Clinical trials: Blood Platelet Disease
NASH - Nonalcoholic Steatohepatitis, NAFLD
Characterization of the Platelet Inflammatory Response in NAFL and NASH
The primary objective of the study is to identify which features of platelet activation promote the inflammatory response that underlies the progression from NAFL to NASH. Therefore, the investigators plan: 1.
- Trial name
- NCT05128253
- Testing
- High fat meal in a subset of patients with NAFL or NASH
- Where
- 2 sites in Italy
- Volunteers
- 44 people
- Sponsor
- Stefania Basili
Stroke, Myocardial Infarctions
Aspirin Resistance and Stroke Risk: Platelet Function Analysis in Patients With Ischemic Events
The purpose of this study is to determine if PFA results correlate with ischemic event outcomes as well as bleeding complications.
- Trial name
- NCT01586975
- Testing
- Clopidogrel, Aspirin 81 mg, Aspirin >300 mg
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Northwestern University
Knee Osteoarthritis
Cellular Matrix Device for the Treatment of Mild to Moderate Knee Osteoarthritis
This is a non-inferiority study on 190 patients to evaluate whether a treatment based on the combination of autologous platelet-rich plasma and hyaluronic acid obtained with Cellular Matrix represents a therapeutic advantage to…
- Trial name
- NCT03328728
- Testing
- Cellular Matrix / A-CP HA Kit, Synvisc-One
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Regen Lab SA
Fetal and Neonatal Alloimmune Thrombocytopenia
Phase 2 Study on the Pharmacokinetics and Safety of RLYB212 in Pregnant Women at Higher Risk for HPA-1a Alloimmunization
The purpose of this Phase 2 study is to assess the pharmacokinetics (PK) and safety of RLYB212 in HPA-1b/b pregnant women at higher risk for HPA-1a alloimmunization and FNAIT.
- Trial name
- NCT06435845
- Testing
- Anti-(integrin beta-3) human monoclonal antibody
- Where
- 3 sites in Netherlands, Norway and 1 more
- Volunteers
- 1 people
- Sponsor
- Rallybio
Pediatric Cancer, Thrombocytopenia
A Pediatric Trial Using Tranexamic Acid in Thrombocytopenia
This study evaluates the use of tranexamic acid (TXA) in addition to standard therapy in children receiving chemotherapy or blood and/or marrow transplantation to decrease the risk of bleeding.
- Conditions
- Pediatric Cancer, Thrombocytopenia, Hemostatic Disorder, Coagulation Defect; Acquired
- Trial name
- NCT03806556
- Testing
- Tranexamic Acid, Normal saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Meghan McCormick
Thrombocytopenic Purpura, Immune
A Clinical Study to Evaluate JCXH-213 in the Treatment of Adults With Primary Immune Thrombocytopenia
This is an open-label, single-arm, dose-escalation study designed to evaluate the safety, tolerability, recommended subsequent dose, pharmacokinetic profile, and preliminary efficacy of JCXH-213 in adult patients with primary…
- Trial name
- NCT07622329
- Testing
- JCXH-213
- Volunteers
- 4 people
- Sponsor
- The General Hospital of Western Theater Command
Thrombotic Thrombocytopenic Purpura (TTP)
Safety and Efficacy Study to Compare Uniplas With Cryosupernatant Plasma in Thrombotic Thrombocytopenic Purpura (TTP)
Prior to the use of plasma products, thrombotic thrombocytopenic purpura (TTP) was usually a fatal condition. During plasma exchange therapy, patients need transfusion plasma that is blood group specific.
- Trial name
- NCT00411801
- Testing
- Uniplas, Cryosupernatant plasma
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Octapharma
Knee Osteoarthritis
Combination of PRP and XLHA Prepared With RegenMatrix Medical Device To Treat Moderate to Severe Knee Osteoarthritis
In this clinical trial the investigator assess the safety and efficacy of a single injection of a combination of cross-linked hyaluronic acid (HA) with autologous platelet-rich plasma (PRP) obtained with the RegenMatrix medical…
- Trial name
- NCT05727371
- Testing
- Regen Matrix-PRP-XLHA, Hylan G-F 20
- Where
- 13 sites in France
- Volunteers
- 280 people
- Sponsor
- RegenLab France SAS
Neonatal Sepsis
Salivary C- Reactive Protein, Mean Platelet Volume and Neutrophil Lymphocyte Ratio as Diagnostic Markers for Neonatal Sepsis
To evaluate reliability of salivary C-reactive protein ,mean platelet volume , neutrophil -lymphocyte ratio , and platelet lymphocyte ratio in diagnosis of neonatal sepsis
- Trial name
- NCT04800445
- Testing
- Salivary CRP
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Immune Thrombocytopenic Purpura
Initial Treatment of Patients With Immune Thrombocytopenic Purpura
This study will compare treatment with 3 courses of high-dose dexamethasone versus treatment with prednisone, for patients recently diagnosed with immune thrombocytopenic purpura (ITP).
- Trial name
- ITP^2 (NCT00991939)
- Testing
- Dexamethasone USP Micronized, Prednisone
- Where
- 18 sites in United States
- Volunteers
- 8 people
- Sponsor
- Carelon Research
Menopause, Cardiac Function Impaired
Effects of Exercise Training on Cardiovascular Health in Middle-aged Women
The hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.
- Conditions
- Menopause, Cardiac Function Impaired, Cardiovascular Diseases, Blood Platelet Disorders
- Trial name
- NCT02135575
- Testing
- Spinning
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Blood Platelet Disorder, Hemorrhage
Correlation Between Platelet Function Analyzer-100 Testing and Bleeding Events After Percutaneous Kidney Biopsy
Kidney biopsy represents the criterion standard to obtain information on diagnosis and prognosis of renal dysfunctions . Many patients with kidney disease have a predisposition to bleed, especially when they undergo an invasive…
- Conditions
- Blood Platelet Disorder, Hemorrhage, Kidney Diseases
- Trial name
- NCT03762707
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Rate of Canine Retraction, Root Resorption
The Effect of Injectable PRF Vs LLL on Orthodontic Tooth Movement
The purpose of the present study is to compare the effect of injectable platelet fibrin and Low Level LASER therapy on the rate of upper canine retraction, and on root resorption of the canine
- Trial name
- NCT06520761
- Testing
- Injectable platelet rich fibrin, Low Level LASER
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Thrombosis, Blood Coagulation Disorder
Dynamics of Platelet Activation in Patients With Ventricular Assist Device (VAD)
Consenting patients with end-stage heart failure that are implanted with/candidates for implant of a short-term/durable mechanical circulatory support device (e.g.: percutaneous microaxial pumps (Impella), extracorporeal membrane…
- Conditions
- Thrombosis, Blood Coagulation Disorder, Platelet Thrombus, Platelet Dysfunction Due to Aspirin
- Trial name
- PASVAD (NCT03255928)
- Testing
- PAS assay, TGT
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Scientific Institute San Raffaele
Periodontitis
Advanced Platelet-Rich Fibrin Plus in Nonsurgical Periodontal Therapy
The purpose of this randomized, controlled, split-mouth clinical trial was to determine whether adding advanced platelet-rich fibrin plus (A-PRF+), an autologous fibrin membrane prepared from the participant's own blood, to…
- Trial name
- NCT07782736
- Testing
- Scaling and Root Planing, Advanced Platelet-Rich Fibrin Plus
- Where
- Vietnam
- Volunteers
- 14 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
ITP - Immune Thrombocytopenia
Explore the Relationship Between Platelet Count and Bleeding Score in ITP
Assessment of bleeding scores in immune thrombocytopenia purpuria to explore the relationship between platelet count and bleeding score in immune thrombocytopenia purpura (ITP) and compare the clinical practicability of bleeding…
- Trial name
- NCT06273956
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Hepatocellular Carcinoma (HCC) Prognosis
ALBI and PALBI Scores and HCC Prognosis
To compare the predictive ability of ALBI and PALBI grades with CTP and MELD scores. To investigate the efficacy of ALBI and PALBI grades for predicting the prognosis of HCC and overall survival among different modalities of…
- Trial name
- NCT05720195
- Testing
- ALBI
- Where
- Egypt
- Volunteers
- 645 people
- Sponsor
- Sohag University
Hemolytic-Uremic Syndrome, Anemia
Erythropoietin in Hemolytic Uremic Syndrome
This study will evaluate the impact of early administration of erythropoietin in the number of red blood cell transfusions in children with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome (STEC-HUS).
- Trial name
- NCT03776851
- Testing
- erythropoietin
- Where
- Argentina
- Volunteers
- 24 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde
Peripheral Arterial Disease
OMEGA-3-Polyunsaturated Fatty-Acids (N3-Pufa) In Patients With Peripheral Arterial Disease
The principal aim of the study is to determine the effects n3-PUFA on top of standard therapy on surrogate markers of disease severity and/or prognosis in patients with PAD.
- Trial name
- NCT01367145
- Testing
- OMACOR
- Where
- Austria
- Volunteers
- 71 people
- Sponsor
- Medical University of Vienna
Ischemic Heart Disease, Acute Coronary Syndromes
Effects of Optimized Antiplatelet Treatment After Percutaneous Coronary Intervention
Effects of dual antiplatelet therapy with aspirin and clopidogrel after percutaneous coronary intervention has been proven. However, patients with low response to those agents are reported be associated with adverse clinical…
- Trial name
- NCT00404781
- Testing
- cilostazol in addition to aspirin and clopidogrel
- Where
- China
- Volunteers
- 305 people
- Sponsor
- Shenyang Northern Hospital