Clinical trials: Blood Pressure Control
Healthy Volunteers
A Phase 1 TR-701 FA Study of Blood Pressure Response Post Tyramine Challenge
Phase 1 study to determine the effect of oral TR-701 FA on SBP response when administered with tyramine
- Trial name
- NCT01539473
- Testing
- TR-701 FA with Tyramine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Diet, Healthy, Weight Change, Body
Effects of a Daily Time-Restricted Feeding Protocol on Diet Quality
As a result of unhealthful lifestyle practices including nighttime ingestion and excess energy-dense food and beverage intake, college students are presenting with metabolic abnormalities and excess weight gain that increases…
- Conditions
- Diet, Healthy, Weight Change, Body, Dyslipidemias, Blood Pressure
- Trial name
- NCT04348019
- Testing
- Fasting
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Blood Pressure, Cardiac Ischemia
The Use of L-arginine to Mitigate the Cardiovascular Effects of Exposure to Traffic-related Air Pollution
The present study is aimed to investigate whether oral L-arginine supplementation reduces the adverse cardiovascular effects of exposure to traffic-related air pollution among a group of non-smoking adults with elevated blood…
- Trial name
- NCT03433963
- Testing
- L-Arg supplement
- Where
- 3 sites in China
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Peking University
Genetic Predisposition to Disease, Breathing, Mouth
Expression of Genes Relating Hypertension and Efficacy of 4-7-8 Breathing Control on Reducing Blood Pressure
This study consists of two sub-studies. Study 1 investigates gene expression related to the development of hypertension in Thailand, and Study 2 examines the effectiveness of the 4-7-8 breathing technique in reducing blood…
- Trial name
- NCT07018128
- Testing
- Study 2: deep breathing, Study 2: 4-7-8 breathing, Study 2: slow breathing with device
- Where
- Thailand
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Burapha University
Restless Legs Syndrome (RLS)
Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome
Several studies report association between restless legs syndrome (RLS), HTA and cardiovascular diseases . The mechanisms involved in this relationship remained unknown, but several evidences favor the role of periodic limb…
- Trial name
- NCT01823770
- Testing
- Rotigotine
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Autonomic Nervous System Imbalance, Blood Pressure
Short-term Cardiovascular Benefits of Wearing Particulate-filtering Respirators
An intervention study to assess the short-term cardiovascular effects of reducing personal air pollution exposure by wearing particulate filtering respirators.
- Conditions
- Autonomic Nervous System Imbalance, Blood Pressure, Inflammation, Vasoconstriction
- Trial name
- NCT02238028
- Testing
- Wear respirator
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fudan University
Healthy Young Adults, Healthy Adult Participants
Foam Rolling and Blood Pressure
Foam rolling (FR) has emerged as a widely adopted modality among rehabilitation practitioners and physically active populations.
- Conditions
- Healthy Young Adults, Healthy Adult Participants, Healthy Participants, Normotensive
- Trial name
- NCT07520474
- Testing
- Foam Rolling Intervention (FR)
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Healthy Volunteers
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9035 in Healthy Adult Volunteers and Mildly Hypertensive Participants
The primary objective of the study is to: Evaluate the safety and tolerability of REGN5381 and REGN9035 administered alone or sequentially.
- Trial name
- NCT05291546
- Testing
- REGN9035, REGN5381
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Metabolic Syndrome
NWT03 and Arterial Stiffness
Rationale: Subjects with the metabolic syndrome have an increased risk of developing cardiovascular disease and a twofold risk of developing hypertension.
- Trial name
- NCT02561663
- Testing
- NWT-03, an egg-white protein hydrolysate
- Where
- Netherlands
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Newtricious R&D BV
Contraception
US Cycle Control and Blood Pressure Study
Birth Control Patch Study
- Trial name
- NCT00920985
- Testing
- Gestodene/EE (FC Patch Low, BAY86-5016), Oral contraceptive (equivalent to the active treatment tablets of Levlite), 21-day blister SH D00593A
- Where
- 28 sites in United States
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- Bayer
Healthy
Isometric Exercises in Healthy Elderly Individuals
A total of 58 participants were selected and divided into two groups equally, namely, elderly, and young groups with the age groups of 60-80 years and 20-30 years, respectively.
- Trial name
- NCT04932733
- Testing
- Exercises, Young isometric exercise
- Where
- Jordan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Salameh Aldaja
Sarcopenia, Hypertension
Effects of Variable Load Exercise on Aging Atrophy
The primary aim of this research proposal is to examine whether this novel training program approach is capable to tackle excessive loss in muscle mass, function and contractile capacity with aging.
- Conditions
- Sarcopenia, Hypertension, Muscle Atrophy
- Trial name
- NCT03690258
- Testing
- Variable load exercise
- Where
- 2 sites in Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital of Split
Physiology, Ocular, Microcirculation
Role of Nitrogen Oxide (NO) in the Control of Choroidal Blood Flow During a Decrease in Ocular Perfusion Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. For a long time it had been assumed that the choroid is a strictly passive vascular bed, which shows no autoregulation.
- Conditions
- Physiology, Ocular, Microcirculation, Regional Blood Flow, Autoregulation
- Trial name
- NCT00810927
- Testing
- Suction cup application, Laser Doppler flowmetry, Measurement of intraocular pressure
- Where
- Austria
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy
A Study of Ponesimod in Healthy Adult Participants Receiving Propranolol at Steady State
The primary purpose of this study is to evaluate the effect of the up-titration regimen of ponesimod on heart rate (HR) and other electrocardiogram (ECG) parameters when administrated to healthy adult participants receiving…
- Trial name
- NCT03882255
- Testing
- Ponesimod dose range (2 - 20 mg), Propranolol 80 mg
- Where
- Belgium
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Well-being, Work Stress
A Randomised Controlled Trial to Investigate the Effects of a Mindfulness Smartphone App on Well-being in the Workplace
We propose a randomised controlled trial in a workplace setting to investigate whether a smartphone-delivered programme of mindfulness meditation influences psychological and biological indicators of well-being.
- Trial name
- NCT01661569
- Testing
- Headspace On-the-go app
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
HIV Infections, Frailty
Sleep Quality and Frailty Among People Living With HIV
With effective antiretroviral therapy (ART), people living with HIV (PLWH) are living longer and are increasingly experiencing aging-related conditions such as frailty and sleep problems.
- Conditions
- HIV Infections, Frailty, Sleep Quality, Oral Frailty
- Trial name
- NCT07880054
- Testing
- No intervention (observational assessments)
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Sun Yat-sen University
Overweight, Obesity
Meta-analyses of the Effect of Liquid Meal Replacements on Cardiometabolic Risk
Obesity is a major risk factor for cardiovascular disease and diabetes. Weight loss is an important therapeutic goal for overweight and obese patients to reduce their risk of developing cardiovascular disease and diabetes.
- Conditions
- Overweight, Obesity, Type 2 Diabetes
- Trial name
- NCT02779790
- Testing
- Liquid Meal Replacements
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Pregnancy, Blood Pressure Measurement in Pregnancy
Arm Position and Blood Pressure Measurement Accuracy During Pregnancy
Accurate blood pressure measurement is essential during pregnancy, as blood pressure readings guide clinical decisions related to the diagnosis and management of hypertensive disorders of pregnancy.
- Conditions
- Pregnancy, Blood Pressure Measurement in Pregnancy, Hypertensive Disorder of Pregnancy
- Trial name
- NCT07405723
- Testing
- Arm Supported at Heart Level, Arm Supported on Lap, Arm Unsupported at Side
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Hypertension
Telemonitoring of Blood Pressure in Local Pharmacies
The TEMPLAR project is an observational, cross-sectional, multicenter study involving several community pharmacies spread all over Italy.
- Trial name
- TEMPLAR (NCT03781401)
- Testing
- Ambulatory blood pressure monitoring
- Where
- Italy
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Italian Institute of Telemedicine
Hypertension
A Controlled Study to Investigate the Effect of Multi-wave Light Emitting Diode (LED) Bed on Blood Pressure and Endothelial Function
The objective of this multi-center study is to investigate the effect of a multi-wave LED light bed on blood pressure and endothelial function in pre-hypertensive and mildly hypertensive adults.
- Trial name
- NCT04006158
- Testing
- LED bed
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- LED Intellectual Properties, LLC