Clinical trials: Bone Changes
Chronic Periodontitis
Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis
The investigators evaluated the effect of initial periodontal treatment on clinical findings and receptor activator of Nuclear Factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) of patients…
- Trial name
- NCT02808988
- Testing
- periodontal phase 1 therapy, gingival crevicular fluid collection, zoledronic acid
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Osteoarthritis, Hip
Femoral Remodeling Following Total Hip Arthroplasty With OMNI Apex Modular™ and OMNI Apex ARC™ Stem Compared to Competitive Designs
This study compares the change in bone density which occurs after hip replacement with different femoral stem devices.
- Trial name
- NCT01359540
- Testing
- OMNI Apex Modular™ Hip Device, OMNI Apex ARC™ Hip Device
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Spokane Joint Replacement Center
Healthy
Effect of Food on Bioavailability of Modified Release Formulations of Imatinib
This study will evaluate the effect of food on the relative bioavailability of a single dose of imatinib given as a 800 mg modified release tablet, compared to twice-daily doses of 400 mg film-coated tablets.
- Trial name
- NCT00420043
- Testing
- imatinib
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis
Edentulous Jaw
Effect of Digital Versus Static Jaw Relation Record on Crestal Bone Changes Around Implants Supporting Maxillary Single Overdenture
patients will be equally and randomly divided into 2 groups. Each group contains seven patients: Digital Group: implant supported maxillary overdenture will be constructed using electronic facebow to record maxillo-mandibular…
- Trial name
- NCT06965517
- Testing
- Maxillary implant supported overdenture , Digital jaw relation group, Maxillary implant supported overdenture , Static jaw relation group
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Osteoporosis
Jogging in the Change of Osteoporosis
To test the changes in osteoarthritis according to the X-rays, and changes in bone quality before and 1 or more years after beginning the jogging
- Trial name
- NCT03359317
- Testing
- jogging
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Chronic Periodontitis
Study on Treatment Results and Bone Changes After Replanting Severely Affected Teeth - A Before-and-After Study.
This research aims to evaluate the effectiveness of intentional replantation (IR) as a treatment for single-rooted teeth diagnosed as hopeless due to true periodontic lesions.
- Trial name
- NCT06893107
- Testing
- Intentional Replantation
- Where
- United Arab Emirates
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Fujairah
Chronic Myeloid Leukemia
Vitro Study of Tigecycline to Treat Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm companies with the BCR-ABL fusion gene encoded by the Philadelphia (Ph) chromosome.
- Trial name
- NCT02883036
- Testing
- blood sampling
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Bone Sarcoma, Childhood Cancer
Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer
This is a prospective study that will conduct a series of focus groups with non-Hispanic Black and Hispanic childhood cancer survivors to obtain their input on culturally adapting a mobile CBT program for chronic pain and tDCS…
- Trial name
- NCT05746429
- Testing
- Cognitive Behavior Therapy, Transcranial Direct Current Stimulation, Questionnaire Administration
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Bone Loss
Crestal Bone Response to Narrow vs. Regular Tie-Base in Subcrestal Implants
This 24-month randomized clinical trial evaluates peri-implant marginal bone changes at subcrestal implants restored with narrow versus regular tie-base abutments.
- Trial name
- NCT07196228
- Testing
- Intervention Name (Arm 1): Narrow tie-base abutment Intervention Name (Arm 2): Regular tie-base abutment
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Phenylketonuria
Nutritional and Neurotransmitter Changes in PKU Subjects on BH4
HYPOTHESIS: The investigators hypothesize that KuvanTM therapy could influence nutritional and body composition parameters and neurotransmitter concentrations in pediatric and adult PKU subjects.
- Trial name
- BH4&PKU (NCT00688844)
- Testing
- KuvanTM Therapy
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Emory University
Bariatric Surgery Candidate, Bone Loss
Weight Loss With Risedronate for Bone Health
This is a pilot project to determine the feasibility of recruiting, enrolling, treating, and following 24 older sleeve gastrectomy patients into a randomized controlled trial (RCT) examining the efficacy of bisphosphonate use…
- Conditions
- Bariatric Surgery Candidate, Bone Loss, Weight Loss
- Trial name
- WERISE (NCT03411902)
- Testing
- Risedronate Sodium 150 MG
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Keratocysts of the Jaw
Adjunctive Methods In Treatment Of Odontogenic Keratocyst
The purpose of this study was to compare both clinically and radiographically the effect of using 5- fluorouracil cream (5-FU) versus modified carnoy's solution (MCS) as adjunctive methods in treatment of odontogenic keratocyst…
- Trial name
- NCT06820229
- Testing
- Enucleation, cyst enucleation
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
Denture, Partial, Removable
Digital Versus Conventional Altered Cast Techniques For Constructing Mandibular Distal Extension Removable Partial Dentures Using Digitally Fabricated Frameworks: Alveolar Bone Height Changes
This clinical study compares between digital and conventional altered cast techniques using digitally constructed frameworks in removable partial dentures' construction regarding their effect on bone height changes around…
- Trial name
- NCT05899712
- Testing
- Removable Partial Denture Construction
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Jaw, Edentulous, Edentulism, Complete
Tri-Lobe vs. Hexagonal Connections in Immediately Loaded Mandibular Overdentures
Objective: Compare changes in crestal bone height and peri-implant bone density using cone-beam computed tomography (CBCT) at baseline, 6 months, and 12 months post-placement.
- Conditions
- Jaw, Edentulous, Edentulism, Complete, Peri-implant Bone Loss
- Trial name
- NCT07824219
- Testing
- ReActive Implant System (Internal Tri-Lobe Platform), Legacy II Implant System (Internal Hexagonal Platform)
- Where
- United Arab Emirates
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Autism Spectrum Disorder
The Listening Program® With Bone Conduction Headphones Changes Hypersensitivity to Sound and Behavioral Responses
There are limited approaches to specifically address auditory sensory over- and under-responsivity (SOR) in children with Autism Spectrum Disorder (ASD).
- Trial name
- NCT05009095
- Testing
- The Listening Program® with bone conduction headphones
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Children's Health
Maxillary Sinus Disease, Periodontal Bone Loss
Association Between Periodontal Bone Loss and Maxillary Sinus Changes.
AIM AND OBJECTIVES: AIM To determine the association between periodontal bone loss and maxillary sinus changes through cone beam computed tomography. OBJECTIVES Primary objectives- 1.
- Trial name
- NCT04702867
- Where
- India
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Bio-Oss; Mucograft
Bone Volume Changes After Socket Preservation Using Geistlich Bio-Oss Collagen and Mucograft Seal
Evaluation of Bone volume Changes after socket preservation using Geistlich Bio-Oss® Collagen and Geistlich Mucograft® Seal compared to natural healing after tooth extraction
- Trial name
- NCT03395145
- Testing
- Geistlich Bio-Oss® Collagen and Geistlich Mucograft® Seal
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Alveolar Bone Atrophy
Effect of Socket Preservation Procedure on Dimensional Changes of the Ridge, and Its Efficacy.
In this study, the investigators will evaluate the dimensional changes of alveolar bone in the preserved sites in comparison with extraction only conventional healed sockets, as well. 1.
- Trial name
- NCT01268982
- Testing
- socket preservation
- Where
- Iran
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Periodontal Pocket
Gingival Crevicular Fluid Bone Morphogenetic Protein - 2 Release Profile Following the Use of Perforated Membrane
One of the most important elements suggested to be provided through membrane perforations to augment regeneration are cell released growth factors from the overlying periosteal and gingival cells.
- Trial name
- MPM (NCT01860495)
- Testing
- perforated membrane, G2
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Osteoporosis, Postmenopausal, Periodontitis
Alterations of GCF Levels of Sclerostin and DKK-1 in Postmenopausal Osteoporosis
Symptoms of periodontal disease are tissue destruction and destruction of the alveolar bone which supports the tooth. Wnt way (wingless-type MMTV integration site family) plays a role in the regulation of bone homeostasis in…
- Trial name
- NCT04149405
- Testing
- Phase 1 periodontal therapy, Bisphosphonate therapy
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University