Clinical trials: Body Fat
Moderate or Severe Submental Fullness
Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area
To evaluate the safety and efficacy of deoxycholic acid injection in the reduction of submental fat (fat below the chin).
- Trial name
- NCT01546142
- Testing
- Deoxycholic acid injection
- Where
- 35 sites in United States, Canada
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
NAFLD
The Role of Microbiome Reprogramming on Liver Fat Accumulation
The purpose of this study is to investigate whether reprogramming the microbiome via soluble fiber supplementation will decrease liver fat in obese individuals.
- Trial name
- MILE (NCT03914495)
- Testing
- Inulin
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Unwanted Flanks Fat
UltraShape Device Using the U-Sculpt/VDF Transducer for Flanks Fat
Prospective, blinded, one arm, baseline-controlled clinical study for the evaluation of the UltraShape treatment for non-invasive fat and circumference reduction.
- Trial name
- NCT02465762
- Testing
- ultrashape Fat reduction
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Syneron Medical
Change in Bone Mineral Density, Change in Bone Marrow Fat Content
The Effect of Glitazone Treatment on Bone Marrow and Bone Marrow Cells
Osteoporosis is a generalised bone disease leading to an increased risk of fractures. The disease is caused partly by environmental and partly by genetic factors.
- Trial name
- NCT00609362
- Testing
- Rosiglitazone
- Where
- Denmark
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cold Exposure
Energy Dense Fueling for Cold-Weather Operations
High daily energy expenditures without compensatory increases in energy intakes results in severe energy deficits during cold-weather military operations.
- Trial name
- NCT07489690
- Testing
- High Fat, High Carbohydrate
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Healthy
Relative Bioavailability DS-1971a Suspension and Tablets and Food Effect on DS-1971a Tablets
This is an open label, randomised, 3 treatment, 3 period crossover study. This study is designed to assess the relative bioavailability of DS 1971a from a tablet formulation and a reconstituted oral suspension and the effect of a…
- Trial name
- NCT02266940
- Testing
- DS-1971a suspension, DS-1971a tablet
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo
Healthy, Volunteers
Effects of Testosterone and Fat Utilization
Evidence is accumulating that there are sex differences in energy and substrate metabolism. The positive or negative consequences of such metabolic differences between men and women need to be evaluated with respect to health…
- Trial name
- NCT03289559
- Testing
- GnRH antagonist, Aromatase Inhibitors, Testosterone gel
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Dyslipidemia
Beetroot Juice and Postprandial Vascular Activity
Increased postprandial lipemia may increase the risk for cardiovascular diseases. An important mechanistic link between lipemia following a high-fat meal and adverse cardiovascular events is lipid-mediated endothelial activation.
- Trial name
- NCT01559441
- Testing
- Beetroot Juice with oral fat load, Carbohydrate control drink with oral fat load
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy Volunteers
A Study Evaluating the Pharmacokinetics of Three QRL-101 Formulations in Healthy Participants
This study aims to evaluate the pharmacokinetics of three QRL-101 formulations in a fasted condition or in the presence of a high-fat meal in healthy participants.
- Trial name
- NCT06877624
- Testing
- QRL-101
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- QurAlis Corporation
Obesity
Very Low Calorie Ketogenic Low-fat Diet (VLCKLFD)
This study aimed to assess the efficacy and safety of the Zélé program, a controlled ketogenic diet, for weight loss and maintenance.
- Trial name
- Zelé2021 (NCT06275347)
- Testing
- Low-fat normoprotein Controlled Ketogenic Diet., Hypocaloric Balanced Diet
- Where
- Mexico
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Universidad Veracruzana
Adipose Tissue Atrophy
Analysis of the Performance of 1060 nm Diode and Radio Frequency Prior to Abdominoplasty
To evaluate the safety and efficacy of treatment with 1060nm diode laser and radio frequency to be analyzed through histological and molecular analysis.
- Trial name
- NCT04616898
- Testing
- Venus Bliss
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Venus Concept
Obesity
Beige Fat, Energy, and the Natriuretic Peptide System
Obese individuals experience an increased risk of cardiovascular and metabolic diseases. Evidence from genetic studies indicate that the natriuretic peptide (NP) system may protect against these diseases.
- Trial name
- NCT04357964
- Where
- 2 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes, Obesity
Activation of Brown Adipose Tissue Thermogenesis in Humans Using Formoterol Fumarate (GB10)
One emerging, highly modifiable homeostatic mechanism for energy expenditure in humans is brown adipose tissue (BAT) thermogenesis.
- Trial name
- GB10 (NCT05553184)
- Testing
- Formoterol Fumarate 12 micrograms Inhalation Powder, Nicotinic Acid 50 MG Oral Tablet, Acute Cold Exposure
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Characteristics of Subcutaneous Fat
ATX-101 Abdominoplasty
Histopathological study of abdominal fat excised from subjects undergoing abdominoplasty
- Trial name
- ATX-101-08-10 (NCT00835952)
- Testing
- ATX-101
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Abdominal Fat
VelaShape III Device in Comparison to Cryolipolysis for Circumferential Reduction
The purpose of this study is to compare the clinical performance of the VelaShape III device with CoolSculpt for reduction of the waist, love handles and flanks.
- Trial name
- NCT02143960
- Testing
- VelaShape III, CoolSculpt
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Syneron Medical
Obesity
Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.
Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes.
- Trial name
- EVO (NCT06444646)
- Testing
- Adipose tissue biopsy, Blood sampling, Questionnaire
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Fat Soluble Vitamin Deficiencies and Disorders
Establishing Reference Ranges for Fat-Soluble Vitamins in Healthy Chinese Adults
Vitamins are essential micronutrients required for maintaining normal physiological functions and metabolism in humans. Among them, fat-soluble vitamins (FSV) such as vitamins A, D, E, and K are absorbed in the intestines in the…
- Trial name
- NCT06512688
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Gout, Hyperuricemia
The Diet Gout Trial
Unhealthy diet has long been associated with high uric acid levels and gout. The DASH diet may lower uric acid levels. This study will examine the effects of the DASH diet on uric acid in adults with a history of gout.
- Trial name
- DIGO (NCT03569020)
- Testing
- Subsidy for food purchases and dietitian education
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dietary Nitrate Supplementation
Evaluating the Metabolic Effects of Dietary Nitrate Supplementation
Dietary nitrate is found to enhance muscle fatty acid oxidation/glucose uptake and increase mitochondrial biogenesis, which in turn, aid in the prevention and management of metabolic diseases.
- Trial name
- NIMMI (NCT05579262)
- Testing
- Beetroot juice
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Taste, Non-esterified Fatty Acids
Free Fatty Acids: Threshold Repeatability Study
This study seeks to determine if non-esterified fatty acid (NEFA) taste detection thresholds change with repeated testing. Threshold testing for NEFA taste has been reported by a number of laboratories, including our own…
- Trial name
- NCT01550120
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Purdue University
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