Clinical trials: Blood Transfusion Reaction
Transfusion-Related Acute Lung Injury, ARDS, Human
Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Retrospective and Prospective Samples
Transfusion-related acute lung injury (TRALI) is a severe complication of blood transfusions. After a transfusion, TRALI develops in 0.08-15% of cases depending on the characteristics of the studied population.
- Trial name
- CURIE (NCT06444750)
- Testing
- Blood sample collection
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Blood Transfusion Associated Adverse Reactions
Antihistamine for Prevention of HTR After Blood Primed CPB
This study will be a randomized, double-blinded, placebo-controlled study conducted at a university hospital. Forty children undergoing elective repair of a congenital heart defect will be included.
- Trial name
- HTR - CPB (NCT07536152)
- Testing
- Antihestamine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kasr El Aini Hospital
Blood Transfusion Complication, Wrong Blood in Tube
Proficiency Based Training to Investigate Blood Sampling Errors Including WBIT
The objective of this study is to determine the effectiveness of a Proficiency Based Progression training programme, together with evidence based individual feedback for any residual errors, which has been specifically developed…
- Conditions
- Blood Transfusion Complication, Wrong Blood in Tube, Pre Analytical Blood Sample Errors
- Trial name
- NCT03577561
- Testing
- Proficiency Based Progression Training in Phlebotomy
- Where
- Ireland
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Patrick Henn
Dyspnea, Pulmonary Edema
The Incidence of TRALI in Patients Undergoing Orthopedic-Oncology Surgery
Currently Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality in the United States, and one of major post-transfusion complications.
- Trial name
- NCT00914784
- Where
- Israel
- Volunteers
- 550 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Blood Transfusion Complications
Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications
This study is designed to determine if point-of-care washing of allogeneic Leukocyte-Reduced Red Blood Cells reduces pulmonary complications when compared to standard-of-care Leukocyte-Reduced Red Blood Cells in a cardiac…
- Trial name
- NCT02094118
- Testing
- Point-of-care washed red blood cell transfusion., Standard of care red blood cell transfusion.
- Where
- 2 sites in United States
- Volunteers
- 171 people
- Sponsor
- Mayo Clinic
Trauma
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as…
- Trial name
- PROPPR (NCT01545232)
- Testing
- 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio
- Where
- 12 sites in United States, Canada
- Volunteers
- 680 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Metastases, Blood Transfusion Complication
The Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis
The goal of this single-center prospective randomized controlled trial is to test and compare the safety and effectiveness of autologous blood transfusion in spinal surgery for lung cancer spinal metastases.
- Conditions
- Spinal Metastases, Blood Transfusion Complication, Lung Cancer, Surgery
- Trial name
- NCT06244264
- Testing
- Autoblood transfusion
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Guangdong Provincial People's Hospital
Blood Transfusion Complication
Blood Transfusion Education Using Blended Virtual Reality and Simulation for Nursing Undergraduate Students
Nurse-administered blood transfusion (BT) is a common form of medical treatment, but nursing students are often excluded from participating in and observing BTs during clinical placements.
- Trial name
- NCT05922163
- Testing
- Evidence-based VR simulation
- Where
- Hong Kong
- Volunteers
- 151 people
- Sponsor
- The University of Hong Kong
Nefopam
Role of Nefopam in Rituximab Transfusion Reaction
the patients will be taken nefopam ampule 50 mg before rituximab in the first group while the second group will be taken diphenhydramine ampule 10 mg before rituximab in the second group
- Trial name
- NCT05648058
- Testing
- Nefopam ampule, diphenhydramine ampule
- Volunteers
- 100 people
- Sponsor
- Ministry Of Health / Nineveh Health Directorate
Allergic Transfusion Reaction
Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions.
This is a prospective, randomized, double-blind controlled trial to evaluate the efficacy of placebo versus chlorpheniramine for the prevention of allergic transfusion reactions.
- Trial name
- NCT04688736
- Testing
- Chlorpheniramine
- Where
- 4 sites in China
- Volunteers
- 6,642 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Transfusion Reaction
Detection of Autologous DEHP (DiEthylHexyl Phthalate)-Free Blood Transfusion in Anti-doping
The aim of the proposed project is to perform a clinical study in which volunteers will receive autologous blood transfusions in DEHP-free blood bags.
- Trial name
- NCT02423135
- Testing
- Autologous blood transfusion
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Orthopedic Disorder
Transfusion Reaction by Washed Red Blood Cell (RBC)
The hypothesis is that transfusion of washed red blood cell can decrease the complication by transfusion.
- Trial name
- NCT01934907
- Testing
- Washing of packed RBC by normal saline
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Seoul National University Bundang Hospital
Transfusion-Transmitted Infection
Blood Transfusion in Patients With Lung Cancer
The main purpose of approaching the anemic patient is to provide and maintain hemoglobin levels that will allow oxygen to reach the tissue at an adequate level.
- Trial name
- NCT05590429
- Testing
- Blood transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Karadeniz Technical University
Bleeding, Cardiac Defect
ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery
In pediatric patients (newborns and infants weighing less than 10 kg) undergoing cardiac surgery with extracorporeal circulation postoperative bleeding represents a known complication with a significant impact on outcome.
- Conditions
- Bleeding, Cardiac Defect, Surgery--Complications, Fibrinogenopenia; Acquired
- Trial name
- ZEPLAST-PED (NCT04434001)
- Testing
- Fibrinogen Concentrate Human, Prothrombin Complex Concentrate, Fresh Frozen Plasma
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Policlinico S. Donato
Transfusion-associated Circulatory Overload
Transfusion-Associated Circulatory Overload Best Eliminated With Lasix
This is a pilot double-blinded placebo-controlled randomized controlled trial (RCT) to evaluate the feasibility of conducting a multicenter, randomized, placebo-controlled trial to assess the efficacy of pre-transfusion…
- Trial name
- NCT02802696
- Testing
- Furosemide, Normal Saline
- Where
- 3 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Sunnybrook Health Sciences Centre
Transfusion Reactions
Mild Pulmonary Function Changes With Transfusion
The purpose of the study is to determine whether transfusion is associated with mild pulmonary changes.
- Trial name
- NCT00681954
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of California, San Francisco
Mitral Valve Replacement, Transfusion Reaction
Blood Transfusion Management in Patients With Mitral Valve Replacement in China
The evaluation uses ΔHb as an independent factor combined with artificial intelligence (AI) to predict its impact on the prognosis and blood transfusion of patients undergoing cardiac surgery, thereby guiding perioperative…
- Conditions
- Mitral Valve Replacement, Transfusion Reaction, Blood Transfusion Complication
- Trial name
- NCT03885570
- Testing
- Mitral valve replacement
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Post-cardiac Surgery, Blood Transfusion Complication
Perioperative Risk Factors of Outcomes for Cardiac Surgery: A Retrospective Study
Based on a review of about 10,000 patients undergoing cardiac surgery under CPB in West China Hospital of Sichuan University and the Second Affiliated Hospital of Zhejiang University, we try to evalute the effect of blood…
- Conditions
- Post-cardiac Surgery, Blood Transfusion Complication, Prognosis
- Trial name
- NCT04980742
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sickle Cell Disease, Pregnancy, High Risk
TAPS2 Transfusion Antenatally in Pregnant Women With SCD
Sickle Cell Disease (SCD) is a serious inherited blood disorder affecting red blood cells. When oxygen levels drop the red cells become abnormally shaped and unable to move through the blood vessels easily.
- Conditions
- Sickle Cell Disease, Pregnancy, High Risk, Blood Transfusion Complication
- Trial name
- TAPS2 (NCT03975894)
- Testing
- Serial prophylactic exchange blood transfusion (SPEBT).
- Where
- 6 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Trauma, Blood Transfusion Complication
UltraMTP in Adult Trauma Patients Undergoing Surgery Within 24 Hours: Effects on Mortality and Clinical Outcomes
The purpose of this study is to determine the effects of ultraMTP (>/=30 units pRBC within 24 hours) in trauma patients on mortality and secondary outcomes.
- Conditions
- Trauma, Blood Transfusion Complication, Death
- Trial name
- NCT04866953
- Testing
- Blood transfusion
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of Southern California