Clinical trials: Blood Loss Massive
Cardiac Surgery, Cardiopulmonary Bypass
AProtinin Versus Tranexamic Acid in Cardiac Surgery Patients With High-risk for Excessive Bleeding
In this before-after multicenter study the authors tested the hypothesis that the prophylactic use of aprotinin compared to tranexamic acid could reduce the proportion of patients presenting severe perioperative bleeding.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, High Risk Bleeding
- Trial name
- APACHE (NCT04804345)
- Testing
- standard of care
- Where
- 7 sites in France
- Volunteers
- 693 people
- Sponsor
- University Hospital, Bordeaux
Bleeding, Aortic Rupture
Life-saving Treatment With Dry-plasma for Massive Bleeding in an Pre-hospital Setting
The overall goal of this clinical trial is to study how prehospital transfused dry plasma affect outcomes in terms of mortality as well as complications and coagulation status of patients in or about to develop bleeding shock.
- Conditions
- Bleeding, Aortic Rupture, Gastrointestinal Hemorrhage, Obstetric Bleeding
- Trial name
- NCT07012863
- Testing
- Dry plasma
- Volunteers
- 650 people
- Sponsor
- Vastra Gotaland Region
Hemorrhage, Trauma
Empiric Calcium in Massive Transfusion
Calcium helps blood to clot and thereby stop bleeding. Trauma patients who experience large volume blood loss often require blood transfusions and bleeding is the most common cause of death.
- Conditions
- Hemorrhage, Trauma, Hypocalcemia, Shock, Hemorrhagic
- Trial name
- NCT05953376
- Testing
- Calcium Gluconate
- Sponsor
- University of California, Irvine
Plasma Volume Substitution (Hypovolemia) Including Massive Hemorrhage
Study to Obtain Volume Effect and Safety Data on 6 % Hydroxyethyl Starch 130/0.4 in Pediatric and Adult Patients Undergoing Major Elective Surgery
The study shall evaluate the volume effect and safety of 6 % hydroxyethyl starch 130/0.4 for restoration and maintenance of hemodynamics during the investigational period in patients undergoing major elective surgery.
- Trial name
- NCT01127477
- Testing
- 1: Hydroxyethyl starch 130/0.4, 6 %
- Where
- 4 sites in Japan
- Volunteers
- 20 people
- Sponsor
- Fresenius Kabi Japan
Massive Transfusion, Hemorrhage
Evaluating of the Hospital Universitario de Canarias Massive Transfusion Protocol
Massive haemorrhage is defined as the necessity of 3 or more packed red blood cells in one hour, the transfusion of 10 packed blood cells, the loss of the half of the blood volume, the loss of 4-5 cc/kg/h or more, and haemorrhage…
- Trial name
- PHM (NCT03074890)
- Testing
- Application Protocol
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario de Canarias
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Nasopharyngeal Carcinoma Patients Treated With Curative Radiotherapy
Massive Nasal Bleeding in Patients With NPC Received Curative RT
To investigate the incidence, predictive markers, and survival impact of massive nasal bleeding in nasopharyngeal carcinoma (NPC) patients who received curative radiotherapy (RT) with/without chemotherapy.
- Trial name
- NCT06348485
- Testing
- Patients without massive nasal bleeding, Patients with massive nasal bleeding
- Where
- Taiwan
- Volunteers
- 1,327 people
- Sponsor
- Taichung Veterans General Hospital
Placenta Accreta, Post Partum Hemorrhage
Conservative Management of Placenta Accreta Spectrum
The resective-constructive surgery, detailed in prior research by Palacios-Jaraquemada JM, involves excising the placenta and its attachment on the myometrium, with modifications including the systematic use of a double JJ probe…
- Conditions
- Placenta Accreta, Post Partum Hemorrhage, Blood Loss Massive
- Trial name
- NCT06253832
- Testing
- conservative surgery for placenta accreta spectrum, hysterectomy
- Where
- Tunisia
- Volunteers
- 36 people
- Sponsor
- Tunis University
Trauma Injury, Haemorrhagic Shock
Prediction of Massive Transfusion in Trauma Patients
Since the 2000s, many prognostic scores were developed to predict traumatic haemorrhage. Most of these studies were retrospectives based on registers.
- Conditions
- Trauma Injury, Haemorrhagic Shock, Bleeding, Emergencies
- Trial name
- MTP (NCT04561050)
- Testing
- Comparison of score performances (Overall performance, discrimination and calibration)
- Where
- Switzerland
- Volunteers
- 13,222 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Trauma
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as…
- Trial name
- PROPPR (NCT01545232)
- Testing
- 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio
- Where
- 12 sites in United States, Canada
- Volunteers
- 680 people
- Sponsor
- The University of Texas Health Science Center, Houston
Placenta Accreta, Post Partum Hemorrhage
Tourniquet Reduces Blood Loss in Postpartum Hemorrhage During Hysterectomy for Placenta Accreta
Monocentric prospective observational study comparing the use of tourniquet in low uterus segement versus standard procedure in hysterectomy owing to placenta accreta
- Conditions
- Placenta Accreta, Post Partum Hemorrhage, Blood Loss Massive
- Trial name
- NCT03707132
- Testing
- Tourniquet: Folley catheter in the low segment of the uterus
- Volunteers
- 43 people
- Sponsor
- University Tunis El Manar
Postpartum Hemorrhage, Uterine Atony
Uterine Cooling During Cesarean Delivery to Reduce Blood Loss and Incidence of Postpartum Hemorrhage
The objective of the study is to demonstrate whether cooling the uterine smooth muscle during cesarean section (following delivery of the fetus) will promote better uterine contraction and involution resulting in lower blood…
- Trial name
- NCT02229513
- Testing
- Uterine Cooling
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Cerebral Hemorrhage, Hypertensive, Intracranial Hypertension
Bleeding Intracerebral Hemorrhage With Early Invasive Intracranial Pressure Monitoring Trial
Spontaneous cerebral hemorrhage (SICH) is a hemorrhage caused by the rupture of a blood vessel within the brain parenchyma that is non-traumatic.
- Conditions
- Cerebral Hemorrhage, Hypertensive, Intracranial Hypertension, Monitoring, Critical Care
- Trial name
- BIATICH (NCT05593380)
- Testing
- Parenchymal Intracranial pressure monitor, Treatment based on clinical and imaging observations
- Where
- 17 sites in China
- Volunteers
- 193 people
- Sponsor
- Xiangya Hospital of Central South University
Cesarean Scar Pregnancy
MRI in Predicting Intraoperative Massive Hemorrhage for Cesarean Scar Pregnancy
MRI features and clinical characteristics to predict massive hemorrhage during hysteroscopic treatment of CSP, and to aid the choice of treatment.
- Trial name
- NCT04955028
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Surgical Blood Loss, Surgical Hemorrhage
TEG Use in Children Undergoing Procedures With High Anticipated Blood Loss
The research team proposes a prospective, observational study to better understand how TEG can be useful in guiding clinical practice in the Main OR for subject's undergoing high transfusion risk surgeries.
- Conditions
- Surgical Blood Loss, Surgical Hemorrhage, Post Operative Hemorrhage
- Trial name
- NCT05379530
- Testing
- Thromboelastography (TEG), Anesthesia Provider Survey
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Trauma, Multiple, Coagulopathy
Use of Viscoelastic Tests in the Treatment of Traumatic Induced Coagulopathy: a Pragmatic Randomized Clinical Trial.
Trauma is the leading cause of death in young people. Trauma-induced coagulopathy (TIC) encompasses several aspects of traumatic bleeding.
- Conditions
- Trauma, Multiple, Coagulopathy, Massive Hemorrhage
- Trial name
- VISCOTRAUMA (NCT03380767)
- Testing
- Trauma-induced coagulopathy treatment
- Where
- Italy
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Blood Loss Massive, Trauma
Evaluation of the Clinical Performance of the Quantra System With the QStat Cartridge
This pilot study will evaluate the performance of the Quantra System comprised of the Quantra Hemostasis Analyzer with the QStat Cartridge in trauma patients or patients with OB hemorrhage.
- Conditions
- Blood Loss Massive, Trauma, Hemorrhage, Postpartum
- Trial name
- NCT03912545
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- HemoSonics LLC
Pulmonary Embolism Subacute Massive, Complication of Treatment
Safe Delivery of Thrombolytic Treatment for Pulmonary Embolism Using ClotPro® Viscoelastic Tests
The aim of this work was to reduce the bleeding risk during thrombolysis using the viscoelastic blood coagulation tests.
- Conditions
- Pulmonary Embolism Subacute Massive, Complication of Treatment, Fibrinolysis; Hemorrhage
- Trial name
- NCT06667882
- Testing
- Alteplase Injectable Product
- Where
- Hungary
- Volunteers
- 33 people
- Sponsor
- Semmelweis University
Massive Blood Loss, Hypothermia
Study to Actively Warm Trauma Patients
This study evaluates the feasibility of using thermal blankets to actively warm massively bleeding trauma patients at Sunnybrook Health Sciences Centre.
- Trial name
- NCT04399902
- Testing
- Thermal Blanket
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Sunnybrook Health Sciences Centre
Massive Hemorrhage, Trauma
Calcium Administration in Life-saving Management During Massive Hemorrhage
This study evaluates the feasibility of conducting a larger study on the impact of treating massive hemorrhage with calcium in trauma patients.
- Conditions
- Massive Hemorrhage, Trauma, Hypocalcemia
- Trial name
- CALM (NCT06820645)
- Testing
- calcium gluconate
- Volunteers
- 81 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's