Clinical trials: Blood-Brain Barrier Permeability
Blood-Brain Barrier Permeability
Blood-brain Barrier Permeability Study in Adults With Meningitis
The purpose of the study is to confirm the applicability and usefulness of the novel method of assessment of the permeability of the blood-brain barrier and in monitoring of the treatment of patients with meningitis.
- Trial name
- NM-BBBP (NCT02902588)
- Testing
- ICG-PULSION, LiMON, Pulsion Medical Systems, Gadolinium (Gadovist, Bayer, Germany)
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences
Traumatic Brain Injury, Cerebral Infarction
Characteristics of Blood- Brain Barrier Permeability in Neurological Patients
The main goal of the present study is to challenge the hypothesis that blood- brain barrier disruption following brain injury increases the risk for long-term disability, development of brain dysfunction, epileptic seizures and…
- Conditions
- Traumatic Brain Injury, Cerebral Infarction, Cerebral Hemorrhage
- Trial name
- NCT00419874
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Pharmacokinetics
Pharmacokinetic and Pharmacodynamic Effects of Escitalopram Depending on Genetic Polymorphisms of the ABCB1-gene
The ABCB1-gene product P-glycoprotein is an integral membrane protein that actively transports substrates out of the intracellular compartment. One of the major sites of its action is the blood-brain-barrier.
- Trial name
- NCT00550485
- Testing
- escitalopram
- Where
- Germany
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Max-Planck-Institute of Psychiatry
Glioblastoma Multiforme of Brain
Effect of Deep TMS on the Permeability of the BBB in Patients With Glioblastoma Multiforme: a Pilot Study
The blood-brain barrier (BBB) is a specialized interface allowing a unique environment for neuro-glia networks. BBB dysfunction is common in brain disorders.
- Trial name
- NCT02474966
- Testing
- Deep Transcranial Magnetic Stimulation (dTMS)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Alzheimer's Disease
Blood-brain Barrier Permeability in Alzheimer's Disease
The main aim of the present study is to improve our understanding of the role of blood-brain barrier function in dementia of the Alzheimer's type.
- Trial name
- NCT01574456
- Where
- 2 sites in Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Alzheimer Disease
Developing Advanced Blood-Brain Barrier Permeability Imaging for Early AD
Aging is the primary risk factor in aging-related dementia. An important initiating factor for the development and progression of cognitive impairment is disruption of the blood-brain barrier (BBB).
- Trial name
- NCT03389698
- Testing
- GRASP Dynamic Contrast-Enhanced (DCE) MRI, 3T Brain Scan, Gadolinium-based Contrast Agent (GBCA) for MRI
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health