Clinical trials: Body Weight Control
Subclinical Hypercortisolism, Cushing Syndrome
Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism
Background: Adrenal tumors are a common kind of tumor. Some of these secrete extra cortisol into the body, which can lead to diabetes, obesity, and other diseases.
- Conditions
- Subclinical Hypercortisolism, Cushing Syndrome, Adrenal Neoplasm
- Trial name
- NCT02001051
- Testing
- Adrenalectomy, Observation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Cancer Institute (NCI)
Schizophrenia
Atomoxetine for Treatment of Weight Gain in Olanzapine or Clozapine Patients
The study investigates the use of Atomoxetine in combination with exercise and a diet support group (Weight Watchers)to treat weight gain associated with Olanzapine or clozapine.
- Trial name
- NCT00176436
- Testing
- Diet support group, Group counseling and exercise
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Obesity
Remote Delivery of Weight Management for Adults With IDD
The purpose of this study is to compare different weight loss programs in people with IDD to see which program works better.
- Trial name
- NCT03291509
- Testing
- Video Conference Meetings, In-person Meetings, Enhanced Stop Light Diet
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Kansas Medical Center
Type 2 Diabetes Mellitus
Study of Multiple Oral Doses of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus
This is a Phase 1, randomized, placebo-controlled, double-blind (investigator- and participant-blinded), sponsor-open study of PF-07081532.
- Trial name
- NCT05158244
- Testing
- PF-07081532
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Pfizer
Obesity, Overweight
A Maintenance Program for the Be Fit Employee Wellness Program
This research study is being done: 1) to determine if the MGH Be Fit program helps employees to change their nutrition and exercise habits and lower their risk for chronic diseases, such as heart disease and diabetes and 2) to…
- Trial name
- NCT00707577
- Testing
- Internet-based maintenance program
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hypertension
Study of the Efficacy and Safety of Aliskiren HCTZ vs Ramipril in Obese Patients (BMI ≥ 30) With Stage 2 Hypertension
Study to Evaluate the Efficacy and Safety of Aliskiren Hydrochlorothiazide (HCTZ) vs Ramipril in Obese patients (BMI ≥ 30) with Stage 2 Hypertension
- Trial name
- ATTAIN (NCT00772577)
- Testing
- Aliskiren Hydrochlorothiazide, Ramipril
- Where
- 6 sites in United States
- Volunteers
- 386 people
- Sponsor
- Novartis
Morbid Obesity, Labor Pain
DPE Technique in Labor Epidural for Morbidly Obese Women
The primary purpose of this study is to determine differences in block quality between the "dural-puncture epidural" (DPE) and standard epidural (EPL) techniques for labor analgesia in the morbidly obese patient.
- Trial name
- NCT03074695
- Testing
- Dural puncture epidural (DPE), Standard Epidural (EPL)
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Duke University
Obesity
Study to Evaluate ARD-101 in Adults With Obesity
The purpose of this study is to evaluate safety and efficacy of twice-daily ARD-101 in obese subjects with a body mass index (BMI) of 30-45 kg/m2.
- Trial name
- NCT05121441
- Testing
- ARD-101
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Aardvark Therapeutics, Inc.
Heart Diseases, Stroke
The HARMONY Study: A Intervention to Reduce Cardiometabolic Risk in African American Women
This study will test whether a culturally-tailored nutrition and exercise intervention designed for African-American women will lead to sustained improvements in exercise and healthy eating through improvements in self-management…
- Conditions
- Heart Diseases, Stroke, Pre-diabetes, Hypertension
- Trial name
- NCT04705779
- Testing
- HARMONY, Nutrition and Exercise Education (NEEW)
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of North Carolina, Chapel Hill
Schizophrenia, Chronic Illness
Implementing Effective, Collaborative Care for Schizophrenia (EQUIP-2)
This project evaluates the implementation and effectiveness of a care model to improve treatment for schizophrenia within the context of diverse VA practices and priorities.
- Conditions
- Schizophrenia, Chronic Illness, Weight Gain, Psychotic Disorder
- Trial name
- EQUIP-2 (NCT00137280)
- Testing
- Collaborative Chronic Illness Care Model
- Where
- 8 sites in United States
- Volunteers
- 1,067 people
- Sponsor
- VA Office of Research and Development
Diabetes Mellitus, Obesity
Study of the Gut Hormone Analogue Y14 in Adult Subjects
A randomised, placebo controlled Phase I study to investigate investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of Y14 in adult subjects.
- Trial name
- NCT03673111
- Testing
- Y14
- Where
- United Kingdom
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Morbid Obesity, Noninvasive Ventilation
Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
This study evaluates the ability of high flow nasal cannula versus nasal cannula to oxygenate morbidly obese patients undergoing moderate to deep sedation for gastrointestinal procedures.
- Conditions
- Morbid Obesity, Noninvasive Ventilation, Deep Sedation
- Trial name
- NCT02859597
- Testing
- High flow nasal cannula, Nasal Cannula
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Obesity
Effect of VI-0521 (Qsymia®) on Glomerular Filtration Rate (GFR) in Overweight or Obese Healthy Subjects
The main purpose of this study is measure the effect of VI-0521 on kidney function. Specifically, glomerular filtration rate (GFR) will be measured at baseline, after 4 weeks of study treatment, and after an additional 4 weeks of…
- Trial name
- NCT02229214
- Testing
- Qsymia
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Obesity
Behavioral Weight Loss and Stigma Reduction
This is a randomized controlled trial to test the effects on long-term weight loss of a novel stigma-reduction intervention combined with standard BWL treatment, as compared to BWL alone.
- Trial name
- NCT03704064
- Testing
- Stigma-Reduction Intervention, Behavioral Weight Loss (BWL)
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Pennsylvania
Life Style, Physical Activity
Reduction of Sitting Time: Sedentarism Intervention Trial
Recent studies have suggested that prolonged daily sitting time may in itself have a negative effect on health, even in people who engage in daily physical activity.
- Conditions
- Life Style, Physical Activity, Sedentary Behavior
- Trial name
- SIT (NCT01221363)
- Testing
- Life style intervention
- Where
- Denmark
- Volunteers
- 171 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Weight Gain
Exenatide for the Treatment of Weight Gain Associated With Olanzapine in Obese Adults
The purpose of this research study is to test the safety and efficacy (how well it works) of exenatide as a treatment for weight gain associated with olanzapine in obese adults with Bipolar Disorder, Major Depressive Disorder…
- Trial name
- NCT00845507
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Cincinnati
Stroke, Stroke, Acute
A Multisite Exploration of Balance Perturbations With and Without Body Weight Support
ZeroG is an FDA-listed robotic body weight support system (BWSS). Mounted on an overhead track, patients are fitted in a harness system tethered to said track, and are able to practice gait and balance activities without the risk…
- Conditions
- Stroke, Stroke, Acute, Balance; Distorted, Balance; Impairment
- Trial name
- NCT05110300
- Testing
- Body weight support system control group, Body weight support system with balance perturbations
- Where
- 4 sites in United States
- Volunteers
- 114 people
- Sponsor
- Gaylord Hospital, Inc
Obese Patients With Non-alcoholic Steatohepatitis (NASH)
Effect of LIK066 on Reduction of Fatty Content in Livers of Obese Patients
The purpose of this study was to assess the effects of LIK066 on a variety of metabolic and inflammation biomarkers in patients with non-alcoholic steatohepatitis (NASH)
- Trial name
- NCT03205150
- Testing
- LIK066
- Where
- 15 sites in United States, Argentina and 6 more
- Volunteers
- 107 people
- Sponsor
- Novartis Pharmaceuticals
Pre-Eclampsia, Hypertension in Pregnancy
Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida
To compare the incidence of preeclampsia in obese pregnant women (BMI greater than 30) with a singleton gestation at less than 20 weeks and either a history of preeclampsia in a prior pregnancy or stage I hypertension or…
- Conditions
- Pre-Eclampsia, Hypertension in Pregnancy, Obesity
- Trial name
- ASPREO (NCT03961360)
- Testing
- Aspirin 81 mg, Aspirin 162 mg
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity
A Study to Evaluate the Efficacy and Safety of PF-06882961 in Adults With Obesity
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-06882961) for the potential treatment of obesity.
- Trial name
- NCT04707313
- Testing
- PF-06882961 (Cohorts 1 and 2), PF-06882961 (Cohort 3)
- Where
- 41 sites in United States, Canada and 2 more
- Volunteers
- 628 people
- Sponsor
- Pfizer