Clinical trials: Blood Plasma Therapy
Carpal Tunnel Syndrome
Radiofrequency, Perineural Injection, Idiopathic Carpal Tunnel Syndrome
Aim of the study The aim of the study is to evaluate the role of pulsed radiofrequency versus platelet rich plasma injection in treatment of idiopathic mild to moderate carpal tunnel syndrome Patients will be classified into…
- Trial name
- NCT05053477
- Testing
- mehylprednisolone injection, pulsed radiofrequency (PRF), platelet-rich plasma
- Where
- 2 sites in Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Alexandria University
AML, ALL
Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders
Allogeneic stem cell transplantation may provide long-term remissions for some patients with hematological malignancies. However, allogeneic transplantation is associated with a significant risk of potentially life threatening…
- Conditions
- AML, ALL, CLL, Myelodysplastic Syndrome
- Trial name
- NCT00533923
- Testing
- Cyclophosphamide; Fludarabine; Cyclosporin; CAMPATH-1H (Alemtuzumab); GM-CSF
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Non-Genital Warts
Efficacy and Safety of Platelet-rich Plasma, Metformin and Cryotherapy in Treatment of Non-genital Warts
1. Evaluation of the efficacy and safety of intralesional injection of autologous platelet-rich plasma in treatment of various types of cutaneous non genital warts 2.
- Trial name
- NCT06691542
- Testing
- platelet-rich plasma, Metformin, cryotherapy
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Assiut University
Esophageal Cancer
The Utility of Circulating Tumour Cells and Plasma microRNA in Esophageal Adenocarcinoma
Circulating microRNA (circ miRNA) and circulating tumor cell (CTC) levels are hypothesized to be associated with response to chemoradiation in patients undergoing treatment for locally advanced esophageal adenocarcinoma.
- Trial name
- NCT02812680
- Testing
- Blood Draw
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
MULTIPLE MYELOMA
UARK 2005-05, Coagulation-Related Effects of Velcade Treatment in Patients With Relapsed or Refractory Multiple Myeloma
To evaluate changes in coagulation (blood clotting) factors and platelet function in multiple myeloma participants undergoing VELCADE treatment for the first time.
- Trial name
- NCT00569868
- Testing
- Velcade
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Multiple Myeloma, M Protein
A Cross-sectional Study on the Positive Rate of M Protein Based on a Highly Sensitive Serum M Protein Detection Method.
By using a highly sensitive serum M protein detection method based on the MALDI-TOF MS platform, serum monoclonal immunoglobul (M protein) in detection was performed on the visiting patients to explore the positive rate of serum…
- Trial name
- NCT06082284
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Striae Gravidarum
Efficacy of Fractional Carbon Dioxide Laser Combined With Platelet-rich Plasma
This study determined the efficacy of ablative fractional carbon dioxide laser combined with autologous platelet-rich plasma versus ablative fractional carbon dioxide laser with placebo in the treatment of striae gravidarum of…
- Trial name
- NCT04956367
- Testing
- Ablative fractional carbon dioxide laser combined with autologous platelet-rich plasma, CO2 laser with PRP
- Where
- Philippines
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jose R. Reyes Memorial Medical Center
Multiple Myeloma, Fatigue
Treating Cancer-Related Fatigue Through Systematic Light Exposure (Light for Fatigue Study)
Cancer related fatigue (CRF) is the most common cancer side effect and can severely interfere with activities of daily living long after completion of medical treatment.
- Trial name
- NCT03119363
- Testing
- AYO light glasses (Experimental), AYO light glasses (Comparator)
- Where
- 3 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gingival Diseases, Traumatic Injury
Injectable Platelet Rich Fibrin With Collagen Matrix in Treatment of Multiple Gingival Recession.
This study is proposing the use of i-PRF clot as a scaffold for the XCM in order to obtain a novel biomaterial, incorporating active growth factors and collagen matrix in a single framework, based on the potential effect of i-PRF…
- Trial name
- NCT05389059
- Testing
- CAF+CM, I-PRF
- Where
- Iraq
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Chronic Graft Versus Host Disease
Study to Compare the Plasma Concentration of Belumosudil Given as an Oral Suspension and as a Tablet to Healthy Adult Male Participants
The purpose of this open-label, randomized, cross-over, Phase 1, 2-treatment, 2-period, 2-sequence study is to assess the bioequivalence of belumosudil oral suspension compared with belumosudil tablet in healthy male participants…
- Trial name
- NCT07726914
- Testing
- Belumosudil
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Sanofi
Drug Interactions
Microgynon Riociguat Drug Interaction Study in Healthy Postmenopausal Women
Physicians might be concerned that Adempas may have a metabolic interaction with oral contraceptives (OC) that could decrease the contraceptive efficacy of the OC.
- Trial name
- NCT02159326
- Testing
- Microgynon, Riociguat (Adempas,BAY63-2521)
- Where
- Germany
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Bayer
Plantar Fasciitis
Comparing Steroid Injections and Platelet Rich Plasma Injections in the Treatment of Plantar Fasciitis
In cases of Plantar Fasciitis not responding to conservative management, minimally invasive techniques may be used. These include platelet rich plasma injections and corticosteroid injections.
- Trial name
- NCT01957631
- Testing
- Corticosteroid injection (Bupivacaine and Depo Medrol), Platelet rich plasma injection
- Where
- Bahrain
- Volunteers
- healthy volunteers welcome
- Sponsor
- King Hamad University Hospital, Bahrain
Tennis Elbow
Platelet Rich Plasma vs Open Surgery in the Treatment of Tennis Elbow
Chronic Lateral Epicondylar Tendinopathy is a debilitating condition that is associated with repetitive use of the forearm extensor muscles.
- Trial name
- NCT02755727
- Testing
- Platelet Rich Plasma Injection, Open Surgical Release
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
HIV-1
TMC278-TiDP15-C150: Trial to Examine Safety, Tolerability and Plasma Pharmacokinetics of Multiple Doses of TMC278LA.
The purpose of this study is: to determine the safety, (local) tolerability and plasma exposure over time of single intramuscular (IM) doses of 600 and 1200 mg of a new formulation (F006) of TMC278LA, to determine the safety…
- Trial name
- NCT00741741
- Testing
- TMC278
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tibotec Pharmaceuticals, Ireland
COVID19
Assessment of the Effect of Convalescent Plasma Therapy in Patients With Life-threatening COVID19 Infection
This clinical trial proposal is based on the FDA protocol for emergency use of convalescent plasma for treatment of COVID-19 cases, and on the WHO guidelines for use of convalescent plasma in other infectious diseases.
- Trial name
- CP IN COVID19 (NCT04438694)
- Testing
- Convalescent Plasma, Standard of Care
- Where
- Egypt
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cardiooncology, Myeloma
Vascular Functions in Myeloma Patients During Anti-tumor Therapy
Treatment options for multiple myeloma have increased significantly over the last years with the approval of immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs).
- Conditions
- Cardiooncology, Myeloma, Endothelial Dysfunction
- Trial name
- NCT03776331
- Testing
- Flow mediated dilation
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Essen
Multiple Myeloma
UARK 2010-35, A Study of Expanded Natural Killer Cell Therapy for Multiple Myeloma
The purpose of this study is to determine the therapeutic efficacy of the exp-NK cell therapy in research participants with relapsed high risk MM [defined as gene expression profile (GEP) 70 gene score ≥0.66 and/or metaphase…
- Trial name
- NK2010-35 (NCT01313897)
- Testing
- Bortezomib
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Temporomandibular Disorders (TMD), Muscle Pain
Autologous Exosomes From Platelet-rich Plasma as a Modern Tool of Regenerative Dentistry
The aim of the research is the laboratory assessment of the content as well as the regenerative and anti-inflammatory potential of autologous exosomes (EXO) from platelet-rich plasma (PRP), as well as their comparison with other…
- Conditions
- Temporomandibular Disorders (TMD), Muscle Pain, TMJ Pain
- Trial name
- NCT07511959
- Testing
- Laboratory analysis of the content and biological activity of PRP, PRF, and exosomes obtained from blood samples
- Where
- Poland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Myeloma Multiple
Minimal Residual Disease Guided Maintenance Therapy With Belantamab Mafodotin and Lenalidomide After Autologous Hematopoietic Cell Transplantation in Patients With Newly Diagnosed Multiple Myeloma
To increase the conversion rate from MRD-positive to MRD-negative CR in patients with newly diagnosed multiple myeloma (NDMM) receiving post-transplant maintenance therapy with belantamab mafodotin plus lenalidomide.
- Trial name
- NCT05091372
- Testing
- Belantamab mafodotin, Lenalidomide
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center