Clinical trials: Bone
Pectus Excavatum
Multicenter Trial of Magnetic Mini-Mover for Pectus Excavatum
This study is a Phase 3, multicenter, non-randomized study to evaluate the safety and efficacy of the next-generation outpatient Magnetic Mini-Mover Procedure (3MP) in 15 patients aged 8-14 years for the correction of pectus…
- Trial name
- 3MP (NCT01327274)
- Testing
- Magnetic Mini-Mover Procedure (Magnimplant)
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Michael Harrison
Unstable Lisfranc Fracture-dislocations of the Midfoot
A Comparison of Stainless Steel and Bioabsorbable Screw Fixation of Lisfranc Foot Injuries
The Lisfranc ligaments are a group of ligaments that connect the bones of the middle portion of the foot to each other. The Lisfranc ligaments allow for a normal and stable range of motion and shape to the foot.
- Trial name
- Lisfranc (NCT00985023)
- Testing
- Steel screw fixation of Lisfranc fracture-dislocation., Absorbable screw fixation of Lisfranc fracture-dislocations.
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Osteoarthitis
The 'Bone-Brain' Crosstalk Mechanism of Subchondral Bone Nociceptive Sensitization Activating SPP1-Positive Microglia in the vlPAG Region Elucidates the Theoretical Connotation of Treating Knee Osteoarthritis Based on Kidney Differentiation
The aim of this observational study is to investigate the relationship between pain severity and alterations in bone-derived and brain-derived signaling molecules (including serum neurotransmitters and inflammatory cytokines), as…
- Trial name
- NCT06977282
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jinchao Xu
Lactation, Bone Diseases, Endocrine
African-American Bone Metabolism and Lactation Study
The primary aim of this study is to obtain measures of amino-terminal telopeptides of procollagen 1 (P1NP), a marker of bone formation, in lactating and non-lactating post-partum African-American women both at 6-8 and at 12-14…
- Trial name
- NCT00785824
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Scheuermann Disease
Clinical and Radiological Correlates of Balance, Pain and Body Image in Adolescents With Scheuermann's Kyphosis
The goal of this observational study is to evaluate the relationship between sagittal and spinopelvic radiological parameters of the spine and clinical outcomes in adolescents with Scheuermann's kyphosis (SK) by assessing dynamic…
- Trial name
- NCT07117448
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Socket Preservation
Sticky Bone vs Xenograft With Cross-linked Hyaluronic Acid in Socket Preservation
The present study aimed to evaluate clinical and radiographic outcomes of sticky bone in comparison to crosslinked hyaluronic acid mixed with xenograft in alveolar ridge preservation.
- Trial name
- NCT06983015
- Testing
- sticky bone, xenograft mixed with cross-linked hyaluronic acid
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Low Back Pain, Leg Pain
Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis
The purpose of this multi-center, randomized, clinical study is to establish the safety and effectiveness of the TOPS™ System, used following decompression, in the treatment of lower back and leg pain with, or without spinal…
- Conditions
- Low Back Pain, Leg Pain, Spondylolisthesis, Lumbar Spinal Stenosis
- Trial name
- NCT00405691
- Testing
- "TOPS System" - Total Posterior Arthroplasty Implant
- Where
- 16 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Impliant, Ltd.
Loss of Chromosome 18q, Growth Hormone Deficiency
Growth Hormone and Chromosome 18q- and Abnormal Growth
We, the investigators at the University of Texas Health Science Center at San Antonio, want to learn if height and IQ (intelligence quotient) scores are improved by growth hormone (GH) treatment in children with chromosome 18…
- Trial name
- NCT00134420
- Testing
- Nutropin AQ, Arginine and Clonidine Stimulation Testing, Growth Factors Laboratory Testing
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Bone Diseases, Metabolic
Effects of Naturally Silicon-Rich Water on Bone Metabolism in Women
The aim of this research study is to determine by laboratory analyses the effects of drinking silicon-rich water on bone health.
- Trial name
- NCT01067508
- Testing
- Fiji Water
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Resting Metabolic Rate, Bone Mineral Density, Low, Susceptibility to
The Health of Competitive Fitness Athletes
Fitness athletes emphasize the value of staying lean, muscular and defined, and motivates and inspires followers through social media.
- Conditions
- Resting Metabolic Rate, Bone Mineral Density, Low, Susceptibility to, Body Image, Perfectionism
- Trial name
- NCT03007459
- Testing
- Psychological health, Physiological health
- Where
- Norway
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Postmenopausal Osteoporosis, Iron Metabolism Disorders
Association of Serum Ferritin and Bone Mineral Density With Bone Metabolism in Chinese Healthy Postmenopausal Women
Large amounts of experimental and animal evidence have confirmed that iron accumulation is associated with bone loss. However, it is still lack of the clinical studies relating iron accumulation to bone loss, especially in the…
- Trial name
- NCT03512743
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Soochow University
Alveolar Bone Loss
Subperiosteal Implants Constructed With Digital Technology
Atrophied jaw is a condition where there is insufficient bone quantity to place root form implants. Several treatment plans are available for treating atrophied jaws, including subperiosteal implants.
- Trial name
- NCT06012643
- Testing
- The purpose of this systematic review of case reports and case series was to evaluate the spectrum of subperiosteal implants for severely atrophied jaws using digital technology.
- Where
- Egypt
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Healthy, Adult
Understanding Effects of Calcium on the Gut-Bone Axis
The study team is inviting 13 healthy people to complete a study to explore how calcium affects hormones and bones after eating. Participants will be asked to complete two study visits within eight weeks.
- Conditions
- Healthy, Adult, Calcium, Bone Resorption
- Trial name
- NCT06383117
- Testing
- Calcium carbonate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Alveolar Bone Loss, Bone Graft Failure
Ridge Preservation In Mandibular Molars Using Mixture Of ABB And Autogenous Particulate VS Sticky Bone
Histological Measurement Comparing the density of the new bone formed during socket preservation technique using a Mixture of Anorganic Bovine Bone(ABB) And Autogenous Particulate vs a Mixture of Injectable Platelets Rich Fibers…
- Conditions
- Alveolar Bone Loss, Bone Graft Failure, Alveolar Bone Resorption
- Trial name
- NCT03584997
- Testing
- ABB And Autogenous Particulate, PRF, ABB & Autogenous Particulate
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Scoliosis Idiopathic Adolescent, Scoliosis
Deep Learning for Early Scoliosis Detection Using mmWave Radar Gait Data
Scoliosis is a sideways curvature of the spine that often develops during childhood and adolescence. When detected early, scoliosis can be managed effectively with non-invasive approaches such as bracing and physiotherapy, while…
- Trial name
- ScoliRadar-AI (NCT07593560)
- Testing
- mmWave Radar Gait Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gebze Technical University
MDS (Myelodysplastic Syndrome)
Luspatercept + Darbepoetin in MDS
This is a single arm open-label Phase II trial of luspatercept and darbepoetin alfa in non-mutated SF3B1 , lower-risk, RBC transfusion dependent MDS participants with an endogenous erythropoietin (EPO) level < 500 IU/L.
- Trial name
- DarbeLus (NCT07096297)
- Testing
- Luspatercept, Darbeopoetin
- Where
- 4 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Tooth Loss
Influence of Soft Tissue Thickness on the Bone Level Around Implants
Healthy soft tissue around the implant are considered as a biological seal to prevent inflammatory periimplant diseases and ensure healthy, stable and long-term survival of a dental implant.
- Trial name
- NCT04243460
- Testing
- Xenogeneic collagen matrix (XCM) graft augmentation, Connective tissue graft augmentation (CTG)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Medical Innovation Center Wroclaw
Lymphoma, Multiple Myeloma
Immunologic Response After Pandemic Influenza A (H1N1) Vaccine in Onco- Hematologic Patients
Primary objective 1) To assess whether oncologic and hematologic patients develop a protective immunological response after pandemic Influenza A (H1N1) vaccine Secondary objectives 1.
- Conditions
- Lymphoma, Multiple Myeloma, Myeloproliferative Disease
- Trial name
- NCT01394640
- Testing
- Reassortant vaccine virus NYMC X-179A (New York Medical College, New York) derived form the A/california/7/2009 (H1N1) virus
- Where
- Italy
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Paolo Corradini
Osteoporosis, Osteopenia
Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise
We are interested in determining if there exist a short-term response in the serum markers and hormones that participate in the regulation of bone tissue formation and breakdown to a single, high-intensity exercise session of…
- Trial name
- NCT00572871
- Testing
- plyometric exercise, resistance exercise, No exercise
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Scoliosis Idiopathic Adolescent Treatment
Myofascial and Articular Treatment of Adolescent Idiopathic Scoliosis
Randomized controlled trial of participants with scoliosis into standard treatment with observation/bracing and the other group will have the added treatment of dynamic myofascial manipulation for 6 months.
- Trial name
- NCT05423509
- Testing
- Dynamic myofascial manipulation, Standard AIS treatment with observation or bracing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
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