Clinical trials: Bone Age
Brain and Central Nervous System Tumors
Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Glioblastoma Multiforme or Brain Stem Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Bone marrow or peripheral stem cell transplantation may be able to replace immune cells that were destroyed…
- Trial name
- NCT00002619
- Testing
- filgrastim, carboplatin, thiotepa
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Distal Radius Fractures, Wrist Fracture
Unstable Distal Radius Fractures With Dorsal Dislocation in Patients Aged 18-64 Years. Volar Locking Plate (VLP) vs Closed Reduction and Percutaenous Pinning (CRPP).
120 patients age 18-64 years with dorsally displaced distal radius fractures AO-type A2, A3 and C1 are recruited from Oslo Casualty Medical Centre (Oslo Skadelegevakt).
- Conditions
- Distal Radius Fractures, Wrist Fracture, Colles' Fracture
- Trial name
- NCT04716309
- Testing
- Open reduction and volar locking plate and closed reduction and K-wires.
- Where
- Norway
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Proximal Humeral Fracture, Humeral Head Fracture
Comparing Outcomes of Non-surgical Versus Surgical Treatment of Shoulder Fractures With Different Shoulder Replacements
The optimal treatment of complex shoulder fracture is controversial. In general, non-surgical treatment is recommended for older patients, but results are often unsatisfying.
- Trial name
- NCT06444828
- Testing
- Non-operative
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- University of Southern Denmark
Aging
Age-related Changes in Ovarian Follicular Wave Dynamics
The investigators hypothesize that age-related changes in the number and growth dynamics of ovarian follicles will be associated with changes in hormone levels and corresponding changes in musculoskeletal health.
- Trial name
- NCT01389141
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Dorsally Displaced Intraarticular Distal Radius Fractures, Age 50 - 74 for Females or 60-74 for Males
Extraarticular Distal Radius Fractures, X-fix or Volar Fixation
Distal radius fractures are treated surgically if severely displaced. This study aims to investigate the outcome after surgery. The investigators will randomize patients to either external fixation with optional addition of…
- Conditions
- Dorsally Displaced Intraarticular Distal Radius Fractures, Age 50 - 74 for Females or 60-74 for Males, Low Energy Trauma
- Trial name
- NCT01034943
- Testing
- External fixation, Volar plate
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Karolinska Institutet
Severe Aplastic Anemia, Aplastic Anaemia
A Novel Conditioning Regimen for Haplo-HSCT in Older Patients With SAA
The goal of this prospective, multicenter, single arm observational study is to evaluate the efficacy and safety of the BFCA regimen in ≥ 40 years old SAA patients undergoing haplo-HSCT.
- Conditions
- Severe Aplastic Anemia, Aplastic Anaemia, Hematopoietic Cell Transplant
- Trial name
- NCT07586735
- Testing
- BFCA conditiong regimen
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Peking University People's Hospital
Fracture Healing, Distal Radius Fracture
Local Remodelling of Bone Fracture Healing
The aim of our study is to improve a mathematical model (FAE) of human bone healing using the example of the distal spoke fracture.
- Trial name
- NCT04783337
- Testing
- HR-pQCT (high resolution computertomograph), Blood withdrawal
- Volunteers
- 106 people
- Sponsor
- Medical University Innsbruck
Growth Hormone Deficiency, Short Stature
Biological Age in Children With GH Deficiency Undergoing Hormone Replacement Therapy
The primary objective of the study is to evaluate the epigenetic age in children with GH deficiency, before and after 6 months of treatment with growth hormone replacement therapy.
- Trial name
- ETABIOGHD (NCT06294860)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Istituto Auxologico Italiano
Radius Fractures, Aged
Cost-effectiveness, Volar Locking Plate or Non-operative Treatment Distal Radius Fracture
A cost-utility analysis based on an earlier published RCT comparing surgery with volar locking plate to non-operative treatment for the elderly with a displaced distal radius fracture.
- Conditions
- Radius Fractures, Aged, Cost-Benefit Analysis, Wrist Fracture
- Trial name
- HE-VOCAL (NCT06067074)
- Testing
- Volar Locking Plate, Plaster Cast
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Karolinska Institutet
Myelodysplasia
Allogeneic Hematopoietic Stem Cell Transplantation Evaluation in High Risk Myelodysplasia: an Observational Non-interventional Study
The purpose of this study is to compare outcome of high risk myelodysplasia patients aged from 50 to 70 years with or without HLA compatible (9 or 10 identities / 10) donor.
- Trial name
- ONIalloMDS (NCT01095874)
- Where
- France
- Volunteers
- 164 people
- Sponsor
- Saint-Louis Hospital, Paris, France
Bone Marrow Failure Syndrome
The Impact of Red Cell Age on Product Utilization in the Chronically Transfused Outpatient Population
In this study, the investigators will be evaluating the impact of red blood cell age in patients receiving chronic blood transfusions in the outpatient setting.
- Trial name
- ABC-TOP (NCT02393508)
- Testing
- Fresh Human Red Blood Cells, Aged Human Red Blood Cells
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Acute Myeloid Leukemia, Adult Acute Megakaryoblastic Leukemia (M7)
Bortezomib, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
This phase II trial studies the side effects and best dose of bortezomib when given together with daunorubicin and cytarabine and to see how well it works in treating older patients with previously untreated acute myeloid…
- Conditions
- Acute Myeloid Leukemia, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a)
- Trial name
- NCT00742625
- Testing
- daunorubicin hydrochloride, cytarabine, bortezomib
- Where
- 22 sites in United States
- Volunteers
- 95 people
- Sponsor
- National Cancer Institute (NCI)
Vitamin D Deficiency, Osteoporosis
Study to Document the Phenomenon of Vitamin D Deficiency and Its Added Value in Patients with Low-energy Osteoporotic Hip Fracture, in Daily Practice in Greece.
Vitamin D, through its action on calcium metabolism, is essential for bone physiology. Vitamin D deficiency can affect muscle function and increase the risk of falls in the elderly, while severe deficiency is common in patients…
- Conditions
- Vitamin D Deficiency, Osteoporosis, Bone Loss, Age-Related, Fracture of Hip
- Trial name
- NCT06643650
- Testing
- CHOLECALCIFEROL ORAL.SOL 25000 IU/2,5ML
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- National and Kapodistrian University of Athens
Accidental Falls, Fractures
Falls With Fracture : Role of Cognitive Disorders and Comparison With Bone Fragility
The purpose of this study is to determine whether cognitive disorders are a risk factor for a fracture after a fall independently of a bone fragility.
- Trial name
- CFC (NCT02292316)
- Testing
- gait and cognitive assessments, blood sample, osteodensitometry
- Where
- 2 sites in France
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Type 2 Diabetes Mellitus
An Investigation Into Bone Micro-architecture in Women With Type 2 Diabetes
The number of people with type 2 diabetes is growing. This puts a lot of pressure on the health care systems. Type 2 diabetes is often associated with health problems, like poor eyesight, muscle coordination, muscle strength, and…
- Trial name
- NCT00982371
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Leukemia, Myeloid, Acute, Myelodysplastic Syndromes
LBH589 Plus Decitabine for Myelodysplastic Syndromes (MDS) or Acute Myeloid Leukemia (AML)
This study is designed to evaluate the combination of LBH589 and decitabine in patients age ≥ 60 years with high risk Myelodysplastic Syndrome (IPSS Int-2 or High) or Acute Myeloid Leukemia.
- Trial name
- NCT00691938
- Testing
- LBH589, Decitabine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Washington University School of Medicine
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Study to Assess the Pharmacokinetics, Safety, and Tolerability of Iptacopan in Pediatric PNH Patients
The purpose of this open-label, single arm, multicenter, phase 3 study is to assess the pharmacokinetics of iptacopan in pediatric patients and to assess whether iptacopan is safe and well tolerated when used for the treatment of…
- Trial name
- NCT06934967
- Testing
- LNP023
- Where
- 15 sites in United States, Brazil and 4 more
- Volunteers
- 12 people
- Sponsor
- Novartis Pharmaceuticals
Growth Hormone Deficiency, Turner Syndrome
Evaluation of Convenience and Compliance of the Easypod™ Electronic Self-injector
This is an international, multicenter study involving children treated with Saizen®, a growth hormone, who will be trained to use easypod, a new electronic injector and will complete a questionnaire after 12 week of use.
- Conditions
- Growth Hormone Deficiency, Turner Syndrome, Chronic Renal Failure, Small for Gestational Age
- Trial name
- NCT00738205
- Volunteers
- 834 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Stunting
LULUN PROJECT II - Cohort Follow-up Study
Child stunting and micronutrient deficiencies are a major problem in developing countries, affecting millions of children. Beginning at 6 months children need foods to complement nutrients received through breastfeeding; however…
- Trial name
- NCT03902145
- Testing
- Egg
- Where
- Ecuador
- Volunteers
- 270 people
- Sponsor
- Washington University School of Medicine
Osteoporosis, Fractures
Determination of Optimum Age for DXA Screening for Osteoporosis in HIV - The Probono 1 Study
The purpose of this study is to determine the bone mineral density in male and female patients with HIV infection according to age groups.
- Conditions
- Osteoporosis, Fractures, HIV Infection
- Trial name
- Probono1 (NCT01669954)
- Where
- United Kingdom
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- King's College London