbed suture, Conventional smooth suture
- Where
- Spain
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Liver Transplant
Fluid Management Strategies on Blood Loss in Liver Transplantation
During liver transplantation, due to the complexity of the operation and abnormal coagulation function, there may be a large amount of bleeding and corresponding blood transfusion.
- Trial name
- NCT06215404
- Testing
- Liberal group, restrictive group
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
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