Clinical trials: Body
Overweight, Obesity
Adolescents Committed to Nutrition and Physical Activity
Community based participatory research principles will be used to create, implement and evaluate a culturally relevant and age-appropriate obesity intervention for adolescents who are overweight or obese.
- Conditions
- Overweight, Obesity, Insulin Resistance
- Trial name
- ACTION (NCT00841334)
- Testing
- ACTION, Usual care
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Obesity
A Study to Investigate the Safety and Pharmacokinetic/Pharmacodynamic Characteristics of HSG4112
1. Study Objective <Part 1> To evaluate the safety and pharmacokinetic/pharmacodynamic characteristics of HSG4112 after multiple oral administration in healthy female subjects.
- Trial name
- NCT04703764
- Testing
- HSG4112
- Where
- 2 sites in South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Glaceum
Overweight and Obesity, PreDiabetes
Effect of Time-restricted Eating on Behaviour and Metabolism in Overweight Individuals at High Risk of Type 2 Diabetes
The aim of the present study is to investigate effects of 12 weeks time-restricted eating on behaviour and metabolism in individuals with overweight or obesity at high risk of type 2 diabetes.
- Trial name
- RESET (NCT03854656)
- Testing
- Time-restricted eating
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kristine Færch
Obesity, Metabolic Syndrome X
The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids
The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association.
- Trial name
- NCT00184899
- Testing
- Intravenous infusion of Intralipid/heparin, Intravenous infusion of Glycerol/heparin
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Childhood Obesity, Insulin Resistance
Effectiveness of Antidiabetic Treatment Applied in Childhood Obesity
In our study, there are 33 healthy children with normal weight (control group) and 52 obese children who will be treated with metformin.
- Trial name
- NCT06266598
- Testing
- Metformin
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- HÜMEYRA ACIKAN
Overweight and Obesity, Hypercholesterolemia
Effect of Silibinin(A) as a Potential Anti-obesity Agent
Our preliminary reports have found in silico and in vitro that the milk thistle derivative Silibinin(A) is able to inhibit pancreatic lipase, in a similar way that the classical anti-obesity drug orlistat.
- Conditions
- Overweight and Obesity, Hypercholesterolemia, Hypertriglyceridemia
- Trial name
- NCT05069298
- Testing
- Silibinin A
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Overweight and Obesity
Evaluate the Safety and Efficacy of HDM1002 Tablets in Overweight and Obese Adults
It is a multicenter, randomized, double-blind, placebo-controlled phase II clinical trial to evaluate the safety and efficacy of HDM1002 tablets in overweight and obese adults.
- Trial name
- NCT06500299
- Testing
- HDM1002 100 mg QD, HDM1002 200 mg QD 12weeks, HDM1002 400 mg QD 12weeks
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Metabolic Diseases, Overweight
Cardiometabolic HIIT-RT Study
Several studies have shown relationship between exercise intensity and improvement cardiometabolic health such as body composition, endothelial function, blood pressure and blood lipids.
- Conditions
- Metabolic Diseases, Overweight, Motor Activity
- Trial name
- NCT02715063
- Testing
- High Intensity Interval, Resistance training, Plus: High Intensity Interval + Resistance Training
- Where
- Colombia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Obesity, Lung Functions
The Effect of CLA on Obesity, Lung Functions, Lipid Profile and Inflammation in Women With BMI≥25
Conjugated linoleic acid or CLA, is one of the food supplements that could be found in meat, fats, and dairy products of ruminants which has been fed grass not on grains.
- Conditions
- Obesity, Lung Functions, Inflammation, Lipid Disorder
- Trial name
- NCT04641494
- Testing
- Conjugated linoleic acid, High oleic acid safflower oil capsules
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Chester
Obesity
Zero Calorie Drink Products
This will be a clinical test to determine if any carbohydrate or a gluconeogenic precursor added to a zero calorie product might be important to consider in the management of obesity, metabolic syndrome and diabetes mellitus.
- Trial name
- GGT (NCT00525694)
- Testing
- Glucose tolerance test, glucose tolerance test solution, Diet Coke
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Obesity, Overweight
Food and Cooking Skills, and Eating Behaviors in People With Overweight or Obesity
In the present study, the authors aimed to determine food skills and cooking skills, and eating behaviors, and to evaluate the relationship between food skills and cooking skills, and eating behaviors in people with overweight or…
- Trial name
- NCT05581251
- Testing
- Food and cooking skills
- Where
- Turkey (Türkiye)
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Obesity, Morbid, Stem Cells
Effect of Weight Loss Surgery on Stem Cells.
Obesity and diabetes are linked to increased risk for health problems such as heart attack, stroke, and death. At the cellular level, obesity and diabetes increase levels of harmful inflammatory cells (M1 macrophages) and…
- Conditions
- Obesity, Morbid, Stem Cells, Cardiovascular Morbidity
- Trial name
- NCT04132531
- Testing
- Bariatric (weight loss) surgery
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Obese or Overweight Healthy Volunteers, Type 2 Diabetes Mellitus (T2DM)
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
The purpose of this study is to: evaluate the safety and tolerability of single ascending doses of ALN-4324 in healthy volunteers and to characterize the single-dose PK of ALN-4324 evaluate the efficacy, safety, tolerability, PK…
- Trial name
- NCT06845202
- Testing
- ALN-4324
- Where
- 22 sites in United States, Argentina and 4 more
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Alnylam Pharmaceuticals
Muscle Mass
Strength Training Response of Muscle in GLP-1 Users
GLP-1 medication is being prescribed for weight loss. However, GLP-1 medication may adversely affect muscle mass and muscle function.
- Trial name
- STRONG-GLP (NCT07104539)
- Testing
- Strength Training, Wait first, then strength training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Post Liver Transplantation Weight Gain, Post Liver Transplantation Obesity
Effect of Dietary and Life Style Modification on Post Liver Transplant Obesity
This study is to assess value of providing classes about dietary and life style modifications to decrease or prevent weight gain, less occurrence or better control of weight gain associated disorders such as high blood sugar…
- Conditions
- Post Liver Transplantation Weight Gain, Post Liver Transplantation Obesity, Nonalcoholic Steatohepatitis
- Trial name
- NCT00878592
- Testing
- Dietary and life style modification
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy
A Study in Healthy Men to Test How BI 1291583 is Taken up by the Body
The main objective of this trial is to investigate the absolute bioavailability of BI 1291583 (test treatment T, not radio-labelled) compared with BI 1291583 (C-14) (reference treatment R).
- Trial name
- NCT06166992
- Testing
- BI 1291583, [14C]-BI 1291583
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Metabolic Disease, Obesity
Determination of the Independent Effects of Beetroot Juice Components, Dietary Nitrate and Antioxidants, on Exercise Tolerance and Health Benefits in Individuals With Obesity
The purpose of this study is to assess the effects of acute beetroot juice supplementation on exercise performance and cardiometabolic health in obese individuals with secondary cardiometabolic complications.
- Conditions
- Metabolic Disease, Obesity, Exercise
- Trial name
- BEETIT (NCT03545009)
- Testing
- Sodium Nitrate, Beetroot Juice no Nitrate, Beetroot Juice
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity, Insulin Resistance
Study of Time-restricted Eating on Weight Loss.
This is a randomized controlled trial studying the effects of time-restricted eating (TRE) on weight loss in obese humans. Obesity is the number one risk factor for type 2 Diabetes Mellitus (T2DM), and numerous studies…
- Trial name
- TREAT (NCT03393195)
- Testing
- Time-restricted Eating plan, Consistent Meal timing plan
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
BMI/Body Composition
Influence of Body Weight and Composition on Immune Recovery
Immune dysfunction in individuals with obesity, secondary to chronic inflammation, may have an acute impact on War fighter health and readiness, and subsequent lethality.
- Trial name
- NCT04737681
- Testing
- body composition
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Obesity
Low Intensity Weight Loss for Young Adults
This is a 3-arm randomized controlled trial to test the efficacy of three novel motivational approaches to weight loss with 18-25 year olds.
- Trial name
- REACH (NCT02736981)
- Testing
- Behavioral Weight Loss (BWL), BWL + Autonomous Motivation, BWL + Extrinsic Motivation
- Where
- United States
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
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