Clinical trials: Body Fat
Obesity, Insulin Resistance
Nicotinamide Riboside and Metabolic Health
This study will investigate the effects of 6 week Nicotinamide Riboside supplementation (1000 mg/day) on metabolic health in healthy (pre)obese humans. The primary objective will be hepatic and whole body insulin sensitivity.
- Trial name
- NCT02835664
- Testing
- Nicotinamide Riboside (Niagen)
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Glucose Metabolism Disorders (Including Diabetes Mellitus), Energy Supply; Deficiency
Effect of Ketogenic Diet on Glucose Metabolism and Energy Expenditure in Type 2 Diabetes
The study team will examine the effect of a ketogenic diet alone and ketogenic diet supplemented with oral ketones on how the body of individuals with type 2 diabetes respond to insulin, regulates insulin secretion, food intake…
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Energy Supply; Deficiency, Type 2 Diabetes
- Trial name
- NCT04791787
- Testing
- Standard weight maintaining diet, Weight maintaining isocaloric ketogenic diet, Beta-hydroxy butyrate
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Healthy, Trained Athletes
Pre-exercise Ingestion of a Low Glycaemic Index Rice-based Mixed Meal Increases Fat Oxidation and Endurance Running in a Hot-humid Environment
The objective of this research is to determine the influence of low and high glycemic index Malaysian pre-exercise mixed meals on endurance exercise performance in a hot-humid environment.
- Trial name
- NCT06544252
- Testing
- Low glycaemic index rice-based mixed meal (GI value = 47), High glycaemic index rice-based mixed meal (GI value = 80)
- Where
- Malaysia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Healthy
Creatine Timing on Resistance Training Adaptations in College Athletes
While the use of creatine monohydrate supplementation and its associated benefits are well researched and supported, the impact of the timing of when creatine is ingested is a highly nuanced topic.
- Trial name
- NCT05451498
- Testing
- Creatine, Maltodextrin
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Rocky Mountain University of Health Professions
Weight Loss
The Effects of Capsinoids on Brown Adipose Tissue Activation in Obesity
This research study is being done to determine whether taking a dietary supplement called capsinoids, derived from sweet peppers, can activate brown fat that is already present or even generate new brown fat in individuals with…
- Trial name
- BATCAP (NCT03110809)
- Testing
- Capsinoid
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Athlete, Relative Energy Deficiency in Sport
Preventing Athlete Under-fueling Through Nutrition.
The goal is to improve nutrition screening and support for Division III athletes. The study will use standard, low-risk nutrition screening methods, such as measuring height, weight, grip strength, and body composition, as well…
- Conditions
- Athlete, Relative Energy Deficiency in Sport, Low Energy Availability
- Trial name
- PERFORM (NCT07136038)
- Testing
- Low Energy Availability Screening and Nutrition Support
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Lumbar Disc Herniation
Imaging Characteristics of Chronic Lumbar Disc Herniation From the Perspective of Core Muscles and Subcutaneous Fat Tissue Thickness
Fat infiltration and atrophy of lumbar muscles are related to spinal degenerative conditions, which can be seen reliably on MRI scans of lumbar disc herniation (LDH) patients.
- Trial name
- ICCLDHPCMSFT (NCT05649592)
- Testing
- Magnetic Resonance Hydrolipid Separation Imaging
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Zhan Yunfan
Obesity
Differences in Nutrient Use During Exercise Between Children of Varying Body Mass Indices and Fitness Levels
Children who have previously participated in the study "MI Energy" will be invited to participate in "SUPER kids". Investigators want to better understand differences in nutrient use (e.g., fatty acid and carbohydrate) during…
- Trial name
- SUPERkids (NCT04819308)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Facial Subcutaneous Fullness, Subcutaneous Fat Accumulation
Efficacy and Safety of High-Dose Oral 35 kDa Hyaluronan for Aesthetic Improvement
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of high-dose oral 70 kDa hyaluronan (HA35) for aesthetic improvement.
- Conditions
- Facial Subcutaneous Fullness, Subcutaneous Fat Accumulation, Facial Inflammatory Erythema, Dull Skin
- Trial name
- HA35-ORAL (NCT07583108)
- Testing
- High-Dose Oral 35 kDa Hyaluronan (HA35)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nakhia Impex LLC
Healthy Subjects
A Phase 1, Open-Label Study to Evaluate the Effect of a Low-Fat Meal and Multiple Doses of Ciprofloxacin on the Pharmacokinetics of Vorasidenib in Healthy Subjects
The objectives of this study are: To evaluate the effect of a low-fat meal on the pharmacokinetics (PK) of vorasidenib following a single oral dose of 40 mg vorasidenib in healthy adult subjects (substudy A) To evaluate the…
- Trial name
- NCT05843708
- Testing
- Vorasidenib 40 mg Oral Tablet, Ciprofloxacin 500 mg Oral Tablet, Vorasidenib 10 mg Oral Tablet
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Servier Bio-Innovation LLC
Obesity
Full-fat Dairy Products, Body Weight Control and Metabolic Health
The aim of this research is to clarify the role of different dairy products including both full-fat and low-fat dairy in maintaining health in adults and children through its effects beyond their well-known contribution of…
- Trial name
- NCT05417347
- Testing
- Low-fat dairy products, Full-fat dairy products
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Laval University
Fat; Liver, NAFLD
The Effect of a High-fat vs. High-sugar Diet on Liver Fat Accumulation and Metabolism
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in the world. It is currently unclear why fat starts to accumulate in the liver, although both the amount and type of food consumed have been…
- Trial name
- NCT03145350
- Testing
- High-fat, low-carbohydrate, Low-fat, high-carbohydrate
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Overweight, Physically Inactive
Is High Intensity Interval Training Effective to Reduce the Waist Circumference and Fat Percentage at Trunk Region
Overweight is a risk factor for a number of non-communicable diseases, and this risk doubles, if an individual is physically inactive.
- Conditions
- Overweight, Physically Inactive, Adults
- Trial name
- NCT04860349
- Testing
- High Intensity Interval Training
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universiti Tunku Abdul Rahman
Type 2 Diabetes
A Food-drug Interaction Study of SY-004 in Healthy Subjects
A randomized, open, two cycle, double crossover, single center study was conducted to evaluate the effect of high-fat diet on the pharmacokinetics of SY-004 in healthy subjects
- Trial name
- NCT04907006
- Testing
- SY-004 capsule
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Suzhou Yabao Pharmaceutical R&D Co., Ltd.
Abdominal Obesity
Single Strain Probiotic
Probiotics have been recognized as functional foods with beneficial effects against obesity and cardiometabolic diseases, such as dyslipidemia, type 2 diabetes and the reduction of visceral fat mass, body weight and waist…
- Trial name
- CHOICE (NCT05882149)
- Testing
- Single strain probiotic
- Where
- Spain
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Rosa Sola
Obesity, Overweight
High Fiber Rye Foods for Body Weight and Body Fat Reduction
The overall aim of this study is to investigate whether a diet rich in rye fiber from wholegrain rye, compared to refined wheat, as part of a hypo-caloric diet leads to larger weight loss and lower body fat content after 12 weeks…
- Trial name
- RyeWeight2 (NCT04203758)
- Testing
- Cereal products based on rye, Cereal products based on wheat
- Where
- Sweden
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Chalmers University of Technology
Moderate or Severe Submental Fullness
Evaluate the Efficacy and Safety of Polyene Phosphatidylcholine Injection (AYP-101) for the Reduction of Submental Fat
Phase 2 trial to evaluate the safety and potential efficacy of three concentration of polyene phosphatidylcholine injection (AYP-101) compared to placebo for the reduction of submental fat.
- Trial name
- AYP-101 (NCT03982225)
- Testing
- Polyene phosphatidylcholine injection
- Where
- 4 sites in South Korea
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- AMIpharm Co., Ltd.
Exercise Fat Oxidation
Effect of a High Calcium Breakfast on Exercise Metabolism and Appetite
The purpose of this study is to assess the effect of a high calcium breakfast on substrate metabolism during exercise and appetite throughout the day.
- Trial name
- NCT01358591
- Testing
- High calcium milk, Control
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Moderate or Severe Submental Fullness
Deoxycholic Acid Injection Submental Fat (SMF) Magnetic Resonance Imaging (MRI) and Subject-reported Outcome Measures Study
Evaluation of the safety, tolerability and efficacy of deoxycholic acid injection in the reduction of submental fat (fat below the chin).
- Trial name
- NCT01032889
- Testing
- Deoxycholic acid injection
- Where
- 10 sites in United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Dietary Habits
Can Food Timing Reduce Your Diabetes Risk?
The goal of this clinical trial is to test whether food timing impacts metabolic health in healthy participants. Participants will: complete 2 inpatient stays be provided with test meals have frequent blood draws
- Trial name
- NCT05862818
- Testing
- Day shift protocol - Diet order A-B, Day shift protocol - Diet order B-A, Night shift protocol - Diet order A-B
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
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