Clinical trials: Blood Platelet Disease
Thrombocytopenia
Safety and Performance of MIRASOL® PRT Treated Platelet Transfusion Products
The primary objective of the study is to measure platelet corrected count increments and the incidence of serious adverse events (SAE).
- Trial name
- NCT00263809
- Testing
- Pathogen Reduction Technology
- Where
- 10 sites in France
- Volunteers
- 118 people
- Sponsor
- Terumo BCTbio
Acquired Bleeding Disorder, Acquired Haemophilia
Bioequivalence of NovoSeven® and a NovoSeven® Formulation Stable at Room Temperature in Healthy Male Subjects
This trial is conducted in Europe. The aim of this trial is to demonstrate bio-equivalence between the marketed activated recombinant human factor VII (NovoSeven®) (CP-rFVIIa) and a new formulation stable at 25°C (VII25).
- Conditions
- Acquired Bleeding Disorder, Acquired Haemophilia, Congenital Bleeding Disorder, Congenital FVII Deficiency
- Trial name
- NCT01561417
- Testing
- activated recombinant human factor VII
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Novo Nordisk A/S
Von Willebrand Disease
National Study of Moderate and Severe Von Willebrand Disease in the Netherlands
The objective of this study is to assess the clinical presentation, the treatment and the complications of the disease and treatment in moderate and severe von Willebrand disease.
- Trial name
- WiN (NCT00510042)
- Where
- 12 sites in Netherlands
- Volunteers
- 1,100 people
- Sponsor
- Erasmus Medical Center
Perineal Trauma, Postpartum Pain
RELIEVE Study- Platelet-Rich Plasma to Reduce Postpartum Pain After Perineal Tears or Episiotomy
Perineal tears and episiotomies are common after vaginal birth and may cause persistent pain, impaired wound healing, pain during sexual activity, and concerns about genital appearance.
- Conditions
- Perineal Trauma, Postpartum Pain, Episiotomy, Perineal Laceration
- Trial name
- RELIEVE (NCT07727213)
- Testing
- Autologous Non-Activated Platelet-Rich Plasma, Saline (0.9%, sterile, for infusion)
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University Hospital, Geneva
Periodontitis
Alb-PRF as an Adjunct to Nonsurgical Periodontal Therapy
Periodontitis is an inflammatory disease that damages the tissues supporting the teeth. Nonsurgical periodontal therapy is the standard initial treatment, but deep periodontal pockets may remain after treatment.
- Trial name
- NCT07794046
- Testing
- Nonsurgical Periodontal Therapy, Albumin Platelet-Rich Fibrin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Halil Ata BIÇAKÇIOĞLU
Intrauterine Adhesion
The Value of Using Platelet Rich Plasma After Hysteroscopic Lysis of Severe Intrauterine Adhesions
The aim of present study is to evaluate the effect of the use of platelet rich plasma in decreasing recurrence of intrauterine adhesions after its lysis.
- Trial name
- NCT03541746
- Testing
- Platelet Rich Plasma, Intrauterine Foley's Catheter
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams Maternity Hospital
Idiopathic Thrombocytopenic Purpura
A Study Evaluating the Addition of MabThera (Rituximab) to Standard Treatment in Patients With Idiopathic Thrombocytopenic Purpura (ITP)
This study will compare the efficacy, safety, and pharmacokinetics of standard treatment versus standard treatment plus MabThera in patients with ITP.
- Trial name
- NCT00770562
- Testing
- rituximab, Dexamethasone
- Where
- 22 sites in Italy
- Volunteers
- 103 people
- Sponsor
- Hoffmann-La Roche
Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders
Arthrocentesis-PRF Versus Botulinum Toxin for Management of ADDwR
Temporomandibular joint (TMJ) internal derangement is a common cause of temporomandibular disorders and is often associated with pain, restricted mandibular movement, joint sounds, and functional limitations during mastication…
- Conditions
- Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders, Temporomandibular Disorders (TMD), TMJ Pain
- Trial name
- NCT07385742
- Testing
- Injectable Platelet-Rich Fibrin (I-PRF) Injection, Botulinum Toxin Type A (BOTOX) Injection
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Osteoarthritis, Knee
Use of Fresh Platelet Rich Plasma With Concentrated Leukocytes or Fresh Platelet Rich Plasma Without Concentrated Leukocytes in the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial
The aim of the study is to compare the triple infiltration of Fresh Platelet Rich Plasma with concentrated Leukocytes against triple infiltration of Fresh Platelet Rich Plasma Without Concentrated Leukocytes in the treatment of…
- Trial name
- PRP019 (NCT04187183)
- Testing
- Fresh Platelet Rich Plasma with leukocyte, Fresh Platelet Rich Plasma without leukocyte
- Where
- Italy
- Volunteers
- 132 people
- Sponsor
- Istituto Ortopedico Rizzoli
Periodontitis Stage II, Gingival Pocket
Use of Injectable Extended Platelet-Rich Fibrin as a Local Drug Delivery in the Treatment of Stage II Periodontitis Patients
The objective of the present study is to assess the clinical effectiveness of local delivery of injectable extended platelet-rich fibrin in subgingival application when used in conjunction with scaling and root planing (SRP) in…
- Trial name
- NCT07080294
- Testing
- extended platelet rich fibrin injection in pocket, albumin injection in pocket, scaling and root planing
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Mansoura University
Liver Transplanatation, Postoperative Complication
Avatrombopag for Severe Thrombocytopenia After Liver Transplantation: A Retrospective Cohort Study
Severe post-transplantation thrombocytopenia (platelet count <30×10⁹/L) occurs frequently after liver transplantation (LT) and is associated with increased bleeding risk, allograft dysfunction, and transfusion-related…
- Conditions
- Liver Transplanatation, Postoperative Complication, Severe Thrombocytopenia
- Trial name
- NCT07600905
- Testing
- Avatrombopag 20 mg Oral Tablet
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Shanghai Zhongshan Hospital
Atrial Fibrillation
The Effect of Pulsed-field and Radiofrequency Ablation on Platelet, Coagulation and Inflammation
The aim of the study is to compare platelet activation, activation of the coagulation and inflammation cascade during catheter ablation for atrial fibrillation using radiofrequency or pulsed-field energy.
- Trial name
- NCT05603637
- Testing
- Catheter ablation using SmartTouch radiofrequency ablation catheter, Catheter ablation using Farawave pulsed-field ablation catheter
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Coronary Artery Disease
Different Platelet Activities Between Intracoronary and Peripheral Blood in Coronary Artery Disease Patients
Antiplatelet treatment is important for coronary artery disease(CAD) patients .Some patients are resistant to antiplatelet treatment based on platelet function tests(PFT).Currently the results of PFT are mainly based on the…
- Trial name
- DPABIAP (NCT03078257)
- Testing
- tirofiban in PV, tirofiban in IC, antiplatelet thrombolysin
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Hematological Diseases, Thrombocytopenia
Megakaryocytic Progenitor Cells for Prophylaxis and Treatment of Thrombocytopenia
The purpose of this study is to evaluate the efficacy of ex vivo generated megakaryocytic progenitor cells (MPs) in prophylaxis and treatment of thrombocytopenia caused by chemotherapy in patients with acute leukemia (AL).
- Trial name
- NCT02241031
- Testing
- MPs, thrombopoietin (TPO) and interleukin-11
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Urinary Incontinence, Stress Urinary Incontinence
Platelet Rich Plasma in Women With Urinary Incontinence
Stress urinary incontinence (SUI) is defined as involuntary loss of urine on effort or physical exertion or on sneezing or coughing.
- Trial name
- NCT05112718
- Testing
- Platelet Rich Plasma Injections, Normal Saline Injections
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- National and Kapodistrian University of Athens
Polycythemia Vera (PV), Essential Thrombocythemia (ET)
MethoTRExATE in MyelOpRolifErative Neoplasms (TREATMORE) Trial
Low-dose MTX is a widely used, inexpensive, and safe therapy used for decades and is well tolerated by patients with rheumatologic diseases. Recently, it was identified as a type 2 JAK inhibitor.
- Conditions
- Polycythemia Vera (PV), Essential Thrombocythemia (ET), Myelofibrosis (MF)
- Trial name
- TREATMORE (NCT06541249)
- Testing
- Methotrexate (MTX)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Thrombocytosis, S. Pneumoniae Infection
The Role of Reactive Thrombocytosis in Children With Pneumococcal Infection
Thrombocytosis, mostly reactive in nature, is common in pediatric hospitalized patients with infections. Streptococcus pneumoniae (S. Pneumoniae) is the most common pathogen.
- Trial name
- NCT01194349
- Where
- Taiwan
- Sponsor
- Taipei Medical University WanFang Hospital
Platelet Aggregation, Platelet Transcriptome
Pharmacogenomics of Antiplatelet Response - I
This clinical trial is examining the role of genetic polymorphism on the effect of clopidogrel (with or without aspirin) on platelet response in persons at high-risk for myocardial infarction or stroke due to family history of…
- Conditions
- Platelet Aggregation, Platelet Transcriptome, Coronary Artery Disease
- Trial name
- PARes-I (NCT01815008)
- Testing
- Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Immune Thrombocytopenia (ITP)
The Efficacy and Safety of Combined Teriflunomide and High-dose Dexamethasone in Newly Diagnosed Primary Immune Thrombocytopenia (TEMPO-2)
A multicenter, open-label, randomized study to report the efficacy and safety of teriflunomide plus high-dose dexamethasone compared to high-dose dexamethasone monotherapy for the first-line treatment of adults with newly…
- Trial name
- NCT07065968
- Testing
- Teriflunomide, Dexamethasone
- Where
- 3 sites in China
- Volunteers
- 132 people
- Sponsor
- Peking University People's Hospital
Ocular Graft-versus-host Disease
Allogeneic Platelet Lysate Eye Drops for the Treatment of Severe Chronic Ocular Graft-versus-host Disease
The study evaluates the efficacy and safety of allogeneic platelet lysate eye drops in patients with severe ocular graft versus host disease refractory to conventional systemic and local treatments.
- Trial name
- NCT05311514
- Testing
- Allogeneic platelet lysate eye drops
- Where
- Russia
- Volunteers
- 38 people
- Sponsor
- St. Petersburg State Pavlov Medical University
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