Clinical trials: Body Temperature Regulation
Heat Stress, Physiological Stress
Physiological Strain in Young Adults During a Simulated Heat Wave
The likelihood of exposure to overheated indoor environments is increasing as climate change is exacerbating the frequency and severity of hot weather and extreme heat events.
- Trial name
- NCT06618352
- Testing
- Simulated indoor overheating exposure
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Amputation, Diabetes
Thermoregulation in Individuals With a Leg Amputation
The goal of this project is to understand the factors that affect skin temperature (e.g., tissue above amputation site, and opposite foot) in people with amputation and diabetes.
- Trial name
- NCT06458426
- Testing
- shock-absorbing prosthesis
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Utah
Sweat Pore Closure
Does Topical Lidocaine Decrease Sweat During Exercise in the Heat?
Subjects will walk on a treadmill at 3 mph and sweat will be collected from both forearms. One arm will be pretreated with topical lidocaine, and the other will act as the control.
- Trial name
- NCT05379283
- Testing
- Lidocaine, control
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Healthy
The Effect of the Window Films on Cognition, Perception, and Health
To enable the Netherlands to reach the 2030 carbon emission goals, older homes need to be renovated to become more energy-efficient and comfortable. This project aims to provide shallow renovations of window films.
- Trial name
- FOIL (NCT07206251)
- Testing
- Foiled Windowed room (foil added)
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Heat Stroke
Study of Thermoregulation in Exercise Heat Stroke in the Military Environment
The EXPLO-MITO study is an ancillary study from the main EXPLO-CCE study (NCT04593316; IDRCB: 2020-A01967-32). The Heat Tolerance Test (HTT) is a physiological exploration that has several advantages for use in research and…
- Trial name
- EXPLO-MITO (NCT05847465)
- Testing
- Bike stress test, Heat Tolerance Test, Heat nociception test
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Caffeine, Thermoregulation
The Effects of Caffeine on Exercise Physiology and Time-trial Performance in a Hot Environment
Maintaining a stable core temperature is vital for physiological function; yet, exercise in heat can be problematic, and there is risk of exertional heat-related illness (Flouris \& Schlader, 2015; Leyk et al., 2019; Périard et…
- Trial name
- NCT07129200
- Testing
- Hot environment, Thermoneutral environment
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham
Body Temperature Changes, Heat Exposure
Preparing for Heat Waves - Enhancing Human Thermophysiological Resilience
As the ongoing progression of climate change exposes individuals to elevated temperatures and an escalating frequency of extreme heat events, the risk of more intense and prolonged heat waves raises significant concerns for…
- Conditions
- Body Temperature Changes, Heat Exposure, Heat Stress, Hyperthermia
- Trial name
- Prep4heat (NCT06389604)
- Testing
- Heat acclimation
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Thermoregulation Impairment, Hypothermia
Incidence and Prevention of Hypothermia in Newborns Bonding During Caesarean Section
This study should evaluate whether newborns during cesarean section are endangered to get hypothermic while bonding on the mothers chest.
- Conditions
- Thermoregulation Impairment, Hypothermia, Postoperative Shivering
- Trial name
- THER5 (NCT01793558)
- Testing
- Forced-air warming
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Spinal Cord Injuries (SCI), Blood Pressure
AI-Guided Predictions of Blood Pressure Dysregulation Using Perfusion Index as a Novel Biomarker in Persons With Spinal Cord Injury
The goal of this clinical trial is to determine if perfusion index (PI) can reliably predict changes in systolic blood pressure (SBP) in persons with spinal cord injury (SCI) during a cool temperature challenge.
- Conditions
- Spinal Cord Injuries (SCI), Blood Pressure, Thermoregulation, Perfusion Index
- Trial name
- NCT07699094
- Testing
- Controlled Cool Thermal Challenge (18°C)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Core Temperature, Heat Stress, Exertional
Initial Stay Times and Heat Mitigation Controls for Uncompensable Occupational Heat Stress - Part I
Workplaces rely on upper heat stress limits provided by the American Conference of Governmental Industrial Hygienists (ACGIH) to manage the health and safety of workers in hot environments.
- Conditions
- Core Temperature, Heat Stress, Exertional, Heat Fatigue, Exercise
- Trial name
- NCT05847712
- Testing
- Simulated work in the heat
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Tetraplegia, Hypothermia
Body Temperature in Persons With Tetraplegia When Exposed to Cold
The ability to maintain normal body core temperature (Tcore = 98.6°F) is impaired in persons with tetraplegia. Despite the known challenges to the ability of persons with spinal cord injury (SCI) to maintain Tcore, and the…
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT01822535
- Testing
- Midodrine hydrochloride
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Burn Injury, Body Temperature Regulation
The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments
Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing…
- Conditions
- Burn Injury, Body Temperature Regulation, Cardiovascular Physiology
- Trial name
- HSR (NCT07050264)
- Testing
- Simulated burn injury via application of absorbent and impermeable material over 60% of the body
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Thermoregulation, Cold Exposure
Effect of Pre-cooling on Whole-body Heat Loss During Exercise-heat Stress
Endurance exercise performance declines in hot environments as core body temperature increases. To enhance performance, body pre-cooling strategies, such as cold-water immersion have been employed to lower resting core…
- Conditions
- Thermoregulation, Cold Exposure, Heat Stress, Exercise
- Trial name
- NCT06670339
- Testing
- No Cooling, Pre-Cooling
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Cooling Fabrics, Exercise Performance
Cooling Fabrics and Exercise Performance in Endurance Athletes
In humans, the primary means of cooling the body during exercise is through the evaporation of sweat from the skin surface. Clothing represents a layer of insulation that hinders the evaporation of sweat from the surface of the…
- Conditions
- Cooling Fabrics, Exercise Performance, Thermoregulation
- Trial name
- NCT02016521
- Testing
- Cooling Fabric
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McGill University
Low Birth Weight Baby, Very Low Birth Weight Baby
Home-based Interventional Program on Low Birth Weight Baby Care
The goal of this interventional study is to evaluate whether a home-based interventional program for mothers can improve their knowledge and performance in caring for their low birth weight baby at home.
- Trial name
- (HBEP-LBWC) (NCT07482904)
- Testing
- Home-based Interventional group
- Where
- Iraq
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Chawarwan Saleem Abdullah
Tetraplegia, Hypothermia
Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia
The ability to maintain normal core body temperature (Tcore = 98.6°F) is impaired in persons with a cervical spinal cord injury (tetraplegia).
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT02379156
- Testing
- Midodrine Hydrochloride, Cool Temperature
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Breast Cancer
Can Exercise Training Reduce the Frequency and Severity of Hot Flushes Associated With Breast Cancer Treatment?
In brief, this study sets out to understand if exercise training can reduce the frequency and severity of hot flushes associated with breast cancer treatment.
- Trial name
- NCT03286257
- Testing
- Exercise Intervention
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Body Temperature Changes, Heat Stress
Initial Stay Times and Heat Mitigation Controls for Uncompensable Occupational Heat Stress - Part III
Occupational heat stress directly threatens workers' ability to live healthy and productive lives. Heat exposed workers are at an elevated risk of experiencing impaired work performance and cognitive function leading to a greater…
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT06630832
- Testing
- Simulated work in the heat with no cooling during rest breaks, Simulated work in the heat with partial cooling during rest breaks, Simulated work in the heat with full cooling during rest breaks
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Body Temperature Changes, Heat Stress
Progressive Heat Exposure and Physiological Strain
Occupational heat-stress guidelines are commonly based on the level of environmental heat exposure and are largely derived from studies conducted under constant environmental conditions.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07847437
- Testing
- Constant Heat Exposure, Progressively Increasing Heat Exposure
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Thermoregulation, Sleep Disturbance
Acute Sleep Deprivation on Whole-body Heat Exchange During Exercise-heat Stress in Young and Older Men
Sleep deprivation has long been thought to modulate thermoregulatory function. Seminal work on sleep deprivation and thermoregulation has demonstrated that sleep-deprived individuals experience greater elevations in core…
- Conditions
- Thermoregulation, Sleep Disturbance, Heat Exchange, Aging
- Trial name
- NCT05838014
- Testing
- Sleep deprivation, Normal sleep
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Ottawa