Clinical trials: Blood Pressures
Hypertension
CART BP Pro-Guided Blood Pressure Management for Uncontrolled Hypertension
This multicenter, prospective, open-label randomized controlled trial evaluates the efficacy and safety of CART BP Pro-guided blood pressure management in Korean patients with uncontrolled hypertension.
- Trial name
- CART-BP RCT (NCT07465549)
- Testing
- CART BP Pro, Usual Care
- Where
- 3 sites in South Korea
- Volunteers
- 400 people
- Sponsor
- Korea University Anam Hospital
Blood Pressure
Optical System to Continuously Measure Arterial Blood Pressure
Comparison of an optical method to continuously measure blood pressure against an invasive arterial catheter.
- Trial name
- BP (NCT02651558)
- Testing
- Experimental: OBPM 2015-MD-0022 - CHEST, Experimental: OBPM 2015-MD-0022 - CHEST & FINGER, Experimental: OBPM 2015-MD-0022 - FINGER
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Developpement
Lumbar Spinal Stenosis, Lumbar Degenerative Disease
Effect of Obesity Phenotype on Intraabdominal Pressure and Bleeding in Major Lumbar Spinal Surgery
Obesity is prevalent among patients with lumbar degenerative disease and is a known risk factor for perioperative complications in spinal surgery.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Degenerative Disease, Obesity, Intraabdominal Hypertension
- Trial name
- OBESPINE (NCT07688265)
- Testing
- Intraabdominal Pressure Measurement via Urinary Bladder Catheter, Total Intravenous Anesthesia (TIVA)
- Volunteers
- 90 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Type 2 Diabetes
Study Looking at Cardiovascular Effects of Exenatide, Its Blood Pressure Lowering Effect and Its Mechanisms
Exenatide is a new drug which lowers blood sugar (glucose) levels for people with type 2 diabetes. It has significant advantages over other treatments such as insulin as it causes weight loss in a group of people that is…
- Trial name
- NCT01046721
- Testing
- Exenatide, Saline
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Intraoperative Arterial Hypotension
Association of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac Surgery
The aim of study is to investigate the clinical relevance of blood pressure (BP) excursions below cerebral autoregulatory boundaries in major noncardiac surgery.
- Trial name
- AR-NONCARDIAC (NCT05336864)
- Testing
- Non-invasive cerebral oximetry monitoring, additional perioperative blood sampling, clinical & telephone assessments
- Where
- 3 sites in Switzerland
- Volunteers
- 650 people
- Sponsor
- University Hospital, Basel, Switzerland
General Anesthesia
Effect of Sevoflurane and Propofol on Hepato-splanchnic Pressure and Flow During Hepatobiliary Surgery
Blood loss in hepatobiliary surgery is correlated with an increase in postoperative complications (e.g. transfusion related lung injury and tumor recurrence) and reduced longterm survival.
- Trial name
- NCT03772106
- Testing
- Propofol Fresenius, sevorane
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- University Hospital, Ghent
Hypertension
Pharmacogenomic Evaluation of Antihypertensive Responses 2
There are many medications available for the treatment of high blood pressure (hypertension), but finding the right one for a specific patient can be challenging.
- Trial name
- PEAR2 (NCT01203852)
- Testing
- Metoprolol, Chlorthalidone
- Where
- 3 sites in United States
- Volunteers
- 839 people
- Sponsor
- University of Florida
Apparent Resistant Hypertension, Hypertension
Rapid Management of Resistant Hypertension in the Public Health System (Fast Control)
This is a single-center, open-label, randomized clinical trial conducted at the Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil.
- Conditions
- Apparent Resistant Hypertension, Hypertension, High Blood Pressure
- Trial name
- FastControl (NCT07259733)
- Testing
- Triple Fixed-Dose Combination (Perindoprile/Indapamide/Amlodipine), Usual Care Antihypertensive Regimen
- Where
- Brazil
- Volunteers
- 142 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Cardiovascular Risk Reduction
Young Hearts, Strong Starts
This is a cluster randomized trial of pediatric cardiovascular risk reduction guideline implementation in 32 clinical practices
- Trial name
- NCT01893593
- Testing
- Intervention, Control
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- RTI International
Hypertension,Essential, Obstructive Sleep Apnea
A Cardiosleep Research Program on Obstructive Sleep Apnea, Blood Pressure Control and Maladaptive Myocardial Remodeling
The objective of this proposal is to evaluate whether mandibular advancement device (MAD) is non-inferior to continuous positive airway pressure (CPAP) in the treatment of obstructive sleep apnea (OSA) and blood pressure…
- Trial name
- CRESCENT (NCT04119999)
- Testing
- Mandibular Advancement Device, Continuous Positive Airway Pressure
- Where
- Singapore
- Volunteers
- 321 people
- Sponsor
- National University of Singapore
Healthy
Regulation of Optic Nerve Head Blood Flow During Combined Changes in Intraocular Pressure and Arterial Blood Pressure
Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance to changes in perfusion pressure. In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of…
- Trial name
- NCT00912665
- Testing
- Laser Doppler Flowmetry, Goldmann applanation tonometer, squatting
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hypertension
A Study to Investigate the Magnitude and Duration of Response of MK0954 Compared to Placebo in Patients With Hypertension (0954-021)(COMPLETED)
The purpose of this study was to evaluate the magnitude and durations of the antihypertensive effects of losartan using ambulatory blood pressure monitoring (ABPM), and to evaluate the safety of losartan 50 and 100 mg doses…
- Trial name
- NCT00886600
- Testing
- losartan potassium, hydrochlorothiazide (HCTZ)
- Volunteers
- 122 people
- Sponsor
- Merck Sharp & Dohme LLC
ESRD, Hemodialysis Complication
Timing of Antihypertensive Medications on Key Outcomes in Hemodialysis
For patients with kidney failure requiring hemodialysis treatment, sometimes the blood pressure will drop too low during dialysis.
- Conditions
- ESRD, Hemodialysis Complication, Blood Pressure
- Trial name
- TAKE-HOLD (NCT03327909)
- Testing
- TAKE vs. HOLD
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Stanford University
High-intensity Interval Exercise, Heart Rate
Acute Physiological and Perceptual Responses to Novel Forms of High-intensity Interval Exercise
Randomised cross-over study seeking to explore the acute physiological and perceptual responses to three novel forms of high-intensity interval training (HIT).
- Conditions
- High-intensity Interval Exercise, Heart Rate, Rating of Perceived Exertion, Blood Pressure
- Trial name
- NCT03359928
- Testing
- Boxing, Stair stepping, Stair climbing
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Teesside University
Blood Pressure, Cardiometabolic Health
The EXPLAIN Study: Exploring Plant-Based Meat Analogues for Their Impact on Health
Plant-based diets with little to no meat are considered healthy and sustainable by the general public. The increasingly popular plant-based meat analogues (PBMAs) allow consumers to easily decrease meat intake while maintaining…
- Trial name
- EXPLAIN (NCT06370936)
- Testing
- Standardized diet with commercially available animal meats (comparator products), Standardized diet with commercially available PBMAs (intervention products)
- Where
- Netherlands
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Glaucoma
Trusopt and Cosopt; Ocular Perfusion Pressure and Blood Flow: New Long-term Prospective Data
To analyze Cosopt® in terms of its effects on ocular perfusion pressure and comprehensive ocular blood flow and in relation to visual field progression and optic nerve structural changes in an ongoing 3 year prospective study…
- Trial name
- NCT01145898
- Testing
- (Cosopt®, prostaglandin)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Indiana University
Cardiovascular Diseases, Heart Diseases
Longitudinal Studies of Blood Pressure in the Elderly
To study further the association between blood pressure mortality among those who participated in both the Hypertension Detection and Follow-up Program (HDFP) screen and the East Boston Established Populations for Epidemiologic…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005409
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aging
Angiotensin-(1-7) Cardiovascular Effects in Aging
Aging is an independent risk factor for developing hypertension and cardiovascular disease; however, the mechanisms underlying age-related cardiovascular disease remain poorly understood.
- Trial name
- NCT05301192
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Cardiovascular Disease
Diet and Vascular Health Study
The aim of this study is to examine the effects of a diet rich in broccoli on cardiovascular disease risk using biochemical indicators such as blood lipid profiles, most notably cholesterol; markers of inflammation as well as…
- Trial name
- BROCCOLI (NCT01114399)
- Testing
- Diet and Vascular Health, Diet and Vascular Health Study
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Hypertension, Diabetes Mellitus Type 2
Effect of Pioglitazone on Ambulatory Blood Pressure
The anti-diabetic pioglitazone has been found to reduce casual blood pressure. To date, no data are available looking at this effect in detail.
- Trial name
- NCT00328393
- Testing
- Pioglitazone
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
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