Clinical trials: Blood Transfusion
Splanchnic Oxygenation, NIRS
Using NIRS to Evaluate Splanchnic Oxygenation During Blood Transfusion in Preterm Infant
To evaluate the differences splanchnic oxygen saturation in preterm infants receiving red blood cell transfusion with and without enteral feeding, and their outcomes.
- Conditions
- Splanchnic Oxygenation, NIRS, PreTerm Neonate, Enteral Feeds
- Trial name
- NCT06663085
- Testing
- Enteral feeding
- Where
- Indonesia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Platelet Transfusion
Cold Apheresis Platelets in PAS
This is a platelet transfusion study. The purpose of this study is to measure the life span and quality of platelets stored in a refrigerator. Participants will give platelets by apheresis.
- Trial name
- CAPP (NCT02754414)
- Testing
- Apheresis platelet collection, Refrigerated storage of apheresis platelets in PAS/plasma, Infusion of aliquot of autologous radiolabeled platelets
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bloodworks
Hemorrhage, Fracture Femur
Comparative Use of Tranexamic Acid Intravenous and Topical Application in Intertrochanteric Fractures With PFNA
An intertrochanteric (ITF) trochanteric fracture of the femur is an exclusively extra capsular fracture in which the fracture line extends from the greater trochanter to the lesser trochanter.
- Trial name
- NCT04696224
- Testing
- Tranexamic acid, Saline solution
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Beta-thalassemia, Glioma
Plasticizer Exposure and Its Consequences on Health
Plasticizers are chemicals commonly found in many everyday items, from food packaging to medical equipment. Although they are pervasive in our daily lives, researchers still don't have a clear picture of their long-term effects…
- Conditions
- Beta-thalassemia, Glioma, Healthy Controls, Transfusion-dependent Beta-Thalassemia
- Trial name
- PEACH (NCT06512298)
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Blood Loss, Surgical, Blood Transfusion
Bleeding in Knee Arthroplasty After Preconditioning With Sevoflurane
Knee arthroplasty is performed with restriction of blood flow by use of the pressure tourniquet. Ischemia of skeletal musculature is accompanied by the formation of reactive oxygen species and release of vasoactive factors.
- Trial name
- NCT03379103
- Testing
- Sevoflurane, Propofol
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Transfusion Reaction
Detection of Autologous DEHP (DiEthylHexyl Phthalate)-Free Blood Transfusion in Anti-doping
The aim of the proposed project is to perform a clinical study in which volunteers will receive autologous blood transfusions in DEHP-free blood bags.
- Trial name
- NCT02423135
- Testing
- Autologous blood transfusion
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Sickle Cell Disease, Pregnancy Related
Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease
The goal of this study is to determine if there is a positive effect of prophylactic red blood cell (RBC) transfusion of leukoreduced, ABO, Rh (D/Cc/Ee) and Kell matched blood compared to standard of care on the number of…
- Trial name
- ProTIP (NCT06979492)
- Testing
- Prophylactic Transfusion Intervention group: Transfusion, Control group
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Blood Transfusion
Blood Transfusion Reduction - QI Project
Blood Banks of large medical centers have large annual budgets, typically millions of dollars. Blood product wastage results in not only in a loss of the product's cost, but also of the fees involved in transporting, handling…
- Trial name
- NCT04823273
- Testing
- General improvement, In-line help text, Interruptive alert
- Where
- United States
- Volunteers
- 1,640 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Beta Thalassemia Transfusion Dependent
Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With β-TTD
The goal of this clinical trial is to compare physical ability of patients with transfusion-dependent β-thalassemia to control subjects.
- Trial name
- THALEX (NCT07207577)
- Testing
- Maximal incremental exercise test
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Metropole Savoie
Healthy
Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide (NO) Homeostasis
The purpose of this study is to explore the impact of aged blood on endothelial function by measuring forearm blood flow during intra-arterial acetylcholine infusion in normal healthy human volunteers after infusion of autologous…
- Trial name
- NCT01137656
- Testing
- Acetylcholine and Blood
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Mark Gladwin
Surgical Blood Loss, Surgical Hemorrhage
TEG Use in Children Undergoing Procedures With High Anticipated Blood Loss
The research team proposes a prospective, observational study to better understand how TEG can be useful in guiding clinical practice in the Main OR for subject's undergoing high transfusion risk surgeries.
- Conditions
- Surgical Blood Loss, Surgical Hemorrhage, Post Operative Hemorrhage
- Trial name
- NCT05379530
- Testing
- Thromboelastography (TEG), Anesthesia Provider Survey
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Prediabetic State
Characterization of the "Transfusion-dependent Prediabetes" Using Continuous Glucose Monitoring
Dysglycemia is a frequent finding in transfusion-dependent thalassemia (TDT). The oral glucose tolerance test (OGTT) remains the only validated screening test, but the procedure is complex and time-consuming.
- Trial name
- NCT06533618
- Testing
- Continuous glucose monitoring system
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Anemia
Mortality After Transfusion of Ever-pregnant Donor Red Blood Cells
The MATER study is an observational cohort study on first ever transfusion recipients in six hospitals in the Netherlands, with information collected on both donor and patient characteristics.
- Trial name
- MATER (NCT06176105)
- Where
- Netherlands
- Volunteers
- 101,000 people, healthy volunteers welcome
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Bleeding, Transfusion Related Complication
Use of Transexamic Acid in Hip Replacement
Studies have shown that tranexamic acid reduces blood loss and transfusion need in patients undergoing total hip arthroplasty. However, no to date, no study has been large enough to determine definitively whether the drug is safe…
- Trial name
- NCT02587845
- Testing
- Tranexamic Acid (IV), Tranexamic Acid (Topical)
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Aging
Young Donor Plasma Transfusion and Age-Related Biomarkers
The purpose of the study is to evaluate the beneficial effects of infusions of plasma from young donors using blood biomarkers.
- Trial name
- NCT02803554
- Testing
- Plasma
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ambrosia LLC
Nephrolithiasis, Staghorn Calculus
Impact of Tranexamic Acid Use in Percutaneous Nephrolithotomy
This study is a double blinded randomized controlled trial evaluating the impact of tranexamic acid use on the transfusion rate in patients with complex kidney stones undergoing percutaneous nephrolithotomy.
- Trial name
- NCT02966236
- Testing
- Tranexamic Acid
- Where
- Brazil
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Leukemia, Lymphoma
Comparing Fresh Random Platelets and Autologous Cryopreserved Thrombosol Treated Autologous Platelets
Objectives: Determine the corrected count increment of autologous transfused platelets that had been stored by cryopreservation with ThromboSol.
- Trial name
- NCT00074763
- Testing
- Platelet Transfusion
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Vaccination Reaction, Hepatitis B Virus Infection
Hepatitis B Vaccination After Neonatal Surgery
At present, whether the hepatitis B vaccine (HBV) can be vaccinated on time after neonatal surgery has become a common problem for children's families, neonatal surgeons, and vaccination departments, but there are few relevant…
- Conditions
- Vaccination Reaction, Hepatitis B Virus Infection, Digestive System Disorders of Fetus and Newborn, Blood Transfusion Complication
- Trial name
- NCT06023056
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Chongqing Medical University
Healthy
G-CSF for Granulocyte Donation
This study will examine the feasibility of giving cell growth stimulants to granulocyte donors the same day of donation rather than the day before.
- Trial name
- NCT00001842
- Testing
- Granulocyte colony-stimulating factor, Dexamethasone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
End Stage Liver DIsease, Liver Transplantation
Effect of Transfusion of Plasma on Endothelial During Liver Transplantation
To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.
- Trial name
- NCT04107883
- Testing
- fresh frozen plasma, blood sample
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital