Clinical trials: Blood Platelet Disease
Atherosclerosis, Angioplasty
Resistance to Antithrombotic Therapy
Clopidogrel plays a pivotal role in the antithrombotic regimen after percutaneous intervention with stent implantation. However, response to clopidogrel shows a wide interindividual variability and a high on-treatment residual…
- Trial name
- Vienna REACT (NCT00858715)
- Testing
- aspirin, clopidogrel
- Where
- Austria
- Volunteers
- 46 people
- Sponsor
- Medical University of Vienna
Essential Thrombocythemia, Polycythemia Vera
Lenalidomide and Prednisone in Treating Patients With Myelofibrosis
This phase II trial is studying how well giving lenalidomide together with prednisone works in treating patients with myelofibrosis. Lenalidomide may stop the growth of myelofibrosis by blocking blood flow to the cancer.
- Conditions
- Essential Thrombocythemia, Polycythemia Vera, Primary Myelofibrosis
- Trial name
- NCT00227591
- Testing
- lenalidomide, prednisone, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Cancer Institute (NCI)
Thrombocytopenia Purpura, Chronic HBV Infection
to Evaluate the Efficacy and Safety of Eltrombopag for Immune Thrombocytopenia With Chronic HBV Infection
Primary Objective: To evaluate the efficacy of 6-week Eltrombopag to treat immune thrombocytopenia with chronic hepatitis B virus infection.
- Trial name
- NCT03664518
- Testing
- Eltrombopag
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Furcation Defects
Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects
Rosuvastatin (RSV) is a new synthetic, second-generation, sulfur-containing, hydrophilic statin, that stimulate bone formation in critical-size cortical bone defects adjacent to titanium implants, when administered locally in…
- Trial name
- NCT02369250
- Testing
- Rosuvastatin, platelet rich fibrin
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Gingival Recession
Platelet Rich Fibrin in the Treatment of Localized Gingival Recessions
The present study deals with treatment of localized gingival recessions. The hypothesis of this study is that platelet rich fibrin can be used an alternative to subepithelial connective tissue graft in the coverage of denuded…
- Trial name
- NCT01793389
- Testing
- Subepithelial connective tissue graft, Platelet Rich Fibrin
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ege University
Osteoarthritis (OA)
Comparison of the Pain and Functional Improvement of Combined Extracorporeal Shockwave Therapy With or Without Intra-articular Hyaluronic Acid and Platelet-rich Plasma Injection on Advanced Osteoarthritis of the Knees.
This was a single group, double-blind, randomized clinical trial that enrolled 48 patients with Kellgren-Lawrence grade II to IV osteoarthritis of the knee.
- Trial name
- NCT07819955
- Testing
- Extracorporeal Shock Wave Therapy, Normal Saline, Hyaluronic Acid (HA)
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chang Gung Memorial Hospital
Purpura, Thrombocytopenic, Idiopathic
A Study of Hetrombopag Olamine in Chronic Idiopathic Thrombocytopenic Purpura (ITP) Patients
The purpose of this study is to obtain information on efficacy, safety and Pharmacokinetics (PK)/Pharmacodynamics (PD) of Hetrombopag over 14 days in Chinese patients with chronic ITP.
- Trial name
- NCT02403440
- Testing
- Hetrombopag Olamine
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Essential Thrombocythemia
CRETA (Clopidogrel Responsiveness in Essential ThrombocithemiA)
Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm associated with increased platelet production and activation, leading to a high risk of thrombotic complications.
- Trial name
- CRETA (NCT07645755)
- Testing
- VerifyNow P2Y12 assay
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Adult Immune Thrombocytopenia (ITP), Dapsone
Efficacy and Safety of DAPSone as a Second-line Option in Adult Immune Thrombocytopenia
Due to its expected efficacy based on the retrospective data available in ITP, its relatively good safety profile and its very low cost , dapsone could be a good steroid-sparing second-line option for adults with ITP.
- Trial name
- DAPS-ITP (NCT02627417)
- Testing
- Dapsone (Disulone®), Prednisone (Cortancyl®) alone followed by monitoring and "standard of care", Prednisone (Cortancyl®)
- Where
- France
- Volunteers
- 216 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontitis, Periodontitis (Stage 3)
Evaluation of Albumin Platelet-Rich Fibrin Following SRP in Patients With Periodontitis
The study aims to investigate whether application of albumin platelet-rich fibrin (Alb-PRF) into the gum pockets after scaling and root planing (SRP) can improve healing in patients with Stage III Grade B periodontitis.
- Trial name
- NCT07363135
- Testing
- Albumin platelet-rich fibrin, Sterile saline (0.9%)
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Saglik Bilimleri Universitesi
Osteoarthritis, Knee
How Does Platelet Dose Impact Clinical Outcomes After PRP Treatment?
The purpose of this study is to determine which platelet rich plasma (PRP) injection dosage provides the most improvement in a patient's knee pain level at 26 weeks post-injection.
- Trial name
- NCT05330689
- Testing
- PRP injection dose (<5 billion platelets), PRP injection dose (between 5 and <10 billion platelets), PRP injection dose (between 10 and <20 billion platelets)
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Primary Immune Thrombocytopenia (ITP)
Study of Immune Thrombocytopenia Pathogenesis:
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet count responsible for bleedings. The disease is mostly mediated by antiplatelet antibodies produced by specific B cells.
- Trial name
- PTI PARI (NCT02042560)
- Testing
- Blood samples, Spleen samples
- Where
- 3 sites in France
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Renal Artery Stenosis
Prospective Randomized Study Comparing Renal Artery Stenting (RESIST)With/Without Distal Protection
This study is designed to demonstrate the safety and efficacy of using a protective device/drug to prevent renal injury during renal artery stenting and to assess whether the preventative effects are measurable and if there is a…
- Trial name
- NCT00234585
- Testing
- Renal Artery Stent with Protective Device/Drug
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Toledo Health Science Campus
Thrombotic Thrombocytopenic Purpura, Hemolytic Uremic Syndrome
Rituximab in Patients With Relapsed or Refractory TTP-HUS
The general objective of this study is to assess the efficacy and safety of Rituximab in the management of patients with refractory or relapsed thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS).
- Trial name
- NCT00531089
- Testing
- Rituximab
- Where
- 11 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Hamilton Health Sciences Corporation
Epicondylitis
Treatment of Epicondylitis by Ultrasound-guided Local Injections of PRP (Platelet Rich Plasma)
The purpose of this study is to assess efficacy of two intra-tendinous injections of platelet-rich plasma (PRP) on epicondylitis of recent evolution (≤ 3 months) compared compared to two intra-tendinous injections of saline…
- Trial name
- NCT02378285
- Testing
- ACP, Saline solution
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Arthrex SAS
Anosmia, Inflammatory Anosmia
Intranasal Platelet-Rich Plasma With or Without Topical Insulin for Post-Inflammatory Anosmia
This study evaluates whether adding topical insulin to intranasal platelet-rich plasma (PRP) improves smell recovery in adults with post-inflammatory anosmia.
- Trial name
- PRP-I RCT (NCT07383415)
- Testing
- Intranasal PRP Plus Topical Insulin
- Volunteers
- 20 people
- Sponsor
- Amin Javer
Thrombocytopenia
A Five-Treatment-Period Study to Evaluate the Single-Dose Pharmacokinetics and Pharmacodynamics of Avatrombopag in Healthy Japanese and White Subjects
This will be a randomized, open-label, 5-treatment-period study to evaluate the PK and PD of avatrombopag following a single administration of avatrombopag in the fed and fasted condition, or the fed condition, to healthy…
- Trial name
- NCT02039076
- Testing
- avatrombopag
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
CCUS Clonal Cytopenia of Undetermined Significance, Anemia
Luspatercept for Clonal Cytopenias of Uncertain Significance
The purpose of this clinical trial is to test how well the drug luspatercept works in improving low blood cell counts in people with clonal cytopenias of uncertain significance (CCUS).
- Conditions
- CCUS Clonal Cytopenia of Undetermined Significance, Anemia, Leukopenia, Thrombocytopenia
- Trial name
- NCT06788691
- Testing
- Luspatercept
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Bleeding, Ischemic Stroke
The Relationship Between Clotting Factor VIII and Bleeding Adverse Reactions in Patients Under the Therapies of Thrombolysis, Anticoagulation and Anti-platelet
The purpose of this study is to determine whether Plasma Factor VIII Levels are related to the treatment of bleeding in ischemic stroke（IS）.
- Trial name
- NCT02677818
- Where
- China
- Sponsor
- Zhujiang Hospital
Tennis Elbow
Comparative Study for the Optimal Treatment Method of Lateral Epicondylosis
The purpose of this study is to find the optimal treatment method for chronic lateral epicondylosis, and focused on the 'healing mechanism' and 'pain modulation' of degenerated tendon.The hypothesis is that there will be…
- Trial name
- NCT02052089
- Testing
- physiotherapy, extracorporeal shockwave therapy, prolotherapy
- Where
- South Korea
- Volunteers
- 231 people
- Sponsor
- CM Chungmu Hospital
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