Clinical trials: Blood Pressure Regulation
High Blood Pressure
Behavioral Economics Trial To Enhance Regulation of Blood Pressure (BETTER-BP)
BETTER-BP (Behavioral Economics Trial To Enhance Regulation of Blood Pressure) is a phase II, single-center, prospective, pragmatic randomized clinical trial within the New York City Health and Hospitals (NYC-H+H) system and NYU…
- Trial name
- BETTER-BP (NCT04114669)
- Testing
- Control Condition, Regret Lottery
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- NYU Langone Health
Parkinson Disease, Orthostatic Hypotension
Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension
Phase 1 objective: test the feasibility of using a 3Tesla MRI scanner instead of a 7Tesla MRI scanner to measure brainstem responses to LBNP in healthy participants.
- Trial name
- HYPOPARK (NCT07139756)
- Testing
- Lower body negative pressure
- Where
- Switzerland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Hypertension, Menopause, Premature
Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women.
- Conditions
- Hypertension, Menopause, Premature, Menopause, Blood Pressure
- Trial name
- NCT04439370
- Testing
- Microneurography to measure muscle sympathetic nerve activity (MSNA), Baroreflex sensitivity testing, Sympathoexcitatory Maneuvers
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Orthostatic Hypotension
Impedance Threshold Device Tilt Study
This study will see if a special piece of equipment can help burn patients who have been in bed for a long time to get out of bed without feeling dizzy or faint.
- Trial name
- NCT00137319
- Testing
- Impedance threshold device
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- United States Army Institute of Surgical Research
Stroke, Ischemic
Antithrombotic Therapy With Regulation of Blood Pressure in Non-Cardioembolic Progressive Stroke
Stroke has become the leading cause of death in China, with acute ischemic stroke still progressing within one week of onset, known as progressive ischemic stroke (PIS), which has a high rate of disability and mortality…
- Trial name
- NCT06551727
- Testing
- Intervention group, Control group
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Ruijin Hospital
Prehypertension, Hypertension
Mindfulness-Based Blood Pressure Reduction (MB-BP) Intervention Development - Stage 1 Single Arm Trial
Specific aims are: 1. To outline and evaluate key active elements of the Mindfulness-Based Blood Pressure Reduction (MB-BP) intervention.
- Trial name
- MB-BP (NCT02702258)
- Testing
- MB-BP
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Brown University
Blood Pressure
Salt and HMB Study
Hypertension affects one-third of adults in the US. High salt diet is a key risk factor for elevated blood pressure (BP). The associations of gut microbiome with high salt diet and hypertension have been established in both…
- Trial name
- NCT05515900
- Testing
- Sodium, HMB
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Augusta University
Healthy
Regulation of Optic Nerve Head Blood Flow During Combined Changes in Intraocular Pressure and Arterial Blood Pressure
Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance to changes in perfusion pressure. In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of…
- Trial name
- NCT00912665
- Testing
- Laser Doppler Flowmetry, Goldmann applanation tonometer, squatting
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hypertension, Hypotension
Efficacy and Safety Evaluation of Non-invasive Temporal Interference Stimulation for Blood Pressure Regulation
The primary objective of this research is to study the efficacy and safety of temporal interference stimulation for regulating the blood pressure.
- Trial name
- NCT07239492
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Xuanwu Hospital, Beijing
Blood Pressure, Hypertension
Blood Pressure Regulation - Role of Potassium
Project titel: Oral potassium supplementation in healthy men - interactions with the renin-angiotensin-aldosterone system and the sympathetic nervous system Protocol number: KARAASS-1 EudraCT number: 2013-004460-66 Introduction…
- Trial name
- NCT02380157
- Testing
- Kaleorid, 750mg (trade name), Potassium chloride (active substance)
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Cardiovascular Diseases, Hypertension
Insulin Resistance and Blood Pressure Regulation in Blacks
To determine the role of insulin resistance in peripheral vascular dynamics, sodium sensitivity, and blood pressure regulation in a young representative Black population and in a group of young Blacks at high risk for…
- Conditions
- Cardiovascular Diseases, Hypertension, Heart Diseases, Insulin Resistance
- Trial name
- NCT00005164
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension
Effects of Coffee Versus Hibiscus Tea Consumption During Prolonged Sitting on Blood Pressure and Heart Rate
Modern lifestyles often involve long periods of sitting, which can increase the risk of heart problems, obesity, and other health issues. Diet also plays a key role in heart health.
- Trial name
- NCT07159152
- Testing
- Coffee, Hibiscus drink
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Saud University
Type 2 Diabetes Mellitus
The HOME Trial: Hyperinsulinaemia: the Outcome of Its Metabolic Effects, a Randomized Controlled Trial
The HOME-trial is a prospective, randomized controlled trial. The purpose of this study is to investigate the effects of metformin HCL in patients with type 2 diabetes mellitus intensively treated with insulin on the quality of…
- Trial name
- NCT00375388
- Testing
- Metformin on top of intensive insulin therapy
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Bethesda General Hospital, Hoogeveen
Diabetes Mellitus, Type 2, Polyneuropathy Diabetes
24-hour Blood Pressure Dynamics and Autonomic Adrenergic Regulation in Type 2 Diabetics
Autonomic neuropathy is a common complication of type 2 diabetes mellitus. Symptoms from cardiovascular autonomic neuropathy include, dizziness, orthostatic hypotension and insufficient heart rate and blood pressure (BP)…
- Conditions
- Diabetes Mellitus, Type 2, Polyneuropathy Diabetes, Autonomic Neuropathy, Diabetic Neuropathies
- Trial name
- NCT04208295
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Spinal Cord Injury, Orthostatic Hypertension
Non-invasive Spinal Cord Stimulation and Blood Pressure Regulation After Spinal Cord Injury
The goal of this clinical trial is to learn if non-invasive spinal cord stimulation intervention improves blood pressure regulation in individuals with chronic spinal cord injury.
- Conditions
- Spinal Cord Injury, Orthostatic Hypertension, Autonomic Dysreflexia
- Trial name
- NCT07504055
- Testing
- Spinal Cord Transcutaneous Stimulation
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Louisville
Hypertension
Effect of Exercise and Diet on Inflammation in Hypertensive Individuals
In addition to high blood pressure, hypertension is characterized by inflammation, which is the body's response to injury or infection. Inflammation has been found to cause plaque formation on artery walls.
- Trial name
- NCT00338572
- Testing
- Exercise Program, Combined Exercise and Diet Program
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- University of California, San Diego
Ocular Physiology, Optic Disk
Role of Endothelin- and Nitric Oxide-system in the Regulation of Optic Nerve Head Blood Flow During Changes in Ocular Perfusion Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. The existence of an effective autoregulation in the optic nerve circulation has been shown in animals and humans.
- Conditions
- Ocular Physiology, Optic Disk, Regional Blood Flow
- Trial name
- NCT00406731
- Testing
- NG-monomethyl-L-arginine (L-NMMA), Endothelin-1 (ET-1), Laser Doppler flowmetry
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy
Regulation of Optic Nerve Head Blood Flow During Combined Changes in Intraocular Pressure and Arterial Blood Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. The existence of an effective autoregulation in the optic nerve head (ONH) circulation has been shown in animals and…
- Trial name
- NCT00915226
- Testing
- Suction cup application, Squatting
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cardiovascular Disease
Cardiometabolic Benefits of Omega-3 Polyunsaturated Fatty Acids
Omega 3 fatty acids have been shown to provide a number of cardiometabolic benefits in both healthy and at risk populations. Specifically, the daily consumption of fish oil supplements has been reported to reduce blood…
- Trial name
- TGIF (NCT03378232)
- Testing
- High EPA Supplement, High DHA Supplement
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Chronic Obstructive Pulmonary Disease
pCO2 Oscillations During Exercise: Relation to Cerebral Blood Flow and to Cognitive Dysfunction in COPD
Investigators wish to identify a relationship between substantial changes in carbon dioxide partial-pressure (pCO2), which frequently occur during the transitions from rest to exercise (ΔpCO2 >4 millimeters of mercury [mmHg] from…
- Trial name
- NCT02660437
- Testing
- Pulmonary Rehabilitation program
- Where
- Germany
- Volunteers
- 91 people
- Sponsor
- Schön Klinik Berchtesgadener Land