Clinical trials: Blood Pressure, High
Glaucoma, Retinal Vein Occlusion
Study of the Retinal Vascularization by Laser Doppler Velocimetry Coupled With an Adaptive Optics Camera ( AO-LDV)
The difficulty to measure blood flow in humans is connected with the necessity of using not invasive, reliable and reproducible techniques.
- Trial name
- AO-LDV (NCT03525132)
- Testing
- Laser Doppler Velocimetry + Optic Adaptative Camera
- Where
- France
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Hypertension, Atrial Fibrillation
Impact of Best Practice Alerts in Cardiology Outpatient Clinics
This quality improvement intervention seeks to implement two Best Practice Alerts (BPAs) for use in cardiology clinics while simultaneously evaluating the impact of each BPA- one for patients with uncontrolled blood pressure and…
- Trial name
- NCT02436421
- Testing
- Best Practice Alert based in the Electronic Medical Record
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Rheumatoid Arthritis
The Effect of the DASH Diet on Treatment Outcomes in Adults Diagnosed With Rheumatoid Arthritis
In this study, it is aimed to determine the effect of the DASH diet model on the treatment of patients with seropositive rheumatoid arthritis, by evaluating its potential impact on inflammatory markers, disease activity scores…
- Trial name
- NCT07170033
- Testing
- Dietary Approach to Stop Hypertension (DASH) Diet
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Istanbul Health and Technology University
Hypertension
Trial Using Motivational Interviewing Positive Affect and Self-Affirmation in Hypertension (TRIUMPH)
The primary aim of this study is to evaluate whether an intervention that combines positive affect and self-affirmation with motivational interviewing (TRIUMPH) improves blood pressure control compared to an…
- Trial name
- Triumph (NCT01024933)
- Testing
- Positive Affect/Self-Affirmation/Motivational Interviewing, Educational and Behavioral
- Where
- United States
- Volunteers
- 238 people
- Sponsor
- Weill Medical College of Cornell University
Elevated Blood Pressure
Acute Effect Of Pilates On Blood Pressure In Women
The objective of this randomized crossover clinical trial was to evaluate the acute effect of a Pilates exercise session on blood pressure in women aged 50 years or older.
- Trial name
- NCT07819058
- Testing
- Pilates Exercise, Walking Exercise
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Universidade Estadual do Norte do Parana
Hypertension, Pulmonary
Long-Term Open-Label, Safety Study Of Sitaxentan Sodium In Japanese Pulmonary Arterial Hypertension Patients
The safety and efficacy at 100 mg once daily for oral dose of sitaxentan sodium were demonstrated in the STRIDE clinical trial program. Sitaxentan sodium was approved in the EU, Canada and Australia.
- Trial name
- NCT01210443
- Testing
- Sitaxentan
- Where
- 2 sites in Japan
- Volunteers
- 2 people
- Sponsor
- Pfizer
Cardiovascular Diseases, Heart Diseases
Longitudinal Studies of Blood Pressure in the Elderly
To study further the association between blood pressure mortality among those who participated in both the Hypertension Detection and Follow-up Program (HDFP) screen and the East Boston Established Populations for Epidemiologic…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005409
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Glaucoma
Development and Implementation of an Educational Program to Enhance Adherence to Glaucoma Treatment
This study evaluates the addition of an educational intervention program in order to improve medication adherence in glaucoma patients.
- Trial name
- NCT04245163
- Testing
- Educational program
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Cyprus University of Technology
Cardiovascular Diseases, Heart Diseases
Treatment of Hypertension
To determine whether the long-term treatment of essential hypertension without significant target organ disease materially influenced mortality and/or cardiovascular renal morbidity.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Vascular Diseases
- Trial name
- NCT00000484
- Testing
- chlorothiazide, Rauwolfia alkaloids
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coma
Optic Nerve Sheath Diameter as a Screening Test for Increased Intracranial Pressure
Patients admitted to the ICU may have delayed awakening after their critical illness has resolved. Though most either are due to metabolic causes or delayed elimination of sedative medications, more serious pathologies such as…
- Trial name
- NCT02338284
- Testing
- ultrasound of globe
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Hypertension
Effectiveness of Inspiratory Muscle Training With Slow Breathing in Elderly With ISH
Study the effects of inspiratory muscle training at Low load of 25 %Maximal inspiratory pressure with slow breathing rate at 6 breaths/min on inspiratory muscle strength, lung function, chest wall expansion, abdominal expansion…
- Trial name
- NCT02752217
- Testing
- Inspiratory Muscle Training, Control
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- Khon Kaen University
Cushing Syndrome
A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome
This is a Phase 3, double-blind, placebo-controlled, randomized-withdrawal study to assess the efficacy, safety and pharmacokinetics (PK) of relacorilant in patients with endogenous Cushing syndrome and concurrent type 2 diabetes…
- Trial name
- GRACE (NCT03697109)
- Testing
- Relacorilant
- Where
- 64 sites in United States, Austria and 9 more
- Volunteers
- 152 people
- Sponsor
- Corcept Therapeutics
Hypertension, Hypercholesterolemia
Vascular Intervention Strategies Trial for Alzheimer's
The proposed pharmacist-led study is a feasibility pilot trial for the management of vascular risk factors of hypertension and hypercholesterolemia in 10 APOE ε4 carriers, 50-75, at-risk for dementia.
- Conditions
- Hypertension, Hypercholesterolemia, Dementia Risk Factors
- Trial name
- VISTA (NCT07447206)
- Testing
- Angiotensin Receptor Blockers (ARBs), Hydrophilic Statins or Non-Statin Alternative
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Chronic Kidney Diseases
miRNA in Chronic Kidney Diseases
Oxidative stress and endoplasmic reticulum (ER) stress play a key role in tubular damage in both acute kidney injury and chronic kidney disease (CKD).
- Trial name
- NCT06316284
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Open-angle Glaucoma, Ocular Hypertension
A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study is to determine whether a glaucoma therapy is safe and effective in treating patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00314158
- Testing
- Brinzolamide 10 mg/ml + Timolol 5 mg/ml eye drops, suspension, Brinzolamide 10 mg/ml (AZOPT) eye drops, suspension, Timolol 5 mg/ml eye drops, solution
- Where
- United States
- Volunteers
- 523 people
- Sponsor
- Alcon Research
Chronic Thromboembolic Pulmonary Hypertension
Registry of Patients With chrOnic thromboemboLic Pulmonary hypErTension
The goal of this observational study is to gather information on background, medical history, symptoms and physical condition, treatment options of people with chronic thromboembolic pulmonary hypertension in real clinical…
- Trial name
- POLET (NCT07254078)
- Testing
- Pulmonary endarterectomy, Balloon pulmonary angioplasty, Pulmonary hypertension-specific therapy
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- Irina E. Chazova
Portal Hypertension, Chronic Liver Disease
EUS vs TJ for Liver Biopsy and Portal Pressure Gradient Measurement
This study will directly compare the endoscopic ultrasound guided approach to obtain adequate liver biopsies and portal pressure gradient measurements to the current standard of care which uses the transjugular approach.
- Conditions
- Portal Hypertension, Chronic Liver Disease, Cirrhosis
- Trial name
- NCT05118308
- Testing
- Transjugular hepatic venous pressure gradient measurement with liver biopsy, Endoscopic ultrasound portal pressure gradient measurement with liver biopsy
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Nutrition, Healthy, Type 2 Diabetes
Medically Tailored Groceries and Food Resource Coaching
Eating healthy foods can help people manage health problems, like Type 2 diabetes and heart disease. Many people want to eat healthier, but changing eating behaviors is hard.
- Conditions
- Nutrition, Healthy, Type 2 Diabetes, Hypertension, Dyslipidemias
- Trial name
- NCT06242808
- Testing
- Food resource coaching, Free community food support, Medically tailored groceries
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension, Aldosteronemia
Decode the Environment Variation of Targeted Aldosterone Inducer and siLencer
Clinical outcome to identify and analyze the epigenetic, phenotypic, protein variation, metabolites of CYP450 Family 11 Subfamily B, both 1 and 2, human-associated aldosterone protein release, and signaling inhibitory pathways…
- Conditions
- Hypertension, Aldosteronemia, CYP11B1, CYP11B2
- Trial name
- DETAIL (NCT07748975)
- Testing
- Aldosterone circulation, Medication, Operation
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- DejthidaNathaphong
Cardiovascular Diseases
Tight Closed-loop Systolic Arterial Pressure Control
The purpose of this case series is to evaluate the performance of a novel closed-loop (automated) vasopressor administration system that delivers norepinephrine using feedback from standard operating room hemodynamic monitoring…
- Trial name
- NCT04357301
- Testing
- Closed-loop vasopressor
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Erasme University Hospital