Clinical trials: Bone Changes
Bone Alteration, Dietary Modification
Efficacy of a Once Daily Calcium and Vitamin D Fortified Food Product to Improve Bone Microarchitecture
The primary objective of this randomized, double-blind, placebo controlled trial is to determine the efficacy of a once per day calcium (1000mg) and vitamin D (1000IU) fortified food product on bone turnover markers, including…
- Trial name
- NCT02375503
- Testing
- Calcium/Vitamin D
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Edentulous Maxilla
4 vs 6 Implants in Totally Edentulous Patient in Maxilla With Ti. Cad-cam Framework
The primary objective of the present study is to evaluate the marginal bone level changes occurring in total edentulous patients treated with six or four implants.
- Trial name
- NCT02405169
- Testing
- 4 vs 6 implant treatment in the maxilla
- Where
- Italy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Institute Franci
Severe Aplastic Anemia
Clinical Study on Modified Allogeneic Hematopoietic Stem Cell Transplantation Regimen for Severe Aplastic Anemia
The aim of this study was to evaluate the safety and efficacy of a modified allogeneic hematopoietic stem cell transplantation regimen for aplastic anemia.
- Trial name
- NCT06378060
- Testing
- Modified transplantation system
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hematology department of the 920th hospital
Vitamin D Deficiency
The Effect of Vitamin D3 Therapy in Post Menopausal Women and Assessment of Changes in Bone Mineral Density After Orally Vitamin D3 Administration
a study design based on vitamin D deficiency in postmenopausal women with low bone density. pre-test for BMD will be done then vitamin D oral supplements will be provided for the period of 3 months.
- Trial name
- NCT05389943
- Testing
- Oral administration of vitamin D3, Vitamin D3 50000 UNT Oral Capsule, milk, Dietary and life style modifications.
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sargodha
Intrabony Periodontal Defect
Evaluation of Autogenous Demineralized Dentin Graft Vs Autogenous Bone Graft in Management of Intrabony Defects
The main goal is to evaluate and compare the clinical and radiographic efficacy of autogenous demineralized dentin as bone graft substitute versus autogenous bone graft when performed with modified minimally invasive surgical…
- Trial name
- NCT06048042
- Testing
- Autogenous Demineralized Dentin Graft, Autogenous Bone Graft
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Orthopedic Disorder
Evaluation of Architectural Changes in Mandibular Bone Pattern After Functional Treatment by Fractal Dimension Analysis
In this study it was aimed to examine the changes in mandibular bone after functional treatment by using fractal dimension (FD) and cortical thickness (CT) analysis.
- Trial name
- NCT04730115
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Muscular Disorders, Atrophic
What Are the Effects of Lower Limb Dysmetria on Gluteus Medius and Erector Spinae Musculature?
Gluteus Medius (GM) has also been implicated in the development of Low Back Pain (LBP). GM is one of the main pelvic, where he actively participates in control of motion in the frontal and transverse plane, and hip , improving…
- Trial name
- s-EMG (NCT06217835)
- Testing
- To evaluate the response of an orthopedic insole, evaluate activation of musculature
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Camilo Jose Cela University
Edentulous Alveolar Ridge, Dental Trauma
Dimensional Changes of the Labial Alveolar Ridge After Socket Shield Technique With Computer Guided Root Sectioning
In this study, the dimensional changes of the labial alveolar ridge are digitally assessed after immediate implant placement using the socket shield technique with computer guided sectioning of the root.
- Trial name
- NCT05366985
- Testing
- Socket shield technique with computer guided sectioning of the root
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Tendon Injuries, Tendinopathy
Identification of Early Changes in Patellar Tendinopathy Using Ultra-high Field Strength MRI
This project will investigate patellar tendon tissue (transmission electron microscopy of structure and protein analyses) coupled with magnetic resonance imaging (1.5T and 7T) from persons with i) chronic patellar tendinopathy…
- Conditions
- Tendon Injuries, Tendinopathy, Patella; Tendinitis
- Trial name
- 7TKnee (NCT04144946)
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Axial Spondyloarthritis, Ankylosing Spondylitis
Is the Human Microbiome Altered in Patients With Axial Spondyloarthritis?
This study aims to compare biological communities in stool samples obtained from age, diet and BMI-matched subjects in five study groups: subjects with ankylosing spondylitis (AS) never treated with tumor necrosing factor (TNF)…
- Trial name
- NCT02962479
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eyal Kedar
Aging
Age-related Changes in Ovarian Follicular Wave Dynamics
The investigators hypothesize that age-related changes in the number and growth dynamics of ovarian follicles will be associated with changes in hormone levels and corresponding changes in musculoskeletal health.
- Trial name
- NCT01389141
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Dental Prosthesis Complication
Functional Relining Versus Digital Altered Cast Using Digitally Fabricated Distal Extension Frameworks
This clinical study will be done to compare between functional relining and digital altered cast of selective pressure impression techniques for constructing mandibular distal extension removable partial dentures using digitally…
- Trial name
- NCT06082609
- Testing
- Removable partial denture
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Phenylketonuria
Nutritional and Neurotransmitter Changes in PKU Subjects on BH4
HYPOTHESIS: The investigators hypothesize that KuvanTM therapy could influence nutritional and body composition parameters and neurotransmitter concentrations in pediatric and adult PKU subjects.
- Trial name
- BH4&PKU (NCT00688844)
- Testing
- KuvanTM Therapy
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Emory University
Osteoporosis, Osteopenia
Effect of Assessing Risk for Osteoporosis on Physician and Patient Behaviors
The study seeks to determine the impact of assessing risk for osteoporosis in women on patient and physician behaviors through a pharmacist directed osteoporosis screening program.
- Trial name
- NCT01572766
- Testing
- FRAX Assessment Tool
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Dental Implant, Peri-Implantitis
Alveolar Ridge Sequelae Due to Peri-implantitis: a Retrospective Observational Study
The scientific evidence available at present regarding the alterations suffered by the alveolar ridge after the explantation of implants that have been considered to be abandoned due to periimplantitis, as well as the remaining…
- Conditions
- Dental Implant, Peri-Implantitis, Bone Remodeling
- Trial name
- NCT04534361
- Testing
- CBCT measurements
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Periodontitis, Periodontal Diseases
Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects
This study is meant to assess clinically and radiographically the possible predictable results regarding the use of nanocrystalline hydroxyapatite bone graft substitute together with papilla preservation flap versus papilla…
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Pocket, Intrabony Periodontal Defect
- Trial name
- NCT03588507
- Testing
- PPF+NCHA bone graft substitute
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Osteoporosis, Sarcopenia
Bone Microstructure After Gastrectomy Evaluating by Using HR-pQCT
Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy.
- Conditions
- Osteoporosis, Sarcopenia, Gastric Cancer
- Trial name
- NCT03398226
- Where
- Japan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nagasaki University
Edentulous Mandible
"Comparative Study of Supra-Structure Materials in Full-Arch Implant Prosthetics: a Randomized Clinical Trial"
after the implants' osseointegration period (4 months), digital scans will be taken for the implant positions and the STL files will be stored and sent for the CAD software to design a full arch restoration.
- Trial name
- CSDSMDA (NCT06673355)
- Testing
- dental implant prosthesis
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Osteoporosis
Changes of Bone Metabolic Markers and Bone Mineral Density After Denosumab and/or Teriparatide Treatment in Japanese Osteoporotic Patients
It has not been well known about the changes of bone metabolic markers, bone mineral density and other bone-related markers after teriparatide and/or denosumab treatment in Japanese osteoporotic patients.
- Trial name
- NCT02156960
- Testing
- Denosumab treatment in osteoporotic patients, Teriparatide treatment in osteoporotic patients, Denosumab and teriparatide treatment in osteoporotic patients
- Where
- Japan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shinshu University
Implant Complication
Digital Versus Conventional Impression CAD\CAM Constructed 4- Implant Supported Mandibular Overdenture Base
This clinical study was done to compare between digital with conventional impression used in the CAD/CAM constructed 4- implant supported mandibular overdenture base regarding their effect on the bone height changes
- Trial name
- NCT06071676
- Testing
- conventional impression group, digital impression group
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University