Clinical trials: Body Temperature Regulation
Thermoregulation
Physiological Responses to Heat Stress During High-risk Events
Exertional heat stroke (EHS) affects ~500 Military Personnel and over 100 Soldiers every year, and it is believed that these numbers are underreported.
- Trial name
- NCT06907225
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Chilblains, Perniosis
Assessment of Vasomotion of People With Idiopathic Chilblains
Chilblains, also known as perniosis, is a non-freezing cold injury causing painful inflammatory skin lesions. Chilblains typically affect the dorsal feet or hands, causing inflammatory skin lesions that are often painful, and…
- Conditions
- Chilblains, Perniosis, Thermoregulation
- Trial name
- NCT06237517
- Testing
- Assessment of Vasomotion of People With Idiopathic Chilblains
- Where
- Greece
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Burn Injury
Cardiovascular Responses in Burn Survivors During Exercise
This project will identify the efficacy of cooling modalities aimed to attenuate excessive elevations in skin and internal body temperatures, and associated indices of cardiovascular stress, during physical activity in…
- Trial name
- NCT06709781
- Testing
- Control (no cooling modalities), Water Spray
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hyperthermia, Heat Exposure
Hot Water Immersion as a Heat Acclimation Strategy in Older Adults
Aging is associated with impairments in heat loss responses of skin blood flow and sweating leading to reductions in whole-body heat loss.
- Conditions
- Hyperthermia, Heat Exposure, Heat Stress, Thermoregulation
- Trial name
- NCT05838612
- Testing
- Heat acclimation
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Hyperthermia, Heat Stress
Efficacy of Ceiling Fans for Mitigating Thermal Strain During Bed Rest in Older Adults During Heat Waves
With the increasing regularity and intensity of hot weather and heat waves, there is an urgent need to develop heat-alleviation strategies able to provide targeted protection for heat-vulnerable older adults.
- Conditions
- Hyperthermia, Heat Stress, Cooling, Aging
- Trial name
- NCT06142890
- Testing
- No cooling (control), Cooling with ceiling fan
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Cigarette Smoking
The Effect of Smoking on Thermoregulation
To the best of our knowledge, a possible relation between smoking and heat injuries or heat intolerance was never scientifically examined, although such a relation is logical according to the observations that smoking has a…
- Trial name
- NCT01596556
- Testing
- Nicotine, cigarette smoking
- Where
- Israel
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
General Population, no Specific Condition
Heat Waves, Urban Heat Islands, and Wellbeing and Health: a Mobile Sensing Approach
The first objective of H3Sensing is to investigate outdoor environmental, building, dwelling, situational, and behavioral determinants of objectively assessed personal heat stress over daily movements during warm periods.
- Trial name
- H3Sensing (NCT06850025)
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Healthy
The Effects of Pre-Loaded Betaine Supplementation on Thermoregulation and Exercise Metabolism in the Heat
This will be a double blind, placebo-controlled, randomized, counterbalanced, crossover study designed to assess the impact of preloaded betaine supplementation on thermoregulation and exercise metabolism in the heat.
- Trial name
- NCT04585295
- Testing
- Betaine, BCAA Big 6
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Florida State University
Temperature Change, Body
The Validity of CORE Sensor in Heat Training for Male and Female Endurance Athletes
This study is investigating the efficacy of CORE™ devices in calculating core body temperature in athletes under varying environmental conditions.
- Trial name
- CORE (NCT05692947)
- Testing
- Core body temperature device
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Diabetes
Body Composition, Fitness, and Thermoregulation in Young Boys With Type I Diabetes vs. Healthy Soccer Players
The study aims to assess differences in body composition, exercise capacity, and thermoregulation between young soccer players with type 1 diabetes and their healthy peers.
- Trial name
- BCFTYR (NCT06676878)
- Testing
- Incremental exercise
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Paweł Korman
Nursing Care
Thermoregulation in the Preterm Infant
The purpose of this study is to compare the response of temperature adaptation in preterm infant using the polyethylene wrap with and without previous drying.
- Trial name
- NCT01236599
- Testing
- Polyethylene for thermoregulation in the preterm infant
- Where
- Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Aging
Cooling Strategies for Older Adults in the Heat
The earth's climate is warming, and the number of heat waves has increased in recent years. At the same time, the number of adults over the age of 65 is growing.
- Trial name
- NCT06349616
- Testing
- Intermittent cold-water hand and forearm immersion, No intermittent cold-water hand and forearm immersion
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Penn State University
Heat Stress, Physiological Stress
Suitability of the 26 °C Indoor Temperature Upper Limit for Older Adults: Impacts of Clothing and Daily Activity
While an upper limit of 26°C has been shown to be protective for heat-vulnerable older occupants (DOI: 10.1289/EHP11651), this recommendation did not consider the added heat burden associated with increases in internal heat…
- Trial name
- NCT07189507
- Testing
- Simulated indoor temperature upper limit
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Obesity, Obesity, Abdominal
Environmental Temperature and Human White Adipose Tissue
Obesity is characterized by excessive white adipose tissue (WAT) that increases risk for disease. About 700 million adults are obese worldwide, designating the need of reducing excessive WAT in humans and subsequently the risk…
- Conditions
- Obesity, Obesity, Abdominal, Obese
- Trial name
- NCT04037371
- Testing
- Cold exposure
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Lower Limb Amputation Below Knee, Diabetes (DM)
Skin Temperature Perception and Prosthetic Thermoregulation
To protect against excessive body temperatures, local thermoregulatory mechanisms include temperature sensory nerves (responsive to warm or cool stimuli) and vasomotors (muscles that constrict or dilate blood vessels).
- Conditions
- Lower Limb Amputation Below Knee, Diabetes (DM), Skin Temperature Change, Vascular Reactivity
- Trial name
- NCT07215442
- Testing
- Warming stimulus starting at 30 C initial temperature, Warming stimulus starting at 32 C initial temperature, Warming stimulus starting at 34 C initial temperature
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- VA Puget Sound Health Care System
Placebo - Control, Experimental
What is the Role of Type III/IV Muscle Afferents in Airway Resistance and Thermoregulatory Responses to Exercise?
Exercise places serious demands on the body. These demands are fundamentally caused by increases in oxygen demand and the consequent increase in body temperature.
- Trial name
- NCT07452094
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Hypothermia
Effectiveness of Nefopam for Thermoregulation During Surgery
Nefopam may help blunt thermoregulatory defenses, thus facilitating induction of therapeutic hypothermia
- Trial name
- NCT03122665
- Testing
- Nefopam Low dose, Nefopam High dose
- Where
- Switzerland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Premature, Thermoregulation
Delaying First Bathing and Skin Barrier Function on Infant
It is still unknown when the first bath should be done in premature newborns. Investigators think that delaying the time of the first bath compared to the time in the clinic will show some positive changes in preterm newborns.
- Trial name
- TEWL (NCT04231799)
- Testing
- Bathing
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Body Temperature Regulation
Intermittent Cold and Dry Air Underneath Football Shoulder Pads
The purpose of this study is to test if temperature homeostasis in football players can be improved by circulating cool, dry air underneath shoulder pads between periods of intense physical activity.
- Trial name
- NCT00349804
- Testing
- cool dry air
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obesity, Normal Physiology
Energy Expenditure Responses to Different Temperatures
Background: The way that the body burns calories is known as energy expenditure. Some studies show that when we are cold, we burn more calories to keep our bodies warm.
- Trial name
- NCT01568671
- Testing
- Room temperatures
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)