Clinical trials: Blood Loss, Surgical
Coronary Artery Disease, Perioperative Bleeding
Oral Versus Intravenous Tranexamic Acid in Off-Pump Coronary Artery Bypass Surgery
Tranexamic acid is commonly administered intravenously during cardiac surgery to reduce perioperative bleeding. Oral tranexamic acid may offer a simpler and less costly alternative, but its effectiveness in patients undergoing…
- Trial name
- TRANSCAB (NCT07740330)
- Testing
- Oral tranexamic acid, Exacyl®
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Clinique Saint-Luc
Periodontitis
Comparison of Adjunctive Chemomechanical Therapy With Standard Care in Patients With Periodontitis
The goal of the clinical trial is to compare adjunctive chemomechanical therapy with standard care regarding root planning in patients with periodontitis.
- Trial name
- NCT05757921
- Testing
- Perisolv (A), Standard (B)
- Volunteers
- 38 people
- Sponsor
- Kristianstad University
Perioperative Bleeding, Opioid Consumption
Ultrasound-Guided Erector Spinae Plane Block in Major Spinal Surgery
This study aims to evaluate the effects of ultrasound-guided bilateral erector spinae plane block on intraoperative pain control and bleeding in patients undergoing major spinal surgery.
- Conditions
- Perioperative Bleeding, Opioid Consumption, Erector Spinae Plane Block, Spinal Stabilization
- Trial name
- NCT07101198
- Testing
- Ultrasound-guided erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Ovarian Cancer
Tranexamic Acid in Surgery of Advanced Ovarian Cancer
The purpose of the study is to determine if a standardized single dose tranexamic acid given intravenously immediately preoperatively reduces the perioperative bleeding volume and reduces the need of blood transfusion in women…
- Trial name
- NCT00740116
- Testing
- Tranexamic acid, 0.9% NaCl solution
- Where
- 3 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Preben Kjolhede, MD, professor
Surgical Site Infection, Bleeding
Mild Hypothermia Influence on Patient Outcome in Major Abdominal Surgery
This study investigate associations between mild hypothermia (patients' core temperature ≤ 36.0 degrees Celsius) and intra-operative blood loss and surgical site infections (SSI) in patients undergoing major abdominal surgery.
- Trial name
- NCT03112317
- Testing
- Prevention of hypothermia
- Where
- 2 sites in Norway
- Volunteers
- 3,059 people
- Sponsor
- Haukeland University Hospital
Surgical Wound
Angiography Combination Laparoscopy in Patients With Obscure Gastrointestinal Bleeding
There were many approaches for patients with obscure gastrointestinal bleeding (OGIB). Capsule endoscopy (CE), double-balloon endoscopy, deep small-bowel spiral enteroscopy, laparoscopy, computed tomography and angiography have…
- Trial name
- NCT02069262
- Testing
- rebleeding
- Where
- China
- Volunteers
- 66 people
- Sponsor
- The Second People's Hospital of GuangDong Province
Coagulation Protein Disorders, Blood Loss, Surgical
Observational Study of Prophylaxis and Treatment of Acute Perioperative Bleeding With Beriplex® P/N (Probe Study)
Beriplex® P/N is made from human plasma (the liquid part of the blood) and contains the coagulation factors II, VII, IX and X which are important for blood clotting (coagulation).
- Conditions
- Coagulation Protein Disorders, Blood Loss, Surgical, Perioperative Care
- Trial name
- NCT01053169
- Testing
- Beriplex® P/N, Fresh Frozen Plasma (FFP) and Beriplex® P/N, Fresh Frozen Plasma
- Where
- 6 sites in United Kingdom
- Volunteers
- 445 people
- Sponsor
- CSL Behring
Vitreous Hemorrhage
Aflibercept Injection for Proliferative Diabetic Retinopathy
To evaluate the ocular and systemic safety of intravitreal aflibercept injection in patients undergoing Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy.
- Trial name
- NCT01805297
- Testing
- Intravitreal Aflibercept Injection, Standard Vitrectomy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Oklahoma
Rectal Bleeding
Diagnostic Outcomes of Patients Presenting With Per Rectal Bleed in Surgical Departments of Services Hospital Lahore
It is a cross sectional study in which investigators will be recruiting patients of any sex above 12 years of age who will present to surgical outdoor with per rectal bleed.
- Trial name
- NCT03594942
- Testing
- procto sigmoidoscopy and biopsy if required
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Services Hospital, Lahore
Parenchymous Tissue Surgical Bleeding
Safety and Efficacy of Fibrin Sealant Grifols (FS Grifols) During Parenchymous Tissue Open Surgeries
This study is designed to assess the safety and efficacy of Fibrin Sealant Grifols in patients undergoing open surgical procedures where bleeding may be present on parenchymous tissue (e.g., solid abdominal organs such as the…
- Trial name
- NCT01754480
- Testing
- Fibrin Sealant Grifols, Surgicel®
- Where
- 33 sites in United States, Hungary and 2 more
- Volunteers
- 325 people
- Sponsor
- Instituto Grifols, S.A.
CVP and SVV During Living Donor Hepatectomy, Surgical Field Grade (Condition of Surgical Field; Bleeding, Tension of the IVC)
Vasodilator-induced Hypovolemia in Living Liver Donors
Induced hypovolemia is known to improve surgical field during living donor hepatectomy. This procedure is conventionally guided by monitoring the central venous pressure (CVP).
- Trial name
- NCT02033967
- Testing
- vasodilator induced hypovolemia
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Seoul National University Hospital
Surgical Complication, COVID-19
The Role of Surgery in Patients With Coronavirus Disease - 19 (COVID-19) Related Thoracic Complications
Thoracic complications directly or indirectly consequence of Coronavirus Disease 2019 (COVID-19) (including either pathologies strictly related to the infection, or iatrogenic effects of therapeutic attempts to treat it) have…
- Conditions
- Surgical Complication, COVID-19, Pneumothorax, Empyema, Pleural
- Trial name
- SThor-CoV-2 (NCT05204537)
- Testing
- Lung parenchyma resection, Empyemectomy
- Where
- 9 sites in United States, Brazil and 3 more
- Volunteers
- 83 people
- Sponsor
- University of Milano Bicocca
Mucositis Oral
Effect of Probiotic Use Bifidobacterium Animalis Subsp. Lactis in Peri-implant Mucositis
Peri-implant disease is an inflammatory process of bacterial etiology that can affect the tissues around the implants and can be classified as peri-implant mucositis or peri-implantitis.
- Trial name
- Mucosite prob (NCT04187222)
- Testing
- Mechanical debridements, Bifidobacterium animalis subsp. lactis
- Where
- Brazil
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic SDH and the Efficacy of Embolization
Endovascular Embolization for Chronic Subdural Hematomas Following Surgical Evacuation
This study is designed to evaluate the effectiveness of endovascular embolization of middle meningeal artery following evacuation of subdural hematomas (SDHs) to assess rate of recurrence.
- Trial name
- endovascular (NCT04272996)
- Testing
- Craniotomy only, Craniotomy + Endovascular embolization of the middle meningeal vessels
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Periapical Lesion
Effect of Piezoelectric Device on Intraoperative Hemorrhage Control and Quality of Life
Most osteotomies and apicoectomies in periapical surgeries are performed by surgical carbide or diamond burs. But greater pressure is applied during cutting which causes more thermal and mechanical damage to the bone.
- Trial name
- NCT06240182
- Testing
- conventional surgery, piezoelectric device
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Blood Loss After a Total Hip Replacement
Blood-sparing During Hip Prosthesis Surgery With Exacyl® in Patients Treated With Rivaroxaban
This study evaluates the efficacy of tranexamic acid versus placebo on perioperative blood loss using two dosage regimens (standard and extended) after a surgery during total hip arthroplasty in patients receiving the novel…
- Trial name
- ESPER (NCT02403596)
- Testing
- Exacyl®
- Where
- 4 sites in France
- Volunteers
- 231 people
- Sponsor
- University Hospital, Brest
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Peri-implantitis
Surgical and Non-surgical Treatment of Peri-implantitis
This study will compare surgical and non surgical treatments of peri-implantitis. Peri-implantitis is an inflammation around dental implants that can lead to the loss of the implant over time if no treatment is established.
- Trial name
- Perio-implants (NCT02241577)
- Testing
- Surgical treatment, Non-surgical treatment
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Federal University of Rio Grande do Sul
Post Operative Hemorrhage
Mechanical Dilatation of the Cervix at Elective Caesarean Section to Reduce Post-Operative Blood Loss
obstetric hemorrhage remains one of the major causes of maternal death in both developed and developing countries. Because of its importance as a leading cause of maternal mortality and morbidity, and because of evidence of…
- Trial name
- NCT03444792
- Testing
- mechanical dilatation of the cervix
- Where
- Egypt
- Volunteers
- 774 people
- Sponsor
- Cairo University
Total Knee Arthroplasty
Impact of Different Perioperative Tourniquets on Blood Loss and Surgeon Satisfaction in Total Knee Arthroplasty
The present study investigates the impact of two different perioperative tourniquets with different closing features on operative blood los, surgical field quality and surgeon satisfaction.
- Trial name
- NCT06947655
- Testing
- VBM Tourniquet, Adaptive Cuff
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bonn